JP2014527079A - 抗真菌剤の効果を高めるアルギネートオリゴマーの使用 - Google Patents
抗真菌剤の効果を高めるアルギネートオリゴマーの使用 Download PDFInfo
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- JP2014527079A JP2014527079A JP2014530315A JP2014530315A JP2014527079A JP 2014527079 A JP2014527079 A JP 2014527079A JP 2014530315 A JP2014530315 A JP 2014530315A JP 2014530315 A JP2014530315 A JP 2014530315A JP 2014527079 A JP2014527079 A JP 2014527079A
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- tissue
- alginate oligomer
- alginate
- fungus
- antifungal agent
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Abstract
【選択図】なし
Description
ェニルフェノキサイド、スピロキサミン、スルトロペン、チシオフェンまたはトリシクラゾールを含むが、これらに限定されない。殺菌剤は、機能上許容可能な任意の塩又は水和物を含む任意の好都合な形態で使用され得る。上に記載される殺菌剤に対する参照は、化合物が2以上のアイソマーの混合物、例えばラセミ混合物と同様に存在し得る任意の異性体型まで拡張する。
真菌における少なくとも1つの抗真菌剤に対する耐性を克服する方法であって、上記真菌を(具体的には効果的な量の)抗真菌剤と共に(具体的には効果的な量の)アルギネートオリゴマーと接触させることを含む、方法。本方法は、in vitro方法又はex vivo方法であり得る。
上記真菌における抗真菌剤に対する耐性を克服するため、上記抗真菌剤に耐性の真菌に感染した、感染の疑いがある、又は感染のリスクがある被験体の治療における少なくとも1つの抗真菌剤と共に使用するアルギネートオリゴマー。
上記真菌における抗真菌剤に対する耐性を克服するため、上記抗真菌剤に耐性の真菌に感染した、感染の疑いがある、又は感染のリスクがある被験体の治療における少なくとも1つの抗真菌剤と共に使用する薬剤の製造のためのアルギネートオリゴマーの使用。
上記真菌における抗真菌剤に対する耐性を克服するため、上記抗真菌剤に耐性の真菌に感染した、感染した疑いがある、又は感染のリスクがある被験体の治療において、別々に、同時に又は順次に使用される複合製剤としてアルギネートオリゴマーと抗真菌剤とを含有する製品。
抗真菌剤に耐性の真菌による部位のコロニー形成を抑制する方法であって、上記部位及び/又は上記真菌を、(具体的には効果的な量の)上記真菌が耐性である抗真菌剤と共に(具体的には効果的な量の)アルギネートオリゴマーに接触させることを含む、方法。そのような方法は、具体的にはin vitro又はex vivo方法であり得る。
抗真菌剤に耐性の真菌(真菌の集団並びに個々の若しくは単一の真菌又は真菌細胞を含む)を抑制する方法であって、上記真菌又は上記真菌が存在するか若しくは位置し得る部位を、(具体的には効果的な量の)上記真菌が耐性である抗真菌剤と共に(具体的には効果的な量)アルギネートオリゴマーに接触させることを含む、方法。そのような方法は、具体的にはin vitro方法であり得る。
使用した抗真菌剤(ナイスタチン及びアムホテリシンB)は、それぞれSigma Aldrich及びUSP Reference Standardsから購入された医薬品グレードのものであった。OligoG CF−5/20 Gブロックアルギネートオリゴマー(DP5〜20、平均分子量2600、G残基90〜95%)はAlgiPharma AS、ノルウェーより提供を受けた。使用したミューラーヒントンブロスはLab M LimitedによるLAB114であった。M19を社内で調製した(ペプトン(Oxoid)9.4g/L;酵母エキス(Oxoid)4.7g/L;牛肉エキス(Difco)2.4g/L;グルコース(BDH)10g/L;除菌濾過の前にHClによりpHを6.1に調整する)。YMアガー/ブロスはDifcoによる271120であった。
