CA2840013C - Selective glycosidase inhibitors and uses thereof - Google Patents

Selective glycosidase inhibitors and uses thereof Download PDF

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Publication number
CA2840013C
CA2840013C CA2840013A CA2840013A CA2840013C CA 2840013 C CA2840013 C CA 2840013C CA 2840013 A CA2840013 A CA 2840013A CA 2840013 A CA2840013 A CA 2840013A CA 2840013 C CA2840013 C CA 2840013C
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Prior art keywords
fluoro
tetrahydro
pyrano
thiazol
hydroxyethyl
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CA2840013A
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English (en)
French (fr)
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CA2840013A1 (en
Inventor
Tong-Shuang Li
Ernest J. Mceachern
David J. Vocadlo
Yuanxi Zhou
Yongbao Zhu
Harold G. Selnick
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Alectos Therapeutics Inc
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Alectos Therapeutics Inc
Merck Sharp and Dohme LLC
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
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    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/06—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing nitrogen as ring hetero atoms
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • G—PHYSICS
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5038—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving detection of metabolites per se
    • G—PHYSICS
    • G01—MEASURING; TESTING
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    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/924—Hydrolases (3) acting on glycosyl compounds (3.2)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • Neurosurgery (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Psychology (AREA)
  • Rheumatology (AREA)
CA2840013A 2011-06-27 2012-06-27 Selective glycosidase inhibitors and uses thereof Active CA2840013C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161501377P 2011-06-27 2011-06-27
US61/501,377 2011-06-27
PCT/CA2012/050433 WO2013000084A1 (en) 2011-06-27 2012-06-27 Selective glycosidase inhibitors and uses thereof

Publications (2)

Publication Number Publication Date
CA2840013A1 CA2840013A1 (en) 2013-01-03
CA2840013C true CA2840013C (en) 2021-02-09

Family

ID=47423333

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2840013A Active CA2840013C (en) 2011-06-27 2012-06-27 Selective glycosidase inhibitors and uses thereof

Country Status (11)

Country Link
US (1) US9409924B2 (https=)
EP (1) EP2723753B1 (https=)
JP (1) JP6147737B2 (https=)
KR (1) KR102054744B1 (https=)
CN (1) CN103889996B (https=)
AU (1) AU2012276257B2 (https=)
BR (1) BR112013033098B8 (https=)
CA (1) CA2840013C (https=)
MX (1) MX364602B (https=)
RU (1) RU2625308C2 (https=)
WO (1) WO2013000084A1 (https=)

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AU2007291870B2 (en) 2006-08-31 2012-12-06 Simon Fraser University Selective glycosidase inhibitors and uses thereof
EP2321289A4 (en) 2008-08-01 2011-11-16 Univ Fraser Simon SELECTIVE GLYCOSIDASE HEMMER AND ITS USE
WO2011140640A1 (en) 2010-05-11 2011-11-17 Simon Fraser University Selective glycosidase inhibitors and uses thereof
US8933040B2 (en) 2010-11-08 2015-01-13 Craig A. Coburn Selective glycosidase inhibitors and uses thereof
RU2609210C2 (ru) 2010-12-23 2017-01-31 Алектос Терапьютикс Инк. Селективные ингибиторы гликозидазы и их применение
EP2688899B1 (en) 2011-03-24 2017-02-22 Alectos Therapeutics Inc. Selective glycosidase inhibitors and uses thereof
EP2691407B1 (en) 2011-03-31 2017-02-22 Alectos Therapeutics Inc. Selective glycosidase inhibitors and uses thereof
US9701693B2 (en) 2011-06-27 2017-07-11 Alectos Therapeutics Inc. Selective glycosidase inhibitors and uses thereof
EP2726468B1 (en) 2011-06-27 2017-04-12 Alectos Therapeutics Inc. Selective glycosidase inhibitors and uses thereof
BR112013033098B8 (pt) 2011-06-27 2021-03-23 Alectos Therapeutics Inc inibidores de glicosidade seletivos e usos dos mesmos
EP2890676B1 (en) 2012-08-31 2018-12-05 Alectos Therapeutics Inc. Glycosidase inhibitors and uses thereof
EP2890675A4 (en) 2012-08-31 2016-01-13 Alectos Therapeutics Inc GLYCOSIDASE INHIBITORS AND USES THEREOF
KR20150079711A (ko) 2012-10-31 2015-07-08 알렉토스 테라퓨틱스 인크. 글리코시다아제 저해제 및 이의 용도
WO2014100934A1 (en) 2012-12-24 2014-07-03 Merck Sharp & Dohme Corp. Glycosidase inhibitors and uses thereof
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GB201907716D0 (en) 2019-05-31 2019-07-17 Smith & Nephew Systems and methods for extending operational time of negative pressure wound treatment apparatuses
GB202000274D0 (en) 2020-01-09 2020-02-26 Smith & Nephew Systems and methods for monitoring operational lifetime of negative pressure wound treatment apparatuses
WO2022073762A1 (en) 2020-10-05 2022-04-14 T.J.Smith And Nephew,Limited Temperature monitoring and control for negative pressure wound therapy systems
GB202104922D0 (en) 2021-04-07 2021-05-19 Smith & Nephew Temperature monitoring and control for negative pressure wound therapy systems
KR102533471B1 (ko) 2020-11-23 2023-05-19 (주) 메디프론디비티 O-GlcNAcase 저해 활성을 갖는 화합물 및 이의 용도
GB202109154D0 (en) 2021-06-25 2021-08-11 Smith & Nephew Liquid ingress protection for negative pressure wound therapy systems
US20240285847A1 (en) 2021-06-25 2024-08-29 T.J.Smith And Nephew,Limited Liquid ingress protection and design of electronic circuitry for negative pressure wound therapy systems
GB202110240D0 (en) 2021-07-16 2021-09-01 Smith & Nephew Reduced pressure apparatuses and methods
US20250050008A1 (en) 2022-01-10 2025-02-13 T.J.Smith And Nephew,Limited Temperature detection and protection for negative pressure wound therapy systems
WO2023135177A1 (en) 2022-01-14 2023-07-20 T.J.Smith And Nephew, Limited Self-calibration with dynamic therapy performance for negative pressure wound therapy devices
GB202304922D0 (en) 2023-04-03 2023-05-17 Smith & Nephew Printed circuit board configurations for negative pressure wound therapy devices

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EP2723753A1 (en) 2014-04-30
MX364602B (es) 2019-05-02
CN103889996B (zh) 2016-02-03
AU2012276257B2 (en) 2017-05-18
JP6147737B2 (ja) 2017-06-14
BR112013033098A2 (pt) 2016-09-06
RU2014102232A (ru) 2015-08-10
CA2840013A1 (en) 2013-01-03
BR112013033098B8 (pt) 2021-03-23
WO2013000084A1 (en) 2013-01-03
JP2014524911A (ja) 2014-09-25
KR102054744B1 (ko) 2019-12-11
RU2625308C2 (ru) 2017-07-13
EP2723753A4 (en) 2014-11-26
US20140296205A1 (en) 2014-10-02
US9409924B2 (en) 2016-08-09
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CN103889996A (zh) 2014-06-25
KR20140043125A (ko) 2014-04-08

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