JP6167173B2 - Ｔ細胞受容体を調節することができる複素環およびそれを使用するための方法 - Google Patents

Ｔ細胞受容体を調節することができる複素環およびそれを使用するための方法 Download PDF

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JP6167173B2
JP6167173B2 JP2015514535A JP2015514535A JP6167173B2 JP 6167173 B2 JP6167173 B2 JP 6167173B2 JP 2015514535 A JP2015514535 A JP 2015514535A JP 2015514535 A JP2015514535 A JP 2015514535A JP 6167173 B2 JP6167173 B2 JP 6167173B2
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phenyl
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JP2015520769A (ja
JP2015520769A5 (OSRAM
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ダーン ホームズ，
ダーン ホームズ，
アウケ フエルハール，
アウケ フエルハール，
デン ブリンク， ヘイス ファン
デン ブリンク， ヘイス ファン
フランチェスカ ビティ，
フランチェスカ ビティ，
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ノグラ ファーマ リミテッド
ノグラ ファーマ リミテッド
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    • C07—ORGANIC CHEMISTRY
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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  • Chemical & Material Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Signal Processing (AREA)
  • Computer Networks & Wireless Communication (AREA)
  • Dermatology (AREA)
  • Environmental & Geological Engineering (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Data Exchanges In Wide-Area Networks (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
JP2015514535A 2012-06-01 2013-05-31 Ｔ細胞受容体を調節することができる複素環およびそれを使用するための方法 Expired - Fee Related JP6167173B2 (ja)

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US201261654385P 2012-06-01 2012-06-01
US61/654,385 2012-06-01
PCT/EP2013/061330 WO2013178816A1 (en) 2012-06-01 2013-05-31 Heterocycles capable of modulating t-cell responses, and methods of using same

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JP2015520769A JP2015520769A (ja) 2015-07-23
JP2015520769A5 JP2015520769A5 (OSRAM) 2016-07-21
JP6167173B2 true JP6167173B2 (ja) 2017-07-19

