JP6058397B2 - 連続非侵襲血圧デバイスからの信号を強化し分析する装置及び方法 - Google Patents
連続非侵襲血圧デバイスからの信号を強化し分析する装置及び方法 Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/021—Measuring pressure in heart or blood vessels
- A61B5/022—Measuring pressure in heart or blood vessels by applying pressure to close blood vessels, e.g. against the skin; Ophthalmodynamometers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/021—Measuring pressure in heart or blood vessels
- A61B5/022—Measuring pressure in heart or blood vessels by applying pressure to close blood vessels, e.g. against the skin; Ophthalmodynamometers
- A61B5/02233—Occluders specially adapted therefor
- A61B5/02241—Occluders specially adapted therefor of small dimensions, e.g. adapted to fingers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7203—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal
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- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
Description
上式で、Tは、拍動の脈間隔[秒]、Nは、拍動の標本piの数である。
p++(t)=p(t)+T[v1(t),v2(t)...vn(t);g1,g2...gn;fc1,fc2...fcn] (2)
0.1Hzよりも低い周波数範囲はp++(t)に寄与しないことが分かっている。vAC(t)及びvLF(t)だけが有意味な信号(meaningful signal)に寄与するため、図4に記載された実施例に対する式(2)は以下のように単純化される。
p++(t)=p(t)+T[vAC(t),vLF(t);gAC,gLF;fLF,fVLF] (3)
正しい設定点が使用されているときには線形関数を使用することができる。図2〜4から分かるように、正しい設定点において、pTは傾きが最大の点であり、したがって拍動性vAC(t)、低周波vLF(t)及び超低周波vVLF(t)は最大に達する。線形補間を以下のように近似することができる。
p++(t)=p(t)+T[vAC(t)・gAC vLF(t)・gLF] (4)
上式で、Tは、線形補間後の残留伝達関数を示す。1つの実例では、Tを、線形化された異なるv(t)×利得倍数間の異なるスケーリング・ファクタ(scaling factor)のベクトルとすることができる。
p++(t)=k×pcuff(t)+d (5)
上式で、k及びdは、NBP値から以下のように計算することができる。
上式で、SBP及びDBPは、NBP較正デバイス(例えば上腕血圧カフ)によって測定した収縮期及び拡張期の値であり、sBP及びdBPは、較正されていない手指カフによって測定した収縮期及び拡張期の値である。
p++(t)=k×pAC(t)+pLF(t)+d (8)
上式で、pAC(t)は、しきい周波数よりも大きな周波数を有する測定された圧力の成分であり、pLF(t)は、しきい周波数よりも低い周波数を有する測定された圧力の成分である。
pbrach(t)=Tnorm(p++(t))=
pbrach(t)=Tnorm(k×pAC(t)+pLF+d)=
pbrach(t)=pLF+d+Tnorm(k×pAC(t)) (9)
上式で、Pn=0→設定点は正しい
Pn<0→設定点を低く
Pn>0→設定点を高く
Claims (17)
- 血圧輪郭曲線を決定する方法であって、
ヒトの手指の動脈の上にフォトプレスチモグラフィ(PPG)システムを有するカフを配置するステップであって、前記PPGシステムが、前記動脈の体積に基づくPPG信号を生成し、且つ少なくとも1つの光源及び少なくとも1つの光検出器を有しており、また前記PPG信号が、予め規定されたしきい周波数より高い周波数を有する拍動性周波成分(vAC(t))、前記予め規定されたしきい周波数より低い周波数を有する低周波成分(vLF(t))、及び前記低周波成分(v LF (t))より低い周波数を有する超低周波成分(vVLF(t))を含んでいる、ステップと、
コンピューティング・デバイスによって前記PPG信号から前記超低周波成分(vVLF(t))を除去すること、及び前記拍動性周波成分(vAC(t))及び前記低周波成分(vLF(t))から前記PPG信号を再構成することによって、前記PPG信号の成分を変更するステップであって、前記カフの圧力は、前記変更されたPPG信号の1つ又は複数の成分によって制御される、ステップと、
前記カフの圧力及び前記PPG信号の少なくとも前記変更された成分を使用して、前記コンピューティング・デバイスによって血圧信号を計算するステップと
を含む方法。 - 前記PPG信号の成分を変更するステップが、
前記PPG信号を、前記予め規定されたしきい周波数よりも高い周波数を有する前記拍動性周波成分(v AC (t))と、前記予め規定されたしきい周波数よりも低い周波数を有する前記低周波成分(v LF (t))とに分離すること、
前記拍動性周波成分(v AC (t))を変更すること、及び
前記変更された拍動性周波成分(v AC (t))を前記低周波成分(v LF (t))に加算して、変更されたPPG信号を生成すること
をさらに含む、請求項1に記載の方法。 - 前記PPG信号の成分を変更するステップが、前記予め規定されたしきい周波数よりも高い周波数を有する前記血圧信号の成分を、ヒトの上腕の動脈上に配置された血圧計によって得た血圧値を使用して較正することをさらに含む、請求項1に記載の方法。
