JP6031510B2 - 異常な線維芽細胞増殖及び細胞外マトリックスの沈着を特徴とする疾患、症状又はプロセスを予防又は治療する組成物及び方法 - Google Patents
異常な線維芽細胞増殖及び細胞外マトリックスの沈着を特徴とする疾患、症状又はプロセスを予防又は治療する組成物及び方法 Download PDFInfo
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Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2614090T3 (es) | 2005-12-29 | 2017-05-29 | Celtaxsys, Inc. | Derivados de diamina como inhibidores de leucotrieno A4 hidrolasa |
| CA2689296C (en) | 2007-01-10 | 2015-11-17 | Purdue Research Foundation | Polypeptide inhibitors of hsp27 kinase and uses therefor |
| WO2009021137A2 (en) | 2007-08-07 | 2009-02-12 | Purdue Research Foundation | Kinase inhibitors and uses thereof |
| DK2378875T3 (en) * | 2008-12-10 | 2018-09-03 | Purdue Research Foundation | CELLE-PERMEANT PEPTID-BASED INHIBITOR OF KINASES |
| US9890195B2 (en) * | 2009-07-27 | 2018-02-13 | Purdue Research Foundation | MK2 inhibitor compositions and methods to enhance neurite outgrowth, neuroprotection, and nerve regeneration |
| US20130115256A1 (en) * | 2010-05-24 | 2013-05-09 | Cynthia Lander | Methods for treating or preventing vascular graft failure |
| US9890200B2 (en) | 2011-04-12 | 2018-02-13 | Moerae Matrix, Inc. | Compositions and methods for preventing or treating diseases, conditions, or processes characterized by aberrant fibroblast proliferation and extracellular matrix deposition |
| CN111110850A (zh) | 2011-04-12 | 2020-05-08 | 莫伊莱麦屈克斯公司 | 用于预防或治疗以成纤维细胞异常增殖及细胞外基质沉积为特征的疾病的组合物和方法 |
| FR2976587B1 (fr) * | 2011-06-20 | 2015-04-03 | Basf Beauty Care Solutions F | Methode de dosage in vitro par technique immunologique |
| US9452218B2 (en) | 2012-03-09 | 2016-09-27 | Purdue Research Foundation | Compositions and methods for delivery of kinase inhibiting peptides |
| CA2884802A1 (en) * | 2012-10-31 | 2014-05-08 | Galecto Biotech Ab | Galactoside inhibitor of galectin-3 and its use for treating pulmonary fibrosis |
| US9757529B2 (en) | 2012-12-20 | 2017-09-12 | Otitopic Inc. | Dry powder inhaler and methods of use |
| US9757395B2 (en) | 2012-12-20 | 2017-09-12 | Otitopic Inc. | Dry powder inhaler and methods of use |
| EP2968359B1 (en) * | 2013-03-12 | 2021-01-20 | Celltaxis, LLC | Methods of inhibiting leukotriene a4 hydrolase |
| MX2015011677A (es) | 2013-03-14 | 2016-07-08 | Celtaxsys Inc | Inhibidores de leucotrieno a4 hidrolasa. |
| JP2016518388A (ja) | 2013-04-30 | 2016-06-23 | オティトピック インク． | 乾燥粉末配合および使用方法 |
| JP6655547B2 (ja) * | 2014-03-14 | 2020-02-26 | モイライ マトリックス インコーポレイテッド | 慢性肺移植片機能不全（ｃｌａｄ）および特発性肺線維症（ｉｐｆ）を予防または処置するための組成物および方法 |
| US10336788B2 (en) * | 2014-04-17 | 2019-07-02 | Moerae Matrix, Inc. | Inhibition of cardiac fibrosis in myocardial infarction |
| BR112017010238A2 (pt) | 2014-11-17 | 2018-02-06 | Moerae Matrix, Inc. | composições e métodos para prevenir ou tratar doenças, condições ou processos caracterizados por proliferação de fibroblastos e a deposição aberrante de matriz extracelular |