24時間のインキュベーションで観察された結果を表1に示す。
実施例1に記載されるロボットアッセイを本実施例において利用した。株をミューラーヒントンブロス(Lab M LimitedによるLAB114)中で成長させ、0%、2%、6%及び10%のOligoG CF−5/20 Gフラグメントの存在下で48時間インキュベートした後、各抗真菌剤についてMIC値(μg ml−1)を判定した。使用した抗真菌剤(ナイスタチン、フルコナゾール及びテルビナフェン)はSigma Aldrichから購入された医薬品グレードのものであった。OligoG CF−5/20 GフラグメントはAlgiPharma AS、ノルウェーにより提供を受けた。
カンジダ・アルビカンスCCUG 39343(微生物株保存機関による株)
カンジダ・パラシローシスATCC 22019T(微生物株保存機関による株)
カンジダ・クルセイ141/03(カンジダ症)
カンジダ・クルセイ249/03(2)(潰瘍形成)
カンジダ・ルシタニエ994/01(2)(カンジダ症)
カンジダ・トロピカリス12(膣)
カンジダ・トロピカリス75(膣)
カンジダ・トロピカリス519468(泌尿器)
カンジダ・トロピカリス544123(泌尿器)
カンジダ・トロピカリス250/03(カンジダ症)
カンジダ・トロピカリスAG1(口腔)
カンジダ・トロピカリスT2.2(口腔)
結果を表2に示す。試験した全ての種及び株に対する2つの異なるタイプの抗真菌剤(ナイスタチン及びフルコナゾール)についてのMIC値は、OligoG CF−5/20の添加により減少した。本研究は、真菌種の種類及び抗真菌剤の分類を超えて抗真菌剤を増強するGブロックアルギネートオリゴマーの可能性を強調する。
本実施例で使用したカンジダ株、抗真菌剤(フルコナゾール)及びOligoG CF−5/20は、実施例2に記載されるものと同じである。
48時間のインキュベーションで観察された結果を表3に示す。
使用した抗真菌剤(ナイスタチン、アムホテリシンB、ミコナゾール、ボリコナゾール、フルコナゾール及びテルビナフェン)は、Sigma Aldrich及びUSP Reference Standardsから購入された医薬品グレードのものであった。OligoG CF−5/20 Gブロックアルギネートオリゴマーは、AlgiPharma AS、ノルウェーにより提供を受けた。使用したミューラーヒントンブロスは、Lab M LimitedによるLAB114であった。YMアガー/ブロスはDifcoによる271120であった。
アスペルギルス・ニガーCCUG 18919(微生物株保存機関による株;ブルーベリー)
アスペルギルス・フミガーツスCCUG 17460(微生物株保存機関による株)
アスペルギルス・フラバスCCUG 28296(微生物株保存機関による株;靴底)
48時間のインキュベーションで観察された結果を表4に示す。
実施例1に記載されるロボットアッセイを本実施例において利用した。さらに、水溶性喘息/COPD薬、臭化イプラトロピウム一水和物、サルブタモール及びブデソニドをOligoG CF−5/20を含む及び含まない、並びに抗真菌剤を含む又は含まないミューラーヒントンブロスに溶解して所望の濃度を得た。水不溶性であるフマル酸ホルモテロール二水和物をDMSOに溶解し、直接384プレートに添加した。培養培地中の最終DMSO濃度は、指標生物の成長に顕著な影響を及ぼさない2%であった。種々の成分について利用された濃度は、Manocha et al. (2006)からの情報に基づくものであった。臭化イプラトロピウム一水和物、サルブタモール、ブデソニド及びフマル酸ホルモテロール二水和物はSigma Aldrichから入手された、医薬品グレードのものであった。
選択されたよく使用される代表的な喘息/COPD薬が、カンジダ・アルビカンスに関するナイスタチン/アムホテリシンB及びGブロックアルギネートオリゴマーの組合せのMIC値に対して影響を及ぼし得るかどうかを試験するため、実施例1に記載されるMICアッセイにおけるこれらの薬剤を添加する効果を判定した。このアッセイにおいて、これが標準化MICアッセイ用に指定された培地であることから(Jorgensen et al., 1999)、ミューラーヒントンブロスのみを使用した。
