JP6073500B2 - 半透多孔性の人工かさぶたの形成 - Google Patents
半透多孔性の人工かさぶたの形成 Download PDFInfo
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- JP6073500B2 JP6073500B2 JP2015550354A JP2015550354A JP6073500B2 JP 6073500 B2 JP6073500 B2 JP 6073500B2 JP 2015550354 A JP2015550354 A JP 2015550354A JP 2015550354 A JP2015550354 A JP 2015550354A JP 6073500 B2 JP6073500 B2 JP 6073500B2
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- Prior art keywords
- semi
- scab
- formation
- artificial scab
- tissue
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0085—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/655—Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/22—Lipids, fatty acids, e.g. prostaglandins, oils, fats, waxes
- A61L2300/222—Steroids, e.g. corticosteroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
- A61L2300/406—Antibiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/43—Hormones, e.g. dexamethasone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/442—Colorants, dyes
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
- Prostheses (AREA)
Description
本発明は人工の瘢痕化手段に関し、これを用いて、壊死組織を除去して損傷した又は火傷した領域を消毒した後に、この損傷した表面、創傷、火傷A−ABに物質(sustancia)を適用する。
この技術は、負傷した領域からの壊死組織の除去、及びそれに続く、発明の名称に記載した人工の被覆の適用からなる。この調剤薬により、負傷した表面に人工かさぶた(costra artisficia)が形成される。
1.ガーゼの使用に取って代わることであり、というのも、ガーゼは、損傷した領域にくっつき、ガーゼを取り外そうとした際に、肉芽領域に損傷を引き起こし、その結果、不完全な瘢痕化を引き起こすためである。
2.外部生物学的因子(agentes biologicos externos)に対する保護を提供することにより、潜在的な感染を回避すること。
3.機械的バリアの完全性が損なわれたことから生じる、体液及び体温の損失を回避すること。
本発明の目的は、人工かさぶたを用いて損傷部分を感染及び体液の損失から保護することであり、よって瘢痕化ははるかに速くなり、新たな組織は欠陥を有しない。
容器内での反応により形成されるこの水性チキソトロピー液は、以下の5つの物質の組み合わせ:アゾスルファミド1〜5% + ゲンチアナバイオレット0.004〜0.007% + デキサメタゾン0.001〜0.003% + パンテノール0.5〜2% + ゲンタマイシン0.03〜0.06%によって製造され、赤色を有する。ねじ蓋で閉鎖された褐色ガラス容器又は加圧プラスチック容器内に12〜15℃の周囲温度で保管されるこの調剤薬は、その元の性質を2年間維持する。
本発明の範囲、及び負傷した組織(図1)に本発明を適用する方法について説明及び特定し、独占的な権利及び所有物として請求するための宣誓を行う。
浸食された又は負傷した表面を保護するための、自己固定型の半透多孔性の人工のかさぶた。前記人工かさぶたはまた、保護性被覆の下での新たな組織の増殖を可能とする(図2参照)。
前記人工かさぶたは、組成物であり、前記組成物は、負傷部位に存在する酵素によって触媒される、適用部位における上述した化合物間の物理的反応によって生成されたウェブである、半透多孔性の人工かさぶたの生成を特徴とする。
前記人工かさぶたは、培養皮膚のように作用するが、化学的ポリマーであり、「化学的ウェブ」特性を有する半透多孔性の人工かさぶたは今のところ事実上存在していない。
前記人工のかさぶたはまた、分泌液、電界質血しょう、タンパク質の損失も防ぐ。
明細書中に記載した5つの物質は、前記5つの物質が損傷部分(A−AB型火傷又は創傷)に適用され、損傷した組織の触媒作用によって物理化学的に反応し、その結果感染並びに血しょう及びタンパク質の損失を防ぐ保護層を生成することを特徴とする。
前記新たな組織は、前記層によってもたらされる保護により、元の構造を失わない。
Claims (3)
- 1〜5重量%のアゾスルファミド、0.004〜0.007重量%のゲンチアナバイオレット、0.001〜0.003重量%のデキサメタゾン、0.5〜2重量%のパンテノール、及び0.03〜0.06重量%のゲンタマイシンを含む、水性組成物。
- 局所用の瘢痕化剤としての請求項1に記載の組成物。
- 損傷、火傷又は創傷を治療するための請求項2に記載の組成物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AR20120105043 | 2012-12-27 | ||
ARP120105043A AR089518A1 (es) | 2012-12-27 | 2012-12-27 | Costra artificial porosa semipermeable |
