CN105073121A - 半透性多孔人造痂的形成 - Google Patents

半透性多孔人造痂的形成 Download PDF

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CN105073121A
CN105073121A CN201380068529.0A CN201380068529A CN105073121A CN 105073121 A CN105073121 A CN 105073121A CN 201380068529 A CN201380068529 A CN 201380068529A CN 105073121 A CN105073121 A CN 105073121A
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帕西法尔·维嘉·比亚维森西奥
米格尔·埃德加多·巴蒂斯塔
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Abstract

一种自固定半透性多孔人造痂，用于保护侵蚀或损坏表面。它可以应用于对任何生命体(包括植物)。通过酶催化反应裂解的细胞释放作用在所应用的受损区域上形成该痂的聚合网状物。在该保护区表面下，促进新的正常细胞生长，其可以自由呼吸，无需干燥。它可以防止水、电解质和蛋白质的流失，还可以防止感染，可取代纱布和敷料的使用，纱布和敷料在去除时会伤害新皮肤的。该红色水性混合物通过刷涂或喷涂应用，其具有触变性质，通过在容器中的下列化合物的物理化学相互作用获得：1～5g％偶氮磺酰胺+0.004～0.007g％的龙胆紫+0.001～0.003g％的地塞米松+0.5～2g％的泛醇+0.03～0.06g％的庆大霉素。

Description

半透性多孔人造痂的形成
1.技术领域
本发明涉及人造治愈装置，在去除坏死组织并对受损区或烧伤区消毒之后，可以将该人造治愈装置应用在受损表面、伤口、A-AB型烧伤处。
2.背景技术
该技术包括：去除受伤区的坏死组织，然后使用在标题中提到的人工覆盖物。该准备(preparado)可以促使在受伤表面上形成人造痂。
要解决的问题是：
1.取代纱布的使用，因为纱布粘附在受损区域，当试图将纱布去除时，会在造粒区引起损伤，从而导致缺陷性结疤。
2.避免因保护外部生物制剂而产生潜在感染。
3.避免因机械性屏障完整性的损失所致的体液和热量损失。
多孔人造痂(costra)可以促使新组织形成，从而使其自然呼吸：其在再生过程中，通过避免破坏过程(如坏死或厌氧菌的产生)实现快速结痂，不需要覆盖和进行进一步处理，直到所述“痂”自然剥离。
4.发明目的
1.人造痂可以防止受损处感染和流体损失，从而加速结痂并使得新组织没有缺陷。
降低传统材料的成本，因为一旦痂形成，没有必要做进一步的处理，且痂可以自然剥离。
5.发明内容
由于反应是由5物质组合在容器中发生的，从而可以形成水溶性触变流体。其中5种物质包括：1～5％的偶氮磺酰胺，0.004～0.007％的龙胆紫，0.001～0.003％的地塞米松，0.5～2％的泛醇，0.03～0.06％的红色庆大霉素，在12～15℃温度下，保存在通过螺帽或压塑封闭的焦糖着色玻璃瓶中，该制剂的原始特性能保持两年。
用户应该注意的是，在广泛损伤的情况下，该红色液体通过微红色的尿液排出，这是对人体无害的。
去除坏死组织，清洗，用石油醚进行脱脂和干燥。
首先摇动容器，采用干净的金属刮刀或通过喷雾将其应用在受伤表面上。
其可以应用在眼睛，耳朵和粘膜上，不需要使用清洗溶剂且没有风险。
一旦应用在生物体组织的表面上，由于酶催化作用会发生物理化学反应，通过反应性基团之间的离子键和共价键产生半紧的网状物。
通过上述暴露的组织将网状物粘接在受损的组织上。
采用下图来表示最可能的结构。
d-泛醇氧化酶促地形成泛酸。
这种酸可以反应以便形成辅酶A的部分，或促使其结合到在该方案中提到的网状物。
磺酰基，羧基，伯或仲羟基酚基或醇基可与暴露的活性蛋白质或氨基糖基团反应，使痂粘接在受损皮肤上且使其保持高浓度。
分子内或分子间及离子型或共价型力赋予结构以强度。
通过疏水相互作用、永久或诱导的偶极-偶极氢键等键在各个层之间提供众多稳定的交叉，形成网状物的连接。
这将产生一级、二级、三级和四级构象，从而使得该结构具有三维结构。
6.附图说明
图1
图1用于示出皮肤的一度烧伤。
图2
该图的目的是显示对物理化学反应的描述，通过其反应性基团之间的离子键和共价键生成半紧网状物。可以看到在结构的各个组件之间的肽键、疏水作用、极性相互作用、永久或诱导的偶极-偶极键、氢键、酰胺、酯、各种酸基在各个组件之间结合，这会产生一级、二级、三级和四级构象，从而使得结构具有三维结构。
图3
半透性多孔人造痂的最有可能的化学式。
图4
龙胆紫：甲基紫，通常也被称为结晶紫或紫药水，是给一组用作pH指示剂和染料的化学化合物名称。龙胆紫(结晶紫，甲基紫10B，六甲基氯化副品红)是抗真菌剂。
图5
地塞米松：具有作用持续时间长，高抗炎性和免疫抑制能力，以及低盐皮质激素活性的含氟皮质激素。它抑制前列腺素和白三烯，血管中和在炎症和免疫应答的细胞过程的中介物质的合成。
图6
庆大霉素：庆大霉素是一种有杀菌作用的广谱抗菌氨基糖苷类。作用机理：本氨基糖苷类主动穿过细菌膜，它们与一种或多种特异性受体蛋白不可逆结合，该特异性受体蛋白具有亚单位30S的细菌核糖体，它们还干预mRNA(信使RNA)和亚单位30S之间的起始复合物。该DNA会被错误地读取，这会引起非功能蛋白质的生产，多核糖体中分离并且不能够合成蛋白质。这也会引起氨基糖苷类的加速运输，导致的结果是：增加细菌的胞质膜的破裂和随后的细胞死亡。
图7
泛醇：泛醇也称为d-泛醇或羟泛酸，是一种无色，高粘度和相对粘稠液体。它是易溶于水和乙醇(96°)。泛醇易溶于头发溶液的制剂，只要它们是水性、水醇性或水烯(hidropropilen)-醇性溶液。
图8
偶氮磺酰胺：该磺酰胺基本上是磺胺的衍生物，其是PABA结构类似物，其中羧基被磺酰基(SO2NH2)取代。因此，磺胺充当PABA的竞争性拮抗剂，阻止二氢叶酸的合成，在没有该代谢物时，不可能合成核酸，从而抑制细菌生长(抑菌效果)。

