JP6134266B2 - 関節炎患者の滑膜の微小血管系に特異的に結合する抗体 - Google Patents

関節炎患者の滑膜の微小血管系に特異的に結合する抗体 Download PDF

Info

Publication number
JP6134266B2
JP6134266B2 JP2013530798A JP2013530798A JP6134266B2 JP 6134266 B2 JP6134266 B2 JP 6134266B2 JP 2013530798 A JP2013530798 A JP 2013530798A JP 2013530798 A JP2013530798 A JP 2013530798A JP 6134266 B2 JP6134266 B2 JP 6134266B2
Authority
JP
Japan
Prior art keywords
antigen
binding polypeptide
substance
synovial
scfv
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2013530798A
Other languages
English (en)
Japanese (ja)
Other versions
JP2014501490A5 (enExample
JP2014501490A (ja
Inventor
コスタンティーノ ピツァリス，
コスタンティーノ ピツァリス，
Original Assignee
クイーン マリー ユニバーシティ オブ ロンドン
クイーン マリー ユニバーシティ オブ ロンドン
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by クイーン マリー ユニバーシティ オブ ロンドン, クイーン マリー ユニバーシティ オブ ロンドン filed Critical クイーン マリー ユニバーシティ オブ ロンドン
Publication of JP2014501490A publication Critical patent/JP2014501490A/ja
Publication of JP2014501490A5 publication Critical patent/JP2014501490A5/ja
Application granted granted Critical
Publication of JP6134266B2 publication Critical patent/JP6134266B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
JP2013530798A 2010-09-30 2011-09-30 関節炎患者の滑膜の微小血管系に特異的に結合する抗体 Expired - Fee Related JP6134266B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1016494.5 2010-09-30
GBGB1016494.5A GB201016494D0 (en) 2010-09-30 2010-09-30 Polypeptide
PCT/GB2011/051854 WO2012042270A1 (en) 2010-09-30 2011-09-30 Antibody specifically binding synovial microvasculature of arthritis patients

Publications (3)

Publication Number Publication Date
JP2014501490A JP2014501490A (ja) 2014-01-23
JP2014501490A5 JP2014501490A5 (enExample) 2014-11-13
JP6134266B2 true JP6134266B2 (ja) 2017-05-24

Family

ID=43243319

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013530798A Expired - Fee Related JP6134266B2 (ja) 2010-09-30 2011-09-30 関節炎患者の滑膜の微小血管系に特異的に結合する抗体

Country Status (8)

Country Link
US (1) US9416174B2 (enExample)
EP (1) EP2621948B1 (enExample)
JP (1) JP6134266B2 (enExample)
CN (1) CN103403028B (enExample)
CA (1) CA2849982A1 (enExample)
ES (1) ES2582041T3 (enExample)
GB (1) GB201016494D0 (enExample)
WO (1) WO2012042270A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10562974B2 (en) * 2013-03-13 2020-02-18 University Of Kentucky Research Foundation Methods of administering IgG1 antibodies and methods of suppressing angiogenesis
GB201315788D0 (en) * 2013-09-05 2013-10-23 Univ London Queen Mary Molecule
US10191068B2 (en) 2014-01-31 2019-01-29 Arizona Board Of Regents On Behalf Of Arizona State University Antibody based reagents that specifically recognize neurodegenerative disease related forms of the protein TDP-43
US10092891B2 (en) * 2014-04-25 2018-10-09 University Of Florida Research Foundation, Incorporated Controlling the activity of growth factors, particularly TGF-β, in vivo
GB201418626D0 (en) 2014-10-20 2014-12-03 Univ London Queen Mary Method
CN110957031B (zh) * 2019-12-13 2023-09-22 重庆首厚智能科技研究院有限公司 一种疾病预防信息服务平台
CN119125571A (zh) * 2024-08-19 2024-12-13 安徽医科大学 用于类风湿关节炎诊断的生物标志物及其应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI903489A0 (fi) 1988-11-11 1990-07-10 Medical Res Council Ligander med en enda sektion, receptorer innehaollande naemnda ligander, foerfaranden foer deras framstaellning samt anvaendning av liganderna och receptorerna.
US5859205A (en) * 1989-12-21 1999-01-12 Celltech Limited Humanised antibodies
CA2447851C (en) 2001-06-28 2012-08-28 Domantis Limited Dual-specific ligand and its use
WO2005058352A2 (en) 2003-12-17 2005-06-30 Entelos, Inc. Treatment of rheumatoid arthritis with galectin-3 antagonists
AU2005271523B2 (en) * 2004-08-03 2011-09-15 Dyax Corp. hk1-binding proteins
US20090098536A1 (en) * 2007-10-12 2009-04-16 C-A-I-R- Biosciences Gmbh Method for subgroup analysis in subjects having or being suspected of having inflammatory disease, use of anti-p38MAPK antibodies, kits and their use
KR20180102215A (ko) * 2007-11-27 2018-09-14 더 유니버시티 오브 브리티쉬 콜롬비아 관절염의 진단과 치료를 위한 14-3-3 에타 항체 및 이의 용도