PCT/PE2013/000010 WO2014104898A2 (es) | 2012-12-27 | 2013-11-04 | Formación de costra artificial porosa semipermeable |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2016504357A JP2016504357A (ja) | 2016-02-12 |
JP6073500B2 true JP6073500B2 (ja) | 2017-02-01 |
Family
ID=49959135
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2015550354A Expired - Fee Related JP6073500B2 (ja) | 2012-12-27 | 2013-11-04 | 半透多孔性の人工かさぶたの形成 |
Country Status (15)
Country | Link |
---|---|
US (2) | US20160000963A1 (ja) |
EP (1) | EP2939678B1 (ja) |
JP (1) | JP6073500B2 (ja) |
CN (1) | CN105073121B (ja) |
AR (1) | AR089518A1 (ja) |
AU (1) | AU2013368699B2 (ja) |
BR (1) | BR112015014785B1 (ja) |
CA (1) | CA2896488C (ja) |
ES (1) | ES2633970T3 (ja) |
IL (1) | IL239618B (ja) |
MX (1) | MX2015007747A (ja) |
PE (1) | PE20160748A1 (ja) |
RU (1) | RU2015128753A (ja) |
UY (1) | UY35111A (ja) |
WO (1) | WO2014104898A2 (ja) |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2364563A (en) * | 1941-09-25 | 1944-12-05 | John B Stribling | Keratitic medicament |
US3146162A (en) * | 1961-05-05 | 1964-08-25 | Harold A Abramson | Gentian violet adsorption complex |
US3238100A (en) * | 1963-07-23 | 1966-03-01 | American Maize Prod Co | Starch phosphate film composition and method of dressing wounds with same |
US3328259A (en) * | 1964-01-08 | 1967-06-27 | Parachem Corp | Dressing for a wound containing a hemostatic agent and method of treating a wound |
US3577516A (en) * | 1969-12-02 | 1971-05-04 | Nat Patent Dev Corp | Preparation of spray on bandage |
US3969498A (en) * | 1973-09-13 | 1976-07-13 | University Of The Pacific | Dressing and method for treating a wound |
JP3261807B2 (ja) * | 1992-06-09 | 2002-03-04 | 味の素株式会社 | チキソトロピーを有するゲル状組成物 |
US20040018241A1 (en) * | 1997-09-26 | 2004-01-29 | Noven Pharmaceuticals, Inc. | Bioadhesive compositions and methods for topical administration of active agents |
FR2819721B1 (fr) * | 2001-01-19 | 2005-02-04 | L M D | Traitement des escarres avec sucre non metabolisable et un absorbant polymerique |
AU2002366209A1 (en) * | 2001-11-20 | 2003-06-10 | Visco Dye Aps | Visco dye |
US20030203032A1 (en) * | 2002-04-25 | 2003-10-30 | Schultz Clyde L. | Growth factor delivery system for the healing of wounds and the prevention of inflammation and disease |
DE60333645D1 (de) * | 2002-08-20 | 2010-09-16 | Gen Wound Kare Inc A Corp Of D | Verfahren zur herstellung eines medizinischen polsters |
DE10357046A1 (de) * | 2003-12-04 | 2005-06-30 | Beiersdorf Ag | Kosmetische oder dermatologische Zubereitungen enthaltend eine Kombination aus grünem Farbstoff und antiinflammatorischem Wirkstoff |
CN1293883C (zh) * | 2004-05-21 | 2007-01-10 | 邹宏 | 一种美容修护液及其制备方法 |
