JP6129203B2 - α−アミノボロン酸誘導体、選択性免疫プロテアソーム阻害剤 - Google Patents
α−アミノボロン酸誘導体、選択性免疫プロテアソーム阻害剤 Download PDFInfo
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- JP6129203B2 JP6129203B2 JP2014548061A JP2014548061A JP6129203B2 JP 6129203 B2 JP6129203 B2 JP 6129203B2 JP 2014548061 A JP2014548061 A JP 2014548061A JP 2014548061 A JP2014548061 A JP 2014548061A JP 6129203 B2 JP6129203 B2 JP 6129203B2
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- boronic acid
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- IRDYSTDGVPTYRF-UHFFFAOYSA-N [1-acetamido-2-(4-fluorophenyl)ethyl]boronic acid Chemical compound CC(=O)NC(B(O)O)CC1=CC=C(F)C=C1 IRDYSTDGVPTYRF-UHFFFAOYSA-N 0.000 claims 1
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Classifications
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- A61P37/00—Drugs for immunological or allergic disorders
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
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PCT/EP2012/076595 WO2013092979A1 (en) | 2011-12-22 | 2012-12-21 | Alpha-amino boronic acid derivatives, selective immunoproteasome inhibitors |
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JP2015502387A JP2015502387A (ja) | 2015-01-22 |
JP2015502387A5 JP2015502387A5 (es) | 2016-02-18 |
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SG (2) | SG11201403254QA (es) |
WO (1) | WO2013092979A1 (es) |
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CN104981239B (zh) | 2013-01-04 | 2019-01-04 | 莱姆派克斯制药公司 | 硼酸衍生物及其治疗用途 |
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KR20150103269A (ko) * | 2013-01-04 | 2015-09-09 | 렘펙스 파머수티클스 인코퍼레이티드 | 보론산 유도체 및 그의 치료적 용도 |
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US11202817B2 (en) | 2014-08-18 | 2021-12-21 | Cornell University | Dipeptidomimetics as inhibitors of human immunoproteasomes |
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BR112017006622A2 (pt) * | 2014-10-01 | 2018-07-03 | Merck Patent Gmbh | derivados de ácido borônico |
RU2017115193A (ru) * | 2014-10-01 | 2018-11-06 | Мерк Патент Гмбх | Производные бороновой кислоты |
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WO2016081297A1 (en) | 2014-11-18 | 2016-05-26 | Rempex Pharmaceuticals, Inc. | Cyclic boronic acid ester derivatives and therapeutic uses thereof |
US20180051041A1 (en) | 2015-03-17 | 2018-02-22 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
EP3347008B1 (en) | 2015-09-11 | 2022-03-09 | Venatorx Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
EP3362754B1 (en) | 2015-10-15 | 2021-12-22 | Cornell University | Proteasome inhibitors and uses thereof |
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CN107151255A (zh) * | 2016-03-06 | 2017-09-12 | 复旦大学 | 硼酸类化合物及其制备方法和用途 |
MY196909A (en) | 2016-06-30 | 2023-05-09 | Qpex Biopharma Inc | Boronic acid derivatives and therapeutic uses thereof |
US11267826B2 (en) | 2017-05-26 | 2022-03-08 | VenatoRx Pharmaceuticals, Inc. | Penicillin-binding protein inhibitors |
EP3630782A4 (en) | 2017-05-26 | 2021-03-03 | Venatorx Pharmaceuticals, Inc. | PENICILLIN BINDING PROTEIN INHIBITORS |
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CN107556336A (zh) * | 2017-10-16 | 2018-01-09 | 康化(上海)新药研发有限公司 | 一种呋喃‑2‑甲烷基硼酸频哪醇酯的合成方法 |
PL3710457T3 (pl) | 2017-11-16 | 2023-02-20 | Principia Biopharma Inc. | Inhibitory immunoproteasomu |
MA50906A (fr) | 2017-11-16 | 2020-09-23 | Principia Biopharma Inc | Inhibiteurs d'immunoprotéasome |
CN108130370B (zh) * | 2018-01-05 | 2020-11-17 | 武汉惠康达科技有限公司 | Psmb8及其抑制剂在制备治疗脂肪肝及其相关疾病药物中的应用 |
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MX352652B (es) | 2017-12-04 |
BR112014015363A2 (pt) | 2017-06-13 |
EA201400735A1 (ru) | 2015-04-30 |
CN104321060B (zh) | 2018-08-07 |
CA2860142A1 (en) | 2013-06-27 |
US9688702B2 (en) | 2017-06-27 |
HK1206261A1 (en) | 2016-01-08 |
MX2014007362A (es) | 2014-08-01 |
SG10201605152SA (en) | 2016-08-30 |
AU2012356890B2 (en) | 2017-06-08 |
JP2015502387A (ja) | 2015-01-22 |
EP2793900A1 (en) | 2014-10-29 |
SG11201403254QA (en) | 2014-07-30 |
WO2013092979A1 (en) | 2013-06-27 |
US20140364396A1 (en) | 2014-12-11 |
IL233200A (en) | 2017-08-31 |
CA2860142C (en) | 2020-10-27 |
BR112014015363A8 (pt) | 2017-06-13 |
ES2699267T3 (es) | 2019-02-08 |
CN104321060A (zh) | 2015-01-28 |
AU2012356890A1 (en) | 2014-08-07 |
EP2793900B1 (en) | 2018-08-22 |
KR20140114391A (ko) | 2014-09-26 |
IL233200A0 (en) | 2014-07-31 |
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