Also Published As

Publication number Publication date
EP2621948A1 (en) 2013-08-07
CN103403028B (zh) 2016-08-24
CA2849982A1 (en) 2012-04-05
EP2621948B1 (en) 2016-04-13
US20130266587A1 (en) 2013-10-10
CN103403028A (zh) 2013-11-20
HK1189004A1 (zh) 2014-05-23
WO2012042270A1 (en) 2012-04-05
GB201016494D0 (en) 2010-11-17
JP2014501490A (ja) 2014-01-23
US9416174B2 (en) 2016-08-16
ES2582041T3 (es) 2016-09-08

Similar Documents

Publication Publication Date Title
CN109963591B (zh) B7h3抗体-药物偶联物及其医药用途
KR101608544B1 (ko) 류마티스 관절염과 연관된 항원
US12018078B2 (en) SEMA4D antibody, preparation method therefor and use thereof
AU2016225810C1 (en) Modified Antibody Compositions, Methods of Making and Using Thereof
JP6134266B2 (ja) 関節炎患者の滑膜の微小血管系に特異的に結合する抗体
KR102134088B1 (ko) Ror1 암을 치료하고 전이를 저해하는데 이용을 위한 항체와 백신
BR112021010402A2 (pt) Anticorpos biespecíficos anti-pd-l1/anti-4-1bb e uso dos mesmos
WO2016023001A1 (en) Multispecific high affinity pd-1 agents and methods of use
JP2017525354A (ja) 高親和性ｐｄ−１薬剤とその使用方法
JP7691720B2 (ja) 抗ヒトｃｄ７３抗体およびその適用
CN110121509A (zh) 中和抗tl1a单克隆抗体
WO2021042694A1 (zh) 抗vegf单域抗体及其应用
JP2003502030A (ja) 高い結合親和性を有する免疫結合体
CN108064243B (zh) 对lox1具有特异性的结合蛋白及其用途
US20230399409A1 (en) Antibody targeting interleukin 36r, preparation method therefor, and application thereof
CN109988240A (zh) 抗gpc-3抗体及其用途
CN108431037B (zh) 抗myl9抗体
JP2013542720A (ja) 抗エフリン−ｂ２抗体およびその使用
CN113993897A (zh) 抗tie2抗体及其用途
WO2024206157A1 (en) Compositions and methods for treating obesity and reducing fat accumulation
WO2005086713A2 (en) Role of human endothelial precursor cells and vascular pericytes tumor in angiogenesis
HK1189004B (en) Antibody specifically binding synovial microvasculature of arthritis patients
US20140302050A1 (en) Targeting an amphiregulin-derived cell surface neo-epitope
US20160215047A1 (en) Bispecific antibody against tnf-alpha and synovial microvasculature of arthritis patients
WO2024153146A1 (zh) 抗nmda受体自身免疫性脑炎新型抗体及其用途

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20140924

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20140924

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20151009

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20160105

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20160205

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20160308

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20160408

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20160809

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20161107

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170105

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20170404

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20170421

R150 Certificate of patent or registration of utility model

Ref document number: 6134266

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

LAPS Cancellation because of no payment of annual fees