JP6099559B2 - 1種以上のチアゾール誘導体を含む美容的または皮膚科学的調製物 - Google Patents
1種以上のチアゾール誘導体を含む美容的または皮膚科学的調製物 Download PDFInfo
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- JP6099559B2 JP6099559B2 JP2013500410A JP2013500410A JP6099559B2 JP 6099559 B2 JP6099559 B2 JP 6099559B2 JP 2013500410 A JP2013500410 A JP 2013500410A JP 2013500410 A JP2013500410 A JP 2013500410A JP 6099559 B2 JP6099559 B2 JP 6099559B2
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- 238000005406 washing Methods 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
Description
A=−N(R1)2 *、−S−R1、−C−(R1)3 *、−O−R1、−CO−R1、−モルホリノ、−モルホリノ誘導体;
R1、XおよびYは異なっても、一部同一でもまたは完全に同一でもよく、かつ相互に
独立であってもよい:
R1=−H、−C1−C24−アルキル(線状および分枝)、−C1−C24−アルケニル(線状および分枝)、−C1−C24−ヒドロキシアルキル(線状および分枝)、−C1−C8−シクロアルキル、−C1−C24−アリール、−C1−C24−ヘテロアリール、−C1−C24−アルキルアリール(線状および分枝)、−C1−C24−アルキルヘテロアリール(線状および分枝)、−アリール、−2−ヒドロキシフェニル、−3−ヒドロキシフェニル、−4−ヒドロキシフェニル、−ピリジン−2−イル、−ピリジン−3−イル、−ピリジン−4−イル、ピリジン−1(2H)−イル、−ピリミジン−2−イル、−ピラジン−2−イル、−ピリミジン−4−イル、−ピリダジン−3−イル、−ピリダジン−4−イル、−ピリミジン−2−イル、−ピリミジン−5−イル、−1,2,4−トリアジン−3−イル、−1,3,5−トリアジン−2−イル、−1,2,3−トリアジン−4−イル、−1,2,3−トリアジン−5−イル、−1,2,3,4−テトラジン−5−イル、−1,2,3,5−テトラジン−4−イル、−1,2,4,5−テトラジン−3−イル、−ペンタジン−6−イル、−モルホリノ、−チアゾール、−C=O−アルキル(線状および分枝)、−C=O−アルケニル(線状および分枝)、−C=O−C1−C8−シクロアルキル、−C=O−アリール、−C=O−ヘテロアリール、−C=O−アルキルアリール(線状および分枝)、−C=O−アルキルヘテロアリール(線状および分枝)、−C=O−NH−アルキル(線状および分枝)、−C=O−NH−アルケニル(線状および分枝)、−C=O−NH−シクロアルキル、−C=O−NH−アリール、−C=O−NH−ヘテロアリール、−C=O−NH−アルキルアリール(線状および分枝)、−C=O−NH−アルキルヘテロアリール(線状および分枝);
X=−H、−C1−C24−アルキル(線状および分枝)、−C1−C24−アルケニル(線状および分枝)、−C1−C8−シクロアルキル、−C1−C24−アリール、−C1−C24−ヘテロアリール、−C1−C24−アルキルアリール(線状および分枝)、−C1−C24−アルキルヘテロアリール(線状および分枝)、−アリール、−フェニル、−2,4−ジヒドロキシフェニル、−2,3−ジヒドロキシフェニル、−2,4−ジメトキシフェニル、−2,3−ジメトキシフェニル;
Y=H、−C1−C24−アルキル(線状および分枝)、−C1−C24−アルケニル(線状および分枝)、−C1−C8−シクロアルキル、−C1−C24−アリール、−C1−C24−ヘテロアリール、−C1−C24−アルキルアリール(線状および分枝)、−C1−C24−アルキルヘテロアリール(線状および分枝)、−アリール、−フェニル、−2,4−ジヒドロキシフェニル、−2,3−ジヒドロキシフェニル、−2,4−ジメトキシフェニル、−2,3−ジメトキシフェニル、−COO−アルキル、−COO−アルケニル、−COO−シクロアルキル、−COO−アリール、−COO−ヘテロアリール;
X,Y=縮合芳香族化合物、ここでXとYは一緒に、n個までの環形成原子をもつ芳香族または脂肪族の同素環式または複素環式環系を形成することができ、また、数字nは5から8の値をもつことができ、そして各環系は順次、n〜1個までのアルキル基、ヒドロキシル基、カルボキシル基、アミノ基、ニトリル官能基、硫黄含有置換基、エステル基および/またはエーテル基により置換されることができる]
の1種以上のチアゾールの有効量を含む、美容的または皮膚科学的調製物により達成される。
のドパオキシダーゼ活性の新アッセイ法)Eur.J.Biochem.(1991),198,317−26)から知られるこの方法において、反応生成物のL−ドパキノンはMBTH(3−メチル−2−ベンゾチアゾリン・ヒドラゾン)と反応され、それが転化されて、ピンク色の物質を形成し、その増加が経時的に490nmにおける吸収により測定される。表1に、幾つかの請求物質の効果のデータが実施例により示される。それから、本発明に従う物質が極めて有効な色素沈着阻害物質であることを結論することができる。
− 鉱油、鉱物ワックス、
− 油、例えばカプリン酸もしくはカプリル酸のトリグリセリド、更に天然の油、例
えばヒマシ油;
− 脂肪、ワックス並びにその他の天然および合成脂肪物体、好適には低炭素数のア
ルコール、例えばイソプロパノール、プロピレングリコールもしくはグリセロー
ルとの脂肪酸のエステル、あるいは低炭素数のアルカン酸または脂肪酸との脂肪
アルコールのエステル;
− 安息香酸アルキル;
− シリコーン油、例えばジメチルポリシロキサン、ジエチルポリシロキサン、ジフ
ェニルポリシロキサンおよびそれらの混合形態。
Claims (6)
- 1種または複数のチアゾールがハロゲン化物、カーボネート、アスコルベート、アセテートまたはフォスフェートとして存在することを特徴とする、請求項1に請求される調製物。
- 調製物の総重量に基づいて0.00001重量%〜10重量%の1種以上のチアゾールを含むことを特徴とする、請求項1−2のいずれか1項に請求される調製物。
- 調製物の総重量に基づいて0.001重量%〜3.0重量%の1種以上のチアゾールを含むことを特徴とする、請求項1−2のいずれか1項に請求される調製物。
- 調製物の総重量に基づいて0.005〜1.0重量%の1種以上のチアゾールを含むことを特徴とする、請求項1−2のいずれか1項に請求される調製物。
