JP6147737B2 - 選択的グリコシダーゼ阻害剤およびその使用 - Google Patents

選択的グリコシダーゼ阻害剤およびその使用 Download PDF

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Publication number
JP6147737B2
JP6147737B2 JP2014517357A JP2014517357A JP6147737B2 JP 6147737 B2 JP6147737 B2 JP 6147737B2 JP 2014517357 A JP2014517357 A JP 2014517357A JP 2014517357 A JP2014517357 A JP 2014517357A JP 6147737 B2 JP6147737 B2 JP 6147737B2
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Japan
Prior art keywords
fluoro
pyrano
tetrahydro
thiazol
hydroxyethyl
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Expired - Fee Related
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JP2014517357A
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Japanese (ja)
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JP2014524911A5 (enExample
JP2014524911A (ja
Inventor
トン−シュアン リ，
トン−シュアン リ，
アーネスト ジェイ． マケーチャン，
アーネスト ジェイ． マケーチャン，
デイビッド ジェイ． ヴォカドゥロ，
デイビッド ジェイ． ヴォカドゥロ，
ユアンシ ジョウ，
ユアンシ ジョウ，
ヨンバオ ジュー，
ヨンバオ ジュー，
ハロルド ジー． セルニック，
ハロルド ジー． セルニック，
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Merck Sharp & Dohme LLC
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Merck Sharp & Dohme LLC
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/06—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing nitrogen as ring hetero atoms
    • A—HUMAN NECESSITIES
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
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    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/924—Hydrolases (3) acting on glycosyl compounds (3.2)
    • G—PHYSICS
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  • Bioinformatics & Cheminformatics (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Molecular Biology (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
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JP2014517357A 2011-06-27 2012-06-27 選択的グリコシダーゼ阻害剤およびその使用 Expired - Fee Related JP6147737B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161501377P 2011-06-27 2011-06-27
US61/501,377 2011-06-27
PCT/CA2012/050433 WO2013000084A1 (en) 2011-06-27 2012-06-27 Selective glycosidase inhibitors and uses thereof

Publications (3)

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JP2014524911A JP2014524911A (ja) 2014-09-25
JP2014524911A5 JP2014524911A5 (enExample) 2015-08-13
JP6147737B2 true JP6147737B2 (ja) 2017-06-14

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Country Link
US (1) US9409924B2 (enExample)
EP (1) EP2723753B1 (enExample)
JP (1) JP6147737B2 (enExample)
KR (1) KR102054744B1 (enExample)
CN (1) CN103889996B (enExample)
AU (1) AU2012276257B2 (enExample)
BR (1) BR112013033098B8 (enExample)
CA (1) CA2840013C (enExample)
MX (1) MX364602B (enExample)
RU (1) RU2625308C2 (enExample)
WO (1) WO2013000084A1 (enExample)

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EP2057171A4 (en) 2006-08-31 2010-04-21 Univ Fraser Simon SELECTIVE GLYCOSIDASE INHIBITORS AND APPLICATIONS THEREOF
JP5687194B2 (ja) 2008-08-01 2015-03-18 サイモン フレイザー ユニバーシティ 選択的グリコシダーゼインヒビターおよびその使用
US9120781B2 (en) 2010-05-11 2015-09-01 Simon Fraser University Selective glycosidase inhibitors and uses thereof
WO2012061927A1 (en) 2010-11-08 2012-05-18 Alectos Therapeutics, Inc. Selective glycosidase inhibitors and uses thereof
BR112013016179A2 (pt) 2010-12-23 2018-07-10 Alectos Therapeutics Inc inibidores seletivos da glicosidase e usos dos mesmos.
WO2012126091A1 (en) 2011-03-24 2012-09-27 Alectos Therapeutics Inc. Selective glycosidase inhibitors and uses thereof
US9718854B2 (en) 2011-03-31 2017-08-01 Alectos Therapeutics Inc. Selective glycosidase inhibitors and uses thereof
MX364602B (es) 2011-06-27 2019-05-02 Alectos Therapeutics Inc Inhibidores selectivos de glicosidasa y usos de los mismos.
WO2013000086A1 (en) 2011-06-27 2013-01-03 Alectos Therapeutics Inc. Selective glycosidase inhibitors and uses thereof
WO2013000085A1 (en) 2011-06-27 2013-01-03 Alectos Therapeutics Inc. Selective glycosidase inhibitors and uses thereof
EP2890675A4 (en) 2012-08-31 2016-01-13 Alectos Therapeutics Inc GLYCOSIDASE INHIBITORS AND USES THEREOF
EP2890676B1 (en) 2012-08-31 2018-12-05 Alectos Therapeutics Inc. Glycosidase inhibitors and uses thereof
EP2914604A4 (en) 2012-10-31 2016-07-20 Alectos Therapeutics Inc GLYCOSIDASE INHIBITORS AND USES THEREOF
WO2014100934A1 (en) 2012-12-24 2014-07-03 Merck Sharp & Dohme Corp. Glycosidase inhibitors and uses thereof
AU2014278178B2 (en) 2013-06-11 2021-01-21 President And Fellows Of Harvard College SC-beta cells and compositions and methods for generating the same
AR106977A1 (es) * 2015-12-14 2018-03-07 Amicus Therapeutics Inc Compuestos para el tratamiento de la enfermedad de alzheimer y/o la angiopatía amiloide cerebral
PE20211273A1 (es) * 2018-02-01 2021-07-19 Japan Tobacco Inc Compuesto de amida heterociclica nitrogenada y su uso para fines medicos
GB201907716D0 (en) 2019-05-31 2019-07-17 Smith & Nephew Systems and methods for extending operational time of negative pressure wound treatment apparatuses
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KR102533471B1 (ko) 2020-11-23 2023-05-19 (주) 메디프론디비티 O-GlcNAcase 저해 활성을 갖는 화합물 및 이의 용도
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GB202110240D0 (en) 2021-07-16 2021-09-01 Smith & Nephew Reduced pressure apparatuses and methods
US20250050008A1 (en) 2022-01-10 2025-02-13 T.J.Smith And Nephew,Limited Temperature detection and protection for negative pressure wound therapy systems
EP4463194A1 (en) 2022-01-14 2024-11-20 T.J. Smith and Nephew, Limited Self-calibration with dynamic therapy performance for negative pressure wound therapy devices
GB202304922D0 (en) 2023-04-03 2023-05-17 Smith & Nephew Printed circuit board configurations for negative pressure wound therapy devices

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AU2012276257A1 (en) 2014-01-23
BR112013033098A2 (pt) 2016-09-06
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US9409924B2 (en) 2016-08-09
EP2723753A4 (en) 2014-11-26
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CA2840013A1 (en) 2013-01-03
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