JP6193570B2 - 産生宿主における抗体／タンパク質パフォーマンス及び発現の同時で統合された選択及び進化 - Google Patents

産生宿主における抗体／タンパク質パフォーマンス及び発現の同時で統合された選択及び進化 Download PDF

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JP6193570B2
JP6193570B2 JP2012520813A JP2012520813A JP6193570B2 JP 6193570 B2 JP6193570 B2 JP 6193570B2 JP 2012520813 A JP2012520813 A JP 2012520813A JP 2012520813 A JP2012520813 A JP 2012520813A JP 6193570 B2 JP6193570 B2 JP 6193570B2
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sequence
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ショート、ジェイ、ミルトン
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バイオアトラ、エルエルシー
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    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1058—Directional evolution of libraries, e.g. evolution of libraries is achieved by mutagenesis and screening or selection of mixed population of organisms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/06—Biochemical methods, e.g. using enzymes or whole viable microorganisms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Genetics & Genomics (AREA)
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  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Biophysics (AREA)
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  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Ecology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2012520813A 2009-07-17 2010-07-16 産生宿主における抗体／タンパク質パフォーマンス及び発現の同時で統合された選択及び進化 Active JP6193570B2 (ja)

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US27116809P 2009-07-17 2009-07-17
US61/271,168 2009-07-17
PCT/US2010/042302 WO2011009058A2 (en) 2009-07-17 2010-07-16 Simultaneous, integrated selection and evolution of antibody/protein performance and expression in production hosts

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JP2012533307A JP2012533307A (ja) 2012-12-27
JP2012533307A5 JP2012533307A5 (enExample) 2013-08-29
JP6193570B2 true JP6193570B2 (ja) 2017-09-13

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JP2015094521A Active JP6193913B2 (ja) 2009-07-17 2015-05-06 産生宿主における抗体／タンパク質パフォーマンス及び発現の同時で統合された選択及び進化
JP2017109593A Active JP6681131B2 (ja) 2009-07-17 2017-06-02 産生宿主における抗体／タンパク質パフォーマンス及び発現の同時で統合された選択及び進化

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JP2017109593A Active JP6681131B2 (ja) 2009-07-17 2017-06-02 産生宿主における抗体／タンパク質パフォーマンス及び発現の同時で統合された選択及び進化

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KR (5) KR20190017070A (enExample)
CN (2) CN102625848A (enExample)
AU (5) AU2010273974B2 (enExample)
BR (2) BR112012001171B1 (enExample)
CA (2) CA2768247C (enExample)
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JP2017205110A (ja) * 2009-07-17 2017-11-24 バイオアトラ、エルエルシー 産生宿主における抗体／タンパク質パフォーマンス及び発現の同時で統合された選択及び進化

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EP3636759B1 (en) 2023-10-11
AU2010273974B2 (en) 2016-01-14
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US20180371452A1 (en) 2018-12-27
EP2454376B1 (en) 2015-12-02
DK3636759T3 (da) 2023-10-23
MX392642B (es) 2025-03-19
EP2454376A4 (en) 2013-07-10
DK2907873T3 (en) 2016-06-13
AU2010273974A8 (en) 2012-02-23
EP2907873A1 (en) 2015-08-19
KR20220002712A (ko) 2022-01-06
MX347654B (es) 2017-05-05
AU2017203243B2 (en) 2019-07-11
JP6681131B2 (ja) 2020-04-15
EP3156485A1 (en) 2017-04-19
KR20120069664A (ko) 2012-06-28
IN2012DN00737A (enExample) 2015-06-19
US20240263354A1 (en) 2024-08-08
AU2015243076A1 (en) 2015-11-05
ES2581318T3 (es) 2016-09-05
EP2454376A2 (en) 2012-05-23
CN107090031A (zh) 2017-08-25
EP3156485B1 (en) 2018-09-12
JP2017205110A (ja) 2017-11-24
AU2019203813A1 (en) 2019-06-20
AU2015243076B2 (en) 2017-02-23
EP2907873B1 (en) 2016-04-06
EP3042957A1 (en) 2016-07-13
DK3406717T3 (da) 2020-03-16
JP6193913B2 (ja) 2017-09-06
MY160472A (en) 2017-03-15
US10047357B2 (en) 2018-08-14
SG10201505075TA (en) 2015-07-30
DK3042957T3 (en) 2018-01-02
PL3042957T3 (pl) 2018-03-30
PL2907873T3 (pl) 2016-10-31
US11976381B2 (en) 2024-05-07
AU2021203220A1 (en) 2021-06-10
CN102625848A (zh) 2012-08-01
JP2012533307A (ja) 2012-12-27
US20210207129A1 (en) 2021-07-08
AU2010273974A1 (en) 2012-02-09
AU2017203243A1 (en) 2017-06-08
HK1210623A1 (en) 2016-04-29
WO2011009058A2 (en) 2011-01-20
US20120245036A1 (en) 2012-09-27
SG177687A1 (en) 2012-02-28
AU2019203813B2 (en) 2021-03-11
WO2011009058A3 (en) 2011-04-14
US8859467B2 (en) 2014-10-14
MY173037A (en) 2019-12-20
ES2701931T3 (es) 2019-02-26
DK3156485T3 (en) 2019-01-07
PT3042957T (pt) 2017-12-21
BR112012001171A2 (pt) 2017-06-13
SG10201700096VA (en) 2017-02-27
CA3034484A1 (en) 2011-01-20
MX2012000803A (es) 2012-06-01
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EP3636759A1 (en) 2020-04-15
KR20190017070A (ko) 2019-02-19
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CA2768247C (en) 2019-04-09
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KR20210013294A (ko) 2021-02-03
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US20150024944A1 (en) 2015-01-22
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