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US (4) US9013997B2 (OSRAM)
EP (1) EP2861575B1 (OSRAM)
JP (1) JP6167173B2 (OSRAM)
KR (1) KR102181914B1 (OSRAM)
CN (1) CN104619691B (OSRAM)
AU (1) AU2013269551B2 (OSRAM)
BR (1) BR112014030050A2 (OSRAM)
CA (1) CA2874938C (OSRAM)
CY (1) CY1122203T1 (OSRAM)
DK (1) DK2861575T3 (OSRAM)
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HR (1) HRP20190764T1 (OSRAM)
HU (1) HUE043201T2 (OSRAM)
LT (1) LT2861575T (OSRAM)
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Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITRM20050389A1 (it) 2005-07-22 2007-01-23 Giuliani Spa Composti e loro sali specifici per i recettori ppar ed i recettori per l'egf e loro uso in campo medico.
UA107562C2 (uk) 2008-12-05 2015-01-26 Спосіб лікування псоріазу
PT2396081T (pt) 2009-02-16 2017-07-11 Nogra Pharma Ltd Compostos alquilamido e suas utilizações
EP2811993B1 (en) 2012-02-09 2019-10-09 Nogra Pharma Limited Methods of treating fibrosis
IN2014DN08157A (OSRAM) 2012-04-18 2015-05-01 Nogra Pharma Ltd
US9013997B2 (en) 2012-06-01 2015-04-21 Broadcom Corporation System for performing distributed data cut-through
US9160671B2 (en) * 2012-12-03 2015-10-13 Hewlett-Packard Development Company, L.P. Ingress traffic classification and prioritization with dynamic load balancing
DE102013008118A1 (de) 2013-05-11 2014-11-13 Merck Patent Gmbh Arylchinazoline
RU2021109549A (ru) 2014-08-29 2021-05-13 Тес Фарма С.Р.Л. ИНГИБИТОРЫ α-АМИНО-β-КАРБОКСИМУКОНАТ ε-СЕМИАЛЬДЕГИД-ДЕКАРБОКСИЛАЗЫ
US9894013B2 (en) 2015-02-03 2018-02-13 Avago Technologies General Ip (Singapore) Pte. Ltd. Early queueing network device
US10567273B2 (en) * 2015-03-27 2020-02-18 Cavium, Llc Method and apparatus for bypass routing of multicast data packets and avoiding replication to reduce overall switch latency
PT3319959T (pt) 2015-07-06 2021-12-06 Alkermes Inc Inibidores hetero-halo de histona desacetilase
EP3319968A1 (en) 2015-07-06 2018-05-16 Rodin Therapeutics, Inc. Heterobicyclic n-aminophenyl-amides as inhibitors of histone deacetylase
US20190068334A1 (en) * 2016-02-03 2019-02-28 Interdigital Patent Holdings, Inc. Methods, systems and apparatus for scheduling of subframes and hybrid automatic repeat request (harq) feedback
US10774064B2 (en) 2016-06-02 2020-09-15 Cadent Therapeutics, Inc. Potassium channel modulators
MA45244A (fr) 2016-06-13 2019-04-17 Cancer Research Tech Ltd Pyridines substituées utilisées en tant qu'inhibiteurs de dnmt1
WO2018009468A1 (en) 2016-07-05 2018-01-11 Idac Holdings, Inc. Latency reduction by fast forward in multi-hop communication systems
WO2018089967A1 (en) 2016-11-14 2018-05-17 Virginia Commonwealth University Inhibitors of cancer invasion, attachment, and/or metastasis
CA3049443A1 (en) 2017-01-11 2018-07-19 Rodin Therapeutics, Inc. Bicyclic inhibitors of histone deacetylase
CU24560B1 (es) 2017-01-23 2021-12-08 Cadent Therapeutics Inc N-(4,4-difluorociclohexil)-2-(3-metil-1h-pirazol-1-il)-6-morfolinopirimidin-4-amina útil como modulador de canales de potasio
US11223495B2 (en) 2017-03-06 2022-01-11 Mitsubishi Electric Corporation Transfer device, transfer method, and transfer system
JP7152471B2 (ja) 2017-08-07 2022-10-12 ロダン・セラピューティクス，インコーポレーテッド ヒストン脱アセチル化酵素の二環阻害剤
US11247987B2 (en) 2017-10-06 2022-02-15 Forma Therapeutics, Inc. Inhibiting ubiquitin specific peptidase 30
US10476815B2 (en) * 2017-12-11 2019-11-12 Ciena Corporation Adaptive communication network with cross-point switches
ES2988920T3 (es) 2018-05-17 2024-11-22 Forma Therapeutics Inc Compuestos bicíclicos fusionados útiles como inhibidores de la peptidasa 30 específica de ubiquitina
JP6977668B2 (ja) * 2018-06-04 2021-12-08 日本電信電話株式会社 測定システム、及び測定方法
MX2021002981A (es) 2018-10-05 2021-05-14 Forma Therapeutics Inc Pirrolinas fusionadas que actuan como inhibidores de la proteasa 30 especifica de la ubiquitina (usp30).
TWI767148B (zh) 2018-10-10 2022-06-11 美商弗瑪治療公司 抑制脂肪酸合成酶(fasn)
AU2019366312B2 (en) 2018-10-22 2025-04-24 Novartis Ag Crystalline forms of potassium channel modulators
CN112996786B (zh) 2018-10-30 2024-08-20 吉利德科学公司 用于抑制α4β7整合素的化合物
US11179383B2 (en) 2018-10-30 2021-11-23 Gilead Sciences, Inc. Compounds for inhibition of α4β7 integrin
ES3013256T3 (en) 2018-10-30 2025-04-11 Gilead Sciences Inc Imidazo[1,2-a]pyridine derivatives as alpha4beta7 integrin inhibitors for the treatment of inflammatory diseases
WO2020092375A1 (en) 2018-10-30 2020-05-07 Gilead Sciences, Inc. Quinoline derivatives as alpha4beta7 integrin inhibitors
US11034669B2 (en) 2018-11-30 2021-06-15 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
SI3921299T1 (sl) 2019-02-08 2025-03-31 Nogra Pharma Limited Postopek izdelave 3-(4'-aminofenil)-2-metoksipropionske kisline in njenih analogov in vmesnih proizvodov
WO2021003417A1 (en) 2019-07-03 2021-01-07 Sumitomo Dainippon Pharma Oncology, Inc. Tyrosine kinase non-receptor 1 (tnk1) inhibitors and uses thereof
US11578069B2 (en) 2019-08-14 2023-02-14 Gilead Sciences, Inc. Compounds for inhibition of α4 β7 integrin
US12441707B2 (en) 2019-12-30 2025-10-14 Tyra Biosciences, Inc. Indazole compounds
WO2021231892A1 (en) 2020-05-15 2021-11-18 Algen Biotechnologies, Inc. Certain chemical compositions and methods of use thereof
AU2021289665A1 (en) 2020-06-10 2022-12-15 Aligos Therapeutics, Inc. Anti-viral compounds for treating coronavirus, picornavirus, and norovirus infections
US12264149B2 (en) 2020-12-30 2025-04-01 Tyra Biosciences, Inc. Indazole compounds as kinase inhibitors
CA3224494A1 (en) 2021-07-09 2023-01-12 Koen Vandyck Anti-viral compounds
WO2023043816A1 (en) 2021-09-17 2023-03-23 Aligos Therapeutics, Inc. Anti-viral compounds for treating coronavirus, picornavirus, and norovirus infections
TWI789116B (zh) * 2021-11-15 2023-01-01 瑞昱半導體股份有限公司 具有資料流傳輸排序機制的網格網路系統及其通訊方法
KR102812054B1 (ko) 2023-07-12 2025-05-23 아주대학교산학협력단 2-하이드록시-5-[[2-(2-나프탈레닐옥시)에틸]아미노]벤조산 제조공정개선