US20070161936A1 (en) * | 2006-01-06 | 2007-07-12 | Svetlik Harvey E | Wound treatment-dressing and method of manufacture |
ES2304103B1 (es) * | 2007-02-22 | 2009-08-07 | Biocosmetics S.L. | Composicion para tratamiento de la xerostomia o boca seca. |
SG186782A1 (en) * | 2010-07-02 | 2013-02-28 | Holden Brien Vision Inst | Composition for prevention and treatment of contact lens papillary conjunctivitis and allergic eye disease |
CN101947226A (zh) * | 2010-09-10 | 2011-01-19 | 李晓倩 | 治疗红眼病的滴液 |
-
2012
- 2012-12-27 AR ARP120105043A patent/AR089518A1/es active IP Right Grant
-
2013
- 2013-11-01 UY UY0001035111A patent/UY35111A/es not_active Application Discontinuation
- 2013-11-04 JP JP2015550354A patent/JP6073500B2/ja not_active Expired - Fee Related
- 2013-11-04 ES ES13867652.3T patent/ES2633970T3/es active Active
- 2013-11-04 PE PE2015000904A patent/PE20160748A1/es not_active Application Discontinuation
- 2013-11-04 RU RU2015128753A patent/RU2015128753A/ru not_active Application Discontinuation
- 2013-11-04 CA CA2896488A patent/CA2896488C/en not_active Expired - Fee Related
- 2013-11-04 MX MX2015007747A patent/MX2015007747A/es unknown
- 2013-11-04 AU AU2013368699A patent/AU2013368699B2/en not_active Ceased
- 2013-11-04 BR BR112015014785-2A patent/BR112015014785B1/pt not_active IP Right Cessation
- 2013-11-04 EP EP13867652.3A patent/EP2939678B1/en not_active Not-in-force
- 2013-11-04 US US14/655,677 patent/US20160000963A1/en not_active Abandoned
- 2013-11-04 WO PCT/PE2013/000010 patent/WO2014104898A2/es active Application Filing
- 2013-11-04 CN CN201380068529.0A patent/CN105073121B/zh not_active Expired - Fee Related
-
2015
- 2015-06-24 IL IL239618A patent/IL239618B/en active IP Right Grant
-
2018
- 2018-08-29 US US16/115,874 patent/US20190022274A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CA2896488A1 (en) | 2014-07-03 |
CN105073121A (zh) | 2015-11-18 |
AR089518A1 (es) | 2014-08-27 |
CN105073121B (zh) | 2018-12-04 |
RU2015128753A (ru) | 2017-02-01 |
BR112015014785B1 (pt) | 2021-11-30 |
BR112015014785A2 (pt) | 2017-08-15 |
EP2939678A4 (en) | 2016-06-08 |
US20190022274A1 (en) | 2019-01-24 |
EP2939678A2 (en) | 2015-11-04 |
IL239618B (en) | 2018-01-31 |
JP2016504357A (ja) | 2016-02-12 |
ES2633970T3 (es) | 2017-09-26 |
CA2896488C (en) | 2017-11-21 |
IL239618A0 (en) | 2015-08-31 |
WO2014104898A3 (es) | 2015-01-08 |
AU2013368699A1 (en) | 2015-07-16 |
AU2013368699B2 (en) | 2017-08-10 |
US20160000963A1 (en) | 2016-01-07 |
WO2014104898A2 (es) | 2014-07-03 |
UY35111A (es) | 2013-12-31 |
EP2939678B1 (en) | 2017-04-19 |
PE20160748A1 (es) | 2016-08-21 |
MX2015007747A (es) | 2015-09-04 |
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