JP6131492B2 - 新しいインダニルオキシジヒドロベンゾフラニル酢酸誘導体およびgpr40受容体作動薬としてのそれらの使用 - Google Patents
新しいインダニルオキシジヒドロベンゾフラニル酢酸誘導体およびgpr40受容体作動薬としてのそれらの使用 Download PDFInfo
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- JP6131492B2 JP6131492B2 JP2015502285A JP2015502285A JP6131492B2 JP 6131492 B2 JP6131492 B2 JP 6131492B2 JP 2015502285 A JP2015502285 A JP 2015502285A JP 2015502285 A JP2015502285 A JP 2015502285A JP 6131492 B2 JP6131492 B2 JP 6131492B2
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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| EP12161240.2 | 2012-03-26 | ||
| PCT/EP2013/056313 WO2013144098A1 (en) | 2012-03-26 | 2013-03-25 | New indanyloxydihydrobenzofuranylacetic acid derivatives and their use as gpr40 receptor agonists |
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| JP2015511613A JP2015511613A (ja) | 2015-04-20 |
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| JP2015502284A Expired - Fee Related JP6040486B2 (ja) | 2012-03-26 | 2013-03-25 | 新しいインダニルオキシジヒドロベンゾフラニル酢酸誘導体およびgpr40受容体作動薬としてのそれらの使用 |
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| EP2646425B1 (en) * | 2010-12-01 | 2015-06-10 | Boehringer Ingelheim International Gmbh | Indanyloxydihydrobenzofuranylacetic acids useful for the treatment of metabolic syndrome |
| US8642585B2 (en) * | 2012-03-26 | 2014-02-04 | Boehringer Ingelheim International Gmbh | Indanyloxydihydrobenzofuranylacetic acids |
| WO2015024526A1 (en) * | 2013-08-23 | 2015-02-26 | Fujian Haixi Pharmaceuticals Co., Ltd | Carboxylic acid compounds in treatment of diabetes mellitus |
| CN105722841A (zh) | 2013-11-14 | 2016-06-29 | 卡迪拉保健有限公司 | 新型杂环化合物 |
| WO2015084692A1 (en) | 2013-12-04 | 2015-06-11 | Merck Sharp & Dohme Corp. | Antidiabetic bicyclic compounds |
| US10059667B2 (en) | 2014-02-06 | 2018-08-28 | Merck Sharp & Dohme Corp. | Antidiabetic compounds |
| US10100042B2 (en) | 2014-08-08 | 2018-10-16 | Merck Sharp & Dohme Corp. | [5,6]—fused bicyclic antidiabetic compounds |
| EP3347358B1 (en) * | 2015-09-09 | 2019-11-27 | Boehringer Ingelheim International GmbH | [{[2,3-dihydro-1h-inden-1-yl]amino}-2h,3h-furo[3,2-b]pyridin-3-yl]acetic acids, pharmaceutical compositions and uses thereof |
| EP3544958B1 (en) | 2016-11-28 | 2021-03-24 | Boehringer Ingelheim International GmbH | Indanylaminopyridylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof |
| WO2018138026A1 (en) | 2017-01-26 | 2018-08-02 | Boehringer Ingelheim International Gmbh | Indanylaminopyrazinylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof |
| JP7049349B2 (ja) | 2017-01-26 | 2022-04-06 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ベンジルアミノピラジニルシクロプロパンカルボン酸、その医薬組成物及び使用 |
| JP7050792B2 (ja) | 2017-01-26 | 2022-04-08 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ベンジルオキシピラジニルシクロプロパンカルボン酸、その医薬組成物及び使用 |
| US10919859B2 (en) | 2017-01-26 | 2021-02-16 | Boehringer Ingelheim International Gmbh | Benzylaminopyridylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof |
| CN110198928B (zh) | 2017-01-26 | 2023-08-29 | 勃林格殷格翰国际有限公司 | 苄氧基吡啶基环丙烷甲酸、其药物组合物和用途 |
| JP7049353B2 (ja) * | 2017-02-08 | 2022-04-06 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 糖尿病の治療のためのインダニルアミノアザジヒドロベンゾフラニル酢酸、医薬組成物 |
| US11186565B2 (en) | 2017-03-31 | 2021-11-30 | Takeda Pharmaceutical Company Limited | Aromatic compound |
| BR102018007822A2 (pt) | 2017-04-20 | 2018-11-06 | Gilead Sciences, Inc. | composto, métodos para inibir pd-1, pd-l1 e/ou interação de pd-1/pd-l1 e para tratamento de câncer, composição farmacêutica, e, kit para tratamento de ou prevenção de câncer ou uma doença ou condição |
| PL3720835T3 (pl) * | 2017-12-04 | 2022-11-21 | Basf Se | Sposób otrzymywania eterów dioli cykloalifatycznych lub aryloalifatycznych |
| CA3089666A1 (en) * | 2018-02-05 | 2019-08-08 | Glaxosmithkline Intellectual Property Development Limited | Ghrelin o-acyltransferase inhibitors |