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1109180B (de) 1953-04-16 1961-06-22 Schering Ag Verfahren zur Herstellung von Chinazolinen
SU1069385A1 (ru) 1982-05-07 1990-11-15 Научно-исследовательский институт фармакологии АМН СССР Бромид 2-амино-3-(1-адамантилкарбонилметил)-1-( @ -пиперидино-этил)-бензимидазоли , обладающий способностью угнетать иммунитет
GB9016800D0 (en) * 1990-07-31 1990-09-12 Shell Int Research Tetrahydropyrimidine derivatives
GB2323842A (en) 1997-04-04 1998-10-07 Ferring Bv Pyridine derivatives
CN1306505A (zh) 1998-04-20 2001-08-01 Basf公司 新的取代酰胺、其制备以及应用
JO2308B1 (en) 1999-05-31 2005-09-12 اف. هوفمان- لاروش أيه جي‏ Derivatives of phenylpyrmidine
GB9915437D0 (en) * 1999-07-01 1999-09-01 Cerebrus Ltd Chemical compounds III
CA2292828A1 (en) * 1999-12-22 2001-06-22 Nortel Networks Corporation Method and apparatus for traffic flow control in data switches
US6765866B1 (en) * 2000-02-29 2004-07-20 Mosaid Technologies, Inc. Link aggregation
US7260104B2 (en) * 2001-12-19 2007-08-21 Computer Network Technology Corporation Deferred queuing in a buffered switch
DE60218511T2 (de) * 2001-10-26 2007-10-25 Istituto Di Richerche Di Biologia Molecolare P. Angeletti S.P.A. Dihydroxypyrimidin-carbonsäueramid-hemmer der hiv-integrase
US7868028B2 (en) 2002-06-17 2011-01-11 Fred Drasner Guanidine compounds as anesthetics and for treatment of nervous system disorders
CN101468965A (zh) * 2003-03-24 2009-07-01 默克公司 联芳基取代的6元杂环钠通道阻滞剂
ATE440825T1 (de) 2003-06-06 2009-09-15 Vertex Pharma Pyrimidin-derivate zur verwendung als modulatoren von atp-bindende kassette transportern
EA010974B1 (ru) * 2004-05-26 2008-12-30 Янссен Фармацевтика Н.В. Меркаптоимидазолы в качестве антагонистов рецепторов ccr2
US7602712B2 (en) * 2004-06-08 2009-10-13 Sun Microsystems, Inc. Switch method and apparatus with cut-through routing for use in a communications network
US20060100226A1 (en) * 2004-09-10 2006-05-11 Sikorski James A 2-Thiopyrimidinones as therapeutic agents
ATE493391T1 (de) 2005-03-15 2011-01-15 Pfizer Benzimidazolonderivate als cb2-rezeptor-liganden
EP1866313A1 (en) 2005-03-31 2007-12-19 Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. Hiv integrase inhibitors
WO2006113261A2 (en) 2005-04-14 2006-10-26 Bristol-Myers Squibb Company Inhibitors of 11-beta hydroxysteroid dehydrogenase type i
CA2619365A1 (en) 2005-08-22 2007-03-01 Amgen Inc. Pyrazolopyridine and pyrazolopyrimidine compounds useful as kinase enzymes modulators
WO2007084728A2 (en) 2006-01-19 2007-07-26 Abbott Laboratories 2-imino-benzimidazoles
JP2008013499A (ja) 2006-07-06 2008-01-24 Sankyo Co Ltd ５−シアノニコチンアミド誘導体
AR063946A1 (es) 2006-09-11 2009-03-04 Cgi Pharmaceuticals Inc Determinadas pirimidinas sustituidas, el uso de las mismas para el tratamiento de enfermedades mediadas por la inhibicion de la actividad de btk y composiciones farmaceuticas que las comprenden.
US7843846B1 (en) * 2006-09-18 2010-11-30 Qlogic, Corporation Method and system for processing network information
WO2008036244A1 (en) 2006-09-18 2008-03-27 The Burham Institute For Medical Research Use of cyclosporin a to sensitize resistant cancer cells to death receptor ligands