| HK1246807A1 (zh) * | 2015-01-08 | 2018-09-14 | Moerae Matrix, Inc. | Mk2抑制剂肽的制剂 |
| JP2018512401A (ja) * | 2015-03-12 | 2018-05-17 | モイライ マトリックス インコーポレイテッド | Ｍｋ２阻害剤ペプチド含有組成物を用いた非小細胞肺癌の治療を目的とするその使用 |
| AU2017432640B2 (en) | 2017-09-22 | 2023-11-30 | Aspeya US Inc. | Dry powder compositions with magnesium stearate |
| US10786456B2 (en) | 2017-09-22 | 2020-09-29 | Otitopic Inc. | Inhaled aspirin and magnesium to treat inflammation |
| CN107987128B (zh) * | 2017-11-17 | 2019-06-11 | 广东医科大学 | 一种功能多肽及其在制备防治肺纤维化药物中的应用 |
| US12083098B2 (en) | 2018-05-17 | 2024-09-10 | Actuate Therapeutics Inc. | Treatment of idiopathic pulmonary fibrosis with glycogen synthase kinase 3 form β inhibitors |
| WO2019232306A1 (en) | 2018-05-31 | 2019-12-05 | Celtaxsys, Inc. | Method of reducing pulmonary exacerbations in respiratory disease patients |
| CN110108883A (zh) * | 2018-10-27 | 2019-08-09 | 广州呼吸健康研究院 | 用于筛选与靶治疗ards患者的msc精准医学的标志物组合 |
| CN109406795A (zh) * | 2018-11-20 | 2019-03-01 | 昆明医科大学 | 一种轻型脑外伤的血清分子诊断标记物及应用 |
| WO2021040673A1 (en) * | 2019-08-26 | 2021-03-04 | Alain Martin | Methods for the treatment of chronic hypoxemia and inhibiting lung fibrosis in patients with pulmonary fibrosis with and without copd |
| USD958124S1 (en) | 2019-12-16 | 2022-07-19 | Samsung Electronics Co., Ltd. | Television receiver |
| USD978094S1 (en) | 2019-12-27 | 2023-02-14 | Samsung Electronics Co., Ltd. | Television receiver |
| WO2021146662A1 (en) * | 2020-01-17 | 2021-07-22 | Muhammed Majeed | Therapeutic compositions and methods for pulmonary fibrosis |
| CN112386682B (zh) * | 2020-02-12 | 2022-12-06 | 王斌 | 纤连蛋白在制备治疗新型冠状病毒肺炎药物中的应用 |
| WO2021202031A1 (en) * | 2020-03-30 | 2021-10-07 | Figene, Llc | Peptides and adjuvants for augmentation of fibroblast therapy for coronavirus |
| US20230141224A1 (en) * | 2020-04-01 | 2023-05-11 | Figene, Llc | Fibroblast mediated expansion and augmentation of immune regulatory cells for treatment of acute respiratory distress syndrome (ards) |
| WO2021214767A1 (en) * | 2020-04-21 | 2021-10-28 | Remodeless Cv Ltd | Novel threrapy for acute damage to lung tissue |
| USD989726S1 (en) | 2020-12-03 | 2023-06-20 | Samsung Electronics Co., Ltd. | Television receiver |
| KR20230117161A (ko) * | 2020-12-03 | 2023-08-07 | 지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 | 항-결합 조직 성장 인자 항체를 포함하는 약학 조성물 |
| USD989017S1 (en) | 2020-12-03 | 2023-06-13 | Samsung Electronics Co., Ltd. | Television receiver |
| US20220202852A1 (en) * | 2020-12-30 | 2022-06-30 | Briotech, Inc. | Methods and compositions of aqueous hypobromous acid for the treatment and prevention of inflammatory conditions |
