JP6193997B2 - 血管壁内へ直接薬剤を送達する針カテーテル - Google Patents
血管壁内へ直接薬剤を送達する針カテーテル Download PDFInfo
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- JP6193997B2 JP6193997B2 JP2015527497A JP2015527497A JP6193997B2 JP 6193997 B2 JP6193997 B2 JP 6193997B2 JP 2015527497 A JP2015527497 A JP 2015527497A JP 2015527497 A JP2015527497 A JP 2015527497A JP 6193997 B2 JP6193997 B2 JP 6193997B2
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- catheter
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Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/0105—Steering means as part of the catheter or advancing means; Markers for positioning
- A61M25/0133—Tip steering devices
- A61M25/0147—Tip steering devices with movable mechanical means, e.g. pull wires
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/02—Holding devices, e.g. on the body
- A61M25/04—Holding devices, e.g. on the body in the body, e.g. expansible
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
- A61M25/0082—Catheter tip comprising a tool
- A61M25/0084—Catheter tip comprising a tool being one or more injection needles
- A61M2025/0089—Single injection needle protruding axially, i.e. along the longitudinal axis of the catheter, from the distal tip
- A61M2025/009—Single injection needle protruding axially, i.e. along the longitudinal axis of the catheter, from the distal tip the needle having a bent tip, i.e. the needle distal tip is angled in relation to the longitudinal axis of the catheter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/1047—Balloon catheters with special features or adapted for special applications having centering means, e.g. balloons having an appropriate shape
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0097—Catheters; Hollow probes characterised by the hub
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Mechanical Engineering (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/586,746 | 2012-08-15 | ||
| US13/586,746 US9033917B2 (en) | 2012-08-15 | 2012-08-15 | Needle catheter for delivery of agents directly into vessel wall |
| PCT/US2013/054188 WO2014028306A1 (en) | 2012-08-15 | 2013-08-08 | Needle catheter for delivery of agents directly into vessel wall |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015524736A JP2015524736A (ja) | 2015-08-27 |
| JP2015524736A5 JP2015524736A5 (enExample) | 2016-09-29 |
| JP6193997B2 true JP6193997B2 (ja) | 2017-09-06 |
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ID=49029220
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015527497A Expired - Fee Related JP6193997B2 (ja) | 2012-08-15 | 2013-08-08 | 血管壁内へ直接薬剤を送達する針カテーテル |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US9033917B2 (enExample) |
| EP (1) | EP2885041B1 (enExample) |
| JP (1) | JP6193997B2 (enExample) |
| CN (1) | CN104661699B (enExample) |
| WO (1) | WO2014028306A1 (enExample) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070135875A1 (en) | 2002-04-08 | 2007-06-14 | Ardian, Inc. | Methods and apparatus for thermally-induced renal neuromodulation |
| US8150519B2 (en) | 2002-04-08 | 2012-04-03 | Ardian, Inc. | Methods and apparatus for bilateral renal neuromodulation |
| US9636174B2 (en) | 2002-04-08 | 2017-05-02 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for therapeutic renal neuromodulation |
| US7617005B2 (en) | 2002-04-08 | 2009-11-10 | Ardian, Inc. | Methods and apparatus for thermally-induced renal neuromodulation |
| US20070129761A1 (en) | 2002-04-08 | 2007-06-07 | Ardian, Inc. | Methods for treating heart arrhythmia |
| US20080213331A1 (en) | 2002-04-08 | 2008-09-04 | Ardian, Inc. | Methods and devices for renal nerve blocking |
| WO2006063199A2 (en) | 2004-12-09 | 2006-06-15 | The Foundry, Inc. | Aortic valve repair |
| EP2694150A1 (en) | 2011-04-08 | 2014-02-12 | Covidien LP | Iontophoresis drug delivery system and method for denervation of the renal sympathetic nerve and iontophoretic drug delivery |
| US9486276B2 (en) | 2012-10-11 | 2016-11-08 | Tva Medical, Inc. | Devices and methods for fistula formation |
| US20140200639A1 (en) | 2013-01-16 | 2014-07-17 | Advanced Neuromodulation Systems, Inc. | Self-expanding neurostimulation leads having broad multi-electrode arrays |
