EP2939678B1 - Thixotropic fluid for use as a cicatrizing agent - Google Patents
Thixotropic fluid for use as a cicatrizing agent Download PDFInfo
- Publication number
- EP2939678B1 EP2939678B1 EP13867652.3A EP13867652A EP2939678B1 EP 2939678 B1 EP2939678 B1 EP 2939678B1 EP 13867652 A EP13867652 A EP 13867652A EP 2939678 B1 EP2939678 B1 EP 2939678B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- weight
- thixotropic fluid
- scab
- fluid
- panthenol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Not-in-force
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0085—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/655—Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/22—Lipids, fatty acids, e.g. prostaglandins, oils, fats, waxes
- A61L2300/222—Steroids, e.g. corticosteroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
- A61L2300/406—Antibiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/43—Hormones, e.g. dexamethasone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/442—Colorants, dyes
Definitions
- the present invention relates to artificial cicatrization means by means of which a substance is applied to the damaged surfaces, wounds, burns A-AB, after removing the necrotic tissue and disinfecting the damaged or burnt zone.
- the technique consists of the removal of the necrotic tissue from the injured zone and subsequent application of the artificial covering mentioned in the title.
- the preparation causes the formation of an artificial scab on the injured surface.
- the porous artificial scab allows the formation of new tissue , allowing its natural respiration: during its regeneration and bringing about a faster development of cicatrization by avoiding disrupted processes such as the necrosis or the development of anaerobes, without the need to cover and without performing further treatments until the natural detachment of the "Scab.”
- the invention discloses an aqueous thixotropic fluid comprising 1-5 weight% of azosulfamide, 0.004-0.007 weight% of gentian violet, 0.001-0.003 weight% of dexamethasone, 0.5-2 weight% of panthenol, and 0.03-0.06 weight% of gentamycin.
- the fluid is for topical use as a cicatrizing agent, in particular for the treatment of lesions, wounds or burns.
- This aqueous thixotropic fluid which forms due to the reaction in the container is produced by the combination of 5 substances; azosulfamide between 1 and 5% + gentian violet between 0.004 and 0.007% + dexamethasone between 0.001 and 0.003% + panthenol between 0.5 and 2% + gentamycin between 0.03 and 0.06% having a red color.
- the preparation keeps its original properties for two years kept in caramel colored glass closed by screw cap or in pressure plastic at ambient temperature between 12 and 15 degrees centigrade.
- necrotic tissues are removed, and a cleaning, degreasing and drying with petroleum ether is carried out.
- the container is first shaken and it is applied on the injured surface with a clean metal spatula or by spray.
- This web adheres to the damaged tissues via exposed groups of said tissues.
- This acid can react so as to form part of the coenzyme A or to bring about its bonding to the web mentioned in the scheme.
- the sulfonyl groups, the carboxyl groups, the primary or secondary hydroxyl phenol or alcohol groups can react with exposed reactive groups of proteins or amino sugars allowing the attachment of the scab to the damaged skin which presents them at a high concentration.
- the forces that confer strength to the structure are intramolecular or intermolecular and of ionic or covalent type.
- bonds of the web which presents numerous crossovers are stabilized between the various layers by hydrophobic interactions, by permanent or induced dipole-dipole hydrogen bonding, and other bonds.
- composition characterized by the formation of a semipermeable porous artificial scab which is a web produced by the physical reactions between the mentioned compounds at the site of the application, catalyzed by the enzymes present at the injured site.
- the five substances described are characterized in that they are applied to a lesion (type A-AB burn or wound) react physicochemically by catalytic action of the damaged tissues thus generating a protective layer which prevents infections and the loss of plasma and proteins.
- the new tissues do not lose their original structures due to the protection provided by this layer.
- Drawing 1 is intended to show a first-degree burn of the skin.
- This drawing is intended to show the description of the physicochemical reactions that produce a semicompact web by ionic and covalent bonds between its reactive groups; between the different components of the formula one can see peptide bonds, hydrophobic interactions, polar interactions, permanent or induced dipole-dipole bonds, hydrogen bonds, amide, ester, acid base bonds between the various components; this generates primary, secondary, tertiary and quaternary conformations which confer three dimensionality to the structure.
- Gentian violet Methyl violet, commonly also called crystal violet or gentian violet, is the name given to a group of chemical compounds used as pH indicators and dyes. Gentian violet of (crystalline violet, methyl violet 10B, hexamethyl pararosaniline chloride) is an antifungal agent.
