CA2789665C - Use of ep4 receptor antagonists in the treatment of il-23 mediated diseases - Google Patents
Use of ep4 receptor antagonists in the treatment of il-23 mediated diseases Download PDFInfo
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- CA2789665C CA2789665C CA2789665A CA2789665A CA2789665C CA 2789665 C CA2789665 C CA 2789665C CA 2789665 A CA2789665 A CA 2789665A CA 2789665 A CA2789665 A CA 2789665A CA 2789665 C CA2789665 C CA 2789665C
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- ILMRJRBKQSSXGY-UHFFFAOYSA-N tert-butyl(dimethyl)silicon Chemical group C[Si](C)C(C)(C)C ILMRJRBKQSSXGY-UHFFFAOYSA-N 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- LPSXSORODABQKT-UHFFFAOYSA-N tetrahydrodicyclopentadiene Chemical compound C1C2CCC1C1C2CCC1 LPSXSORODABQKT-UHFFFAOYSA-N 0.000 description 1
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- 125000004187 tetrahydropyran-2-yl group Chemical group [H]C1([H])OC([H])(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
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- 230000000699 topical effect Effects 0.000 description 1
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- 125000001425 triazolyl group Chemical group 0.000 description 1
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- 125000000025 triisopropylsilyl group Chemical group C(C)(C)[Si](C(C)C)(C(C)C)* 0.000 description 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
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- 230000008026 type II hypersensitivity Effects 0.000 description 1
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- 230000005951 type IV hypersensitivity Effects 0.000 description 1
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- 125000000297 undecanoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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- Health & Medical Sciences (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CA3009937A CA3009937C (en) | 2010-02-22 | 2011-02-22 | Use of ep4 receptor antagonists in the treatment of il-23 mediated diseases |
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| US28250610P | 2010-02-22 | 2010-02-22 | |
| US61/282,506 | 2010-02-22 | ||
| PCT/JP2011/000994 WO2011102149A1 (en) | 2010-02-22 | 2011-02-22 | Use of ep4 receptor antagonists in the treatment of il-23 mediated diseases |
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| CA2789665A1 CA2789665A1 (en) | 2011-08-25 |
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| EP (1) | EP2538978B1 (enExample) |
| JP (2) | JP6152643B2 (enExample) |
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| AR091429A1 (es) | 2012-06-29 | 2015-02-04 | Lilly Co Eli | Compuestos de fenoxietil piperidina |
| UA115576C2 (uk) * | 2012-12-06 | 2017-11-27 | Байєр Фарма Акцієнгезелльшафт | Похідні бензимідазолу як антагоністи ер4 |
| EP2765128A1 (en) * | 2013-02-07 | 2014-08-13 | Almirall, S.A. | Substituted benzamides with activity towards EP4 receptors |
| TW201443004A (zh) | 2013-02-15 | 2014-11-16 | Lilly Co Eli | 苯氧基乙氧基化合物 |
| TWI636046B (zh) | 2013-05-17 | 2018-09-21 | 美國禮來大藥廠 | 苯氧基乙基二氫－１ｈ－異喹啉化合物 |
| BR112016011016A8 (pt) | 2013-12-17 | 2018-01-30 | Lilly Co Eli | derivados de fenoxietila de amina cíclica, seus usos, e composição farmacêutica. |
| TW201607943A (zh) * | 2013-12-19 | 2016-03-01 | 拜耳製藥公司 | 作為ｅｐ４配體之新穎苯并咪唑衍生物 |
| US12109218B2 (en) | 2014-12-09 | 2024-10-08 | Aratana Therapeutics, Inc. | Compositions of grapiprant and methods for using the same |
| TWI708606B (zh) | 2014-03-06 | 2020-11-01 | 美商雅瑞塔那醫療公司 | 格拉匹綸(grapiprant)組合物及其使用方法 |
| MX390051B (es) * | 2015-10-16 | 2025-03-20 | Eisai R&D Man Co Ltd | Antagonistas de ep4. |
| US10342785B2 (en) * | 2016-11-04 | 2019-07-09 | Askat Inc. | Use of EP4 receptor antagonists for the treatment of NASH-associated liver cancer |
