JP6092264B2 - 脊髄性筋委縮症を処置するための化合物 - Google Patents

脊髄性筋委縮症を処置するための化合物 Download PDF

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JP6092264B2
JP6092264B2 JP2014560007A JP2014560007A JP6092264B2 JP 6092264 B2 JP6092264 B2 JP 6092264B2 JP 2014560007 A JP2014560007 A JP 2014560007A JP 2014560007 A JP2014560007 A JP 2014560007A JP 6092264 B2 JP6092264 B2 JP 6092264B2
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pyridin
alkyl
pyrano
amino
formula
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JP2015509956A (ja
JP2015509956A5 (enExample
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イ，チャン−ソン
チェ，スンギュ
ミッチェル カープ，ゲーリー
ミッチェル カープ，ゲーリー
小山　裕雄
裕雄 小山
ラトニ，ハッサン
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F Hoffmann La Roche AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
JP2014560007A 2012-03-01 2013-02-28 脊髄性筋委縮症を処置するための化合物 Active JP6092264B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261605487P 2012-03-01 2012-03-01
US61/605,487 2012-03-01
PCT/US2013/028131 WO2013130689A1 (en) 2012-03-01 2013-02-28 Compounds for treating spinal muscular atrophy

Publications (3)

Publication Number Publication Date
JP2015509956A JP2015509956A (ja) 2015-04-02
JP2015509956A5 JP2015509956A5 (enExample) 2016-03-17
JP6092264B2 true JP6092264B2 (ja) 2017-03-08

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JP2014560007A Active JP6092264B2 (ja) 2012-03-01 2013-02-28 脊髄性筋委縮症を処置するための化合物

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US (1) US9371336B2 (enExample)
EP (1) EP2819519B1 (enExample)
JP (1) JP6092264B2 (enExample)
KR (1) KR102099997B1 (enExample)
CN (1) CN104302181B (enExample)
BR (1) BR112014021531B1 (enExample)
CA (1) CA2865957C (enExample)
EA (1) EA029155B1 (enExample)
MX (1) MX352962B (enExample)
WO (1) WO2013130689A1 (enExample)

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RU2016109324A (ru) 2013-08-19 2017-09-26 Ф. Хоффманн-Ля Рош Аг Способ скрининга
US10195202B2 (en) 2013-12-19 2019-02-05 Ptc Therapeutics, Inc. Methods for modulating the amount of RNA transcripts
US10668171B2 (en) 2015-05-30 2020-06-02 Ptc Therapeutics, Inc. Methods for modulating RNA splicing
EP3133065A1 (en) 2015-08-21 2017-02-22 Merck Patent GmbH Compounds for optically active devices
KR102488323B1 (ko) 2015-12-10 2023-01-12 피티씨 테라퓨틱스, 인크. 헌팅턴병 치료 또는 개선을 위한 조성물
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EP3363793A1 (en) 2017-02-15 2018-08-22 Merck Patent GmbH Hydrophobic compounds for optically active devices
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KR20200033249A (ko) 2017-06-05 2020-03-27 피티씨 테라퓨틱스, 인크. 헌팅턴병 치료 화합물
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CN111194215B (zh) 2017-08-04 2024-03-01 斯基霍克疗法公司 用于调节剪接的方法和组合物
US12103926B2 (en) 2018-03-27 2024-10-01 Ptc Therapeutics, Inc. Compounds for treating huntington's disease
AU2019294478B2 (en) 2018-06-27 2023-03-23 Ptc Therapeutics, Inc. Heterocyclic and heteroaryl compounds for treating Huntington's disease
US11685746B2 (en) 2018-06-27 2023-06-27 Ptc Therapeutics, Inc. Heteroaryl compounds for treating Huntington's disease
WO2020005877A1 (en) 2018-06-27 2020-01-02 Ptc Therapeutics, Inc. Heteroaryl compounds for treating huntington's disease
MX2020014116A (es) 2018-06-27 2021-06-15 Reborna Biosciences Inc Agente profilactico o terapeutico para atrofia muscular espinal.
WO2020163405A1 (en) 2019-02-05 2020-08-13 Skyhawk Therapeutics, Inc. Methods and compositions for modulating splicing
JP7603595B2 (ja) 2019-02-06 2024-12-20 スカイホーク・セラピューティクス・インコーポレーテッド スプライシングを調節するための方法および組成物
US11129829B2 (en) 2019-06-17 2021-09-28 Skyhawk Therapeutics, Inc. Methods for modulating splicing
CN111116460A (zh) * 2019-12-31 2020-05-08 阿里生物新材料（常州）有限公司 一种2-氯-4-羟基吡啶-3-甲醛氢溴酸盐的合成方法
WO2021233800A1 (en) 2020-05-20 2021-11-25 Merck Patent Gmbh Azacoumarin and azathiocoumarin derivatives for use in optically active devices
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WO2024251925A1 (en) * 2023-06-09 2024-12-12 F. Hoffmann-La Roche Ag Inducible gene expression system

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Also Published As

Publication number Publication date
JP2015509956A (ja) 2015-04-02
CA2865957C (en) 2020-02-11
EP2819519B1 (en) 2019-10-23
US20150166575A1 (en) 2015-06-18
US9371336B2 (en) 2016-06-21
CA2865957A1 (en) 2013-09-06
BR112014021531B1 (pt) 2022-10-04
CN104302181A (zh) 2015-01-21
EP2819519A1 (en) 2015-01-07
CN104302181B (zh) 2017-09-15
HK1200056A1 (en) 2015-07-31
WO2013130689A1 (en) 2013-09-06
MX2014010406A (es) 2015-03-10
EP2819519A4 (en) 2015-09-02
BR112014021531A8 (pt) 2021-06-15
MX352962B (es) 2017-12-15
EA029155B1 (ru) 2018-02-28
KR102099997B1 (ko) 2020-04-13
KR20140131384A (ko) 2014-11-12
BR112014021531A2 (pt) 2017-06-20
EA201491617A1 (ru) 2015-01-30

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