JP6095075B2 - キナーゼ阻害剤としてのプリノン化合物 - Google Patents

キナーゼ阻害剤としてのプリノン化合物 Download PDF

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JP6095075B2
JP6095075B2 JP2014555678A JP2014555678A JP6095075B2 JP 6095075 B2 JP6095075 B2 JP 6095075B2 JP 2014555678 A JP2014555678 A JP 2014555678A JP 2014555678 A JP2014555678 A JP 2014555678A JP 6095075 B2 JP6095075 B2 JP 6095075B2
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cycloalkyl
compound
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JP2015509927A (ja
JP2015509927A5 (enExample
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チェン,ウェイ
ロウリー,デイビッド,ジェイ.
ヤン,シュンキ
ワン,ロンチェン
フライ,リア,リン
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ファーマサイクリックス エルエルシー
ファーマサイクリックス エルエルシー
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/26Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32Nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/26Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32Nitrogen atom
    • C07D473/34Nitrogen atom attached in position 6, e.g. adenine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52Purines, e.g. adenine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52Purines, e.g. adenine
    • A61K31/522Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • AHUMAN NECESSITIES
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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oncology (AREA)
  • Otolaryngology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Reproductive Health (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
JP2014555678A 2012-01-31 2013-01-30 キナーゼ阻害剤としてのプリノン化合物 Expired - Fee Related JP6095075B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201261593146P 2012-01-31 2012-01-31
US61/593,146 2012-01-31
US201261637765P 2012-04-24 2012-04-24
US61/637,765 2012-04-24
US13/460,524 2012-04-30
US13/460,524 US8501724B1 (en) 2012-01-31 2012-04-30 Purinone compounds as kinase inhibitors
PCT/US2013/023918 WO2013116382A1 (en) 2012-01-31 2013-01-30 Purinone compounds as kinase inhibitors

Related Child Applications (1)

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JP2017020756A Division JP6501209B2 (ja) 2012-01-31 2017-02-07 キナーゼ阻害剤としてのプリノン化合物

Publications (3)

Publication Number Publication Date
JP2015509927A JP2015509927A (ja) 2015-04-02
JP2015509927A5 JP2015509927A5 (enExample) 2016-03-03
JP6095075B2 true JP6095075B2 (ja) 2017-03-15

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JP2014555678A Expired - Fee Related JP6095075B2 (ja) 2012-01-31 2013-01-30 キナーゼ阻害剤としてのプリノン化合物
JP2017020756A Expired - Fee Related JP6501209B2 (ja) 2012-01-31 2017-02-07 キナーゼ阻害剤としてのプリノン化合物
JP2018228582A Pending JP2019059758A (ja) 2012-01-31 2018-12-05 キナーゼ阻害剤としてのプリノン化合物

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JP2017020756A Expired - Fee Related JP6501209B2 (ja) 2012-01-31 2017-02-07 キナーゼ阻害剤としてのプリノン化合物
JP2018228582A Pending JP2019059758A (ja) 2012-01-31 2018-12-05 キナーゼ阻害剤としてのプリノン化合物

Country Status (14)

Country Link
US (3) US8501724B1 (enExample)
EP (2) EP3147285A3 (enExample)
JP (3) JP6095075B2 (enExample)
KR (2) KR20180030730A (enExample)
CN (2) CN104640861B (enExample)
AU (3) AU2013215166B2 (enExample)
BR (1) BR112014018728A8 (enExample)
CA (2) CA2940039A1 (enExample)
HK (1) HK1203489A1 (enExample)
IL (1) IL261282A (enExample)
MX (1) MX2014009219A (enExample)
PH (1) PH12014501815B1 (enExample)
RU (2) RU2018118216A (enExample)
WO (1) WO2013116382A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017114880A (ja) * 2012-01-31 2017-06-29 ファーマサイクリックス エルエルシー キナーゼ阻害剤としてのプリノン化合物
JP2019069977A (ja) * 2013-07-02 2019-05-09 ファーマサイクリックス エルエルシー キナーゼ阻害剤としてのプリノン化合物

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