| US20220296645A1 (en) * | 2021-03-22 | 2022-09-22 | Spiritus Therapeutics, Inc. | Diagnostic and therapeutic uses of compositions comprising purified, enriched potent exosomes containing disease-based and therapy based signature cargo |
| CN113440431A (zh) * | 2021-08-02 | 2021-09-28 | 山西锦波生物医药股份有限公司 | 重组ⅲ型人源化胶原蛋白在头皮护理中的用途及包含其的头皮护理产品 |
| CN116262112A (zh) * | 2021-12-14 | 2023-06-16 | 南京安吉生物科技有限公司 | 一种雾化吸入用融合多肽制剂及其制备方法和应用 |
| US20250066360A1 (en) | 2022-01-14 | 2025-02-27 | Shanghai Hansoh Biomedical Co., Ltd. | Pyridine-containing polycyclic derivative, and preparation method therefor and use thereof |
| CN114522221B (zh) * | 2022-02-28 | 2024-04-19 | 中国人民解放军陆军特色医学中心 | 分泌蛋白ctgf在用于制备治疗急性肺损伤药物中的应用 |
| WO2023178169A2 (en) * | 2022-03-15 | 2023-09-21 | Anemoi Biotech Holdings, Inc. | Compositions and methods for treating the pathophysiology of severe viral infection |
| CN116421704A (zh) * | 2023-02-20 | 2023-07-14 | 成都佩德生物医药有限公司 | 多肽pd-dp-005在制备治疗肺部疾病药物中的应用及其药物 |
| CN116789751B (zh) * | 2023-08-22 | 2023-11-17 | 中国农业大学 | 预防和/或治疗纤维化疾病的多肽及其应用 |
| CN117577330B (zh) * | 2024-01-15 | 2024-04-02 | 北京大学 | 预测非酒精性脂肪性肝病肝纤维化程度的装置及存储介质 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1521000A (en) | 1975-06-13 | 1978-08-09 | Syntex Puerto Rico Inc | Inhalation device |
| US4227522A (en) | 1978-09-05 | 1980-10-14 | Syntex Puerto Rico, Inc. | Inhalation device |
| US4192309A (en) | 1978-09-05 | 1980-03-11 | Syntex Puerto Rico, Inc. | Inhalation device with capsule opener |
| AT396333B (de) | 1982-10-08 | 1993-08-25 | Glaxo Group Ltd | Vorrichtung zur verabreichung von medikamenten an patienten, einrichtung mit mehreren solchen vorrichtungen und traeger mit medikamentbehaeltern hiefuer |
| US4778054A (en) | 1982-10-08 | 1988-10-18 | Glaxo Group Limited | Pack for administering medicaments to patients |
| GR861995B (en) | 1985-07-30 | 1986-11-04 | Glaxo Group Ltd | Devices for administering medicaments to patients |
| JPH05963A (ja) | 1990-04-13 | 1993-01-08 | Toray Ind Inc | ポリペプチド類組成物 |
| US6331318B1 (en) | 1994-09-30 | 2001-12-18 | Emisphere Technologies Inc. | Carbon-substituted diketopiperazine delivery systems |
| US5352461A (en) | 1992-03-11 | 1994-10-04 | Pharmaceutical Discovery Corporation | Self assembling diketopiperazine drug delivery system |
| WO1993022443A1 (en) | 1992-04-24 | 1993-11-11 | Sri International | In vivo homologous sequence targeting in eukaryotic cells |
| US6582728B1 (en) | 1992-07-08 | 2003-06-24 | Inhale Therapeutic Systems, Inc. | Spray drying of macromolecules to produce inhaleable dry powders |
| US5565350A (en) | 1993-12-09 | 1996-10-15 | Thomas Jefferson University | Compounds and methods for site directed mutations in eukaryotic cells |
| US6428771B1 (en) | 1995-05-15 | 2002-08-06 | Pharmaceutical Discovery Corporation | Method for drug delivery to the pulmonary system |
| CA2367131C (en) | 1999-04-05 | 2007-07-03 | Solomon S. Steiner | Methods for fine powder formation |
