DK2784157T3 - Designfremgangsmåde til et rna-bindende protein under anvendelse af ppr-motiv og anvendelse deraf - Google Patents

Designfremgangsmåde til et rna-bindende protein under anvendelse af ppr-motiv og anvendelse deraf

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Publication number
DK2784157T3
DK2784157T3 DK12841435.6T DK12841435T DK2784157T3 DK 2784157 T3 DK2784157 T3 DK 2784157T3 DK 12841435 T DK12841435 T DK 12841435T DK 2784157 T3 DK2784157 T3 DK 2784157T3
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DK
Denmark
Prior art keywords
motives
ppr
binding protein
rna binding
design procedure
Prior art date
Application number
DK12841435.6T
Other languages
Danish (da)
English (en)
Inventor
Takahiro Nakamura
Keiko Kobayashi
Yusuke Yagi
Original Assignee
Univ Kyushu Nat Univ Corp
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Filing date
Publication date
Application filed by Univ Kyushu Nat Univ Corp filed Critical Univ Kyushu Nat Univ Corp
Application granted granted Critical
Publication of DK2784157T3 publication Critical patent/DK2784157T3/da

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    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00—ICT specially adapted for analysing two-dimensional [2D] or three-dimensional [3D] molecular structures, e.g. structural or functional relations or structure alignment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8287—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for fertility modification, e.g. apomixis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8287—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for fertility modification, e.g. apomixis
    • C12N15/8289—Male sterility
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/30—Detection of binding sites or motifs
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/50—Mutagenesis
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/10—Sequence alignment; Homology search
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B35/00—ICT specially adapted for in silico combinatorial libraries of nucleic acids, proteins or peptides
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/60—In silico combinatorial chemistry
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/85—Fusion polypeptide containing an RNA binding domain
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2522/00—Reaction characterised by the use of non-enzymatic proteins
    • C12Q2522/10—Nucleic acid binding proteins
    • C12Q2522/101—Single or double stranded nucleic acid binding proteins
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Evolutionary Biology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Botany (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Library & Information Science (AREA)
  • Computing Systems (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
DK12841435.6T 2011-10-21 2012-10-22 Designfremgangsmåde til et rna-bindende protein under anvendelse af ppr-motiv og anvendelse deraf DK2784157T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2011231346 2011-10-21
PCT/JP2012/077274 WO2013058404A1 (ja) 2011-10-21 2012-10-22 Pprモチーフを利用したrna結合性蛋白質の設計方法及びその利用

Publications (1)

Publication Number Publication Date
DK2784157T3 true DK2784157T3 (da) 2019-10-21

Family

ID=48141047

Family Applications (1)

Application Number Title Priority Date Filing Date
DK12841435.6T DK2784157T3 (da) 2011-10-21 2012-10-22 Designfremgangsmåde til et rna-bindende protein under anvendelse af ppr-motiv og anvendelse deraf

Country Status (8)

Country Link
US (7) US9513283B2 (https=)
EP (2) EP2784157B1 (https=)
JP (9) JP6164488B2 (https=)
AU (5) AU2012326971C1 (https=)
DK (1) DK2784157T3 (https=)
ES (1) ES2751126T3 (https=)
PT (1) PT2784157T (https=)
WO (1) WO2013058404A1 (https=)

