JP6182141B2 - 抗真菌剤の効果を高めるアルギネートオリゴマーの使用 - Google Patents

抗真菌剤の効果を高めるアルギネートオリゴマーの使用 Download PDF

Info

Publication number
JP6182141B2
JP6182141B2 JP2014530315A JP2014530315A JP6182141B2 JP 6182141 B2 JP6182141 B2 JP 6182141B2 JP 2014530315 A JP2014530315 A JP 2014530315A JP 2014530315 A JP2014530315 A JP 2014530315A JP 6182141 B2 JP6182141 B2 JP 6182141B2
Authority
JP
Japan
Prior art keywords
tissue
mer
subject
antifungal agent
alginate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2014530315A
Other languages
English (en)
Japanese (ja)
Other versions
JP2014527079A5 (https=
JP2014527079A (ja
Inventor
エドヴァル オンソイェン
エドヴァル オンソイェン
アルネ デッセン
アルネ デッセン
デイビッド ウィリアム トーマス
デイビッド ウィリアム トーマス
カティヤ エテル ヒル
カティヤ エテル ヒル
ホーバー スレッタ
ホーバー スレッタ
アン トゥンデルヴィク
アン トゥンデルヴィク
ゲイル クリンケンベルグ
ゲイル クリンケンベルグ
ロルフ ミルヴォルド
ロルフ ミルヴォルド
Original Assignee
アルギファルマ エーエス
アルギファルマ エーエス
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by アルギファルマ エーエス, アルギファルマ エーエス filed Critical アルギファルマ エーエス
Publication of JP2014527079A publication Critical patent/JP2014527079A/ja
Publication of JP2014527079A5 publication Critical patent/JP2014527079A5/ja
Application granted granted Critical
Publication of JP6182141B2 publication Critical patent/JP6182141B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
    • A01N33/02—Amines; Quaternary ammonium compounds
    • A01N33/04—Nitrogen directly attached to aliphatic or cycloaliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
    • A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
    • A01N43/14—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings
    • A01N43/16—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings with oxygen as the ring hetero atom
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/50—1,3-Diazoles; Hydrogenated 1,3-diazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
    • A01N43/647—Triazoles; Hydrogenated triazoles
    • A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/734—Alginic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Emergency Medicine (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
JP2014530315A 2011-09-15 2012-09-14 抗真菌剤の効果を高めるアルギネートオリゴマーの使用 Active JP6182141B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1116010.8A GB201116010D0 (en) 2011-09-15 2011-09-15 Use of alginate oligomers to enhance the effects of antifungal agents
GB1116010.8 2011-09-15
PCT/GB2012/052274 WO2013038197A1 (en) 2011-09-15 2012-09-14 Use of alginate oligomers to enhance the effects of antifungal agents

Publications (3)

Publication Number Publication Date
JP2014527079A JP2014527079A (ja) 2014-10-09
JP2014527079A5 JP2014527079A5 (https=) 2015-11-05
JP6182141B2 true JP6182141B2 (ja) 2017-08-16

Family

ID=44908661

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014530315A Active JP6182141B2 (ja) 2011-09-15 2012-09-14 抗真菌剤の効果を高めるアルギネートオリゴマーの使用

Country Status (7)