- 前記PPG信号の成分を変更するステップが、前記予め規定されたしきい周波数よりも高い周波数を有する前記血圧信号の成分に較正係数を乗じることを含み、前記較正係数が、ヒトの上腕の動脈上に配置された血圧計からの血圧測定値から計算される、請求項1に記載の方法。
- 前記予め規定されたしきい周波数が約0.3Hzである、請求項1に記載の方法。
- 前記血圧信号を計算するステップが人体計測パラメータを使用する、請求項1に記載の方法。
- 前記血圧輪郭曲線から生理パラメータを計算することをさらに含む、請求項1に記載の方法。
- 前記パラメータが、多ポート・アルゴリズムを使用することによって計算される、請求項7に記載の方法。
- 前記パラメータが、入力信号の1つ又は複数のマーカを使用することによって計算される、請求項7に記載の方法。
- 前記再構成されたPPG信号が
である、請求項1に記載の方法。 - 血圧輪郭曲線を決定するデバイスであって、
ヒトの手指の動脈の上に配置されるように適合された圧力カフであって、少なくとも1つの光源及び少なくとも1つの光検出器を有するPPGシステムを含む圧力カフと、
圧力センサと、
前記カフ内の圧力を制御するコントローラと
を有し、
前記PPGシステムが、前記動脈の体積に基づくPPG信号を生成し、前記PPG信号を使用してコンピューティング・デバイスにより圧力信号が計算され、前記カフ及び前記手指に前記圧力信号が連続的に加えられ、前記PPG信号が、予め規定されたしきい周波数より高い周波数を有する拍動性周波成分(vAC(t))、前記予め規定されたしきい周波数より低い周波数を有する低周波成分(vLF(t))、及び前記低周波成分(v LF (t))より低い周波数を有する超低周波成分(vVLF(t))を含み、
前記コンピューティング・デバイスが、前記超低周波成分(vVLF(t))を前記PPG信号から除去すること、及び前記拍動性周波成分(vAC(t))及び前記低周波成分(vLF(t))から前記PPG信号を再構成することによって、前記PPG信号の成分を変更し、且つ前記カフの圧力及び変更された前記PPG信号を使用して血圧信号を計算し、
前記コントローラが、前記変更されたPPG信号の1つ又は複数の成分を使用して前記カフの圧力を制御する
血圧輪郭曲線を決定するデバイス。 - 前記コンピューティング・デバイスが、前記コントローラから制御状態情報を受け取る、請求項11に記載のデバイス。
- 前記コンピューティング・デバイスが、較正デバイスから情報を受け取る、請求項11に記載のデバイス。
- 前記コンピューティング・デバイスが、別のデバイスからスケーリング情報を受け取る、請求項11に記載のデバイス。
- 前記コンピューティング・デバイスが、静水力学的補正システムから情報を受け取る、請求項11に記載のデバイス。
- 前記コンピューティング・デバイスが、患者から人体計測情報を受け取る、請求項11に記載のデバイス。
- 前記コンピューティング・デバイスが、1つ又は複数の入力信号から生理パラメータを計算する、請求項11に記載のデバイス。
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US25611009P | 2009-10-29 | 2009-10-29 | |
US25608109P | 2009-10-29 | 2009-10-29 | |
US61/256,081 | 2009-10-29 | ||
US61/256,110 | 2009-10-29 | ||
PCT/IB2010/003325 WO2011051822A1 (en) | 2009-10-29 | 2010-10-29 | Apparatus and methods for enhancing and analyzing signals from a continous non-invasive blood pressure device |
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JP6058397B2 true JP6058397B2 (ja) | 2017-01-11 |
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JP2012535957A Pending JP2013509225A (ja) | 2009-10-29 | 2010-10-29 | 血圧測定のデジタル式制御方法 |
JP2012535959A Active JP6058397B2 (ja) | 2009-10-29 | 2010-10-29 | 連続非侵襲血圧デバイスからの信号を強化し分析する装置及び方法 |
JP2015187209A Pending JP2016025935A (ja) | 2009-10-29 | 2015-09-24 | 血圧測定のデジタル式制御方法 |
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JP (3) | JP2013509225A (ja) |
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US8343062B2 (en) | 2013-01-01 |
JP2013509226A (ja) | 2013-03-14 |
CN102647940A (zh) | 2012-08-22 |
EP2493370B1 (en) | 2016-03-16 |
EP2493370A1 (en) | 2012-09-05 |
CN102647940B (zh) | 2015-02-04 |
EP2493373A1 (en) | 2012-09-05 |
CN102791192A (zh) | 2012-11-21 |
JP2016025935A (ja) | 2016-02-12 |
JP2013509225A (ja) | 2013-03-14 |
US20110105918A1 (en) | 2011-05-05 |
CN102791192B (zh) | 2015-02-25 |
US8814800B2 (en) | 2014-08-26 |
US20110105917A1 (en) | 2011-05-05 |
WO2011051819A1 (en) | 2011-05-05 |
EP2493373B1 (en) | 2016-03-16 |
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