JP6008937B2 - １−（３−シアノ−１−イソプロピル−インドール−５−イル）ピラゾール−４−カルボン酸の結晶形とその製造方法 - Google Patents

１−（３−シアノ−１−イソプロピル−インドール−５−イル）ピラゾール−４−カルボン酸の結晶形とその製造方法 Download PDF

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JP6008937B2
JP6008937B2 JP2014503602A JP2014503602A JP6008937B2 JP 6008937 B2 JP6008937 B2 JP 6008937B2 JP 2014503602 A JP2014503602 A JP 2014503602A JP 2014503602 A JP2014503602 A JP 2014503602A JP 6008937 B2 JP6008937 B2 JP 6008937B2
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ユン・ジョンミン
パク・キスク
ユン・ジュヨン
リー・ジュヨン
キム・グゥンテ
ジョン・チョルキュ
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    • C—CHEMISTRY; METALLURGY
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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
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  • Diabetes (AREA)
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  • Heart & Thoracic Surgery (AREA)
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  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2014503602A 2011-04-06 2012-04-05 １−（３−シアノ−１−イソプロピル−インドール−５−イル）ピラゾール−４−カルボン酸の結晶形とその製造方法 Active JP6008937B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR10-2011-0031490 2011-04-06
KR20110031490 2011-04-06
PCT/KR2012/002575 WO2012138147A2 (fr) 2011-04-06 2012-04-05 Forme cristalline de l'acide 1-(3-cyano-1-isopropyl-indol-5-yl)pyrazole-4-carboxylique et son procédé de préparation

Publications (2)

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JP2014510133A JP2014510133A (ja) 2014-04-24
JP6008937B2 true JP6008937B2 (ja) 2016-10-19

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JP2014503602A Active JP6008937B2 (ja) 2011-04-06 2012-04-05 １−（３−シアノ−１−イソプロピル−インドール−５−イル）ピラゾール−４−カルボン酸の結晶形とその製造方法

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JP (1) JP6008937B2 (fr)
KR (1) KR101424013B1 (fr)
CN (1) CN103459381B (fr)
TW (1) TWI548630B (fr)
WO (1) WO2012138147A2 (fr)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106008488B (zh) * 2016-05-20 2018-10-30 广东东阳光药业有限公司 氰基吲哚类衍生物及其制备方法和用途
CN106045898B (zh) * 2016-06-28 2019-05-24 广东东阳光药业有限公司 一种吲哚类化合物及其制备方法和用途
AU2017364804A1 (en) * 2016-11-28 2019-05-02 Teijin Pharma Limited Therapeutic drug or prophylactic drug for diabetic nephropathy
CN116456979A (zh) * 2020-11-04 2023-07-18 株式会社Lg化学 1-(3-氰基-1-异丙基-吲哚-5-基)吡唑-4-甲酸结晶粒子的制备方法以及包含其的药物组合物
JP2023551712A (ja) 2020-12-01 2023-12-12 エルジー・ケム・リミテッド １－（３－シアノ－１－イソプロピル－インドール－５－イル）ピラゾール－４－カルボン酸を含む安定した経口用製剤
CN116528853A (zh) 2020-12-01 2023-08-01 株式会社Lg化学 包含1-(3-氰基-1-异丙基-吲哚-5-基)吡唑-4-甲酸的口服制剂及其制备方法
PE20240764A1 (es) 2021-04-16 2024-04-17 Lg Chemical Ltd Formulacion compuesta para administracion oral que comprende acido 1-(3-ciano-1-isopropil-indol-5-il)pirazol-4-carboxilico
KR20220147532A (ko) * 2021-04-27 2022-11-03 주식회사 엘지화학 잔틴 옥시다아제 저해제 합성을 위한 중간체의 제조 방법
BR112023022484A2 (pt) * 2021-04-29 2024-01-09 Jiangsu Atom Bioscience And Pharmaceutical Co Ltd Composto na fórmula geral (i) ou um sal farmaceuticamente aceitável deste, composição farmacêutica e uso do composto ou sais farmaceuticamente aceitáveis deste
CN117425477A (zh) 2021-06-15 2024-01-19 株式会社Lg化学 包含1-(3-氰基-1-异丙基-吲哚-5-基)吡唑-4-甲酸的药物组合物
AR126164A1 (es) 2021-06-17 2023-09-27 Lg Chemical Ltd Formulación compuesta para dosificación oral que comprende ácido 1-(3-ciano-1-isopropil-indol-5-il)pirazol-4-carboxílico
TWI822151B (zh) * 2021-07-02 2023-11-11 南韓商Ｌｇ化學股份有限公司 製備黃嘌呤氧化酶抑制劑的方法
CN116836154A (zh) * 2022-04-27 2023-10-03 江苏新元素医药科技有限公司 可用于痛风的化合物
CN116715633A (zh) * 2022-04-27 2023-09-08 江苏新元素医药科技有限公司 可用于降尿酸的化合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19602505A1 (de) * 1996-01-25 1997-07-31 Merck Patent Gmbh 1-(Pyrazol-4-Indol-3-yl)-Piperidine
WO2007113647A1 (fr) * 2006-04-04 2007-10-11 Pfizer Products Inc. Formes polymorphes de (2r,z)-2-amino-2-cyclohexyl-n-(5-(1-méthyl-1h-pyrazol-4υl)-1-oxo-2,6-dihydro-1h-[1,2]diazépino[4,5,6-cd]indol-8-yl)acétamide
BRPI0810524B8 (pt) * 2007-04-11 2021-05-25 Kissei Pharmaceutical derivado de (aza)indol, inibidor de xantina oxidase e composição farmacêutica compreendendo o dito derivado
WO2008126901A1 (fr) * 2007-04-11 2008-10-23 Kissei Pharmaceutical Co., Ltd. Composé hétérocyclique contenant de l'azote et composition pharmaceutique le contenant
TWI423962B (zh) * 2009-10-07 2014-01-21 Lg Life Sciences Ltd 有效作為黃嘌呤氧化酶抑制劑之新穎化合物、其製備方法及含該化合物之醫藥組成物

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Publication number Publication date
CN103459381A (zh) 2013-12-18
WO2012138147A3 (fr) 2012-11-29
WO2012138147A2 (fr) 2012-10-11
KR101424013B1 (ko) 2014-08-18
TWI548630B (zh) 2016-09-11
JP2014510133A (ja) 2014-04-24
TW201245182A (en) 2012-11-16
KR20120114174A (ko) 2012-10-16
CN103459381B (zh) 2015-12-09

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