| CN110366549A (zh) | 2017-01-23 | 2019-10-22 | 基因泰克公司 | 作为白介素-1活性抑制剂的化合物 |
| CN109836434B (zh) * | 2017-11-27 | 2020-09-25 | 上海宇耀生物科技有限公司 | 噻吩并环类化合物及其合成方法和应用 |
| CA3096546A1 (en) | 2018-04-16 | 2019-10-24 | Arrys Therapeutics, Inc. | Ep4 inhibitors and use thereof |
| US10239885B1 (en) | 2018-06-18 | 2019-03-26 | Avista Pharma Solutions, Inc. | Compound 1-[2-[4-(2-ethyl-6,8-dimethylimidazo[1,2-α]pyrazin-3-yl)phenyl]ethyl]-3-(p-tolylsulfonyl)urea as a prostaglandin EP4 receptor antagonist |
| WO2020014465A1 (en) | 2018-07-11 | 2020-01-16 | Arrys Therapeutics, Inc. | Polymorphic compounds and uses thereof |
| KR20210034596A (ko) | 2018-07-20 | 2021-03-30 | 에프. 호프만-라 로슈 아게 | 인터류킨-1 활성의 저해제로서 술폰이미드아미드 화합물 |
| WO2020018970A1 (en) * | 2018-07-20 | 2020-01-23 | Genentech, Inc. | Sulfonylurea compounds as inhibitors of interleukin-1 activity |
| IL316875A (en) | 2018-10-05 | 2025-01-01 | Annapurna Bio Inc | Compounds and compositions for treating conditions associated with APJ receptor activity |
| MX2021009251A (es) | 2019-01-30 | 2021-09-21 | Avista Pharma Solutions Inc | Proceso de sintesis y nuevos compuestos intermedios. |
| WO2020160075A1 (en) | 2019-01-30 | 2020-08-06 | Avista Pharma Solutions, Inc. | Chemical compounds |
| WO2021205367A1 (en) * | 2020-04-08 | 2021-10-14 | Askat Inc. | Use of ep4 receptor antagonists for the treatment of liver cancer, melanoma, lymphoma and leukemia |
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| HN2001000224A (es) | 2000-10-19 | 2002-06-13 | Pfizer | Compuestos de imidazol condensado con arilo o heteroarilo como agentes anti - inflamatorios y analgesicos. |
| IL164263A0 (en) | 2002-04-12 | 2005-12-18 | Pfizer | Use of ep4 receptor ligands on the treatment of il-6 involved diseases |
| AU2004207675B2 (en) * | 2003-01-29 | 2010-05-20 | Asterand Uk Acquisition Limited | EP4 receptor antagonists |
| GB0302094D0 (en) | 2003-01-29 | 2003-02-26 | Pharmagene Lab Ltd | EP4 receptor antagonists |
| BRPI0414130B8 (pt) * | 2003-09-03 | 2021-05-25 | Askat Inc | compostos de fenilamida ou piridilamida, seu uso e composições farmacêuticas que os compreendem. |
| JP2007533723A (ja) * | 2004-04-20 | 2007-11-22 | ファイザー・プロダクツ・インク | α２δリガンドを含む組合せ |
| AP2006003785A0 (en) | 2004-05-04 | 2006-10-31 | Pfizer | Substituted methylaryl or heteroaryl amide compounds |
| AU2006221699A1 (en) | 2005-03-11 | 2006-09-14 | Pfizer Inc. | Crystal forms of an imidazole derivative |
| US8969394B2 (en) | 2006-08-11 | 2015-03-03 | Merck Frosst Canada Ltd. | Thiophenecarboxamide derivatives as EP4 receptor ligands |
| EP1886987A1 (en) * | 2006-08-11 | 2008-02-13 | Givaudan S.A. | Process for producing 2,2,3-trimethylcyclopent-3-enecarbaldehyde (campholytic aldehyde) |
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2018
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Also Published As
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| HK1178088A1 (zh) | 2013-09-06 |
| MX2012009503A (es) | 2012-09-12 |
| JP2013520397A (ja) | 2013-06-06 |
| ES2600355T3 (es) | 2017-02-08 |
| RU2571816C2 (ru) | 2015-12-20 |
| JP2017095511A (ja) | 2017-06-01 |
| CN102770159A (zh) | 2012-11-07 |
| KR20130040787A (ko) | 2013-04-24 |
| EP2538978A4 (en) | 2013-10-16 |
| RU2012140450A (ru) | 2014-03-27 |
| CA3009937C (en) | 2020-12-15 |
| WO2011102149A1 (en) | 2011-08-25 |
| US9457084B2 (en) | 2016-10-04 |
| KR101780666B1 (ko) | 2017-09-21 |
| EP2538978A1 (en) | 2013-01-02 |
| CN107693518A (zh) | 2018-02-16 |
| JP6152643B2 (ja) | 2017-06-28 |
| HK1249401A1 (zh) | 2018-11-02 |
| US20120316197A1 (en) | 2012-12-13 |
| MX341482B (es) | 2016-08-22 |
| CA2789665A1 (en) | 2011-08-25 |
| BR112012020236A2 (pt) | 2016-05-17 |
| CA3009937A1 (en) | 2011-08-25 |
| EP2538978B1 (en) | 2016-09-07 |
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