- 望ましくない皮膚色素沈着の状態を有する患者に投与することにより該状態の処置および/または予防をするための投与物を製造するための、請求項1−5のいずれか1項に定義された1種以上のチアゾール、あるいは1種以上のこれらのチアゾールを含む調製物の使用。
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DE102010012594A DE102010012594A1 (de) | 2010-03-23 | 2010-03-23 | Kosmetische oder dermatologische Zubereitungen mit einem Gehalt an einem oder mehreren Thiazolderivaten |
DE102010012594.6 | 2010-03-23 | ||
PCT/EP2011/052479 WO2011117034A2 (de) | 2010-03-23 | 2011-02-21 | Kosmetische oder dermatologische zubereitungen mit einem gehalt an einem oder mehreren thiazolderivaten |
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JP2013530927A JP2013530927A (ja) | 2013-08-01 |
JP6099559B2 true JP6099559B2 (ja) | 2017-03-22 |
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JP2013500410A Active JP6099559B2 (ja) | 2010-03-23 | 2011-02-21 | 1種以上のチアゾール誘導体を含む美容的または皮膚科学的調製物 |
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US (1) | US8920785B2 (ja) |
EP (1) | EP2549979B1 (ja) |
JP (1) | JP6099559B2 (ja) |
KR (2) | KR102013424B1 (ja) |
CN (1) | CN103179947B (ja) |
BR (1) | BR112012023910B1 (ja) |
DE (1) | DE102010012594A1 (ja) |
ES (1) | ES2733130T3 (ja) |
MX (1) | MX2012010939A (ja) |
PL (1) | PL2549979T3 (ja) |
WO (1) | WO2011117034A2 (ja) |
Cited By (1)
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JP2017141242A (ja) * | 2011-09-23 | 2017-08-17 | バイエルスドルフ・アクチエンゲゼルシヤフトBeiersdorf AG | 芳香族アミドチアゾール、それを含有する化粧用または皮膚科用製剤、ならびに望ましくない皮膚の色素沈着を治療および予防するためのその使用 |
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DE102011083283A1 (de) * | 2011-09-23 | 2013-03-28 | Beiersdorf Ag | Heteroalkylamidothiazole, deren kosmetische oder dermatologische Verwendung sowie kosmetische oder dermatologische Zubereitungen mit einem Gehalt an solchen Heteroalkylamidothiazolen |
DE102011083259A1 (de) * | 2011-09-23 | 2013-03-28 | Beiersdorf Ag | Alkylamidothiazole, deren kosmetische oder dermatologische Verwendung sowie kosmetische oder dermatologische Zubereitungen mit einem Gehalt an solchen Alkylamidothiazolen |
DE102013204088A1 (de) * | 2013-03-11 | 2014-09-11 | Beiersdorf Ag | Wirkstoffkombinationen aus Alkylamidothiazolen und einen oder mehreren kosmetisch oder dermatologisch relevanten Duftstoffen |
DE102013204081A1 (de) * | 2013-03-11 | 2014-09-11 | Beiersdorf Ag | Wirkstoffkombinationen aus Alkylamidothiazolen und einen oder mehreren kosmetisch oder dermatologisch unbedenklichen Konservierungsmitteln |
DE102013204097A1 (de) * | 2013-03-11 | 2014-10-30 | Beiersdorf Ag | Wirkstoffkombinationen aus Alkylamidothiazolen und einer oder mehreren kosmetisch oder dermatologisch unbedenklichen UV-Filtersubstanzen |
DE102013204110A1 (de) * | 2013-03-11 | 2014-09-25 | Beiersdorf Ag | Wirkstoffkombinationen aus Alkylamidothiazolen und einem oder mehreren Cyclodextrinen |
WO2014158942A1 (en) | 2013-03-13 | 2014-10-02 | Avon Products, Inc | Compositions for improving the appearance of skin |
US9364405B2 (en) | 2013-03-13 | 2016-06-14 | Avon Products, Inc. | Tyrosinase inhibitors |