Country Link
US (1) US20150126467A1 (https=)
EP (1) EP2755481B1 (https=)
JP (1) JP6182141B2 (https=)
DK (1) DK2755481T3 (https=)
ES (1) ES2798775T3 (https=)
GB (1) GB201116010D0 (https=)
WO (1) WO2013038197A1 (https=)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20150132585A (ko) * 2013-03-22 2015-11-25 요우이치 미즈타 식물 조직의 배양용 배지의 제조 방법 및 식물 조직의 배양 방법 및 멸균 처리제, 살균 처리제, 및 식물 조직 배양용 배지 조성물
KR101870846B1 (ko) * 2013-05-30 2018-06-25 수저우 시스케이프 바이오메디신 사이언스 앤드 테크놀로지 컴퍼니 리미티드 다기능성 조성물 및 이의 제조 방법과 용도
CN104435823B (zh) * 2014-11-14 2018-02-27 西藏月王藏药科技有限公司 一种青稞红曲藏药饮片的制备方法
WO2018127819A1 (en) 2017-01-03 2018-07-12 The University Of North Carolina At Chapel Hill Nitric oxide-releasing alginates as biodegradable antibacterial scaffolds and methods pertaining thereto
JP7112706B2 (ja) * 2017-01-16 2022-08-04 御木本製薬株式会社 抗菌性組成物並びに該抗菌性組成物を配合した皮膚外用剤
US10548948B2 (en) * 2017-03-02 2020-02-04 The United States Of America As Represented By The Secretary Of The Navy Methods of treating fungal infections
JP7403152B2 (ja) 2017-03-28 2023-12-22 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル 生分解可能な抗菌性スキャフォールドとしての一酸化窒素放出性ポリアミノグリコシドおよびそれに関する方法背景
EP3710514B1 (en) 2017-11-15 2023-06-07 The University of North Carolina at Chapel Hill Nitric oxide-releasing hyperbranched compounds as antibacterial scaffolds and methods pertaining thereto
CN107904179B (zh) * 2017-12-18 2020-10-23 云南天禾地生物科技股份有限公司 一株兼具植物促生长和抗病性的罗伦隐球酵母及其应用
CA3091458A1 (en) 2018-03-06 2019-09-12 The University Of North Carolina At Chapel Hill Nitric oxide-releasing cyclodextrins as biodegradable antibacterial scaffolds and methods pertaining thereto
WO2019180047A1 (en) * 2018-03-19 2019-09-26 Algipharma As Use of alginate oligomers to enhance the translocation of micro/nanoparticles across mucus layers
CN113383019B (zh) 2018-12-28 2023-11-17 北卡罗来纳大学教堂山分校 一氧化氮释放型抗菌聚合物和由其制成的支架和其相关方法
EP3841248A4 (en) * 2019-04-08 2022-05-04 Main Choice Paper Products Limited GERMAN BOOK AND FOOD PAPER PACKAGING AND METHOD OF MANUFACTURE
EP3837977A1 (en) 2019-12-19 2021-06-23 Université de Bourgogne Use of alginates oligomers to improve plant protection against pathogens
DE102020101110A1 (de) 2020-01-17 2021-07-22 Beuth Hochschule Für Technik Berlin Antimykotische Aktivitäten von Hydrogelen auf Basis von Polysacchariden
CN111701013A (zh) * 2020-07-02 2020-09-25 深圳市恩瑜生物科技有限公司 一种具有治疗真菌感染的外用药物及制备方法
CN113430125B (zh) * 2021-07-27 2022-11-08 塔里木大学 一种高酯化力与糖化力的混合菌剂及其培养方法
CN114009440A (zh) * 2021-11-22 2022-02-08 兰州大学 阿巴芬净在防治农业病原菌中的用途
US20230346101A1 (en) * 2022-04-29 2023-11-02 Distinct Dermatology Inc. Treatment of fungal nail infection
WO2026008878A1 (en) * 2024-07-04 2026-01-08 Algipharma As Antimycotic polyene-alginate oligomer conjugates

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991011205A1 (en) 1990-01-23 1991-08-08 Trancel Corporation Mannuronic acid containing alginate wound healing composition and method
US5169840A (en) 1991-03-27 1992-12-08 Nobipols Forskningsstiftelse Diequatorially bound β-1, 4 polyuronates and use of same for cytokine stimulation
US5217493A (en) * 1992-03-11 1993-06-08 Board Of Regents, The University Of Texas System Antibacterial coated medical implants
CA2106609A1 (en) 1992-09-28 1994-03-29 Irene Yeatman Aldridge Proteases to inhibit and remove biofilm
GB9221163D0 (en) 1992-10-08 1992-11-25 Nobipol And Protan Biopolymer Dna compounds
JPH093031A (ja) * 1995-04-17 1997-01-07 Mitsubishi Chem Corp ヒドロキサム酸誘導体並びにそれを含有する農園芸用殺菌剤
EP0807631B1 (en) * 1996-05-15 2003-03-12 Sankyo Company Limited Tricyclic compounds having fungicidal activity, their preparation and their use
NO305033B1 (no) 1997-05-09 1999-03-22 Algipharma As Fremgangsmate for fremstilling av uronsyreblokker fra alginat
US7494669B2 (en) 2001-02-28 2009-02-24 Carrington Laboratories, Inc. Delivery of physiological agents with in-situ gels comprising anionic polysaccharides
NO326145B1 (no) 2001-11-30 2008-10-06 Fmc Biopolymer As Fremgangsmate for a stimulere vektokning hos pattedyr, fugler og krypdyr.
NO20023581D0 (no) 2002-07-26 2002-07-26 Fmc Biopolymer As Nye mutantstammer av Pseudomonas fluorescens og varianter derav, metoder for produksjon og bruk derav til produksjon avalginat
GB2430881B (en) 2005-10-06 2010-10-13 Ntnu Technology Transfer As Oligoelectrolyte polyols for the treatment of mucosal hyperviscosity
GB0707096D0 (en) 2007-04-12 2007-05-23 Ntnu Technology Transfer As Method
HUE034051T2 (en) * 2007-11-27 2018-01-29 Algipharma As Use of alginate-containing oligomers to combat biofilms

