JP6125614B2 - ピロロベンゾジアゼピン - Google Patents

ピロロベンゾジアゼピン Download PDF

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Publication number
JP6125614B2
JP6125614B2 JP2015509487A JP2015509487A JP6125614B2 JP 6125614 B2 JP6125614 B2 JP 6125614B2 JP 2015509487 A JP2015509487 A JP 2015509487A JP 2015509487 A JP2015509487 A JP 2015509487A JP 6125614 B2 JP6125614 B2 JP 6125614B2
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Japanese (ja)
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JP2015516987A (ja
Inventor
フィリップ・ウィルソン・ハワード
デイビッド・エドウィン・サーストン
コンデーカー・ミラズール・ラフマーン
ピーター・ウィリアム・テイラー
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MedImmune Ltd
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MedImmune Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2015509487A 2012-04-30 2013-04-30 ピロロベンゾジアゼピン Active JP6125614B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261640316P 2012-04-30 2012-04-30
US61/640,316 2012-04-30
PCT/GB2013/051097 WO2013164592A1 (en) 2012-04-30 2013-04-30 Pyrrolobenzodiazepines

Publications (2)

Publication Number Publication Date
JP2015516987A JP2015516987A (ja) 2015-06-18
JP6125614B2 true JP6125614B2 (ja) 2017-05-10

Family

ID=48289484

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015509487A Active JP6125614B2 (ja) 2012-04-30 2013-04-30 ピロロベンゾジアゼピン

Country Status (14)

Country Link
US (1) US9321774B2 (cg-RX-API-DMAC10.html)
EP (1) EP2855481A1 (cg-RX-API-DMAC10.html)
JP (1) JP6125614B2 (cg-RX-API-DMAC10.html)
KR (1) KR101960130B1 (cg-RX-API-DMAC10.html)
CN (1) CN104540827B (cg-RX-API-DMAC10.html)
AU (1) AU2013255612B2 (cg-RX-API-DMAC10.html)
BR (1) BR112014027190B1 (cg-RX-API-DMAC10.html)
CA (1) CA2872205C (cg-RX-API-DMAC10.html)
HK (1) HK1208217A1 (cg-RX-API-DMAC10.html)
IN (1) IN2014MN02175A (cg-RX-API-DMAC10.html)
MX (1) MX2014013144A (cg-RX-API-DMAC10.html)
NZ (1) NZ701478A (cg-RX-API-DMAC10.html)
WO (1) WO2013164592A1 (cg-RX-API-DMAC10.html)
ZA (1) ZA201408043B (cg-RX-API-DMAC10.html)

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CA3060520C (en) 2012-10-12 2022-05-17 Medimmune Limited Pyrrolobenzodiazepines and conjugates thereof
CA2885305C (en) 2012-10-12 2019-11-12 Spirogen Sarl Synthesis and intermediates of pyrrolobenzodiazepine derivatives for conjugation
JP6392763B2 (ja) 2012-10-12 2018-09-19 エイディーシー・セラピューティクス・エス・アーＡｄｃ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｓａ ピロロベンゾジアゼピン−抗体結合体
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EA031585B1 (ru) 2012-12-21 2019-01-31 Медимьюн Лимитед Пирролобензодиазепины и их конъюгаты
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GB201601431D0 (en) 2016-01-26 2016-03-09 Medimmune Ltd Pyrrolobenzodiazepines
GB201602356D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201602359D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201607478D0 (en) 2016-04-29 2016-06-15 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
TW201808936A (zh) 2016-05-18 2018-03-16 美商梅爾莎納醫療公司 吡咯并苯并二氮呯類及其共軛物
CN109641910A (zh) * 2016-06-24 2019-04-16 梅尔莎纳医疗公司 吡咯并苯二氮*及其缀合物
GB201617466D0 (en) 2016-10-14 2016-11-30 Medimmune Ltd Pyrrolobenzodiazepine conjugates
WO2018146189A1 (en) 2017-02-08 2018-08-16 Adc Therapeutics Sa Pyrrolobenzodiazepine-antibody conjugates
GB201702031D0 (en) 2017-02-08 2017-03-22 Medlmmune Ltd Pyrrolobenzodiazepine-antibody conjugates
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AU2018285562B2 (en) 2017-06-14 2024-01-18 Adc Therapeutics Sa Dosage regimes for the administration of an anti-CD19 ADC
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SG11202001430SA (en) 2017-09-29 2020-04-29 Daiichi Sankyo Co Ltd Antibody-pyrrolobenzodiazepine derivative conjugate
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GB201900929D0 (en) * 2019-01-23 2019-03-13 King S College London Nf-kappa b inhibitors
EP3938372B1 (en) 2019-03-15 2023-10-25 MedImmune Limited Azetidobenzodiazepine dimers and conjugates comprising them for use in the treatment of cancer
CN115210247A (zh) 2019-12-31 2022-10-18 乐高化学生物科学股份有限公司 吡咯并苯二氮卓类衍生物及其配体-接头偶联物
GB2597532A (en) 2020-07-28 2022-02-02 Femtogenix Ltd Cytotoxic compounds
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WO2025262641A1 (en) 2024-06-19 2025-12-26 Pheon Therapeutics Ltd Antibody drug conjugates that bind cdcp1 and uses thereof

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Also Published As

Publication number Publication date
WO2013164592A1 (en) 2013-11-07
AU2013255612B2 (en) 2017-06-22
KR20150014935A (ko) 2015-02-09
AU2013255612A1 (en) 2014-11-20
HK1208217A1 (en) 2016-02-26
IN2014MN02175A (cg-RX-API-DMAC10.html) 2015-08-28
KR101960130B1 (ko) 2019-03-19
CA2872205C (en) 2020-07-21
CA2872205A1 (en) 2013-11-07
NZ701478A (en) 2016-08-26
US9321774B2 (en) 2016-04-26
CN104540827A (zh) 2015-04-22
CN104540827B (zh) 2018-03-23
EP2855481A1 (en) 2015-04-08
JP2015516987A (ja) 2015-06-18
BR112014027190B1 (pt) 2020-03-03
ZA201408043B (en) 2017-08-30
MX2014013144A (es) 2015-05-11
BR112014027190A2 (pt) 2017-06-27
US20150126495A1 (en) 2015-05-07

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