使用した抗真菌剤(ナイスタチン、アムホテリシンB、ミコナゾール、及びフルコナゾール)は、Sigma Aldrich及びUSP Reference Standardsから購入した医薬品グレードのものであった。OligoG CF−5/20 Gブロックアルギネートオリゴマーは、AlgiPharma AS、ノルウェーより提供を受けた。使用したミューラーヒントンブロスは、Lab M LimitedによるLAB114であった。YMアガー/ブロスはDifcoによる271120であった。サブロー培地を社内で作製した(グルコース、20g/l;トリプトン、5g/l;ペプトン、5g/l)。RPMIはSigmaによるものであり、グルコース2%で補填した。
クリプトコッカス・ネオフォルマンスCCUG 23451(ヒト脳脊髄液)
クリプトコッカス・ネオフォルマンスに対する異なる分類由来の抗真菌剤、すなわちポリエン抗真菌剤(ナイスタチン及びアムホテリシンB)及びアゾール抗真菌剤(フルコナゾール及びミコナゾール)の効果を増強するOligoG CF−5/20の能力をMICアッセイにおいて検討した。
Claims (36)
- 真菌に対する抗真菌剤の有効性を改善する方法であって、前記抗真菌剤をアルギネートオリゴマーと共に使用することを含む、方法。
- 前記真菌、又は該真菌が位置するか、若しくは位置し得る部位を、前記抗真菌剤及び前記アルギネートオリゴマーに接触させることを含む、請求項1に記載の方法。
- 真菌に感染した、感染した疑いがある、又は感染のリスクがある被験体の治療において、少なくとも1つの抗真菌剤と共に使用されるアルギネートオリゴマー。
- 真菌に感染した、感染した疑いがある、又は感染のリスクがある被験体の治療において、少なくとも1つの抗真菌剤と共に使用される薬剤の製造におけるアルギネートオリゴマーの使用。
- 真菌に感染した、感染した疑いがある、又は感染のリスクがある被験体の治療において、別々に、同時に又は順次に使用される複合製剤としてアルギネートオリゴマーと抗真菌剤とを含有する製品。
- 真菌による部位のコロニー形成を抑制するin vitro方法であって、前記部位及び/又は前記真菌を、少なくとも1つの抗真菌剤と共にアルギネートオリゴマーに接触させることを含む、方法。
- 前記抗真菌剤の抗菌効果が高められる、請求項1〜6のいずれか一項に記載のアルギネートオリゴマー、使用、製品又は方法。
- 前記抗真菌剤が、抗真菌性抗生物質であり、好ましくはポリエン抗真菌剤、アゾール抗真菌剤、アリルアミン抗真菌剤及びエキノキャンディン抗真菌剤から選択される、請求項1〜7のいずれか一項に記載の方法、アルギネートオリゴマー、使用又は製品。
- 前記抗真菌剤が、ナタマイシン、リモシジン、ナイスタチン、アムホテリシンB、カンジシン、ハマイシン、ペリマイシン、ミコナゾール、ケトコナゾール、クロトリマゾール、エコナゾール、オモコナゾール、ビホナゾール、ブトコナゾール、フェンチコナゾール、イソコナゾール、オキシコナゾール、セルタコナゾール、スルコナゾール、チオコナゾール、フルコナゾール、ホスフルコナゾール、イトラコナゾール、イサブコナゾール、ラブコナゾール、ポサコナゾール、ボリコナゾール、テルコナゾール、アルバコナゾール、アバファンギン、テルビナフェン、ナフティフィン、ブテナフィン、アモロルフィン、アニデュラファンギン、カスポファンギン、ミカファンギン、シクロピロックス、トルナフテート、及びフルシトシンから選択される、請求項8に記載の方法、アルギネートオリゴマー、使用、又は製品。
- 前記抗真菌剤が殺菌剤である、請求項1〜7のいずれか一項に記載の方法、アルギネートオリゴマー、使用、又は製品。
- 前記真菌が、動物病原体、植物病原体、木材腐朽菌及び/又はマイコトキシンを産生する真菌である、請求項1〜10のいずれか一項に記載の方法、アルギネートオリゴマー、使用、又は製品。
- 前記真菌が、分類上のカンジダ属、アスペルギルス属、クリプトコッカス属、マラセチア属、トリコスポロン属、フザリウム属、アクレモニウム属、ペシロマイセス属、リゾプス属、ムコール属、セドスポリウム属、アブシディア属、ウスチラゴ属、アルテルナリア属、コクリオボルス属、セルプラ属、メールリポリア属、フィブロポリア属、コニオフォラ属、フェリナス属、ペニシリウム属、モナスカス属、クラビセプス属、ミロテシウム属、トリコデルマ属、トリコテシウム属、セファロスポリウム属、バーティシモノスポリウム属、及びスタキボトリス属から選択される1種である、請求項1〜11のいずれか一項に記載の方法、アルギネートオリゴマー、使用、又は製品。
- 前記真菌が、
