JP6147737B2 - 選択的グリコシダーゼ阻害剤およびその使用 - Google Patents

選択的グリコシダーゼ阻害剤およびその使用 Download PDF

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Publication number
JP6147737B2
JP6147737B2 JP2014517357A JP2014517357A JP6147737B2 JP 6147737 B2 JP6147737 B2 JP 6147737B2 JP 2014517357 A JP2014517357 A JP 2014517357A JP 2014517357 A JP2014517357 A JP 2014517357A JP 6147737 B2 JP6147737 B2 JP 6147737B2
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Japan
Prior art keywords
fluoro
pyrano
tetrahydro
thiazol
hydroxyethyl
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Expired - Fee Related
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JP2014517357A
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Japanese (ja)
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JP2014524911A5 (https=
JP2014524911A (ja
Inventor
トン−シュアン リ，
トン−シュアン リ，
アーネスト ジェイ． マケーチャン，
アーネスト ジェイ． マケーチャン，
デイビッド ジェイ． ヴォカドゥロ，
デイビッド ジェイ． ヴォカドゥロ，
ユアンシ ジョウ，
ユアンシ ジョウ，
ヨンバオ ジュー，
ヨンバオ ジュー，
ハロルド ジー． セルニック，
ハロルド ジー． セルニック，
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Merck Sharp and Dohme LLC
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Merck Sharp and Dohme LLC
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    • C07—ORGANIC CHEMISTRY
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    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/06—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing nitrogen as ring hetero atoms
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
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    • G01N2333/914—Hydrolases (3)
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    • G—PHYSICS
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  • General Health & Medical Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
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  • Heart & Thoracic Surgery (AREA)
JP2014517357A 2011-06-27 2012-06-27 選択的グリコシダーゼ阻害剤およびその使用 Expired - Fee Related JP6147737B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161501377P 2011-06-27 2011-06-27
US61/501,377 2011-06-27
PCT/CA2012/050433 WO2013000084A1 (en) 2011-06-27 2012-06-27 Selective glycosidase inhibitors and uses thereof

Publications (3)

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JP2014524911A JP2014524911A (ja) 2014-09-25
JP2014524911A5 JP2014524911A5 (https=) 2015-08-13
JP6147737B2 true JP6147737B2 (ja) 2017-06-14

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US (1) US9409924B2 (https=)
EP (1) EP2723753B1 (https=)
JP (1) JP6147737B2 (https=)
KR (1) KR102054744B1 (https=)
CN (1) CN103889996B (https=)
AU (1) AU2012276257B2 (https=)
BR (1) BR112013033098B8 (https=)
CA (1) CA2840013C (https=)
MX (1) MX364602B (https=)
RU (1) RU2625308C2 (https=)
WO (1) WO2013000084A1 (https=)

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EP2057171A4 (en) 2006-08-31 2010-04-21 Univ Fraser Simon SELECTIVE GLYCOSIDASE INHIBITORS AND APPLICATIONS THEREOF
EP2321289A4 (en) 2008-08-01 2011-11-16 Univ Fraser Simon SELECTIVE GLYCOSIDASE HEMMER AND ITS USE
US9120781B2 (en) 2010-05-11 2015-09-01 Simon Fraser University Selective glycosidase inhibitors and uses thereof
US8933040B2 (en) 2010-11-08 2015-01-13 Craig A. Coburn Selective glycosidase inhibitors and uses thereof
DK2655388T3 (en) 2010-12-23 2016-09-19 Alectos Therapeutics Inc Selective glykosidaseinhibitorer and uses thereof
WO2012126091A1 (en) 2011-03-24 2012-09-27 Alectos Therapeutics Inc. Selective glycosidase inhibitors and uses thereof
WO2012129651A1 (en) 2011-03-31 2012-10-04 Alectos Therapeutics Inc. Selective glycosidase inhibitors and uses thereof
WO2013000085A1 (en) 2011-06-27 2013-01-03 Alectos Therapeutics Inc. Selective glycosidase inhibitors and uses thereof
CN103889996B (zh) 2011-06-27 2016-02-03 阿列科托斯治疗有限公司 选择性糖苷酶抑制剂及其用途
WO2013000086A1 (en) 2011-06-27 2013-01-03 Alectos Therapeutics Inc. Selective glycosidase inhibitors and uses thereof
WO2014032185A1 (en) 2012-08-31 2014-03-06 Alectos Therapeutics Inc. Glycosidase inhibitors and uses thereof
WO2014032188A1 (en) 2012-08-31 2014-03-06 Alectos Therapeutics Inc. Glycosidase inhibitors and uses thereof
WO2014067003A1 (en) 2012-10-31 2014-05-08 Alectos Therapeutics Inc. Glycosidase inhibitors and uses thereof
WO2014100934A1 (en) 2012-12-24 2014-07-03 Merck Sharp & Dohme Corp. Glycosidase inhibitors and uses thereof
CN120796168A (zh) 2013-06-11 2025-10-17 哈佛学院校长同事会 SC-β细胞以及用于产生其的组合物和方法
US9994589B2 (en) * 2015-12-14 2018-06-12 Amicus Therapeutics, Inc. Compounds and methods for the treatment of alzheimer's disease and/or cerebral amyloid angiopathy
AR114237A1 (es) * 2018-02-01 2020-08-05 Japan Tobacco Inc Compuesto de amida heterocíclica que contiene nitrógeno y su uso farmacéutico
GB201907716D0 (en) 2019-05-31 2019-07-17 Smith & Nephew Systems and methods for extending operational time of negative pressure wound treatment apparatuses
GB202000274D0 (en) 2020-01-09 2020-02-26 Smith & Nephew Systems and methods for monitoring operational lifetime of negative pressure wound treatment apparatuses
JP7797489B2 (ja) 2020-10-05 2026-01-13 ティージェイ スミス アンド ネフュー リミテッド 陰圧創傷療法システムのための温度監視及び制御
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GB202110240D0 (en) 2021-07-16 2021-09-01 Smith & Nephew Reduced pressure apparatuses and methods
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WO2023135177A1 (en) 2022-01-14 2023-07-20 T.J.Smith And Nephew, Limited Self-calibration with dynamic therapy performance for negative pressure wound therapy devices
GB202304922D0 (en) 2023-04-03 2023-05-17 Smith & Nephew Printed circuit board configurations for negative pressure wound therapy devices

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CN103889996B (zh) 2016-02-03
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US20140296205A1 (en) 2014-10-02
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MX364602B (es) 2019-05-02
CN103889996A (zh) 2014-06-25
RU2625308C2 (ru) 2017-07-13
RU2014102232A (ru) 2015-08-10
JP2014524911A (ja) 2014-09-25
US9409924B2 (en) 2016-08-09
BR112013033098B1 (pt) 2020-10-20
WO2013000084A1 (en) 2013-01-03
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