| JP4713798B2 (ja) | 1999-06-29 | 2011-06-29 | マンカインド コーポレイション | ペプチドおよびタンパク質の薬学的因子の精製および安定化 |
| WO2003090682A2 (en) | 2002-04-25 | 2003-11-06 | The Scripps Research Institute | Treatment and prevention of pulmonary conditions |
| CA2493067A1 (en) * | 2002-07-19 | 2004-01-29 | Abbott Biotechnology Ltd. | Treatment of tnf.alpha. related disorders |
| AU2004293110C1 (en) * | 2003-11-25 | 2011-06-02 | Virginia Tech Intellectual Properties, Inc. | Composition for animal consumption and method for reducing map kinase activity |
| US20060074102A1 (en) * | 2004-05-14 | 2006-04-06 | Kevin Cusack | Kinase inhibitors as therapeutic agents |
| DE602005024413D1 (de) | 2004-08-20 | 2010-12-09 | Mannkind Corp | Katalyse der diketopiperazinsynthese |
| CN104436170B (zh) | 2004-08-23 | 2018-02-23 | 曼金德公司 | 用于药物输送的二酮哌嗪盐 |
| CA2575684A1 (en) | 2004-08-23 | 2006-03-02 | Mannkind Corporation | Pulmonary delivery of inhibitors of phosphodiesterase type 5 |
| CN101227918A (zh) * | 2005-04-29 | 2008-07-23 | 加州大学评议会 | 治疗以炎症反应为特征的病理的肽和肽模拟物 |
| JP5167133B2 (ja) | 2005-09-14 | 2013-03-21 | マンカインド コーポレイション | 結晶性微粒子表面に対する活性薬剤の親和性の増大に基づく薬物処方の方法 |
| MX2008010721A (es) | 2006-02-22 | 2008-09-01 | Mannkind Corp | Un metodo para mejorar las propiedades farmaceuticas de microparticulas que contienen dicetopiperazina y un agente activo. |
| WO2007117661A2 (en) * | 2006-04-03 | 2007-10-18 | Teva Pharmaceutical Industries Ltd, | Drug microparticles |
| CA2689296C (en) | 2007-01-10 | 2015-11-17 | Purdue Research Foundation | Polypeptide inhibitors of hsp27 kinase and uses therefor |
| WO2008098096A1 (en) | 2007-02-08 | 2008-08-14 | Boehringer Ingelheim International Gmbh | Anti-cytokine heterocyclic compounds |
| US20080282320A1 (en) | 2007-05-11 | 2008-11-13 | Denovo Andrew | Security Compliance Methodology and Tool |
| WO2009021137A2 (en) | 2007-08-07 | 2009-02-12 | Purdue Research Foundation | Kinase inhibitors and uses thereof |
| WO2009085191A2 (en) | 2007-12-21 | 2009-07-09 | Cabot Corporation | Syntactic foam compositions, pipelines insulated with same, and method |
| KR20170001756A (ko) * | 2008-10-20 | 2017-01-04 | 모레 매트릭스 인코포레이티드 | 유착 치료 또는 예방용 폴리펩티드 |
| DK2378875T3 (en) * | 2008-12-10 | 2018-09-03 | Purdue Research Foundation | CELLE-PERMEANT PEPTID-BASED INHIBITOR OF KINASES |
| US20130115256A1 (en) | 2010-05-24 | 2013-05-09 | Cynthia Lander | Methods for treating or preventing vascular graft failure |
| CN111110850A (zh) | 2011-04-12 | 2020-05-08 | 莫伊莱麦屈克斯公司 | 用于预防或治疗以成纤维细胞异常增殖及细胞外基质沉积为特征的疾病的组合物和方法 |
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| CN111110850A (zh) | 2020-05-08 |
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| ES2711670T3 (es) | 2019-05-06 |
| WO2012142320A2 (en) | 2012-10-18 |
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