JP6164488B2 - Ｐｐｒモチーフを利用したｒｎａ結合性蛋白質の設計方法及びその利用 - Google Patents

Ｐｐｒモチーフを利用したｒｎａ結合性蛋白質の設計方法及びその利用 Download PDF

Info

Publication number
JP6164488B2
JP6164488B2 JP2013539727A JP2013539727A JP6164488B2 JP 6164488 B2 JP6164488 B2 JP 6164488B2 JP 2013539727 A JP2013539727 A JP 2013539727A JP 2013539727 A JP2013539727 A JP 2013539727A JP 6164488 B2 JP6164488 B2 JP 6164488B2
Authority
JP
Japan
Prior art keywords
rna
amino acids
ppr
motif
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2013539727A
Other languages
English (en)
Japanese (ja)
Other versions
JPWO2013058404A1 (ja
Inventor
崇裕 中村
崇裕 中村
祐介 八木
祐介 八木
啓子 小林
啓子 小林
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kyushu University NUC
Original Assignee
Kyushu University NUC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyushu University NUC filed Critical Kyushu University NUC
Priority to JP2013539727A priority Critical patent/JP6164488B2/ja
Publication of JPWO2013058404A1 publication Critical patent/JPWO2013058404A1/ja
Application granted granted Critical
Publication of JP6164488B2 publication Critical patent/JP6164488B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00—ICT specially adapted for analysing two-dimensional [2D] or three-dimensional [3D] molecular structures, e.g. structural or functional relations or structure alignment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8287—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for fertility modification, e.g. apomixis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8287—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for fertility modification, e.g. apomixis
    • C12N15/8289—Male sterility
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/30—Detection of binding sites or motifs
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/50—Mutagenesis
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/10—Sequence alignment; Homology search
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B35/00—ICT specially adapted for in silico combinatorial libraries of nucleic acids, proteins or peptides
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/60—In silico combinatorial chemistry
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/85—Fusion polypeptide containing an RNA binding domain
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2522/00—Reaction characterised by the use of non-enzymatic proteins
    • C12Q2522/10—Nucleic acid binding proteins
    • C12Q2522/101—Single or double stranded nucleic acid binding proteins
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Evolutionary Biology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Botany (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Library & Information Science (AREA)
  • Computing Systems (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
JP2013539727A 2011-10-21 2012-10-22 Ｐｐｒモチーフを利用したｒｎａ結合性蛋白質の設計方法及びその利用 Active JP6164488B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2013539727A JP6164488B2 (ja) 2011-10-21 2012-10-22 Ｐｐｒモチーフを利用したｒｎａ結合性蛋白質の設計方法及びその利用

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2011231346 2011-10-21
JP2011231346 2011-10-21
JP2013539727A JP6164488B2 (ja) 2011-10-21 2012-10-22 Ｐｐｒモチーフを利用したｒｎａ結合性蛋白質の設計方法及びその利用
PCT/JP2012/077274 WO2013058404A1 (ja) 2011-10-21 2012-10-22 Pprモチーフを利用したrna結合性蛋白質の設計方法及びその利用

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2017112764A Division JP6270192B2 (ja) 2011-10-21 2017-06-07 Ｐｐｒモチーフを利用したｒｎａ結合性蛋白質の設計方法及びその利用
JP2017112765A Division JP6267388B2 (ja) 2011-10-21 2017-06-07 Ｐｐｒモチーフを利用したｒｎａ結合性蛋白質の設計方法及びその利用

Publications (2)

Publication Number Publication Date
JPWO2013058404A1 JPWO2013058404A1 (ja) 2015-04-02
JP6164488B2 true JP6164488B2 (ja) 2017-07-19

Family

ID=48141047

Family Applications (9)

