KR20180030730A - 키나제 억제제로서 푸리논 화합물 - Google Patents

키나제 억제제로서 푸리논 화합물 Download PDF

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Publication number
KR20180030730A
KR20180030730A KR1020187007316A KR20187007316A KR20180030730A KR 20180030730 A KR20180030730 A KR 20180030730A KR 1020187007316 A KR1020187007316 A KR 1020187007316A KR 20187007316 A KR20187007316 A KR 20187007316A KR 20180030730 A KR20180030730 A KR 20180030730A
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South Korea
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substituted
unsubstituted
alkyl
cycloalkyl
compound
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Korean (ko)
Inventor
웨이 천
데이비드 제이 로리
순치 얀
룽청 왕
리 린 프라이
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파마싸이클릭스 엘엘씨
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
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    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A—HUMAN NECESSITIES
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Transplantation (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Reproductive Health (AREA)
  • Otolaryngology (AREA)
  • Biomedical Technology (AREA)
KR1020187007316A 2012-01-31 2013-01-30 키나제 억제제로서 푸리논 화합물 Ceased KR20180030730A (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201261593146P 2012-01-31 2012-01-31
US61/593,146 2012-01-31
US201261637765P 2012-04-24 2012-04-24
US61/637,765 2012-04-24
US13/460,524 US8501724B1 (en) 2012-01-31 2012-04-30 Purinone compounds as kinase inhibitors
US13/460,524 2012-04-30
PCT/US2013/023918 WO2013116382A1 (en) 2012-01-31 2013-01-30 Purinone compounds as kinase inhibitors

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020147024260A Division KR101841325B1 (ko) 2012-01-31 2013-01-30 키나제 억제제로서 푸리논 화합물

Publications (1)

Publication Number Publication Date
KR20180030730A true KR20180030730A (ko) 2018-03-23

Family

ID=48870746

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020187007316A Ceased KR20180030730A (ko) 2012-01-31 2013-01-30 키나제 억제제로서 푸리논 화합물
KR1020147024260A Expired - Fee Related KR101841325B1 (ko) 2012-01-31 2013-01-30 키나제 억제제로서 푸리논 화합물

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020147024260A Expired - Fee Related KR101841325B1 (ko) 2012-01-31 2013-01-30 키나제 억제제로서 푸리논 화합물

Country Status (14)

Country Link
US (3) US8501724B1 (enExample)
EP (2) EP2809672A4 (enExample)
JP (3) JP6095075B2 (enExample)
KR (2) KR20180030730A (enExample)
CN (2) CN106279172A (enExample)
AU (3) AU2013215166B2 (enExample)
BR (1) BR112014018728A8 (enExample)
CA (2) CA2940039A1 (enExample)
HK (1) HK1203489A1 (enExample)
IL (1) IL261282A (enExample)
MX (1) MX2014009219A (enExample)
PH (1) PH12014501815B1 (enExample)
RU (2) RU2655388C2 (enExample)
WO (1) WO2013116382A1 (enExample)

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