JP6154004B2 - ブロモドメイン阻害剤のベンゾ［ｃ］イソオキサゾロアゼピン及びその使用 - Google Patents

ブロモドメイン阻害剤のベンゾ［ｃ］イソオキサゾロアゼピン及びその使用 Download PDF

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Publication number
JP6154004B2
JP6154004B2 JP2015516192A JP2015516192A JP6154004B2 JP 6154004 B2 JP6154004 B2 JP 6154004B2 JP 2015516192 A JP2015516192 A JP 2015516192A JP 2015516192 A JP2015516192 A JP 2015516192A JP 6154004 B2 JP6154004 B2 JP 6154004B2
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cancer
alkyl
compound
methyl
pharmaceutically acceptable
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JP2015518899A5 (cg-RX-API-DMAC10.html
JP2015518899A (ja
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アルブレヒト，ブライアン・ケイ
ヒューイット，マイケル・チャールズ
ゲーリング，ヴィクター・エス
ヴァスワニ，リシ・ジー
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Constellation Pharmaceuticals Inc
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Constellation Pharmaceuticals Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2015516192A 2012-06-06 2013-06-06 ブロモドメイン阻害剤のベンゾ［ｃ］イソオキサゾロアゼピン及びその使用 Active JP6154004B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261656205P 2012-06-06 2012-06-06
US61/656,205 2012-06-06
PCT/US2013/044444 WO2013184876A1 (en) 2012-06-06 2013-06-06 Benzo [c] isoxazoloazepine bromodomain inhibitors and uses thereof

Publications (3)

Publication Number Publication Date
JP2015518899A JP2015518899A (ja) 2015-07-06
JP2015518899A5 JP2015518899A5 (cg-RX-API-DMAC10.html) 2016-06-30
JP6154004B2 true JP6154004B2 (ja) 2017-06-28

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JP2015516192A Active JP6154004B2 (ja) 2012-06-06 2013-06-06 ブロモドメイン阻害剤のベンゾ［ｃ］イソオキサゾロアゼピン及びその使用

Country Status (19)

Country Link
US (2) US9493483B2 (cg-RX-API-DMAC10.html)
EP (1) EP2859000B1 (cg-RX-API-DMAC10.html)
JP (1) JP6154004B2 (cg-RX-API-DMAC10.html)
KR (1) KR20150023562A (cg-RX-API-DMAC10.html)
CN (1) CN104428304B (cg-RX-API-DMAC10.html)
AR (1) AR091285A1 (cg-RX-API-DMAC10.html)
AU (1) AU2013271569B2 (cg-RX-API-DMAC10.html)
BR (1) BR112014030165A2 (cg-RX-API-DMAC10.html)
CA (1) CA2874774C (cg-RX-API-DMAC10.html)
EA (1) EA026894B1 (cg-RX-API-DMAC10.html)
ES (1) ES2632774T3 (cg-RX-API-DMAC10.html)
IL (1) IL235844A (cg-RX-API-DMAC10.html)
IN (1) IN2014DN10386A (cg-RX-API-DMAC10.html)
MX (1) MX360598B (cg-RX-API-DMAC10.html)
NZ (1) NZ702458A (cg-RX-API-DMAC10.html)
SG (1) SG11201407900WA (cg-RX-API-DMAC10.html)
TW (1) TWI602820B (cg-RX-API-DMAC10.html)
WO (1) WO2013184876A1 (cg-RX-API-DMAC10.html)
ZA (1) ZA201408720B (cg-RX-API-DMAC10.html)

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WO2013184878A1 (en) 2012-06-06 2013-12-12 Constellation Pharmaceuticals, Inc. Benzo [b] isoxazoloazepine bromodomain inhibitors and uses thereof
TWI602820B (zh) 2012-06-06 2017-10-21 星宿藥物公司 溴域抑制劑及其用途
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US20160009725A1 (en) 2013-02-22 2016-01-14 Bayer Pharma Aktiengesellschaft Pyrrolo- and pyrazolo-triazolodiazepines as bet-protein inhibitors for treating hyperproliferative diseases
US20150376196A1 (en) 2013-02-22 2015-12-31 Bayer Pharma Aktiengesellschaft 4-substituted pyrrolo- and pyrazolo-diazepines
WO2014143768A1 (en) 2013-03-15 2014-09-18 Incyte Corporation Tricyclic heterocycles as bet protein inhibitors
ES2635560T3 (es) 2013-07-08 2017-10-04 Incyte Holdings Corporation Heterociclos tricíclicos como inhibidores de la proteína NET
WO2015081189A1 (en) 2013-11-26 2015-06-04 Incyte Corporation Bicyclic heterocycles as bet protein inhibitors
US9399640B2 (en) 2013-11-26 2016-07-26 Incyte Corporation Substituted pyrrolo[2,3-c]pyridines and pyrazolo[3,4-c]pyridines as BET protein inhibitors
US9309246B2 (en) 2013-12-19 2016-04-12 Incyte Corporation Tricyclic heterocycles as BET protein inhibitors
US20170027955A1 (en) * 2014-04-04 2017-02-02 Constellation Pharmaceuticals, Inc. Expression levels of bcl-xl, bcl2, bcl-w, and bad and cancer therapies
ES2942723T3 (es) 2014-04-23 2023-06-06 Incyte Holdings Corp 1H-pirrolo[2,3-C]piridin-7(6H)-onas y pirazolo[3,4-C]piridin-7(6H)-onas como inhibidores de proteínas BET
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AR105124A1 (es) 2015-06-26 2017-09-06 Tensha Therapeutics Inc Tratamiento de carcinoma de la línea media nut
RU2734959C2 (ru) * 2015-09-09 2020-10-26 Джубилант Байосис Лимитед Трициклические конденсированные производные пиридин-2-она и их применение в качестве ингибиторов brd4
WO2017075377A1 (en) 2015-10-29 2017-05-04 Incyte Corporation Amorphous solid form of a bet protein inhibitor
EP3397640B1 (en) 2015-12-29 2021-08-04 INSERM - Institut National de la Santé et de la Recherche Médicale Xanthine derivative inhibitors of bet proteins
KR20250163425A (ko) 2016-06-20 2025-11-20 인사이트 코포레이션 Bet 저해제의 결정질 고체 형태
WO2018133139A1 (zh) 2017-01-21 2018-07-26 宁波知明生物科技有限公司 芍药苷-6'-o-苯磺酸酯在治疗干燥综合征的应用
EP3707139B1 (en) 2017-11-06 2022-02-16 Centre National de la Recherche Scientifique Xanthine derivatives and uses thereof as inhibitors of bromodomains of bet proteins
KR102026243B1 (ko) * 2018-01-19 2019-09-27 연세대학교 산학협력단 백혈병 치료용 약학적 조성물
CA3095415A1 (en) 2018-03-30 2019-10-03 Kyowa Kirin Co., Ltd. Compound with anticancer activity
CN111518045A (zh) * 2019-02-02 2020-08-11 博诺康源(北京)药业科技有限公司 一种具有苯并七元环结构的化合物、其制备方法及用途
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