CA2849982A1 - Antibody specifically binding synovial microvasculature of arthritis patients - Google Patents

Antibody specifically binding synovial microvasculature of arthritis patients Download PDF

Info

Publication number
CA2849982A1
CA2849982A1 CA2849982A CA2849982A CA2849982A1 CA 2849982 A1 CA2849982 A1 CA 2849982A1 CA 2849982 A CA2849982 A CA 2849982A CA 2849982 A CA2849982 A CA 2849982A CA 2849982 A1 CA2849982 A1 CA 2849982A1
Authority
CA
Canada
Prior art keywords
binding polypeptide
antigen binding
agent
polypeptide according
synovial
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2849982A
Other languages
English (en)
French (fr)
Inventor
Costantino Pitzalis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Queen Mary University of London
Original Assignee
Queen Mary and Westfiled College University of London
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Queen Mary and Westfiled College University of London filed Critical Queen Mary and Westfiled College University of London
Publication of CA2849982A1 publication Critical patent/CA2849982A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA2849982A 2010-09-30 2011-09-30 Antibody specifically binding synovial microvasculature of arthritis patients Abandoned CA2849982A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1016494.5 2010-09-30
GBGB1016494.5A GB201016494D0 (en) 2010-09-30 2010-09-30 Polypeptide
PCT/GB2011/051854 WO2012042270A1 (en) 2010-09-30 2011-09-30 Antibody specifically binding synovial microvasculature of arthritis patients

Publications (1)

Publication Number Publication Date
CA2849982A1 true CA2849982A1 (en) 2012-04-05

Family

ID=43243319

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2849982A Abandoned CA2849982A1 (en) 2010-09-30 2011-09-30 Antibody specifically binding synovial microvasculature of arthritis patients

Country Status (8)

Country Link
US (1) US9416174B2 (enExample)
EP (1) EP2621948B1 (enExample)
JP (1) JP6134266B2 (enExample)
CN (1) CN103403028B (enExample)
CA (1) CA2849982A1 (enExample)
ES (1) ES2582041T3 (enExample)
GB (1) GB201016494D0 (enExample)
WO (1) WO2012042270A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2907548A1 (en) * 2013-03-13 2014-10-02 University Of Kentucky Research Foundation Methods of administering igg1 antibodies and methods of suppressing angiogenesis
GB201315788D0 (en) * 2013-09-05 2013-10-23 Univ London Queen Mary Molecule
US10191068B2 (en) 2014-01-31 2019-01-29 Arizona Board Of Regents On Behalf Of Arizona State University Antibody based reagents that specifically recognize neurodegenerative disease related forms of the protein TDP-43
US10092891B2 (en) * 2014-04-25 2018-10-09 University Of Florida Research Foundation, Incorporated Controlling the activity of growth factors, particularly TGF-β, in vivo
GB201418626D0 (en) 2014-10-20 2014-12-03 Univ London Queen Mary Method
CN110957031B (zh) * 2019-12-13 2023-09-22 重庆首厚智能科技研究院有限公司 一种疾病预防信息服务平台
CN119125571A (zh) * 2024-08-19 2024-12-13 安徽医科大学 用于类风湿关节炎诊断的生物标志物及其应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE68913658T3 (de) 1988-11-11 2005-07-21 Stratagene, La Jolla Klonierung von Immunglobulin Sequenzen aus den variablen Domänen
US5859205A (en) * 1989-12-21 1999-01-12 Celltech Limited Humanised antibodies
ATE477280T1 (de) 2001-06-28 2010-08-15 Domantis Ltd Doppelspezifischer ligand und dessen verwendung
US20050158321A1 (en) 2003-12-17 2005-07-21 Entelos, Inc. Treatment of rheumatoid arthritis with galectin-3 antagonists
CA2575791A1 (en) * 2004-08-03 2006-02-16 Dyax Corp. Hk1-binding proteins
US20090098536A1 (en) * 2007-10-12 2009-04-16 C-A-I-R- Biosciences Gmbh Method for subgroup analysis in subjects having or being suspected of having inflammatory disease, use of anti-p38MAPK antibodies, kits and their use
AU2008329529B2 (en) 2007-11-27 2015-02-19 The University Of British Columbia 14-3-3 eta antibodies and uses thereof for the diagnosis and treatment of arthritis

Also Published As

Publication number Publication date
ES2582041T3 (es) 2016-09-08
CN103403028A (zh) 2013-11-20
US9416174B2 (en) 2016-08-16
EP2621948A1 (en) 2013-08-07
GB201016494D0 (en) 2010-11-17
HK1189004A1 (zh) 2014-05-23
EP2621948B1 (en) 2016-04-13
US20130266587A1 (en) 2013-10-10
JP2014501490A (ja) 2014-01-23
CN103403028B (zh) 2016-08-24
WO2012042270A1 (en) 2012-04-05
JP6134266B2 (ja) 2017-05-24

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Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20160926

FZDE Discontinued

Effective date: 20200930