US20150174034A1 (en) | 2013-03-13 | 2015-06-25 | Avon Products, Inc. | Tyrosinase inhibitors |
DE102013226746A1 (de) * | 2013-12-19 | 2015-06-25 | Beiersdorf Ag | Verwendung von Alkylamidothiazolen als Antioxidans oder Radikalfänger in kosmetischen oder dermatologischen Zubereitungen |
DE102013226711A1 (de) * | 2013-12-19 | 2015-06-25 | Beiersdorf Ag | Verwendung von Alkylamidothiazolen in kosmetischen oder dermatologischen Zubereitungen zur Prophylaxe vor und Behandlung von sensibler Haut |
BR112016018691A2 (pt) * | 2014-02-14 | 2017-08-08 | Univ British Columbia | Compostos do domínio de ligação ao dna (dbd) de receptor de andrógeno humano como terapêuticos e métodos para seu uso |
JP6483272B2 (ja) * | 2015-02-17 | 2019-03-13 | グアンジョウ インスティテュート オブ バイオメディスン アンド ヘルス,チャイニーズ アカデミー オブ サイエンスィズ | 白色脂肪組織の褐色化を誘導するための化合物および方法 |
KR102075560B1 (ko) * | 2017-07-05 | 2020-02-10 | 한국화학연구원 | 피부 미백용 조성물 |
DE102018211412A1 (de) * | 2018-07-10 | 2020-01-16 | Beiersdorf Ag | Selbstklebende flächige Produkte enthaltend ein oder mehrere Alkylamidothiazole |
WO2020106307A1 (en) * | 2018-11-20 | 2020-05-28 | Nflection Therapeutics, Inc. | Aryl-aniline and heteroaryl-aniline compounds for treatment of birthmarks |
KR102076936B1 (ko) * | 2019-08-12 | 2020-02-13 | 연세대학교 산학협력단 | 티아졸 또는 이의 염을 유효성분으로 포함하는 알러지성 질환 또는 아토피 피부염 예방 또는 치료용 조성물 |
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US20030158199A1 (en) * | 2002-01-25 | 2003-08-21 | Kylix, B.V. | Novel compounds for inhibition of Tie-2 |
ES2294344T3 (es) | 2002-08-02 | 2008-04-01 | Ab Science | 2-(3-aminoaril)amino-4-aril-tiazoles y su utilizacion como inhibidores de c-kit. |
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KR20060054308A (ko) * | 2003-07-16 | 2006-05-22 | 가부시키가이샤 이야쿠 분지 셋케이 겐쿠쇼 | 피부 색소침착의 치료제 |
US20050137239A1 (en) * | 2003-12-17 | 2005-06-23 | Hines Michelle D. | Thiazole derivatives |
EP2946779A1 (en) | 2007-02-22 | 2015-11-25 | Beiersdorf AG | Cosmetic and pharmaceutical applications of n-acetylhydroxyproline |
CN101965176B (zh) * | 2008-02-08 | 2012-06-20 | 株式会社资生堂 | 美白剂和皮肤外用剂 |
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JP2017141242A (ja) * | 2011-09-23 | 2017-08-17 | バイエルスドルフ・アクチエンゲゼルシヤフトBeiersdorf AG | 芳香族アミドチアゾール、それを含有する化粧用または皮膚科用製剤、ならびに望ましくない皮膚の色素沈着を治療および予防するためのその使用 |
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PL2549979T3 (pl) | 2019-09-30 |
EP2549979B1 (de) | 2019-05-22 |
CN103179947B (zh) | 2016-10-19 |
DE102010012594A1 (de) | 2011-09-29 |
JP2013530927A (ja) | 2013-08-01 |
EP2549979A2 (de) | 2013-01-30 |
BR112012023910A2 (pt) | 2016-08-02 |
KR20180003646A (ko) | 2018-01-09 |
ES2733130T3 (es) | 2019-11-27 |
KR102013424B1 (ko) | 2019-08-22 |
KR102013433B1 (ko) | 2019-08-22 |
WO2011117034A2 (de) | 2011-09-29 |
CN103179947A (zh) | 2013-06-26 |
US8920785B2 (en) | 2014-12-30 |
WO2011117034A3 (de) | 2013-06-06 |
MX2012010939A (es) | 2013-02-07 |
US20130039870A1 (en) | 2013-02-14 |
KR20130010480A (ko) | 2013-01-28 |
BR112012023910B1 (pt) | 2017-10-31 |
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