JP6092264B2 - 脊髄性筋委縮症を処置するための化合物 - Google Patents

脊髄性筋委縮症を処置するための化合物 Download PDF

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JP6092264B2
JP6092264B2 JP2014560007A JP2014560007A JP6092264B2 JP 6092264 B2 JP6092264 B2 JP 6092264B2 JP 2014560007 A JP2014560007 A JP 2014560007A JP 2014560007 A JP2014560007 A JP 2014560007A JP 6092264 B2 JP6092264 B2 JP 6092264B2
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pyridin
alkyl
pyrano
amino
formula
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JP2015509956A5 (enExample
JP2015509956A (ja
Inventor
イ，チャン−ソン
チェ，スンギュ
ミッチェル カープ，ゲーリー
ミッチェル カープ，ゲーリー
小山　裕雄
裕雄 小山
ラトニ，ハッサン
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F Hoffmann La Roche AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2014560007A 2012-03-01 2013-02-28 脊髄性筋委縮症を処置するための化合物 Active JP6092264B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261605487P 2012-03-01 2012-03-01
US61/605,487 2012-03-01
PCT/US2013/028131 WO2013130689A1 (en) 2012-03-01 2013-02-28 Compounds for treating spinal muscular atrophy

Publications (3)

Publication Number Publication Date
JP2015509956A JP2015509956A (ja) 2015-04-02
JP2015509956A5 JP2015509956A5 (enExample) 2016-03-17
JP6092264B2 true JP6092264B2 (ja) 2017-03-08

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JP2014560007A Active JP6092264B2 (ja) 2012-03-01 2013-02-28 脊髄性筋委縮症を処置するための化合物

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US (1) US9371336B2 (enExample)
EP (1) EP2819519B1 (enExample)
JP (1) JP6092264B2 (enExample)
KR (1) KR102099997B1 (enExample)
CN (1) CN104302181B (enExample)
BR (1) BR112014021531B1 (enExample)
CA (1) CA2865957C (enExample)
EA (1) EA029155B1 (enExample)
MX (1) MX352962B (enExample)
WO (1) WO2013130689A1 (enExample)

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WO2020005882A1 (en) 2018-06-27 2020-01-02 Ptc Therapeutics, Inc. Heteroaryl compounds for treating huntington's disease
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KR102913697B1 (ko) 2019-02-05 2026-01-15 스카이호크 테라퓨틱스, 인코포레이티드 스플라이싱을 조절하는 방법 및 조성물
WO2020163541A1 (en) 2019-02-05 2020-08-13 Skyhawk Therapeutics, Inc. Methods and compositions for modulating splicing
KR102925385B1 (ko) 2019-02-06 2026-02-11 스카이호크 테라퓨틱스, 인코포레이티드 스플라이싱을 조절하는 방법 및 조성물
JP7603594B2 (ja) 2019-02-06 2024-12-20 スカイホーク・セラピューティクス・インコーポレーテッド スプライシングを調節するための方法および組成物
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Also Published As

Publication number Publication date
KR102099997B1 (ko) 2020-04-13
CN104302181B (zh) 2017-09-15
BR112014021531A8 (pt) 2021-06-15
US20150166575A1 (en) 2015-06-18
US9371336B2 (en) 2016-06-21
EP2819519A4 (en) 2015-09-02
EP2819519A1 (en) 2015-01-07
BR112014021531B1 (pt) 2022-10-04
CA2865957C (en) 2020-02-11
KR20140131384A (ko) 2014-11-12
WO2013130689A1 (en) 2013-09-06
MX352962B (es) 2017-12-15
CN104302181A (zh) 2015-01-21
MX2014010406A (es) 2015-03-10
EA029155B1 (ru) 2018-02-28
EP2819519B1 (en) 2019-10-23
JP2015509956A (ja) 2015-04-02
EA201491617A1 (ru) 2015-01-30
HK1200056A1 (en) 2015-07-31
CA2865957A1 (en) 2013-09-06
BR112014021531A2 (pt) 2017-06-20

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