US7847099B2 (en) * 2006-09-21 2010-12-07 California Institute Of Technology Non-metallocene organometallic complexes and related methods and systems
US8093246B2 (en) 2006-12-14 2012-01-10 Lexicon Pharmaceuticals, Inc. O-linked pyrimidin-4-amine-based compounds, compositions comprising them, and methods of their use to treat cancer
US8278337B2 (en) * 2006-12-20 2012-10-02 Merck Sharp & Dohme Substituted pyridines that are JNK inhibitors
MY153979A (en) * 2007-10-19 2015-04-30 Boehringer Ingelheim Int Substituted piperidino-dihydrothienopyrimidine
MX2010009625A (es) 2008-03-07 2010-09-28 Acraf Derivados de 1-bencil-3-hidroximetilindazol y uso de los mismos en el tratamiento de enfermedades basadas en la expresion de mcp-1, cx3cr1 y p40.
GEP20135913B (en) 2008-03-07 2013-08-26 Acraf 1-benzyl-3-hydroxymethylindazole derivatives and use thereat treatment of diseases based on mcp-1 and cx3cr1 expression
US8859109B2 (en) 2008-03-24 2014-10-14 Nippon Steel & Sumikin Chemical Co., Ltd. Compound for organic electroluminescent device and organic electroluminescent device using the same
CN102203074A (zh) 2008-06-20 2011-09-28 麦它波莱克斯股份有限公司 芳基gpr119激动剂及其用途
RU2011101661A (ru) 2008-07-16 2012-08-27 Астразенека Аб (Se) Пиримидилсульфонамидное производное и его применение для лечения хемокин-опосредованных заболеваний
KR20110039563A (ko) 2008-07-23 2011-04-19 버텍스 파마슈티칼스 인코포레이티드 피라졸로피리딘 키나제 억제제
AU2009279611A1 (en) 2008-08-06 2010-02-11 Vertex Pharmaceuticals Incorporated Aminopyridine kinase inhibitors
WO2010068806A1 (en) * 2008-12-10 2010-06-17 Cgi Pharmaceuticals, Inc. Amide derivatives as btk inhibitors in the treatment of allergic, autoimmune and inflammatory disorders as well as cancer
EP2419423A1 (en) * 2009-04-14 2012-02-22 Cellzome Limited Fluoro substituted pyrimidine compounds as jak3 inhibitors
US8367689B2 (en) * 2009-05-06 2013-02-05 Portola Pharmaceuticals, Inc. Inhibitors of JAK
CA2763730A1 (en) * 2009-06-18 2010-12-23 Cellzome Limited Heterocyclylaminopyrimidines as kinase inhibitors
US20120172385A1 (en) 2009-09-11 2012-07-05 Richard John Harrison Ortho substituted pyrimidine compounds as jak inhibitors
TWI555746B (zh) * 2009-12-28 2016-11-01 財團法人生物技術開發中心 作為ｍＴＯＲ及ＰＩ３Ｋ抑制劑之新穎嘧啶化合物
UY33213A (es) 2010-02-18 2011-09-30 Almirall Sa Derivados de pirazol como inhibidores de jak
DE102010034699A1 (de) * 2010-08-18 2012-02-23 Merck Patent Gmbh Pyrimidinderivate
US20120184572A1 (en) 2011-01-13 2012-07-19 Metabolex, Inc. Aryl gpr119 agonists and uses thereof
US9428490B2 (en) 2011-07-29 2016-08-30 Karyopharm Therapeutics Inc. Nuclear transport modulators and uses thereof
WO2013131018A1 (en) 2012-03-02 2013-09-06 Zalicus Pharmaceuticals Ltd. Biaryl inhibitors of the sodium channel
EP2861563B1 (en) 2012-06-01 2017-07-12 Nogra Pharma Limited Bicyclic heterocycles capable of modulating t-cell responses, and methods of using same
US9013997B2 (en) 2012-06-01 2015-04-21 Broadcom Corporation System for performing distributed data cut-through
US20150087673A1 (en) 2013-09-26 2015-03-26 Rigel Pharmaceuticals, Inc. Methods for using and biomarkers for ampk-activating compounds
HUE044683T2 (hu) 2013-10-21 2019-11-28 Merck Patent Gmbh Heteroaril vegyületek mint BTK inhibitorok és alkalmazásuk

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