Application Number Title Priority Date Filing Date
JP2013539727A Active JP6164488B2 (ja) 2011-10-21 2012-10-22 Ｐｐｒモチーフを利用したｒｎａ結合性蛋白質の設計方法及びその利用
JP2017112765A Active JP6267388B2 (ja) 2011-10-21 2017-06-07 Ｐｐｒモチーフを利用したｒｎａ結合性蛋白質の設計方法及びその利用
JP2017112764A Active JP6270192B2 (ja) 2011-10-21 2017-06-07 Ｐｐｒモチーフを利用したｒｎａ結合性蛋白質の設計方法及びその利用
JP2017244766A Active JP6934644B2 (ja) 2011-10-21 2017-12-21 Ｐｐｒモチーフを利用したｒｎａ結合性蛋白質の設計方法及びその利用
JP2017244765A Active JP6454398B2 (ja) 2011-10-21 2017-12-21 Ｐｐｒモチーフを利用したｒｎａ結合性蛋白質の設計方法及びその利用
JP2021086108A Active JP7157483B2 (ja) 2011-10-21 2021-05-21 Ｐｐｒモチーフを利用したｒｎａ結合性蛋白質の設計方法及びその利用
JP2022158241A Active JP7381133B2 (ja) 2011-10-21 2022-09-30 Ｐｐｒモチーフを利用したｒｎａ結合性蛋白質の設計方法及びその利用
JP2023183886A Active JP7590019B2 (ja) 2011-10-21 2023-10-26 Ｐｐｒモチーフを利用したｒｎａ結合性蛋白質の設計方法及びその利用
JP2024194918A Active JP7789426B2 (ja) 2011-10-21 2024-11-07 Ｐｐｒモチーフを利用したｒｎａ結合性蛋白質の設計方法及びその利用

Family Applications After (8)

Application Number Title Priority Date Filing Date
JP2017112765A Active JP6267388B2 (ja) 2011-10-21 2017-06-07 Ｐｐｒモチーフを利用したｒｎａ結合性蛋白質の設計方法及びその利用
JP2017112764A Active JP6270192B2 (ja) 2011-10-21 2017-06-07 Ｐｐｒモチーフを利用したｒｎａ結合性蛋白質の設計方法及びその利用
JP2017244766A Active JP6934644B2 (ja) 2011-10-21 2017-12-21 Ｐｐｒモチーフを利用したｒｎａ結合性蛋白質の設計方法及びその利用
JP2017244765A Active JP6454398B2 (ja) 2011-10-21 2017-12-21 Ｐｐｒモチーフを利用したｒｎａ結合性蛋白質の設計方法及びその利用
JP2021086108A Active JP7157483B2 (ja) 2011-10-21 2021-05-21 Ｐｐｒモチーフを利用したｒｎａ結合性蛋白質の設計方法及びその利用
JP2022158241A Active JP7381133B2 (ja) 2011-10-21 2022-09-30 Ｐｐｒモチーフを利用したｒｎａ結合性蛋白質の設計方法及びその利用
JP2023183886A Active JP7590019B2 (ja) 2011-10-21 2023-10-26 Ｐｐｒモチーフを利用したｒｎａ結合性蛋白質の設計方法及びその利用
JP2024194918A Active JP7789426B2 (ja) 2011-10-21 2024-11-07 Ｐｐｒモチーフを利用したｒｎａ結合性蛋白質の設計方法及びその利用

Country Status (8)