| HK1219068A1 (zh) | 2013-03-14 | 2017-03-24 | Tva Medical, Inc. | 瘻管配制装置和用於配制瘻管的方法 |
| CN105682729B (zh) | 2013-10-25 | 2019-06-18 | 直观外科手术操作公司 | 具有带槽的可操控管的柔性器械 |
| WO2015061692A1 (en) * | 2013-10-25 | 2015-04-30 | Intuitive Surgical Operations, Inc. | Flexible instrument with embedded actuation conduits |
| JP6268673B2 (ja) * | 2014-03-17 | 2018-01-31 | ニプロ株式会社 | 子カテーテル |
| WO2015171418A2 (en) | 2014-05-06 | 2015-11-12 | St. Jude Medical, Cardiology Division, Inc. | Electrode support structure assembly |
| US10118022B2 (en) | 2014-06-05 | 2018-11-06 | St. Jude Medical, Cardiology Division, Inc. | Deflectable catheter shaft section |
| US9844645B2 (en) | 2014-06-17 | 2017-12-19 | St. Jude Medical, Cardiology Division, Inc. | Triple coil catheter support |
| US10898096B2 (en) | 2014-10-27 | 2021-01-26 | St. Jude Medical, Cardiology Division, Inc. | Apparatus and method for connecting elements in medical devices |
| EP3209235B1 (en) | 2015-01-28 | 2019-06-26 | St. Jude Medical, Cardiology Division, Inc. | Thermal mapping catheter |
| US10603040B1 (en) | 2015-02-09 | 2020-03-31 | Tva Medical, Inc. | Methods for treating hypertension and reducing blood pressure with formation of fistula |
| WO2016176515A1 (en) * | 2015-04-28 | 2016-11-03 | Kassab Ghassan S | Materials and methods of using the same to improve structural integrity of a wall of a mammalian luminal organ |
| US10602983B2 (en) | 2015-05-08 | 2020-03-31 | St. Jude Medical International Holding S.À R.L. | Integrated sensors for medical devices and method of making integrated sensors for medical devices |
| JP6445742B1 (ja) | 2015-10-21 | 2018-12-26 | セント・ジュード・メディカル,カーディオロジー・ディヴィジョン,インコーポレイテッド | 高密度電極マッピングカテーテル |
| EP4205685B1 (en) | 2015-10-21 | 2024-08-28 | St. Jude Medical, Cardiology Division, Inc. | High density electrode mapping catheter |
| CA3011240A1 (en) | 2016-01-15 | 2017-07-20 | Tva Medical, Inc. | Systems and methods for adhering vessels |
| EP3402432B1 (en) | 2016-01-15 | 2023-05-31 | TVA Medical, Inc. | Devices for forming a fistula |
| AU2017207507B2 (en) | 2016-01-15 | 2021-11-11 | Tva Medical, Inc. | Devices and methods for advancing a wire |
| US10874422B2 (en) | 2016-01-15 | 2020-12-29 | Tva Medical, Inc. | Systems and methods for increasing blood flow |
| JP6528010B1 (ja) | 2016-05-03 | 2019-06-12 | セント・ジュード・メディカル,カーディオロジー・ディヴィジョン,インコーポレイテッド | イリゲーション型高密度電極カテーテル |
| WO2018080985A1 (en) | 2016-10-24 | 2018-05-03 | St. Jude Medical, Cardiology Division, Inc. | Catheter insertion devices |
| US11172858B2 (en) | 2016-10-28 | 2021-11-16 | St. Jude Medical, Cardiology Division, Inc. | Flexible high-density mapping catheter |
| CN110177494A (zh) | 2017-01-19 | 2019-08-27 | 圣犹达医疗用品心脏病学部门有限公司 | 鞘可视化 |
| JP6845337B2 (ja) * | 2017-03-27 | 2021-03-17 | ボストン サイエンティフィック サイムド,インコーポレイテッドBoston Scientific Scimed,Inc. | 組織構造を移動させるためのシステム |
| US11647935B2 (en) | 2017-07-24 | 2023-05-16 | St. Jude Medical, Cardiology Division, Inc. | Masked ring electrodes |
| CN111491582B (zh) | 2017-11-28 | 2023-12-05 | 圣犹达医疗用品心脏病学部门有限公司 | 受控式可膨胀导管 |
| US11116561B2 (en) | 2018-01-24 | 2021-09-14 | Medtronic Ardian Luxembourg S.A.R.L. | Devices, agents, and associated methods for selective modulation of renal nerves |
| US12156979B2 (en) | 2018-05-21 | 2024-12-03 | St. Jude Medical, Cardiology Division, Inc. | Deflectable catheter shaft with pullwire anchor feature |
| EP3768185B1 (en) | 2018-05-21 | 2023-06-14 | St. Jude Medical, Cardiology Division, Inc. | Radio-frequency ablation and direct current electroporation catheters |
| WO2020039392A2 (en) | 2018-08-23 | 2020-02-27 | St. Jude Medical, Cardiology Division, Inc. | Curved high density electrode mapping catheter |
| US12082936B2 (en) | 2018-09-27 | 2024-09-10 | St. Jude Medical, Cardiology Division, Inc. | Uniform mapping balloon |
| US11918762B2 (en) | 2018-10-03 | 2024-03-05 | St. Jude Medical, Cardiology Division, Inc. | Reduced actuation force electrophysiology catheter handle |
| US20210186601A1 (en) * | 2019-12-23 | 2021-06-24 | Ethicon, Inc. | Transesophageal Catheter for Thermal Protection of the Esophagus |
| EP4167886B1 (en) | 2020-08-18 | 2024-05-01 | St. Jude Medical, Cardiology Division, Inc. | High-density electrode catheters with magnetic position tracking |
