RU2571816C2 - Применение антагонистов рецептора ep4 в лечении il-23-опосредуемых заболеваний - Google Patents

Применение антагонистов рецептора ep4 в лечении il-23-опосредуемых заболеваний Download PDF

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RU2571816C2
RU2571816C2 RU2012140450/15A RU2012140450A RU2571816C2 RU 2571816 C2 RU2571816 C2 RU 2571816C2 RU 2012140450/15 A RU2012140450/15 A RU 2012140450/15A RU 2012140450 A RU2012140450 A RU 2012140450A RU 2571816 C2 RU2571816 C2 RU 2571816C2
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amino
alkyl
groups
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RU2012140450A (ru
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Кийоси КАНАЗАВА
Кадзухико НОНОМУРА
Такако ОКУМУРА
Синити КОИДЗУМИ
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Раквалиа Фарма Инк.
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
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RU2012140450/15A 2010-02-22 2011-02-22 Применение антагонистов рецептора ep4 в лечении il-23-опосредуемых заболеваний RU2571816C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28250610P 2010-02-22 2010-02-22
US61/282,506 2010-02-22
PCT/JP2011/000994 WO2011102149A1 (en) 2010-02-22 2011-02-22 Use of ep4 receptor antagonists in the treatment of il-23 mediated diseases

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RU2012140450A RU2012140450A (ru) 2014-03-27
RU2571816C2 true RU2571816C2 (ru) 2015-12-20

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US (1) US9457084B2 (enExample)
EP (1) EP2538978B1 (enExample)
JP (2) JP6152643B2 (enExample)
KR (1) KR101780666B1 (enExample)
CN (2) CN102770159A (enExample)
BR (1) BR112012020236A2 (enExample)
CA (2) CA2789665C (enExample)
ES (1) ES2600355T3 (enExample)
HK (1) HK1249401A1 (enExample)
MX (1) MX341482B (enExample)
RU (1) RU2571816C2 (enExample)
WO (1) WO2011102149A1 (enExample)

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RU2717331C2 (ru) * 2016-11-04 2020-03-23 Аскат Инк. Применение антагонистов рецептора ep4 для лечения nash-ассоциированного рака печени

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AR091429A1 (es) 2012-06-29 2015-02-04 Lilly Co Eli Compuestos de fenoxietil piperidina
UA115576C2 (uk) * 2012-12-06 2017-11-27 Байєр Фарма Акцієнгезелльшафт Похідні бензимідазолу як антагоністи ер4
EP2765128A1 (en) 2013-02-07 2014-08-13 Almirall, S.A. Substituted benzamides with activity towards EP4 receptors
TW201443004A (zh) 2013-02-15 2014-11-16 Lilly Co Eli 苯氧基乙氧基化合物
TWI636046B (zh) 2013-05-17 2018-09-21 美國禮來大藥廠 苯氧基乙基二氫－１ｈ－異喹啉化合物
HUE035698T2 (en) 2013-12-17 2018-05-28 Lilly Co Eli Phenoxyethyl ring amine derivatives and their activity as EP4 receptor modulator
TW201607943A (zh) * 2013-12-19 2016-03-01 拜耳製藥公司 作為ｅｐ４配體之新穎苯并咪唑衍生物
TWI664969B (zh) 2014-03-06 2019-07-11 雅瑞塔那醫療公司 格拉匹綸(ｇｒａｐｉｐｒａｎｔ)組合物及其使用方法
US12109218B2 (en) 2014-12-09 2024-10-08 Aratana Therapeutics, Inc. Compositions of grapiprant and methods for using the same
CA3002144C (en) * 2015-10-16 2024-01-23 Eisai R&D Management Co., Ltd. Ep4 antagonists
UA126675C2 (uk) 2017-01-23 2023-01-11 Дженентек, Інк. Хімічні сполуки як інгібітори активності інтерлейкіну-1
CN109836434B (zh) * 2017-11-27 2020-09-25 上海宇耀生物科技有限公司 噻吩并环类化合物及其合成方法和应用
CN112292128A (zh) 2018-04-16 2021-01-29 阿瑞斯医疗有限公司 Ep4抑制剂和其用途
WO2019245590A1 (en) 2018-06-18 2019-12-26 Avista Pharma Solutions, Inc. Chemical compounds
US20210315909A1 (en) 2018-07-11 2021-10-14 Arrys Therapeutics, Inc. Polymorphic compounds and uses thereof
MA53172A (fr) 2018-07-20 2021-05-26 Hoffmann La Roche Composés de sulfonimidamide en tant qu'inhibiteurs de l'activité de l'interleukine 1
MX2021000660A (es) 2018-07-20 2021-03-25 Hoffmann La Roche Compuestos de sulfonilurea como inhibidores de la actividad de interleucina 1.
LT3860998T (lt) 2018-10-05 2024-06-25 Annapurna Bio Inc. Junginiai ir kompozicijos, skirti gydyti būkles, susijusias su apj receptoriaus aktyvumu
CA3128024A1 (en) 2019-01-30 2020-08-06 Avista Pharma Solutions, Inc. Chemical compounds
US11512088B2 (en) 2019-01-30 2022-11-29 Avista Pharma Solutions, Inc. Synthetic process and intermediates
BR112022014480A2 (pt) 2020-01-22 2022-09-13 Hoffmann La Roche Compostos, composições farmacêutica, método para tratar um distúrbio em um paciente, usos de um composto e de uma composição farmacêutica e kit
WO2021205367A1 (en) * 2020-04-08 2021-10-14 Askat Inc. Use of ep4 receptor antagonists for the treatment of liver cancer, melanoma, lymphoma and leukemia
EP4200281A4 (en) 2020-08-18 2024-09-25 Hutchison Medipharma Limited PYRIMIDINONE COMPOUNDS AND THEIR USES

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Publication number Priority date Publication date Assignee Title
RU2717331C2 (ru) * 2016-11-04 2020-03-23 Аскат Инк. Применение антагонистов рецептора ep4 для лечения nash-ассоциированного рака печени

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WO2011102149A1 (en) 2011-08-25
JP2013520397A (ja) 2013-06-06
CA2789665A1 (en) 2011-08-25
CN102770159A (zh) 2012-11-07
US9457084B2 (en) 2016-10-04
MX2012009503A (es) 2012-09-12
CA3009937A1 (en) 2011-08-25
JP2017095511A (ja) 2017-06-01
HK1178088A1 (zh) 2013-09-06
CN107693518A (zh) 2018-02-16
KR20130040787A (ko) 2013-04-24
EP2538978B1 (en) 2016-09-07
RU2012140450A (ru) 2014-03-27
JP6152643B2 (ja) 2017-06-28
BR112012020236A2 (pt) 2016-05-17
MX341482B (es) 2016-08-22
HK1249401A1 (zh) 2018-11-02
EP2538978A4 (en) 2013-10-16
US20120316197A1 (en) 2012-12-13
CA3009937C (en) 2020-12-15
ES2600355T3 (es) 2017-02-08
EP2538978A1 (en) 2013-01-02
CA2789665C (en) 2020-06-16
KR101780666B1 (ko) 2017-09-21

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