JP6152643B2 - Ｉｌ−２３媒介疾患を治療するためのｅｐ４受容体拮抗薬の使用 - Google Patents
Ｉｌ−２３媒介疾患を治療するためのｅｐ４受容体拮抗薬の使用 Download PDFInfo
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- JP6152643B2 JP6152643B2 JP2012538520A JP2012538520A JP6152643B2 JP 6152643 B2 JP6152643 B2 JP 6152643B2 JP 2012538520 A JP2012538520 A JP 2012538520A JP 2012538520 A JP2012538520 A JP 2012538520A JP 6152643 B2 JP6152643 B2 JP 6152643B2
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| AR091429A1 (es) | 2012-06-29 | 2015-02-04 | Lilly Co Eli | Compuestos de fenoxietil piperidina |
| UA115576C2 (uk) * | 2012-12-06 | 2017-11-27 | Байєр Фарма Акцієнгезелльшафт | Похідні бензимідазолу як антагоністи ер4 |
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| TW201443004A (zh) | 2013-02-15 | 2014-11-16 | Lilly Co Eli | 苯氧基乙氧基化合物 |
| TWI636046B (zh) | 2013-05-17 | 2018-09-21 | 美國禮來大藥廠 | 苯氧基乙基二氫－１ｈ－異喹啉化合物 |
| HUE035698T2 (en) | 2013-12-17 | 2018-05-28 | Lilly Co Eli | Phenoxyethyl ring amine derivatives and their activity as EP4 receptor modulator |
| TW201607943A (zh) * | 2013-12-19 | 2016-03-01 | 拜耳製藥公司 | 作為ｅｐ４配體之新穎苯并咪唑衍生物 |
| TWI664969B (zh) | 2014-03-06 | 2019-07-11 | 雅瑞塔那醫療公司 | 格拉匹綸(ｇｒａｐｉｐｒａｎｔ)組合物及其使用方法 |
| US12109218B2 (en) | 2014-12-09 | 2024-10-08 | Aratana Therapeutics, Inc. | Compositions of grapiprant and methods for using the same |
| CA3002144C (en) * | 2015-10-16 | 2024-01-23 | Eisai R&D Management Co., Ltd. | Ep4 antagonists |
| US10342785B2 (en) * | 2016-11-04 | 2019-07-09 | Askat Inc. | Use of EP4 receptor antagonists for the treatment of NASH-associated liver cancer |
| UA126675C2 (uk) | 2017-01-23 | 2023-01-11 | Дженентек, Інк. | Хімічні сполуки як інгібітори активності інтерлейкіну-1 |
| CN109836434B (zh) * | 2017-11-27 | 2020-09-25 | 上海宇耀生物科技有限公司 | 噻吩并环类化合物及其合成方法和应用 |
| CN112292128A (zh) | 2018-04-16 | 2021-01-29 | 阿瑞斯医疗有限公司 | Ep4抑制剂和其用途 |
| WO2019245590A1 (en) | 2018-06-18 | 2019-12-26 | Avista Pharma Solutions, Inc. | Chemical compounds |
| US20210315909A1 (en) | 2018-07-11 | 2021-10-14 | Arrys Therapeutics, Inc. | Polymorphic compounds and uses thereof |
| MA53172A (fr) | 2018-07-20 | 2021-05-26 | Hoffmann La Roche | Composés de sulfonimidamide en tant qu'inhibiteurs de l'activité de l'interleukine 1 |
| MX2021000660A (es) | 2018-07-20 | 2021-03-25 | Hoffmann La Roche | Compuestos de sulfonilurea como inhibidores de la actividad de interleucina 1. |
| LT3860998T (lt) | 2018-10-05 | 2024-06-25 | Annapurna Bio Inc. | Junginiai ir kompozicijos, skirti gydyti būkles, susijusias su apj receptoriaus aktyvumu |
| CA3128024A1 (en) | 2019-01-30 | 2020-08-06 | Avista Pharma Solutions, Inc. | Chemical compounds |
| US11512088B2 (en) | 2019-01-30 | 2022-11-29 | Avista Pharma Solutions, Inc. | Synthetic process and intermediates |
| BR112022014480A2 (pt) | 2020-01-22 | 2022-09-13 | Hoffmann La Roche | Compostos, composições farmacêutica, método para tratar um distúrbio em um paciente, usos de um composto e de uma composição farmacêutica e kit |
| WO2021205367A1 (en) * | 2020-04-08 | 2021-10-14 | Askat Inc. | Use of ep4 receptor antagonists for the treatment of liver cancer, melanoma, lymphoma and leukemia |
| EP4200281A4 (en) | 2020-08-18 | 2024-09-25 | Hutchison Medipharma Limited | PYRIMIDINONE COMPOUNDS AND THEIR USES |
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| BR0309200A (pt) | 2002-04-12 | 2005-02-22 | Pfizer | Uso de ligandos receptores ep4 no tratamento de doenças envolvidas com a il-6 |
| CN100408570C (zh) * | 2003-01-29 | 2008-08-06 | 阿斯特兰德英国有限公司 | Ep4受体拮抗剂 |
| GB0302094D0 (en) | 2003-01-29 | 2003-02-26 | Pharmagene Lab Ltd | EP4 receptor antagonists |
| CA2536870C (en) * | 2003-09-03 | 2009-10-27 | Pfizer Inc. | Phenyl or pyridyl amide compounds as prostaglandin e2 antagonists |
| JP2007533723A (ja) * | 2004-04-20 | 2007-11-22 | ファイザー・プロダクツ・インク | α２δリガンドを含む組合せ |
| AU2005238291A1 (en) | 2004-05-04 | 2005-11-10 | Pfizer Inc. | Substituted methyl aryl or heteroaryl amide compounds |
| AU2006221699A1 (en) | 2005-03-11 | 2006-09-14 | Pfizer Inc. | Crystal forms of an imidazole derivative |
| AU2007283404B2 (en) * | 2006-08-11 | 2013-04-18 | Merck Canada Inc. | Thiophenecarboxamide derivatives as EP4 receptor ligands |
| EP1886987A1 (en) * | 2006-08-11 | 2008-02-13 | Givaudan S.A. | Process for producing 2,2,3-trimethylcyclopent-3-enecarbaldehyde (campholytic aldehyde) |
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| WO2011102149A1 (en) | 2011-08-25 |
| JP2013520397A (ja) | 2013-06-06 |
| CA2789665A1 (en) | 2011-08-25 |
| RU2571816C2 (ru) | 2015-12-20 |
| CN102770159A (zh) | 2012-11-07 |
| US9457084B2 (en) | 2016-10-04 |
| MX2012009503A (es) | 2012-09-12 |
| CA3009937A1 (en) | 2011-08-25 |
| JP2017095511A (ja) | 2017-06-01 |
| HK1178088A1 (zh) | 2013-09-06 |
| CN107693518A (zh) | 2018-02-16 |
| KR20130040787A (ko) | 2013-04-24 |
| EP2538978B1 (en) | 2016-09-07 |
| RU2012140450A (ru) | 2014-03-27 |
| BR112012020236A2 (pt) | 2016-05-17 |
| MX341482B (es) | 2016-08-22 |
| HK1249401A1 (zh) | 2018-11-02 |
| EP2538978A4 (en) | 2013-10-16 |
| US20120316197A1 (en) | 2012-12-13 |
| CA3009937C (en) | 2020-12-15 |
| ES2600355T3 (es) | 2017-02-08 |
| EP2538978A1 (en) | 2013-01-02 |
| CA2789665C (en) | 2020-06-16 |
| KR101780666B1 (ko) | 2017-09-21 |
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