JP6147737B2 - 選択的グリコシダーゼ阻害剤およびその使用 - Google Patents

選択的グリコシダーゼ阻害剤およびその使用 Download PDF

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JP6147737B2
JP6147737B2 JP2014517357A JP2014517357A JP6147737B2 JP 6147737 B2 JP6147737 B2 JP 6147737B2 JP 2014517357 A JP2014517357 A JP 2014517357A JP 2014517357 A JP2014517357 A JP 2014517357A JP 6147737 B2 JP6147737 B2 JP 6147737B2
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fluoro
pyrano
tetrahydro
thiazol
hydroxyethyl
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JP2014524911A (ja
JP2014524911A5 (enExample
Inventor
トン−シュアン リ，
トン−シュアン リ，
アーネスト ジェイ． マケーチャン，
アーネスト ジェイ． マケーチャン，
デイビッド ジェイ． ヴォカドゥロ，
デイビッド ジェイ． ヴォカドゥロ，
ユアンシ ジョウ，
ユアンシ ジョウ，
ヨンバオ ジュー，
ヨンバオ ジュー，
ハロルド ジー． セルニック，
ハロルド ジー． セルニック，
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Merck Sharp and Dohme LLC
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Merck Sharp and Dohme LLC
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    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/06—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing nitrogen as ring hetero atoms
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    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
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    • G01N2333/914—Hydrolases (3)
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    • G—PHYSICS
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JP2014517357A 2011-06-27 2012-06-27 選択的グリコシダーゼ阻害剤およびその使用 Active JP6147737B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161501377P 2011-06-27 2011-06-27
US61/501,377 2011-06-27
PCT/CA2012/050433 WO2013000084A1 (en) 2011-06-27 2012-06-27 Selective glycosidase inhibitors and uses thereof

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JP2014524911A JP2014524911A (ja) 2014-09-25
JP2014524911A5 JP2014524911A5 (enExample) 2015-08-13
JP6147737B2 true JP6147737B2 (ja) 2017-06-14

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US (1) US9409924B2 (enExample)
EP (1) EP2723753B1 (enExample)
JP (1) JP6147737B2 (enExample)
KR (1) KR102054744B1 (enExample)
CN (1) CN103889996B (enExample)
AU (1) AU2012276257B2 (enExample)
BR (1) BR112013033098B8 (enExample)
CA (1) CA2840013C (enExample)
MX (1) MX364602B (enExample)
RU (1) RU2625308C2 (enExample)
WO (1) WO2013000084A1 (enExample)

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JP5380293B2 (ja) 2006-08-31 2014-01-08 サイモン・フレーザー・ユニバーシティ 選択的グリコシダーゼ阻害剤およびその使用
WO2010012107A1 (en) 2008-08-01 2010-02-04 Simon Fraser University Selective glycosidase inhibitors and uses thereof
US9120781B2 (en) 2010-05-11 2015-09-01 Simon Fraser University Selective glycosidase inhibitors and uses thereof
WO2012061927A1 (en) 2010-11-08 2012-05-18 Alectos Therapeutics, Inc. Selective glycosidase inhibitors and uses thereof
RU2609210C2 (ru) 2010-12-23 2017-01-31 Алектос Терапьютикс Инк. Селективные ингибиторы гликозидазы и их применение
WO2012126091A1 (en) 2011-03-24 2012-09-27 Alectos Therapeutics Inc. Selective glycosidase inhibitors and uses thereof
WO2012129651A1 (en) 2011-03-31 2012-10-04 Alectos Therapeutics Inc. Selective glycosidase inhibitors and uses thereof
EP2726468B1 (en) 2011-06-27 2017-04-12 Alectos Therapeutics Inc. Selective glycosidase inhibitors and uses thereof
US9701693B2 (en) 2011-06-27 2017-07-11 Alectos Therapeutics Inc. Selective glycosidase inhibitors and uses thereof
RU2625308C2 (ru) 2011-06-27 2017-07-13 Алектос Терапьютикс Инк. Селективные ингибиторы гликозидазы и их применение
EP2890676B1 (en) 2012-08-31 2018-12-05 Alectos Therapeutics Inc. Glycosidase inhibitors and uses thereof
EP2890675A4 (en) 2012-08-31 2016-01-13 Alectos Therapeutics Inc GLYCOSIDASE INHIBITORS AND USES THEREOF
KR20150079711A (ko) 2012-10-31 2015-07-08 알렉토스 테라퓨틱스 인크. 글리코시다아제 저해제 및 이의 용도
WO2014100934A1 (en) 2012-12-24 2014-07-03 Merck Sharp & Dohme Corp. Glycosidase inhibitors and uses thereof
KR102423106B1 (ko) 2013-06-11 2022-07-21 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 SC-β 세포 및 조성물 그리고 그 생성 방법
US9994589B2 (en) * 2015-12-14 2018-06-12 Amicus Therapeutics, Inc. Compounds and methods for the treatment of alzheimer's disease and/or cerebral amyloid angiopathy
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US20140296205A1 (en) 2014-10-02
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