Country Link
US (7) US9513283B2 (https=)
EP (2) EP2784157B1 (https=)
JP (9) JP6164488B2 (https=)
AU (5) AU2012326971C1 (https=)
DK (1) DK2784157T3 (https=)
ES (1) ES2751126T3 (https=)
PT (1) PT2784157T (https=)
WO (1) WO2013058404A1 (https=)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013058404A1 (ja) * 2011-10-21 2013-04-25 国立大学法人九州大学 Pprモチーフを利用したrna結合性蛋白質の設計方法及びその利用
AU2013248928A1 (en) * 2012-04-16 2014-12-04 The State Board Of Higher Education On Behalf Of The University Of Oregon Peptides for the binding of nucleotide targets
KR102893770B1 (ko) 2013-04-22 2025-11-28 고쿠리쓰다이가쿠호진 규슈다이가쿠 피피알 단백질을 이용하는 dna 결합성 단백질 및 그의 이용
SG11201609211VA (en) 2014-03-05 2016-12-29 Nat Univ Corp Univ Kobe Genomic sequence modification method for specifically converting nucleic acid bases of targeted dna sequence, and molecular complex for use in same
ES2938623T3 (es) 2015-09-09 2023-04-13 Univ Kobe Nat Univ Corp Método para convertir una secuencia del genoma de una bacteria gram-positiva mediante una conversión específica de una base de ácido nucleico de una secuencia de ADN seleccionada como diana y el complejo molecular utilizado en el mismo
JP2019500899A (ja) 2015-11-23 2019-01-17 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア ＣＲＩＳＰＲ／Ｃａｓ９の核送達を通じた細胞ＲＮＡの追跡と操作
ES2914623T3 (es) 2015-11-27 2022-06-14 Univ Kobe Nat Univ Corp Método para convertir una secuencia genómica de una planta monocotiledónea en la que una base de ácido nucleico en la secuencia de ADN diana se convierte de manera específica y el complejo molecular utilizado en el mismo
ES2874230T3 (es) * 2016-06-03 2021-11-04 Univ Kyushu Nat Univ Corp Proteína de fusión para mejorar la expresión de proteínas a partir de ARNm diana
WO2017209122A1 (ja) 2016-06-03 2017-12-07 国立大学法人九州大学 標的ｍＲＮＡからのタンパク質発現量を向上させるための融合タンパク質
JPWO2018030488A1 (ja) * 2016-08-10 2019-06-13 富士フイルム和光純薬株式会社 Ｐｐｒモチーフを利用したｄｎａ結合性タンパク質およびその利用
EP3622062A4 (en) 2017-05-10 2020-10-14 The Regents of the University of California DIRECTED EDITING OF CELLULAR RNA BY NUCLEAR ADMINISTRATION OF CRISPR / CAS9
CN108959852B (zh) * 2017-05-24 2021-12-24 北京工业大学 基于氨基酸-核苷酸成对偏好性信息的蛋白质上与rna结合模块的预测方法
CN108932400B (zh) * 2017-05-24 2021-07-23 北京工业大学 一种考虑界面信息的有效的蛋白质-rna复合物结构预测方法
JP2021526858A (ja) 2018-06-08 2021-10-11 ロックアネイビオ， インコーポレイテッド Ｒｎａ標的化融合タンパク質組成物および使用方法
CN114729017A (zh) * 2019-05-29 2022-07-08 日商基因编辑力股份有限公司 Ppr蛋白的有效制作方法及其应用
EP3977849A4 (en) 2019-05-29 2023-06-28 Editforce, Inc. Ppr protein with less aggregation and use thereof
AU2020310201A1 (en) 2019-07-10 2022-01-27 Locanabio, Inc. RNA-targeting knockdown and replacement compositions and methods for use
WO2021201198A1 (ja) * 2020-03-31 2021-10-07 エディットフォース株式会社 標的ｒｎａを編集する方法
KR20230127221A9 (ko) 2020-12-01 2024-12-06 로카나바이오 인크. Cag 반복 질환을 치료하기 위한 rna 표적화 조성물 및 방법
US20240108751A1 (en) 2020-12-01 2024-04-04 Locanabio, Inc. Rna-targeting compositions and methods for treating myotonic dystrophy type 1
WO2022221278A1 (en) 2021-04-12 2022-10-20 Locanabio, Inc. Compositions and methods comprising hybrid promoters
CA3216419A1 (en) 2021-04-23 2022-10-27 Greg NACHTRAB Tissue-targeted modified aav capsids and methods of use thereof
WO2022226375A1 (en) 2021-04-23 2022-10-27 Locanabio, Inc. Tissue-targeted modified aav capsids and methods of use thereof
CA3216313A1 (en) * 2021-04-30 2022-11-03 Masayuki NAKAMORI Myotonic dystrophy type 1 therapeutic drug
JP7125727B1 (ja) 2021-09-07 2022-08-25 国立大学法人千葉大学 核酸配列改変用組成物および核酸配列の標的部位を改変する方法
WO2023050204A1 (zh) * 2021-09-29 2023-04-06 京东方科技集团股份有限公司 Rna-蛋白质相互作用预测方法、装置、介质及电子设备
US20250302993A1 (en) * 2021-12-24 2025-10-02 GeCoRT Co., Ltd. Enzyme, complex, recombinant vector, therapeutic agent for genetic disorder, and polynucleotide
WO2023154807A2 (en) 2022-02-09 2023-08-17 Locanabio, Inc. Compositions and methods for modulating pre-mrna splicing