カンジダ・アルビカンス、カンジダ・グラブラタ、カンジダ・トロピカリス、カンジダ・ルシタニエ、カンジダ・ドュブリニエンシス、カンジダ・パラシローシス、カンジダ・クルセイ、カンジダ・ルゴサ、アスペルギルス・ニガー、アスペルギルス・フミガーツス、アスペルギルス・フラバス、アスペルギルス・クラバタス、アスペルギルス・テレウス、クリプトコッカス・ネオフォルマンス、クリプトコッカス・ガッティ、クリプトコッカス・ローレンティ、クリプトコッカス・アルビダス、マラセチア・パキデルマティス、マラセチア・フルフル、トリコスポロン・クタネウム、フザリウム・オキシスポラム、フザリウム・バーティシリオイデス、フザリウム・プロリフェラタム、フザリウム・モニリフォルメ、アクレモニウム・キリエンセ、アクレモニウム・ストリクタム、ペシロマイセス・リラシヌス、リゾプス・オリゼ、ムコール・インディカス、セドスポリウム・プロリフィカンス、アブシディア・コリンビフェラ、フザリウム・グラミネアラム、フザリウム・オキシスポラムf.sp.キューベンセ、フザリウム・アベナセウム、フザリウム・カルモラム、フザリウム・グラミネアラム、フザリウム・ポアエ、フザリウム・ニバーレ、トウモロコシ黒穂病菌、ウスチラゴ・ヌーダ、ウスチラゴ・トリティキ、ウスチラゴ・ホルディ、ウスチラギノイデア・ビレンス、エンバク裸黒穂病菌、アルテルナリア・アルテルナータ、アルテルナリア・アルボレセンス、アルテルナリア・アルブスティ、アルテルナリア・ブルメアエ、アルテルナリア・ブラシカ、アルテルナリア・ブラッシコーラ、アルテルナリア・ブルンシイ、アルテルナリア・カロチインクルタエ、アルテルナリア・コンジュンクタ、アルテルナリア・エウフォルビイコラ、アルテルナリア・ガイセン、アルテルナリア・インフェクトリア、アルテルナリア・ジャポニカ、アルテルナリア・パナックス、アルテルナリア・ペトロセリニ、アルテルナリア・ラディキナ、アルテルナリア・ラファニ、アルテルナリア・サポナリエ、アルテルナリア・セリニ、アルテルナリア・ソラニ、アルテルナリア・スミルニイ、コクリオボルス・カルボヌム、コクリオボルス・ヘテロストロフス、コクリオボルス・ルナツス、コクリオボルス・ステノスピルス、セルプラ・ラクリマンス、メールリポリア・インクラサタ、フィブロポリア・バイランティー、コニオフォラ・プテアナ、フェリウス・コンティグウス、ペニシリウム・クリソゲナム、リゾプス・ストロニファー、ペニシリウム・エクスパンサム、アスペルギルス・パラジチカス、アスペルギルス・オクラセウス、アスペルギルス・カーボナリウス、ペニシリウム・ビリディカータム、アスペルギルス・ニベウス、アスペルギルス・オリゼ、アスペルギルス・テレウス、モナスカス・ルバー、モナスカス・プルプレウス、ペニシリウム・シトリヌム、ペニシリウム・カメンベルティ、モロコシ麦角病菌、クラビセプス・フシホルミス、クラビセプス・パスパリ、クラビセプス・プルプレア及びペニシリウム・エクスパンサムから選択される、請求項1〜12のいずれか一項に記載の方法、アルギネートオリゴマー、使用、又は製品。 - 前記真菌が、カンジダ・アルビカンス、カンジダ・グラブラタ、カンジダ・トロピカリス、カンジダ・パラプローシス、カンジダ・クルセイ及びカンジダ・ルシタニエ、アスペルギルス・フラバス、アスペルギルス・ニガー、アスペルギルス・フミガーツス及びクリプトコッカス・ネオフォルマンスから選択される、請求項13に記載の方法、アルギネートオリゴマー、使用又は製品。
- 前記感染が、アスペルギルス症、カンジダ症、コクシジオイデス症、クリプトコッカス症、ヒストプラスマ症、ブラストミセス症、パラコクシジオイデス症、ニューモシスチス症、フザリウム症、アルテルナリア症、リノスポリジウム症、バシディオボルス症、コニディオボルス症、ムコール症、トリコスポロン症、ゲオトリクム症、アレシェリア症、スポロトリクム症、ペニシリウム症、ロボア症又はピチロスポルム毛包炎である、請求項3〜5及び7〜11のいずれか一項に記載のアルギネートオリゴマー、使用又は製品。
- 前記アルギネートオリゴマーが35000ダルトン未満、好ましくは30000ダルトン、25000ダルトン又は20000ダルトン未満の平均分子量を有する、請求項1〜15のいずれか一項に記載の方法、アルギネートオリゴマー、使用又は製品。
- 前記アルギネートオリゴマーが2〜100、好ましくは2〜75、2〜50、2〜35、2〜30、2〜25又は2〜20の数平均重合度を有する、請求項1〜15のいずれか一項に記載の方法、アルギネートオリゴマー、使用又は製品。