Claims (1)

  1. 本发明的范围和在受损组织(附图1)上生产该人造痂的方法已经进行了描述和详细说明，下面通过权利要求声明专利权和所有权：
    1.一种用于保护侵蚀或受伤表面的自固定半透性多孔人造痂，在其保护层下促进新组织的生长(见附图2)。
    其为一种组合物，其特征在于，所述半透性多孔人造痂为网状物，所述网状物通过在上述化合物应用部位和存在酶催化的受伤部位之间的物理化学反应产生。
    其类似于培养的皮肤，为一种化学聚合物，在尽可能多的半透性多孔人造痂中，该半透性多孔人造痂具有目前还不存在“化学纤维网”特征。
    其还能防止水、电解质血浆和蛋白质的损失。
    所述的五种物质使其具有在应用在损伤处(A-AB类型烧伤处或伤口)时能通过受损组织的催化作用发生反应的特性，从而产生保护层，该保护层能防止感染，及血浆和蛋白质的损失。
    由于该保护层的保护作用，新组织不会失去其原有的结构。
CN201380068529.0A 2012-12-27 2013-11-04 半透性多孔人造痂的形成 Expired - Fee Related CN105073121B (zh)

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ARP120105043A AR089518A1 (es) 2012-12-27 2012-12-27 Costra artificial porosa semipermeable
AR20120105043 2012-12-27
PCT/PE2013/000010 WO2014104898A2 (es) 2012-12-27 2013-11-04 Formación de costra artificial porosa semipermeable

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AU2013368699A1 (en) 2015-07-16
AR089518A1 (es) 2014-08-27
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JP6073500B2 (ja) 2017-02-01
CN105073121B (zh) 2018-12-04
UY35111A (es) 2013-12-31
EP2939678A4 (en) 2016-06-08
AU2013368699B2 (en) 2017-08-10
US20160000963A1 (en) 2016-01-07
MX2015007747A (es) 2015-09-04
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PE20160748A1 (es) 2016-08-21
WO2014104898A3 (es) 2015-01-08
US20190022274A1 (en) 2019-01-24
EP2939678A2 (en) 2015-11-04
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IL239618B (en) 2018-01-31
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