CN103403028B - 特异性结合关节炎患者的滑膜微血管系统的抗体 - Google Patents

特异性结合关节炎患者的滑膜微血管系统的抗体 Download PDF

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Publication number
CN103403028B
CN103403028B CN201180057703.2A CN201180057703A CN103403028B CN 103403028 B CN103403028 B CN 103403028B CN 201180057703 A CN201180057703 A CN 201180057703A CN 103403028 B CN103403028 B CN 103403028B
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China
Prior art keywords
antigen
antibody
binding fragment
scfv
synovial
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Expired - Fee Related
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CN201180057703.2A
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English (en)
Chinese (zh)
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CN103403028A (zh
Inventor
C.皮特扎里斯
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Queen Mary University of London
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Queen Mary and Westfiled College University of London
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201180057703.2A 2010-09-30 2011-09-30 特异性结合关节炎患者的滑膜微血管系统的抗体 Expired - Fee Related CN103403028B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1016494.5 2010-09-30
GBGB1016494.5A GB201016494D0 (en) 2010-09-30 2010-09-30 Polypeptide
PCT/GB2011/051854 WO2012042270A1 (en) 2010-09-30 2011-09-30 Antibody specifically binding synovial microvasculature of arthritis patients

Publications (2)

Publication Number Publication Date
CN103403028A CN103403028A (zh) 2013-11-20
CN103403028B true CN103403028B (zh) 2016-08-24

Family

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CN201180057703.2A Expired - Fee Related CN103403028B (zh) 2010-09-30 2011-09-30 特异性结合关节炎患者的滑膜微血管系统的抗体

Country Status (8)

Country Link
US (1) US9416174B2 (enExample)
EP (1) EP2621948B1 (enExample)
JP (1) JP6134266B2 (enExample)
CN (1) CN103403028B (enExample)
CA (1) CA2849982A1 (enExample)
ES (1) ES2582041T3 (enExample)
GB (1) GB201016494D0 (enExample)
WO (1) WO2012042270A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2907548A1 (en) * 2013-03-13 2014-10-02 University Of Kentucky Research Foundation Methods of administering igg1 antibodies and methods of suppressing angiogenesis
GB201315788D0 (en) * 2013-09-05 2013-10-23 Univ London Queen Mary Molecule
US10191068B2 (en) 2014-01-31 2019-01-29 Arizona Board Of Regents On Behalf Of Arizona State University Antibody based reagents that specifically recognize neurodegenerative disease related forms of the protein TDP-43
US10092891B2 (en) * 2014-04-25 2018-10-09 University Of Florida Research Foundation, Incorporated Controlling the activity of growth factors, particularly TGF-β, in vivo
GB201418626D0 (en) 2014-10-20 2014-12-03 Univ London Queen Mary Method
CN110957031B (zh) * 2019-12-13 2023-09-22 重庆首厚智能科技研究院有限公司 一种疾病预防信息服务平台
CN119125571A (zh) * 2024-08-19 2024-12-13 安徽医科大学 用于类风湿关节炎诊断的生物标志物及其应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009067820A1 (en) * 2007-11-27 2009-06-04 The University Of British Columbia 14-3-3 antagonists for the prevention and treatment of arthritis

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE68913658T3 (de) 1988-11-11 2005-07-21 Stratagene, La Jolla Klonierung von Immunglobulin Sequenzen aus den variablen Domänen
US5859205A (en) * 1989-12-21 1999-01-12 Celltech Limited Humanised antibodies
ATE477280T1 (de) 2001-06-28 2010-08-15 Domantis Ltd Doppelspezifischer ligand und dessen verwendung
US20050158321A1 (en) 2003-12-17 2005-07-21 Entelos, Inc. Treatment of rheumatoid arthritis with galectin-3 antagonists
CA2575791A1 (en) * 2004-08-03 2006-02-16 Dyax Corp. Hk1-binding proteins
US20090098536A1 (en) * 2007-10-12 2009-04-16 C-A-I-R- Biosciences Gmbh Method for subgroup analysis in subjects having or being suspected of having inflammatory disease, use of anti-p38MAPK antibodies, kits and their use

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009067820A1 (en) * 2007-11-27 2009-06-04 The University Of British Columbia 14-3-3 antagonists for the prevention and treatment of arthritis

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Identification of single-chain antibody fragments specific for human synovial microvascular endothelium by in vivo phage display;Kamperidis P S等;《Annals of the rheumatic diseases》;20070301;第66卷;第A12-A13页 *
Isolating ligands specific for human vasculature using in vivo phage selection;George A J T等;《Trends in biotechnology》;20030501;第21卷(第5期);第199-203页 *

Also Published As

Publication number Publication date
ES2582041T3 (es) 2016-09-08
CA2849982A1 (en) 2012-04-05
CN103403028A (zh) 2013-11-20
US9416174B2 (en) 2016-08-16
EP2621948A1 (en) 2013-08-07
GB201016494D0 (en) 2010-11-17
HK1189004A1 (zh) 2014-05-23
EP2621948B1 (en) 2016-04-13
US20130266587A1 (en) 2013-10-10
JP2014501490A (ja) 2014-01-23
WO2012042270A1 (en) 2012-04-05
JP6134266B2 (ja) 2017-05-24

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Granted publication date: 20160824

Termination date: 20190930