JP6109863B2 - 医療用途のための伸張性電子部品を使用する装置 - Google Patents
医療用途のための伸張性電子部品を使用する装置 Download PDFInfo
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Description
一例として、消化(GI)管の内視鏡撮像は、炎症、潰瘍、膿瘍、癌検出を含む種々のGI疾病の有効な診断および処置のために必須である。精巧なものとして、内視鏡撮像用カプセルは、種々の理由で従来の内視鏡と比べて一定の利点を提供する可能性がある。すなわち、内視鏡撮像用カプセルは、最小の患者の不快感を伴い、従来の内視鏡でアクセスできないGI管に沿う領域を撮像しうる。全てのコンポーネントは、その容積が、嚥下され摂取されるのに十分に小さくなければならない楕円本体内にカプセル化される。したがって、これらの摂取可能カプセルの容積を最小にすることに対してさらなる利益が存在する。カプセル内のコンポーネントの空間レイアウトが最適化される場合に著しく改善されうる電力貯蔵および撮像品質を含む種々の特徴も存在する。さらに、現行の内視鏡カプセル内の光学イメージャは、一般に平面幾何形状を有し、イメージャはレンズの光学中心と整列する。この幾何形状は、収差、周辺歪み、および照明不均一性などの固有の制限を受ける。伸張性および/または可撓性回路要素は、カプセル型内視鏡ならびに従来の内視鏡デバイスに関して上述した欠点の一部を軽減しうる。
上述した態様では、処理設備はさらに、神経源の導電率に関連するデータを生成するように構成される。処理設備は、出力設備と電子通信状態にあってよく、また、神経源の導電率に関連するデータに基づいてマップを生成するよう出力設備にさせてもよい。
そのため、本発明の別の態様によれば、方法およびシステムは装置を含み、装置は、膨張性基板であって、その膨張性基板上には、基板の膨張時にも機能性を維持する回路要素が配置されてもよく、また、組織に関連するパラメータを指示するデータを検出する検知デバイスを含む能動デバイスのアレイを含んでもよい膨張性基板と、回路要素と電子通信状態にある処理設備であって、組織に関連するパラメータを指示するデータを受信する処理設備と、その処理設備と電子通信状態にある出力設備とを含んでもよく、処理設備は、組織に関連する出力データを生成し、出力設備に出力データを生成させるように構成されてもよい。
組織パラメータを検知することに関して上述したこの態様では、組織に関連する出力データは、組織の電気活性のマップを含むマップであってよい。出力データは、動脈プラーク内に存在する温度不均一性に関連するデータを含んでもよい。さらに、出力データは、プラークタイプの指示を含んでもよい。
本発明の別の態様では、方法およびシステムは、個人の身体内の管腔に関連するパラメータを検出する方法を含む。その方法は、膨張していないバルーンカテーテルを管腔内に挿入する工程であって、バルーンカテーテルは、伸張性回路要素が取付けられている伸張性バルーンを有するとともに、伸張性回路要素は検知デバイスを備えている工程、管腔内の対象領域内に検知デバイスを移動させる工程、および、バルーンを膨張させ、管腔内で検知デバイスを対象領域の表面と共形接触状態にする工程を含みうる。
そのため、本発明のなお別の態様では、方法およびシステムは、組織スクリーニングデバイスを含み、組織スクリーニングデバイスは、能動デバイスのアレイを含む伸張性回路要素がその上に固着されうる、身体上の対象領域の輪郭に共形性の伸張性基板と、能動デバイスのアレイと電子通信状態にある処理設備と、処理設備と電子通信状態にある出力設備とを備え、処理設備は、能動デバイスのアレイによって生成されるデータに基づいて出力データを生成し、出力設備に出力データを表示させるようにプログラムされる。
所定の実施形態では、センサデバイスは、圧力センサを含み、圧力センサは、圧力センサが起動されたかどうかを指示するための、圧力センサに結合したオン−オフスイッチを含んでもよい。