| WO2019160882A1 (en) | 2018-02-13 | 2019-08-22 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| US12083118B2 (en) | 2018-03-29 | 2024-09-10 | Arbutus Biopharma Corporation | Substituted 1,1′-biphenyl compounds, analogues thereof, and methods using same |
| KR102591947B1 (ko) | 2018-04-19 | 2023-10-25 | 길리애드 사이언시즈, 인코포레이티드 | Pd-1/pd-l1 억제제 |
| PE20210642A1 (es) | 2018-07-13 | 2021-03-23 | Gilead Sciences Inc | Inhibidores de pd-1/pd-l1 |
| US20210236476A1 (en) * | 2018-08-29 | 2021-08-05 | Chemocentryx, Inc. | Methods of treating cancer with small molecule pd-l1 inhibitors |
| TW202028183A (zh) * | 2018-10-10 | 2020-08-01 | 大陸商江蘇豪森藥業集團有限公司 | 含氮雜芳類衍生物調節劑、其製備方法和應用 |
| US11236085B2 (en) | 2018-10-24 | 2022-02-01 | Gilead Sciences, Inc. | PD-1/PD-L1 inhibitors |
| JP2022552655A (ja) | 2019-10-07 | 2022-12-19 | キャリーオペ,インク. | Gpr119アゴニスト |
| MX2022010548A (es) | 2020-02-28 | 2022-09-23 | Kallyope Inc | Agonistas de gpr40. |
| MX2022014505A (es) | 2020-05-19 | 2022-12-13 | Kallyope Inc | Activadores de la ampk. |
| CA3183575A1 (en) | 2020-06-26 | 2021-12-30 | Iyassu Sebhat | Ampk activators |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1735408A (zh) * | 2002-11-08 | 2006-02-15 | 武田药品工业株式会社 | 受体机能调节剂 |
| JP4594611B2 (ja) * | 2002-11-08 | 2010-12-08 | 武田薬品工業株式会社 | 受容体機能調節剤 |
| AU2003277576A1 (en) * | 2002-11-08 | 2004-06-07 | Takeda Pharmaceutical Company Limited | Receptor function controlling agent |
| US7820837B2 (en) | 2003-05-30 | 2010-10-26 | Takeda Pharmaceutical Company Limited | Condensed ring compound |
| JP4805552B2 (ja) * | 2003-05-30 | 2011-11-02 | 武田薬品工業株式会社 | 縮合環化合物 |
| EP2006271A4 (en) | 2006-03-30 | 2011-08-10 | Asahi Kasei Pharma Corp | SUBSTITUTED BICYCLIC CYCLIC DERIVATIVE AND USE THEREOF |
| AU2007265966B2 (en) | 2006-06-27 | 2012-05-17 | Takeda Pharmaceutical Company Limited | Fused cyclic compounds |
| NZ588983A (en) | 2008-06-25 | 2011-11-25 | Daiichi Sankyo Co Ltd | Carboxylic acid compound |
| AU2009303475B2 (en) | 2008-10-15 | 2012-09-13 | Amgen Inc. | Spirocyclic GPR40 modulators |
| US20120172351A1 (en) | 2009-06-09 | 2012-07-05 | Nobuyuki Negoro | Novel fused cyclic compound and use thereof |
| TW201643169A (zh) * | 2010-07-09 | 2016-12-16 | 艾伯維股份有限公司 | 作為s1p調節劑的螺-哌啶衍生物 |
| EP2646425B1 (en) | 2010-12-01 | 2015-06-10 | Boehringer Ingelheim International Gmbh | Indanyloxydihydrobenzofuranylacetic acids useful for the treatment of metabolic syndrome |
| US8642585B2 (en) * | 2012-03-26 | 2014-02-04 | Boehringer Ingelheim International Gmbh | Indanyloxydihydrobenzofuranylacetic acids |
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| EP2831064A1 (en) | 2015-02-04 |
| HK1201260A1 (en) | 2015-08-28 |
| CO7091175A2 (es) | 2014-10-21 |
| ECSP14023238A (es) | 2015-09-30 |
| AU2013241926A1 (en) | 2014-09-18 |
| UY34704A (es) | 2013-09-30 |
| TW201400466A (zh) | 2014-01-01 |
| KR20140139088A (ko) | 2014-12-04 |
| TN2014000398A1 (en) | 2015-12-21 |
| AR090493A1 (es) | 2014-11-19 |
| CA2868474A1 (en) | 2013-10-03 |
| EP2831064B1 (en) | 2016-02-17 |
| PH12014502141A1 (en) | 2014-12-01 |
| EP2831053B1 (en) | 2016-06-22 |
| WO2013144098A1 (en) | 2013-10-03 |
| JP2015511613A (ja) | 2015-04-20 |
| PE20142019A1 (es) | 2014-12-18 |
| AP2014007903A0 (en) | 2014-08-31 |
| EA201401053A1 (ru) | 2015-04-30 |
| CL2014002556A1 (es) | 2015-02-13 |
| WO2013144097A1 (en) | 2013-10-03 |
| US20130252937A1 (en) | 2013-09-26 |
| CN104321319A (zh) | 2015-01-28 |
| SG11201405713UA (en) | 2014-10-30 |
| MA20150065A1 (fr) | 2015-02-27 |
| EP2831053A1 (en) | 2015-02-04 |
| JP6040486B2 (ja) | 2016-12-07 |
| US8642585B2 (en) | 2014-02-04 |
| MX2014011465A (es) | 2015-01-12 |
| JP2015511612A (ja) | 2015-04-20 |
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