- Dexamethasone Is a fluorinated corticoid having a long duration of action, a high antiinflammatory and immunosuppressant power, and a low mineralocorticoid activity. It inhibits the synthesis of prostaglandins and leukotrienes, mediator substances in the vascular and cellular processes of inflammation and immunological response.
- Gentamycin is a broad-spectrum aminoglucoside antibiotic with bactericidal action. Mechanism of action: The aminoglucosides are transported actively through the bacterial membrane, they bind irreversibly to one or more specific receptor proteins of the subunit 30S of the bacterial ribosomes and interfere with the initiation complex between mRNA (messenger RNA) and the subunit 30S. The DNA can be read incorrectly, which gives rise to the production of nonfunctional proteins; the polyribosomes separate and are not capable of synthesizing proteins. This gives rise to an accelerated transport of aminoglucosides, as a result of which there is an increase in the rupture of the cytoplasmic membranes of the bacteria and consequent cell death.
- mRNA messenger RNA
- Panthenol also referred to as D-pantothenyl alcohol or pantothenol, is a colorless, highly viscous and relatively sticky liquid. It is easily soluble in water and in alcohol (96°). Panthenol dissolves without difficulty in the formulation of hair solutions, provided they are aqueous, hydroalcoholic or hydropropylene-alcoholic solutions.
- the sulfamides are basically derivatives of sulfanilamide which is a structural analog of PABA in which the carboxyl group is replaced by a sulfonyl group (SO2NH2).
- SO2NH2 a sulfonyl group
- the sulfas act as competitive antagonists of PABA, preventing the synthesis of dihydrofolate; in the absence of that metabolite, the synthesis of nucleic acids becomes impossible and as a result bacterial growth is inhibited (bacteriostatic effect).
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
- Prostheses (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ARP120105043A AR089518A1 (es) | 2012-12-27 | 2012-12-27 | Costra artificial porosa semipermeable |
PCT/PE2013/000010 WO2014104898A2 (es) | 2012-12-27 | 2013-11-04 | Formación de costra artificial porosa semipermeable |
Publications (3)
Publication Number | Publication Date |
---|---|
EP2939678A2 EP2939678A2 (en) | 2015-11-04 |
EP2939678A4 EP2939678A4 (en) | 2016-06-08 |
EP2939678B1 true EP2939678B1 (en) | 2017-04-19 |
Family
ID=49959135
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP13867652.3A Not-in-force EP2939678B1 (en) | 2012-12-27 | 2013-11-04 | Thixotropic fluid for use as a cicatrizing agent |
Country Status (14)
Country | Link |
---|---|
US (2) | US20160000963A1 (zh) |
EP (1) | EP2939678B1 (zh) |
JP (1) | JP6073500B2 (zh) |
CN (1) | CN105073121B (zh) |
AR (1) | AR089518A1 (zh) |
AU (1) | AU2013368699B2 (zh) |
CA (1) | CA2896488C (zh) |
ES (1) | ES2633970T3 (zh) |
IL (1) | IL239618B (zh) |
MX (1) | MX2015007747A (zh) |
PE (1) | PE20160748A1 (zh) |
RU (1) | RU2015128753A (zh) |
UY (1) | UY35111A (zh) |
WO (1) | WO2014104898A2 (zh) |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2364563A (en) * | 1941-09-25 | 1944-12-05 | John B Stribling | Keratitic medicament |
US3146162A (en) * | 1961-05-05 | 1964-08-25 | Harold A Abramson | Gentian violet adsorption complex |
US3238100A (en) * | 1963-07-23 | 1966-03-01 | American Maize Prod Co | Starch phosphate film composition and method of dressing wounds with same |
US3328259A (en) * | 1964-01-08 | 1967-06-27 | Parachem Corp | Dressing for a wound containing a hemostatic agent and method of treating a wound |
US3577516A (en) * | 1969-12-02 | 1971-05-04 | Nat Patent Dev Corp | Preparation of spray on bandage |
US3969498A (en) * | 1973-09-13 | 1976-07-13 | University Of The Pacific | Dressing and method for treating a wound |