- 前記アルギネートオリゴマーが最大100個のモノマー残基を有し、好ましくは2−mer〜35−mer、2−mer〜30−mer、3−mer〜35−mer、3−mer〜28−mer、4−mer〜25−mer、5−mer〜20−mer、6−mer〜22−mer、8−mer〜20−mer又は10−mer〜15−merである、請求項1〜15のいずれか一項に記載の方法、アルギネートオリゴマー、使用又は製品。
- 前記アルギネートオリゴマーが少なくとも70%のG残基を有する、請求項1〜18のいずれか一項に記載の方法、アルギネートオリゴマー、使用又は製品。
- 前記アルギネートオリゴマーが少なくとも80%又は少なくとも90%、好ましくは少なくとも95%のG残基を有する、請求項19に記載の方法、アルギネートオリゴマー、使用又は製品。
- 前記G残基の少なくとも80%がGブロック中に配置される、請求項18又は20に記載の方法、アルギネートオリゴマー、使用又は製品。
- 前記アルギネートオリゴマーが少なくとも70%のM残基を有する、請求項1〜18のいずれか一項に記載の方法、アルギネートオリゴマー、使用又は製品。
- 前記アルギネートオリゴマーが少なくとも80%又は少なくとも90%のM残基、好ましくは少なくとも95%又は100%のM残基を有する、請求項22に記載の方法、アルギネートオリゴマー、使用又は製品。
- 前記M残基の少なくとも80%がMブロック中に配置される、請求項22又は23に記載の方法、アルギネートオリゴマー、使用又は製品。
- 前記感染が、表在性真菌症、皮膚真菌症、皮下真菌症又は全身性真菌症、侵襲性真菌症若しくは播種性真菌症である、請求項3〜5及び7〜24のいずれか一項に記載のアルギネートオリゴマー、使用又は製品。
- 前記感染が口腔、生殖器官、尿路、気道、胃腸管、腹膜、中耳、前立腺、血管内膜、結膜若しくは角膜組織を含む眼、肺組織、心臓弁、皮膚、頭皮、爪、創傷内側における表面、若しくは副腎組織、肝臓組織、腎臓組織、膵臓組織、下垂体組織、甲状腺組織、免疫組織、卵巣組織、精巣組織、前立腺組織、子宮内膜組織、眼組織、乳房組織、脂肪組織、上皮組織、内皮組織、神経組織、筋肉組織、肺組織、表皮組織若しくは骨組織の表面から選択される身体の内部若しくは外部の表面の感染、又は血液、血漿、血清、脳脊髄液、消化管内容物、痰、肺分泌物及び精液から選択される体液中の感染、又は副腎組織、肝臓組織、腎臓組織、膵臓組織、下垂体組織、甲状腺組織、免疫組織、卵巣組織、精巣組織、前立腺組織、子宮内膜組織、眼組織、乳房組織、脂肪組織、上皮組織、内皮組織、神経組織、筋肉組織、肺組織、表皮組織又は骨組織から選択される身体組織内若しくは身体組織上の感染である、請求項3〜5及び7〜25のいずれか一項に記載のアルギネートオリゴマー、使用又は製品。
- 前記真菌症が、真菌性副鼻腔炎、耳真菌炎、真菌性角膜炎、爪真菌症、真菌性髄膜炎、菌腫、皮膚糸状菌症、微胞子虫症、黒色菌糸症、ムコール症、黒色分芽菌症及び砂毛症から選択される、請求項25に記載の方法、アルギネートオリゴマー、使用、又は製品。
- 前記被験体が、予め確立した感染を有する被験体、免疫不全状態の被験体、集中治療若しくは救急治療を受けている被験体、外傷を患っている被験体、火傷を有する被験体、急性及び/又は慢性の創傷を有する被験体、新生児被験体、高齢の被験体、がんを有する被験体、栄養失調の被験体、アルコール依存症の被験体、自己免疫状態を患う被験体、上皮分泌物若しくは内皮分泌物、及び/又は分泌物の排出の減少若しくは抑制を伴う被験体、抗生物質療法を受けているか若しくは該療法から回復している被験体、ステロイド療法を受けているか若しくは該療法から回復している被験体、又は医療用デバイスが取り付けられた被験体である、請求項3〜5、又は7〜27のいずれか一項に記載のアルギネートオリゴマー、使用、又は製品。
- 前記被験体がHIV、敗血症、敗血症ショック、AIDS、免疫系のがん、関節リウマチ、I型糖尿病、クローン病、COPD、COAD、COAP、気管支炎、嚢胞性線維症、気腫、肺がん、喘息、肺炎及び副鼻腔炎から選択される病状を有する被験体、化学療法及び/又は放射線療法の準備をしている、該療法を受けている、若しくは該療法から回復している被験体、臓器移植被験体、健康管理機関に居住している被験体、又は喫煙者から選択される、請求項28に記載のアルギネートオリゴマー、使用又は製品。
- 前記被験体が、好ましくはCOPD、COAD、COAP、気管支炎、嚢胞性線維症、気腫、肺がん、喘息及び肺炎から選択される呼吸器の病状又は疾患を有する被験体から選択される、請求項28に記載のアルギネートオリゴマー、使用又は製品。