本発明のある態様では、方法およびシステムは、癌性組織または疑わしい組織のための検査方法を含み、検査方法は、被検者の身体上の対象領域と共形になる装着可能デバイスを被検者に提供する工程であって、装着可能デバイスは伸張性圧力センサのアレイを備える工程、圧力センサのアレイを起動するのに十分な手動による力を装着可能デバイスに加える工程、圧力センサからのデータを受信する工程、および、受信されたデータに基づいて対象領域内の組織の特徴付けを行う工程を含みうる。さらにこの態様では、方法およびシステムは、手動による力を加えるように被検者に命令する工程を含む。この態様では、装着可能デバイスは膨張性であってよい。この態様では、装着可能デバイスはブラジャーに固着されてもよい。所定の実施形態では、装着可能デバイスはシートであってよい。
そのため、本発明の別の態様では、方法およびシステムは内視鏡デバイスを含み、内視鏡デバイスは、ハウジングであって、その上およびその内部に視覚データを生成する焦点面アレイを含む曲線の回路要素が取付けられてもよいハウジングと、回路要素と電子通信状態にあり、視覚データを無線送信するように構成された送信設備と、視覚データを受信し表示する出力設備とを含む。
この態様では、視覚データは画像である。この態様では、視覚データはマップであってよい。
そのため、本発明の別の態様では、方法およびシステムは、電子デバイスの設定変更可能なシートを含み、電子デバイスの設定変更可能なシートは、互いに電子通信状態にある電子デバイスのアレイを収容する伸張性回路要素がその上に配設されてもよい実質的に平面の基板と、アレイ内の各電子デバイスの識別および場所に関連する第1の情報セットを確定するために電子デバイスのアレイをポーリングすることが可能な処理設備とを含み、処理設備は、アレイ内の各電子デバイスの識別および場所に関連する第2の情報セットに関連する情報に基づいてアレイの動作を調整するように構成される。この態様では、第2の情報セットは、回路要素が再整形された後に受信され、再整形は、回路要素を切断することによってもたらされてもよい。
「機能層(functional layer)」は、ある機能をデバイスに与えるデバイス層を指す。たとえば、機能層は、半導体層などの薄膜であってよい。あるいは、機能層は、支持層によって分離された複数の半導体層などの複数の層を備えてもよい。機能層は、デバイス受容パッド間に延びる相互接続などの複数のパターン形成された要素を備えてもよい。
本発明の実施形態では、可撓性プラスチック基板上に半導体を印刷し、屈曲性マクロ電子部品、マイクロ電子部品、および/またはナノ電子部品を作出する。プラスチック上に設けられたそれらの屈曲可能な薄型フィルム電子部品は、従来の高温処理方法によって製造される薄型フィルム電子部品と同様かそれを上回る電界効果を呈し得る。加えて、プラスチック構造上のこれらの可撓性半導体は、プラスチック基板に対する室温処理など、可撓性基板の広域において低温でも効率的な高スループット処理と両立する屈曲可能な電子部品を提供し得る。この技術は、単結晶シリコンリボン、GaAs、INPワイヤ、およびカーボンナノチューブなど多岐にわたる幅広い高品質半導体をプラスチック基板上に堆積させることにより、屈曲可能な薄型フィルム電子部品を組み立てることのできる乾式転写接触印刷技法を提供し得る。可撓性基板上に設けられたこの高性能印刷回路により、幅広い用途を有する電子構造を実現する。’367号特許および関連開示に、屈曲可能な薄型フィルム電子部品をこの方法で製造するための手順の例が例示されている(例えば’367号特許の図26Aを参照)。