JP3261807B2 (ja) * | 1992-06-09 | 2002-03-04 | 味の素株式会社 | チキソトロピーを有するゲル状組成物 |
US20040018241A1 (en) * | 1997-09-26 | 2004-01-29 | Noven Pharmaceuticals, Inc. | Bioadhesive compositions and methods for topical administration of active agents |
FR2819721B1 (fr) * | 2001-01-19 | 2005-02-04 | L M D | Traitement des escarres avec sucre non metabolisable et un absorbant polymerique |
US20050031540A1 (en) * | 2001-11-20 | 2005-02-10 | Nielsen Per Julius | Visco dye |
US20030203032A1 (en) * | 2002-04-25 | 2003-10-30 | Schultz Clyde L. | Growth factor delivery system for the healing of wounds and the prevention of inflammation and disease |
AU2003290517A1 (en) * | 2002-08-20 | 2004-04-19 | General Wound Kare, Inc. (A Corporation Of Deleware) | Medical pad, and method for making and using |
DE10357046A1 (de) * | 2003-12-04 | 2005-06-30 | Beiersdorf Ag | Kosmetische oder dermatologische Zubereitungen enthaltend eine Kombination aus grünem Farbstoff und antiinflammatorischem Wirkstoff |
CN1293883C (zh) * | 2004-05-21 | 2007-01-10 | 邹宏 | 一种美容修护液及其制备方法 |
US20070161936A1 (en) * | 2006-01-06 | 2007-07-12 | Svetlik Harvey E | Wound treatment-dressing and method of manufacture |
ES2304103B1 (es) * | 2007-02-22 | 2009-08-07 | Biocosmetics S.L. | Composicion para tratamiento de la xerostomia o boca seca. |
EP2588096A4 (en) * | 2010-07-02 | 2013-12-25 | Holden Brien Vision Inst | COMPOSITION FOR THE PREVENTION AND TREATMENT OF CONTACT LENS-RELATED PAPILLAR TIN TREATMENT AND ALLERGIC EYE DISEASES |
CN101947226A (zh) * | 2010-09-10 | 2011-01-19 | 李晓倩 | 治疗红眼病的滴液 |
-
2012
- 2012-12-27 AR ARP120105043A patent/AR089518A1/es active IP Right Grant
-
2013
- 2013-11-01 UY UY0001035111A patent/UY35111A/es not_active Application Discontinuation
- 2013-11-04 AU AU2013368699A patent/AU2013368699B2/en not_active Ceased
- 2013-11-04 WO PCT/PE2013/000010 patent/WO2014104898A2/es active Application Filing
- 2013-11-04 PE PE2015000904A patent/PE20160748A1/es not_active Application Discontinuation
- 2013-11-04 MX MX2015007747A patent/MX2015007747A/es unknown
- 2013-11-04 RU RU2015128753A patent/RU2015128753A/ru not_active Application Discontinuation
- 2013-11-04 US US14/655,677 patent/US20160000963A1/en not_active Abandoned
- 2013-11-04 ES ES13867652.3T patent/ES2633970T3/es active Active
- 2013-11-04 JP JP2015550354A patent/JP6073500B2/ja not_active Expired - Fee Related
- 2013-11-04 CN CN201380068529.0A patent/CN105073121B/zh not_active Expired - Fee Related
- 2013-11-04 EP EP13867652.3A patent/EP2939678B1/en not_active Not-in-force
- 2013-11-04 CA CA2896488A patent/CA2896488C/en not_active Expired - Fee Related
-
2015
- 2015-06-24 IL IL239618A patent/IL239618B/en active IP Right Grant
-
2018
- 2018-08-29 US US16/115,874 patent/US20190022274A1/en not_active Abandoned
Non-Patent Citations (1)
Title |
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None * |
Also Published As
Publication number | Publication date |
---|---|
IL239618A0 (en) | 2015-08-31 |
CA2896488A1 (en) | 2014-07-03 |
CA2896488C (en) | 2017-11-21 |
AU2013368699A1 (en) | 2015-07-16 |
AR089518A1 (es) | 2014-08-27 |
JP2016504357A (ja) | 2016-02-12 |
JP6073500B2 (ja) | 2017-02-01 |
CN105073121B (zh) | 2018-12-04 |
UY35111A (es) | 2013-12-31 |
EP2939678A4 (en) | 2016-06-08 |
AU2013368699B2 (en) | 2017-08-10 |
US20160000963A1 (en) | 2016-01-07 |
MX2015007747A (es) | 2015-09-04 |
CN105073121A (zh) | 2015-11-18 |
ES2633970T3 (es) | 2017-09-26 |
PE20160748A1 (es) | 2016-08-21 |
WO2014104898A3 (es) | 2015-01-08 |
US20190022274A1 (en) | 2019-01-24 |
EP2939678A2 (en) | 2015-11-04 |
RU2015128753A (ru) | 2017-02-01 |
IL239618B (en) | 2018-01-31 |
WO2014104898A2 (es) | 2014-07-03 |
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