- 前記真菌が無生物の表面上又は無生物の材料中のものである、請求項1、2、6〜14及び16〜24のいずれか一項に記載の方法。
- 前記真菌が食品若しくは飲料の加工処理、調製、貯蔵若しくは充填用の機械若しくは設備の表面、空調装置の表面、工業用機械の表面、貯蔵タンクの表面、医療用設備若しくは外科用設備の表面、水上用/海洋用設備の表面、又は建築物及び他の構造の表面から選択される表面上のものである、請求項1、2、6〜14、16〜24及び31のいずれか一項に記載の方法。
- 前記表面が食品の加工処理、貯蔵、充填若しくは調製用の設備若しくは表面、タンク、コンベヤ、床、ドレイン、クーラー、フリーザ、設備表面、壁、バルブ、ベルト、パイプ、空調管、冷却装置、食品若しくは飲料の充填ライン、熱交換器、ボートの船体、歯科用水道、石油掘削管、コンタクトレンズ、コンタクトレンズ貯蔵ケース、カテーテル、補綴デバイス又は植込式医療デバイスから選択される、請求項32に記載の方法。
- 前記真菌が医療廃棄物/実験廃棄物、土壌、堆肥、動物製品及び植物製品、動物又はヒト用の食品、個人衛生用品、化粧品、飲料水、廃水、農業用飼料及び農業用水、殺虫剤製剤、農薬製剤、除草剤製剤、工業用潤滑油、工業材料、細胞及び組織の培養培地、細胞及び組織の培養物、植物培養培地、並びに植物培養物から選択される材料中のものである、請求項1、2、6〜14、16〜24及び31のいずれか一項に記載の方法。
- 前記真菌が植物、又は好ましくは、根、地下茎、葉状体、茎、枝、葉、針状葉、棘、種子、莢、種殻、球根、球果、果実、液果、核果、袋果、豆果、さく果、穀粒、胞子嚢、蕾、穀皮、花、花弁、心皮、雄ずい、柱頭、花柱、葯、花糸、樹皮、巻髭、木部液及び師管液から選択されるその一部の中又は上にある、請求項1、2、6〜14、及び16〜24のいずれか一項に記載方法。
- 前記植物が、好ましくは、エンバク、オオムギ、トウモロコシ、コメ、コムギ、ソルガム、キビ、ライコムギ、フォニオ、ソバ、キノア、サトウキビ、セイヨウアブラナ、ダイズ、ヤシ、ヒマワリ、ピーナッツ、ワタ、ココナッツ、オリーブ、キャスター、リンゴ、ナシ、プラム、モモ、ネクタリン、イチゴ、キイチゴ、クロスグリ、アカスグリ、シロスグリ、グーズベリー、ブルーベリー、クランベリー、グリーンゲージ、キウイ、マンゴー、パッションフルーツ、メロン、トマト、ジャガイモ、ニンジン、バナナ、カカオ、ライム、レモン、オレンジ、グレープフルーツ、マンダリン、タンジェリン、ウンシュウミカン、クレメンタイン、パイナップル、チャ、コーヒー、ブドウ、アーモンド、クルミ、カシュー、ヘーゼルナッツ、レンズマメ、エンドウマメ、インゲンマメ、キャベツ、タマネギ、レタス、トウガラシ、キュウリ、アスパラガス、ブロッコリー、カリフラワー、サツマイモ、オーク、マツ、クルミ、ブナ、カバノキ、トウヒ、モミ、コルク、バルサ、綿、リネン、ラテックスゴム及びタケから選択される作物である、請求項35に記載の方法。
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PCT/GB2012/052274 WO2013038197A1 (en) | 2011-09-15 | 2012-09-14 | Use of alginate oligomers to enhance the effects of antifungal agents |
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JP2018115147A (ja) * | 2017-01-16 | 2018-07-26 | 御木本製薬株式会社 | 抗菌性組成物並びに該抗菌性組成物を配合した皮膚外用剤 |
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KR20150132585A (ko) * | 2013-03-22 | 2015-11-25 | 요우이치 미즈타 | 식물 조직의 배양용 배지의 제조 방법 및 식물 조직의 배양 방법 및 멸균 처리제, 살균 처리제, 및 식물 조직 배양용 배지 조성물 |
GB2529962B (en) * | 2013-05-30 | 2017-11-22 | Suzhou Sciscape Bio-Pharmaceutical Tech Co Ltd | Composition Comprising Marine-Algae Derived Material and an Inhibitor of an Enzyme which Decomposes the Material |