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WO2013058404A1 (ja) * 2011-10-21 2013-04-25 国立大学法人九州大学 Pprモチーフを利用したrna結合性蛋白質の設計方法及びその利用
AU2013248928A1 (en) * 2012-04-16 2014-12-04 The State Board Of Higher Education On Behalf Of The University Of Oregon Peptides for the binding of nucleotide targets
KR102893770B1 (ko) 2013-04-22 2025-11-28 고쿠리쓰다이가쿠호진 규슈다이가쿠 피피알 단백질을 이용하는 dna 결합성 단백질 및 그의 이용
SG11201609211VA (en) 2014-03-05 2016-12-29 Nat Univ Corp Univ Kobe Genomic sequence modification method for specifically converting nucleic acid bases of targeted dna sequence, and molecular complex for use in same
ES2938623T3 (es) 2015-09-09 2023-04-13 Univ Kobe Nat Univ Corp Método para convertir una secuencia del genoma de una bacteria gram-positiva mediante una conversión específica de una base de ácido nucleico de una secuencia de ADN seleccionada como diana y el complejo molecular utilizado en el mismo
JP2019500899A (ja) 2015-11-23 2019-01-17 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア ＣＲＩＳＰＲ／Ｃａｓ９の核送達を通じた細胞ＲＮＡの追跡と操作
ES2914623T3 (es) 2015-11-27 2022-06-14 Univ Kobe Nat Univ Corp Método para convertir una secuencia genómica de una planta monocotiledónea en la que una base de ácido nucleico en la secuencia de ADN diana se convierte de manera específica y el complejo molecular utilizado en el mismo
ES2874230T3 (es) * 2016-06-03 2021-11-04 Univ Kyushu Nat Univ Corp Proteína de fusión para mejorar la expresión de proteínas a partir de ARNm diana
WO2017209122A1 (ja) 2016-06-03 2017-12-07 国立大学法人九州大学 標的ｍＲＮＡからのタンパク質発現量を向上させるための融合タンパク質
JPWO2018030488A1 (ja) * 2016-08-10 2019-06-13 富士フイルム和光純薬株式会社 Ｐｐｒモチーフを利用したｄｎａ結合性タンパク質およびその利用
EP3622062A4 (en) 2017-05-10 2020-10-14 The Regents of the University of California DIRECTED EDITING OF CELLULAR RNA BY NUCLEAR ADMINISTRATION OF CRISPR / CAS9
CN108959852B (zh) * 2017-05-24 2021-12-24 北京工业大学 基于氨基酸-核苷酸成对偏好性信息的蛋白质上与rna结合模块的预测方法
CN108932400B (zh) * 2017-05-24 2021-07-23 北京工业大学 一种考虑界面信息的有效的蛋白质-rna复合物结构预测方法
JP2021526858A (ja) 2018-06-08 2021-10-11 ロックアネイビオ， インコーポレイテッド Ｒｎａ標的化融合タンパク質組成物および使用方法
CN114729017A (zh) * 2019-05-29 2022-07-08 日商基因编辑力股份有限公司 Ppr蛋白的有效制作方法及其应用
EP3977849A4 (en) 2019-05-29 2023-06-28 Editforce, Inc. Ppr protein with less aggregation and use thereof
AU2020310201A1 (en) 2019-07-10 2022-01-27 Locanabio, Inc. RNA-targeting knockdown and replacement compositions and methods for use
WO2021201198A1 (ja) * 2020-03-31 2021-10-07 エディットフォース株式会社 標的ｒｎａを編集する方法
KR20230127221A9 (ko) 2020-12-01 2024-12-06 로카나바이오 인크. Cag 반복 질환을 치료하기 위한 rna 표적화 조성물 및 방법
US20240108751A1 (en) 2020-12-01 2024-04-04 Locanabio, Inc. Rna-targeting compositions and methods for treating myotonic dystrophy type 1
WO2022221278A1 (en) 2021-04-12 2022-10-20 Locanabio, Inc. Compositions and methods comprising hybrid promoters
CA3216419A1 (en) 2021-04-23 2022-10-27 Greg NACHTRAB Tissue-targeted modified aav capsids and methods of use thereof
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WO2023050204A1 (zh) * 2021-09-29 2023-04-06 京东方科技集团股份有限公司 Rna-蛋白质相互作用预测方法、装置、介质及电子设备
US20250302993A1 (en) * 2021-12-24 2025-10-02 GeCoRT Co., Ltd. Enzyme, complex, recombinant vector, therapeutic agent for genetic disorder, and polynucleotide
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JP4102099B2 (ja) 2001-04-25 2008-06-18 アンスティテュ ナシオナル ドゥ ラ ルシェルシュ アグロノミック 細胞質雄性不稔から可稔への回復に関与するタンパク質及びそれをコードする遺伝子
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WO2013058404A1 (ja) * 2011-10-21 2013-04-25 国立大学法人九州大学 Pprモチーフを利用したrna結合性蛋白質の設計方法及びその利用
AU2013248928A1 (en) * 2012-04-16 2014-12-04 The State Board Of Higher Education On Behalf Of The University Of Oregon Peptides for the binding of nucleotide targets

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US20200294626A1 (en) 2020-09-17
ES2751126T3 (es) 2020-03-30
JP7789426B2 (ja) 2025-12-22
US20210249103A1 (en) 2021-08-12
JP2024010112A (ja) 2024-01-23
JP7590019B2 (ja) 2024-11-26
US10679731B2 (en) 2020-06-09
JP2017148078A (ja) 2017-08-31
AU2012326971A1 (en) 2014-06-12
JP7381133B2 (ja) 2023-11-15
JP6267388B2 (ja) 2018-01-24
JP6164488B2 (ja) 2017-07-19
AU2017254874A1 (en) 2017-11-16
EP2784157A1 (en) 2014-10-01
EP2784157A4 (en) 2015-07-01
US20140335521A1 (en) 2014-11-13
JP2018078896A (ja) 2018-05-24
JP2022177289A (ja) 2022-11-30
AU2022204654A1 (en) 2022-07-21
JPWO2013058404A1 (ja) 2015-04-02
JP7157483B2 (ja) 2022-10-20
AU2017254874B2 (en) 2019-09-12
JP2021130678A (ja) 2021-09-09
US20240047005A1 (en) 2024-02-08
WO2013058404A1 (ja) 2013-04-25
US20170124252A1 (en) 2017-05-04
AU2019280013B2 (en) 2022-03-31
US20180247018A1 (en) 2018-08-30
JP2018042569A (ja) 2018-03-22
AU2012326971C1 (en) 2018-02-08
AU2012326971B2 (en) 2017-10-19
EP3611261A1 (en) 2020-02-19
AU2022204654B2 (en) 2025-04-03
AU2025204996A1 (en) 2025-07-24
JP6270192B2 (ja) 2018-01-31
AU2019280013A1 (en) 2020-01-16
JP6934644B2 (ja) 2021-09-15
US20190311783A1 (en) 2019-10-10
US10340028B2 (en) 2019-07-02
US9984202B2 (en) 2018-05-29
JP2017192391A (ja) 2017-10-26
JP6454398B2 (ja) 2019-01-16
EP2784157B1 (en) 2019-09-18
US11742056B2 (en) 2023-08-29
PT2784157T (pt) 2019-10-29
US10943671B2 (en) 2021-03-09
US9513283B2 (en) 2016-12-06
JP2025020327A (ja) 2025-02-12

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