所定の実施形態では、電子デバイスは、本明細書で述べるように、任意選択で、デバイスアイランド配置構成でレイアウトされる。そのため、回路要素1000S、したがって電子デバイスに関して本明細書で述べる機能は、電子デバイス自体に存在してもよく、電子デバイスおよび/または電子コンポーネントのアレイにわたって分散されてもよく、あるいは、他の電子デバイスおよび/またはデバイスコンポーネントであって、各電子デバイス(または電子デバイスとデバイスコンポーネントの組合せ)が、本開示から明らかになる、別個の機能または追加の機能であるが相補的な機能を有する、他の電子デバイスおよび/またはデバイスコンポーネントとの電子通信および連携によって達成されてもよい。所定の実施形態では、こうした電子通信は無線でありうる。したがって、前記デバイスは、こうした無線伝送が可能な変換器、送信機、または受信機を備えてもよい。
ΔR/R=αT
によって関係づけられる。
本発明の実施形態では、基板は、プラーク導電率を測定するために使用される刺激および記録電極で覆われる。不安定プラークは、安定したプラークおよび動脈組織よりかなり導電性が低いため、この形態のセンサアレイは、測定されるプラークの導電率に基づいてプラークタイプを確定するのに役立ちうる。膨張性本体が展開されると、電極は、プラーク付着物と直接接触および/または共形接触状態で位置決めされ、導電率が測定される。再び、このデバイスは、伸張性および膨張性の本体内に埋め込まれた他のセンサアレイタイプと組合されて、複数の検知および治療機能を並列に提供しうる。
カテーテルを利用する実施形態は、本明細書に記載の本発明のカテーテルを利用してもよい。図10Eは、3つの管腔、すなわち、(ガイドワイヤを収容する)ガイドワイヤ管腔7002、流体注入管腔7006(バルーンを膨張させるか、または、バルーン表面上の電極または能動デバイスの温度を制御するために使用されることになる流体用のチャネル)、および(DAQに接続されることになる可撓性PCBおよび配線を収容する)回路要素管腔7004を備えるカテーテル7000を示す。カテーテルシステムの組立てにおいて、可撓性PCBは、DAQへの接続のために配線され、伸張性電極アレイにも電気接続される。このユニットは、その後、最初に入り、DAQへの接続のためにカテーテルの近位端を通して出るDAQに向かうワイヤを用いて、示される3管腔押出し品の回路要素管腔内に通される。
所定の実施形態は、アレイ化された圧力センサを備える回路要素/アレイ1000Tを含んでもよい。したがって、電子デバイス1010Tは圧力センサを含みうる。各圧力センサアイランドは、可撓性隔膜を備え、隔膜は、偏向に応答してキャパシタンスの変化を記録しうる。圧力センサは、一連の圧抵抗性歪みゲージおよび/または導電性ポリマーで作られうる。各電子デバイスは、各アイランド上でローカル信号処理を提供するために、増幅器およびA/D変換器を含んでもよい。センサアイランドは、相互接続および回路要素を保護するために、ポリマーの薄い(約100μm厚の)層で被覆される。薄い層を含む表面は、処置中に乳房組織と直接接触状態になるよう位置決めされる。センサに対向する表面は、空気充填ギャップを有する格納部として形成される、さらなるポリマー層(300〜500μm厚)を装備しうる。この空気充填空間を既知の量だけ(蠕動ポンプによって)膨張させることは、乳房組織に対する既知の歪みの印加を容易にする。したがって、乳房組織は、空気充填空間を膨張させることによって、その表面全体にわたって一定量だけ押し下げられることができ、各場所における圧力が、圧力センサによって記録される。
所定の実施形態では、圧力変換器のアレイ1000Tからのセンサデータは、各センサのレベルで増幅され、デジタル形態に変換され、その後、マルチプレクサに送信されうる。あるいは、アナログ回路要素を各デバイス1010Tのレベルで含むことができ、デジタル処理回路は、ポリマーから離れて収容されうる。データが、各ポイントから収集され、コンピュータ端末に送信されると、ユーザは、検査が終了したことをプロンプト表示で知らされてもよい。ユーザは、(一例として)自分自身でデータを調査してもよく、かつ/または、さらなる検討のために自分の医師にデータを送信してもよい。