Also Published As

Publication number Publication date
DK2755481T3 (da) 2020-06-15
EP2755481A1 (en) 2014-07-23
WO2013038197A1 (en) 2013-03-21
US20150126467A1 (en) 2015-05-07
EP2755481B1 (en) 2020-03-18
GB201116010D0 (en) 2011-10-26
ES2798775T3 (es) 2020-12-14
JP2014527079A (ja) 2014-10-09

Similar Documents

Publication Publication Date Title
JP6182141B2 (ja) 抗真菌剤の効果を高めるアルギネートオリゴマーの使用
JP5202763B2 (ja) アルギネートオリゴマーと抗生物質とによるアシネトバクター感染の治療
Wei et al. In vitro synergism between berberine and miconazole against planktonic and biofilm Candida cultures
Shahzad et al. Utilising polyphenols for the clinical management of Candida albicans biofilms
US20150030701A1 (en) Antimicrobial compositions and methods
Ngono Ngane et al. Antifungal activity of Chromolaena odorata (L.) King & Robinson (Asteraceae) of cameroon
CN108348453B (zh) 包含莫匹罗星及新霉素的抗微生物组合物
US12403169B2 (en) Compositions and methods related to Rhamnus prinoides (gesho) extract for the inhibition of polymicrobial biofilm formation
US9474723B2 (en) Anti-microbial composition
CN115120602A (zh) 一种抗真菌药物增效剂
CN105102441A (zh) 抗真菌化合物及其用途
Santos et al. Biofilm: A robust and efficient barrier to antifungal chemotherapy
CN115397409A (zh) 用于破坏生物膜形成和治疗生物膜相关疾病的组合物
FR2966698A1 (fr) Composition dermo-cosmetique anti-microbienne pour animaux
CN106572995B (zh) 含有fk506衍生物的用于治疗隐球菌属霉菌和念珠菌属霉菌引起的真菌感染的药剂学组合物及其用途
JPWO2017038872A1 (ja) 抗真菌活性を有する組成物
CN108653717A (zh) ε-聚赖氨酸联合抗真菌药物的应用及其产品
KR101326164B1 (ko) 항균성 피부 외용제 조성물
Maghfiroh et al. Effect of propolis on the adhesion index, morphology and viability of Candida albicans cells on biofilm formation
US20190075794A1 (en) Biodegradable antimicrobial compositions and uses thereof to combat microorganisms
Abdulghani et al. Clinical Significance, Molecular Formation, and Natural Antibiofilm Agents of Candida albicans
US20200237705A1 (en) Method to treat antimicrobial resistant candida
Saad et al. Antimicrobial Activity of Mangrove Plant Acrostichum speciosum
Roilides et al. Fusarium and Scedosporium: emerging fungal pathogens
Rasi-Bonab et al. Evaluation of silver nanoparticles and alcoholic extract of Amaranthus retroflexus on pathogenic bacteria

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20150911

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20150911

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20160830

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20161128

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170127

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20170509

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170530

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20170627

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20170721

R150 Certificate of patent or registration of utility model

Ref document number: 6182141

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250