| CN115530910B (zh) * | 2022-10-21 | 2024-10-29 | 苏州心锐医疗科技有限公司 | 一种定量式医用液体输送系统 |
| US20250144382A1 (en) * | 2023-11-03 | 2025-05-08 | Theraheart Inc. | Expandable apposition elements for shunting catheters |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1466889B1 (de) * | 1965-07-28 | 1970-04-23 | Eberhard Dr Regenbogen | Rektoskop zur Endoskopie des als Sigma bezeichneten Bereichs des menschlichen Darmes |
| US4578061A (en) | 1980-10-28 | 1986-03-25 | Lemelson Jerome H | Injection catheter and method |
| US5509900A (en) | 1992-03-02 | 1996-04-23 | Kirkman; Thomas R. | Apparatus and method for retaining a catheter in a blood vessel in a fixed position |
| DE4235506A1 (de) | 1992-10-21 | 1994-04-28 | Bavaria Med Tech | Katheter zur Injektion von Arzneimitteln |
| DE4408108A1 (de) | 1994-03-10 | 1995-09-14 | Bavaria Med Tech | Katheter zur Injektion eines Fluid bzw. eines Arneimittelns |
| US5464395A (en) | 1994-04-05 | 1995-11-07 | Faxon; David P. | Catheter for delivering therapeutic and/or diagnostic agents to the tissue surrounding a bodily passageway |
| US6375615B1 (en) | 1995-10-13 | 2002-04-23 | Transvascular, Inc. | Tissue penetrating catheters having integral imaging transducers and their methods of use |
| US6283951B1 (en) | 1996-10-11 | 2001-09-04 | Transvascular, Inc. | Systems and methods for delivering drugs to selected locations within the body |
| US6302875B1 (en) | 1996-10-11 | 2001-10-16 | Transvascular, Inc. | Catheters and related devices for forming passageways between blood vessels or other anatomical structures |
| US6726677B1 (en) * | 1995-10-13 | 2004-04-27 | Transvascular, Inc. | Stabilized tissue penetrating catheters |
| IL124037A (en) | 1995-10-13 | 2003-01-12 | Transvascular Inc | Device and system for interstitial transvascular intervention |
| GB2327614B (en) | 1997-07-30 | 2002-03-06 | Univ Dundee | A hypodermic needle |
| WO1999065561A1 (en) | 1998-06-19 | 1999-12-23 | Cordis Webster, Inc. | Method and apparatus for transvascular treatment of tachycardia and fibrillation |
| KR20010040761A (ko) | 1998-12-09 | 2001-05-15 | 쿡 인코포레이티드 | 중공의 만곡형 초탄성 의료용 니들 |
| US6217554B1 (en) | 1999-02-12 | 2001-04-17 | Pharmaspec Corporation | Methods and apparatus for delivering substances into extravascular tissue |
| US6302870B1 (en) | 1999-04-29 | 2001-10-16 | Precision Vascular Systems, Inc. | Apparatus for injecting fluids into the walls of blood vessels, body cavities, and the like |
| US6213976B1 (en) | 1999-07-22 | 2001-04-10 | Advanced Research And Technology Institute, Inc. | Brachytherapy guide catheter |
| US6629987B1 (en) | 1999-07-30 | 2003-10-07 | C. R. Bard, Inc. | Catheter positioning systems |
| US6458098B1 (en) | 2000-03-17 | 2002-10-01 | Nozomu Kanesaka | Vascular therapy device |
| JP4229621B2 (ja) | 2002-03-05 | 2009-02-25 | 修 加藤 | 薬液注入カテーテル |
| US7141041B2 (en) | 2003-03-19 | 2006-11-28 | Mercator Medsystems, Inc. | Catheters having laterally deployable needles |
| US20060167437A1 (en) | 2003-06-17 | 2006-07-27 | Flowmedica, Inc. | Method and apparatus for intra aortic substance delivery to a branch vessel |
| US7682358B2 (en) * | 2003-10-30 | 2010-03-23 | Medtronic, Inc. | Steerable catheter |
| DE602004032469D1 (de) * | 2003-11-17 | 2011-06-09 | Cook Critical Care Inc | Katheter mit zentrierdraht |
| JP5173799B2 (ja) * | 2005-05-19 | 2013-04-03 | オリンパス エンド テクノロジー アメリカ インコーポレイテッド | 回転前進カテーテル挿入システム |
| DE102007052513A1 (de) | 2007-10-26 | 2009-04-30 | Karl Storz Gmbh & Co. Kg | Medizinisches Instrument mit seitlich ausspreizbaren Injektionsnadeln |
| JP2012020105A (ja) * | 2010-06-18 | 2012-02-02 | Olympus Corp | カテーテル |
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- 2013-08-08 EP EP13752760.2A patent/EP2885041B1/en not_active Not-in-force
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| US20140052052A1 (en) | 2014-02-20 |
| WO2014028306A1 (en) | 2014-02-20 |
| JP2015524736A (ja) | 2015-08-27 |
| CN104661699A (zh) | 2015-05-27 |
| EP2885041A1 (en) | 2015-06-24 |
| US9033917B2 (en) | 2015-05-19 |
| CN104661699B (zh) | 2016-06-08 |
| EP2885041B1 (en) | 2015-12-30 |
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