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040117868A1 (en) 2002-01-29 2004-06-17 Jun Imamura Protein participating in restoration from cytoplasmic male sterility to fertility and gene encoding the same
JP4102099B2 (ja) 2001-04-25 2008-06-18 アンスティテュ ナシオナル ドゥ ラ ルシェルシュ アグロノミック 細胞質雄性不稔から可稔への回復に関与するタンパク質及びそれをコードする遺伝子
AU2002251533B2 (en) 2001-04-25 2006-09-28 Institut National De La Recherche Agronomique Protein involved in restoration of cytoplasmic male sterility to fertility and gene encoding the protein and gene
JP2002355041A (ja) 2001-04-25 2002-12-10 Mitsubishi Chemicals Corp 細胞質雄性不稔から可稔への回復に関与する遺伝子
US20060041961A1 (en) * 2004-03-25 2006-02-23 Abad Mark S Genes and uses for pant improvement
US8344122B2 (en) 2008-03-12 2013-01-01 Tohoku University Fertility restorer gene and fertility restoration method for CW-type male sterile cytoplasm of rice
HUE041436T2 (hu) 2009-12-10 2019-05-28 Univ Minnesota Tal-effektor-közvetített DNS-módosítás
JP2013128413A (ja) 2010-03-11 2013-07-04 Kyushu Univ Ｐｐｒモチーフを利用したｒｎａ結合性蛋白質の改変方法
WO2013058404A1 (ja) * 2011-10-21 2013-04-25 国立大学法人九州大学 Pprモチーフを利用したrna結合性蛋白質の設計方法及びその利用
AU2013248928A1 (en) * 2012-04-16 2014-12-04 The State Board Of Higher Education On Behalf Of The University Of Oregon Peptides for the binding of nucleotide targets

Also Published As

Publication number Publication date
US20200294626A1 (en) 2020-09-17
ES2751126T3 (es) 2020-03-30
JP7789426B2 (ja) 2025-12-22
US20210249103A1 (en) 2021-08-12
JP2024010112A (ja) 2024-01-23
JP7590019B2 (ja) 2024-11-26
US10679731B2 (en) 2020-06-09
JP2017148078A (ja) 2017-08-31
AU2012326971A1 (en) 2014-06-12
JP7381133B2 (ja) 2023-11-15
JP6267388B2 (ja) 2018-01-24
AU2017254874A1 (en) 2017-11-16
EP2784157A1 (en) 2014-10-01
EP2784157A4 (en) 2015-07-01
US20140335521A1 (en) 2014-11-13
JP2018078896A (ja) 2018-05-24
JP2022177289A (ja) 2022-11-30
AU2022204654A1 (en) 2022-07-21
JPWO2013058404A1 (ja) 2015-04-02
JP7157483B2 (ja) 2022-10-20
AU2017254874B2 (en) 2019-09-12
JP2021130678A (ja) 2021-09-09
US20240047005A1 (en) 2024-02-08
WO2013058404A1 (ja) 2013-04-25
US20170124252A1 (en) 2017-05-04
AU2019280013B2 (en) 2022-03-31
US20180247018A1 (en) 2018-08-30
JP2018042569A (ja) 2018-03-22
AU2012326971C1 (en) 2018-02-08
AU2012326971B2 (en) 2017-10-19
DK2784157T3 (da) 2019-10-21
EP3611261A1 (en) 2020-02-19
AU2022204654B2 (en) 2025-04-03
AU2025204996A1 (en) 2025-07-24
JP6270192B2 (ja) 2018-01-31
AU2019280013A1 (en) 2020-01-16
JP6934644B2 (ja) 2021-09-15
US20190311783A1 (en) 2019-10-10
US10340028B2 (en) 2019-07-02
US9984202B2 (en) 2018-05-29
JP2017192391A (ja) 2017-10-26
JP6454398B2 (ja) 2019-01-16
EP2784157B1 (en) 2019-09-18
US11742056B2 (en) 2023-08-29
PT2784157T (pt) 2019-10-29
US10943671B2 (en) 2021-03-09
US9513283B2 (en) 2016-12-06
JP2025020327A (ja) 2025-02-12

Similar Documents

Publication Publication Date Title
JP7381133B2 (ja) Ｐｐｒモチーフを利用したｒｎａ結合性蛋白質の設計方法及びその利用
Delannoy et al. Arabidopsis tRNA adenosine deaminase arginine edits the wobble nucleotide of chloroplast tRNAArg (ACG) and is essential for efficient chloroplast translation
Le Ret et al. Efficient replication of the plastid genome requires an organellar thymidine kinase
HK40024684A (en) Method for designing rna binding protein uitilizing ppr motif, and use thereof
JP5194250B2 (ja) Ｒｎａ分解酵素活性を有するタンパク質及びその利用

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20151021

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20160906

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20161107

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20170509

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20170607

R150 Certificate of patent or registration of utility model

Ref document number: 6164488

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

S531 Written request for registration of change of domicile

Free format text: JAPANESE INTERMEDIATE CODE: R313531

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250