JP6125614B2 - ピロロベンゾジアゼピン - Google Patents

ピロロベンゾジアゼピン Download PDF

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Publication number
JP6125614B2
JP6125614B2 JP2015509487A JP2015509487A JP6125614B2 JP 6125614 B2 JP6125614 B2 JP 6125614B2 JP 2015509487 A JP2015509487 A JP 2015509487A JP 2015509487 A JP2015509487 A JP 2015509487A JP 6125614 B2 JP6125614 B2 JP 6125614B2
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Japanese (ja)
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JP2015516987A (ja
Inventor
フィリップ・ウィルソン・ハワード
デイビッド・エドウィン・サーストン
コンデーカー・ミラズール・ラフマーン
ピーター・ウィリアム・テイラー
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MedImmune Ltd
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MedImmune Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2015509487A 2012-04-30 2013-04-30 ピロロベンゾジアゼピン Active JP6125614B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261640316P 2012-04-30 2012-04-30
US61/640,316 2012-04-30
PCT/GB2013/051097 WO2013164592A1 (en) 2012-04-30 2013-04-30 Pyrrolobenzodiazepines

Publications (2)

Publication Number Publication Date
JP2015516987A JP2015516987A (ja) 2015-06-18
JP6125614B2 true JP6125614B2 (ja) 2017-05-10

Family

ID=48289484

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015509487A Active JP6125614B2 (ja) 2012-04-30 2013-04-30 ピロロベンゾジアゼピン

Country Status (14)

Country Link
US (1) US9321774B2 (cg-RX-API-DMAC7.html)
EP (1) EP2855481A1 (cg-RX-API-DMAC7.html)
JP (1) JP6125614B2 (cg-RX-API-DMAC7.html)
KR (1) KR101960130B1 (cg-RX-API-DMAC7.html)
CN (1) CN104540827B (cg-RX-API-DMAC7.html)
AU (1) AU2013255612B2 (cg-RX-API-DMAC7.html)
BR (1) BR112014027190B1 (cg-RX-API-DMAC7.html)
CA (1) CA2872205C (cg-RX-API-DMAC7.html)
HK (1) HK1208217A1 (cg-RX-API-DMAC7.html)
IN (1) IN2014MN02175A (cg-RX-API-DMAC7.html)
MX (1) MX2014013144A (cg-RX-API-DMAC7.html)
NZ (1) NZ701478A (cg-RX-API-DMAC7.html)
WO (1) WO2013164592A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201408043B (cg-RX-API-DMAC7.html)

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CN103987718A (zh) 2011-09-20 2014-08-13 斯皮罗根有限公司 作为非对称二聚体pbd化合物用于内含在靶向结合物中的吡咯并苯并二氮杂卓
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JP6399930B2 (ja) 2011-10-14 2018-10-03 シアトル ジェネティクス，インコーポレーテッド ピロロベンゾジアゼピンおよび標的コンジュゲート
BR112014008981A2 (pt) 2011-10-14 2017-05-02 Spirogen Sàrl pirrolobenzodiazepinas
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SMT202200490T1 (it) 2017-04-18 2023-01-13 Medimmune Ltd Coniugati di pirrolobenzodiazepina
PL3612234T3 (pl) 2017-04-20 2024-09-02 Adc Therapeutics Sa Terapia skojarzona z koniugatem anty-AXL przeciwciało-lek
BR112019026564A2 (pt) 2017-06-14 2020-06-30 Adc Therapeutics Sa regimes de dosagem para a administração de um adc anti-cd19
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WO2019104289A1 (en) 2017-11-27 2019-05-31 Mersana Therapeutics, Inc. Pyrrolobenzodiazepine antibody conjugates
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GB201806022D0 (en) 2018-04-12 2018-05-30 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
GB201900929D0 (en) * 2019-01-23 2019-03-13 King S College London Nf-kappa b inhibitors
AU2020242747B2 (en) 2019-03-15 2025-09-18 Medimmune Limited Azetidobenzodiazepine dimers and conjugates comprising them for use in the treatment of cancer
WO2021137646A1 (ko) 2019-12-31 2021-07-08 주식회사 레고켐바이오사이언스 피롤로벤조디아제핀 유도체 및 이의 리간드-링커 접합체
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Also Published As

Publication number Publication date
HK1208217A1 (en) 2016-02-26
CN104540827B (zh) 2018-03-23
CA2872205C (en) 2020-07-21
EP2855481A1 (en) 2015-04-08
AU2013255612B2 (en) 2017-06-22
ZA201408043B (en) 2017-08-30
NZ701478A (en) 2016-08-26
KR101960130B1 (ko) 2019-03-19
IN2014MN02175A (cg-RX-API-DMAC7.html) 2015-08-28
KR20150014935A (ko) 2015-02-09
JP2015516987A (ja) 2015-06-18
CN104540827A (zh) 2015-04-22
US9321774B2 (en) 2016-04-26
CA2872205A1 (en) 2013-11-07
BR112014027190B1 (pt) 2020-03-03
BR112014027190A2 (pt) 2017-06-27
WO2013164592A1 (en) 2013-11-07
MX2014013144A (es) 2015-05-11
AU2013255612A1 (en) 2014-11-20
US20150126495A1 (en) 2015-05-07

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