JP6095075B2 - キナーゼ阻害剤としてのプリノン化合物 - Google Patents

キナーゼ阻害剤としてのプリノン化合物 Download PDF

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JP6095075B2
JP6095075B2 JP2014555678A JP2014555678A JP6095075B2 JP 6095075 B2 JP6095075 B2 JP 6095075B2 JP 2014555678 A JP2014555678 A JP 2014555678A JP 2014555678 A JP2014555678 A JP 2014555678A JP 6095075 B2 JP6095075 B2 JP 6095075B2
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cycloalkyl
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JP2015509927A (ja
JP2015509927A5 (enExample
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チェン,ウェイ
ロウリー,デイビッド,ジェイ.
ヤン,シュンキ
ワン,ロンチェン
フライ,リア,リン
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ファーマサイクリックス エルエルシー
ファーマサイクリックス エルエルシー
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/26Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32Nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/26Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32Nitrogen atom
    • C07D473/34Nitrogen atom attached in position 6, e.g. adenine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52Purines, e.g. adenine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52Purines, e.g. adenine
    • A61K31/522Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • AHUMAN NECESSITIES
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  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Transplantation (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Reproductive Health (AREA)
  • Otolaryngology (AREA)
  • Biomedical Technology (AREA)
JP2014555678A 2012-01-31 2013-01-30 キナーゼ阻害剤としてのプリノン化合物 Expired - Fee Related JP6095075B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201261593146P 2012-01-31 2012-01-31
US61/593,146 2012-01-31
US201261637765P 2012-04-24 2012-04-24
US61/637,765 2012-04-24
US13/460,524 US8501724B1 (en) 2012-01-31 2012-04-30 Purinone compounds as kinase inhibitors
US13/460,524 2012-04-30
PCT/US2013/023918 WO2013116382A1 (en) 2012-01-31 2013-01-30 Purinone compounds as kinase inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2017020756A Division JP6501209B2 (ja) 2012-01-31 2017-02-07 キナーゼ阻害剤としてのプリノン化合物

Publications (3)

Publication Number Publication Date
JP2015509927A JP2015509927A (ja) 2015-04-02
JP2015509927A5 JP2015509927A5 (enExample) 2016-03-03
JP6095075B2 true JP6095075B2 (ja) 2017-03-15

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Family Applications (3)

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JP2014555678A Expired - Fee Related JP6095075B2 (ja) 2012-01-31 2013-01-30 キナーゼ阻害剤としてのプリノン化合物
JP2017020756A Expired - Fee Related JP6501209B2 (ja) 2012-01-31 2017-02-07 キナーゼ阻害剤としてのプリノン化合物
JP2018228582A Pending JP2019059758A (ja) 2012-01-31 2018-12-05 キナーゼ阻害剤としてのプリノン化合物

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JP2017020756A Expired - Fee Related JP6501209B2 (ja) 2012-01-31 2017-02-07 キナーゼ阻害剤としてのプリノン化合物
JP2018228582A Pending JP2019059758A (ja) 2012-01-31 2018-12-05 キナーゼ阻害剤としてのプリノン化合物

Country Status (14)

Country Link
US (3) US8501724B1 (enExample)
EP (2) EP2809672A4 (enExample)
JP (3) JP6095075B2 (enExample)
KR (2) KR20180030730A (enExample)
CN (2) CN106279172A (enExample)
AU (3) AU2013215166B2 (enExample)
BR (1) BR112014018728A8 (enExample)
CA (2) CA2940039A1 (enExample)
HK (1) HK1203489A1 (enExample)
IL (1) IL261282A (enExample)
MX (1) MX2014009219A (enExample)
PH (1) PH12014501815B1 (enExample)
RU (2) RU2655388C2 (enExample)
WO (1) WO2013116382A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017114880A (ja) * 2012-01-31 2017-06-29 ファーマサイクリックス エルエルシー キナーゼ阻害剤としてのプリノン化合物
JP2019069977A (ja) * 2013-07-02 2019-05-09 ファーマサイクリックス エルエルシー キナーゼ阻害剤としてのプリノン化合物

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NZ604040A (en) 2010-06-03 2015-02-27 Pharmacyclics Inc The use of inhibitors of bruton’s tyrosine kinase (btk)
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US9376438B2 (en) 2011-05-17 2016-06-28 Principia Biopharma, Inc. Pyrazolopyrimidine derivatives as tyrosine kinase inhibitors
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US9416132B2 (en) 2011-07-21 2016-08-16 Tolero Pharmaceuticals, Inc. Substituted imidazo[1,2-b]pyridazines as protein kinase inhibitors
US8377946B1 (en) 2011-12-30 2013-02-19 Pharmacyclics, Inc. Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors
EA201492082A1 (ru) 2012-06-04 2015-03-31 Фармасайкликс, Инк. Кристаллические формы ингибитора тирозинкиназы брутона
KR20150032340A (ko) 2012-07-24 2015-03-25 파마시클릭스, 인코포레이티드 브루톤 티로신 키나제(btk)의 억제제에 대한 내성과 관련된 돌연변이
PL2892900T3 (pl) 2012-09-10 2018-02-28 Principia Biopharma Inc. Związki pyrazolopirymidonowe jako inhibitory kinazy
MA38183A1 (fr) 2012-11-15 2017-03-31 Pharmacyclics Inc Composés pyrrolopyrimidines en tant qu'inhibiteurs de kinase
US20140142099A1 (en) * 2012-11-20 2014-05-22 Principia Biopharma Inc. Purinone Derivatives as Tyrosine Kinase Inhibitors
DK2970205T3 (da) 2013-03-14 2019-07-29 Tolero Pharmaceuticals Inc JAK2- og ALK2-inhibitorer og fremgangsmåder til anvendelse deraf
JP2016519684A (ja) 2013-04-08 2016-07-07 デニス エム ブラウン 準最適に投与された薬物療法の有効性を改善するための及び/又は副作用を低減するための方法および組成物
US8957080B2 (en) 2013-04-09 2015-02-17 Principia Biopharma Inc. Tyrosine kinase inhibitors
JP6800750B2 (ja) 2013-08-02 2020-12-16 ファーマサイクリックス エルエルシー 固形腫瘍の処置方法
EP3033079B1 (en) 2013-08-12 2018-10-31 Pharmacyclics LLC Methods for the treatment of her2 amplified cancer
JP2016531941A (ja) 2013-09-30 2016-10-13 ファーマサイクリックス エルエルシー ブルトン型チロシンキナーゼの阻害剤
CA2939186C (en) 2014-02-21 2023-03-07 Principia Biopharma Inc. Salts and solid form of a btk inhibitor
JP2017509336A (ja) 2014-03-20 2017-04-06 ファーマサイクリックス エルエルシー ホスホリパーゼcガンマ2及び耐性に関連した変異
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IL284255B (en) * 2016-08-29 2022-07-01 Hoffmann La Roche 7-substituted sulfonimidoylpurinone compounds for the treatment and prophylaxis of virus infection
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