CN104435823B (zh) * | 2014-11-14 | 2018-02-27 | 西藏月王藏药科技有限公司 | 一种青稞红曲藏药饮片的制备方法 |
CA3048785A1 (en) | 2017-01-03 | 2018-07-12 | The University Of North Carolina At Chapel Hill | Nitric oxide-releasing alginates as biodegradable antibacterial scaffolds and methods pertaining thereto |
US10548948B2 (en) * | 2017-03-02 | 2020-02-04 | The United States Of America As Represented By The Secretary Of The Navy | Methods of treating fungal infections |
WO2018178902A1 (en) | 2017-03-28 | 2018-10-04 | The University Of North Carolina At Chapel Hill | Nitric oxide-releasing polyaminoglycosides as biodegradable antibacterial scaffolds and methods pertaining thereto |
CN107904179B (zh) * | 2017-12-18 | 2020-10-23 | 云南天禾地生物科技股份有限公司 | 一株兼具植物促生长和抗病性的罗伦隐球酵母及其应用 |
EP3762039A4 (en) | 2018-03-06 | 2021-12-22 | The University of North Carolina at Chapel Hill | NITRIC OXIDE RELEASING CYCLODEXTRINS AS BIODEGRADABLE ANTIBACTERIAL SCAFFOLDS AND RELATED PROCESSES |
CA3094015A1 (en) * | 2018-03-19 | 2019-09-26 | Algipharma As | Use of alginate oligomers to enhance the translocation of micro/nanoparticles across mucus layers |
CN113383019B (zh) | 2018-12-28 | 2023-11-17 | 北卡罗来纳大学教堂山分校 | 一氧化氮释放型抗菌聚合物和由其制成的支架和其相关方法 |
US20220064861A1 (en) * | 2019-04-08 | 2022-03-03 | Main Choice Paper Products Limited | Germ-repellent book and food paper packaging, and method of manufacture |
EP3837977A1 (en) | 2019-12-19 | 2021-06-23 | Université de Bourgogne | Use of alginates oligomers to improve plant protection against pathogens |
DE102020101110A1 (de) | 2020-01-17 | 2021-07-22 | Beuth Hochschule Für Technik Berlin | Antimykotische Aktivitäten von Hydrogelen auf Basis von Polysacchariden |
CN113430125B (zh) * | 2021-07-27 | 2022-11-08 | 塔里木大学 | 一种高酯化力与糖化力的混合菌剂及其培养方法 |
CN114009440A (zh) * | 2021-11-22 | 2022-02-08 | 兰州大学 | 阿巴芬净在防治农业病原菌中的用途 |
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