該方法はそのステップを実施するシステムとして具体化され、様々な方法でデバイス全体に分散されてもよいし、全ての機能が専用のスタンドアロン型デバイスまたは他のハードウェアに統合されてもよい。別の態様では、上述の処理に関連したステップを実施するための手段には、上述のハードウェアおよび/またはソフトウェアのうち任意のものが挙げられる。そのような置換および組み合わせは全て本開示の範囲内にあることが意図される。
本明細書で参照されたすべての文献は、参照により本明細書に援用される。
Claims (13)
- 装置であって、
膨張性の基板と、
前記基板上に配置された回路要素であって、前記回路要素は能動デバイスのアレイを備え、かつ、前記回路要素は、前記基板の膨張時にも前記回路要素が機能性を維持するように、前記能動デバイスのアレイ中の能動デバイスを電気的に相互接続する伸張性電気相互接続を含み、前記能動デバイスのアレイは組織に関連するパラメータを指示するデータを検出する検知デバイスを含む回路要素と、
前記回路要素と電子通信状態にある処理設備であって、前記組織に関連するパラメータを指示するデータを受信する処理設備と、
前記処理設備と電子通信状態にある出力設備とを備え、
前記処理設備は前記組織に関連する出力データを生成し、前記出力設備に前記出力データを出力させるように構成されている、
装置。 - 前記基板が伸張性である、請求項1に記載の装置。
- 前記回路要素が前記組織と共形接触状態になる、請求項1に記載の装置。
- 前記回路要素がポリマーの薄層で被覆されている、請求項1に記載の装置。
- 前記回路要素が300%まで伸張可能である、請求項1に記載の装置。
- 前記検知デバイスは、1つ以上の温度センサ、接触センサ、または圧力センサを含む、請求項1に記載の装置。
- 前記検知デバイスは超音波エミッタおよび受信機を含む、請求項1に記載の装置。
- 前記処理設備は、前記検知デバイスによって生成されたデータを受信し、前記組織の画像を生成する、請求項7に記載の装置。
- 前記検知デバイスは能動マトリックスとして構成されており、前記回路要素は、前記検知デバイスを前記能動マトリックスにおいて動作させるための増幅器およびロジック回路の少なくとも一方を備える、請求項1に記載の装置。
- 前記装置はマルチプレクサをさらに含み、前記基板はカテーテルガイドワイヤに結合したバルーンであり、前記マルチプレクサは前記カテーテルガイドワイヤの基部に配置されている、請求項1に記載の装置。
- 前記回路要素は、前記処理設備と通信状態にある光検出器のアレイを備え、前記処理設備は前記出力データとして前記組織の画像を生成し、前記出力設備に前記画像を出力させるように構成されている、請求項1に記載の装置。
- 前記回路要素は、前記処理設備と通信状態にある光検出器のアレイを備え、前記回路要素はガイドワイヤを有するカテーテルによって送出され、前記ガイドワイヤは、前記光検出器に光を提供する光源を含む、請求項1に記載の装置。
- 前記基板は、前記基板の表面に連通するリザーバを含み、前記回路要素は、前記基板上で弁を開放して前記リザーバ内に収容された薬物を放出するように構成されており、前記回路要素は、制御された方式で前記弁に前記薬物を放出させる、請求項1に記載の装置。
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JP2015154928A (ja) | 2015-08-27 |
JP5694947B2 (ja) | 2015-04-01 |
JP2012511963A (ja) | 2012-05-31 |
EP2378956A4 (en) | 2017-12-27 |
WO2010082993A2 (en) | 2010-07-22 |
JP2017148514A (ja) | 2017-08-31 |
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WO2010082993A3 (en) | 2010-09-23 |
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