JP5993459B2 - アルギナーゼ阻害剤およびそれらの治療用途 - Google Patents
アルギナーゼ阻害剤およびそれらの治療用途 Download PDFInfo
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- JP5993459B2 JP5993459B2 JP2014537234A JP2014537234A JP5993459B2 JP 5993459 B2 JP5993459 B2 JP 5993459B2 JP 2014537234 A JP2014537234 A JP 2014537234A JP 2014537234 A JP2014537234 A JP 2014537234A JP 5993459 B2 JP5993459 B2 JP 5993459B2
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- Prior art keywords
- disease
- condition
- arginase
- disorders
- amino
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- 0 C*CCCCC([C@](C1)C[C@]1NCCCC(C)=CC(F)=C(C=C)F)(C(O)=O)N Chemical compound C*CCCCC([C@](C1)C[C@]1NCCCC(C)=CC(F)=C(C=C)F)(C(O)=O)N 0.000 description 11
- WJRQXPLHHGJDBM-UHFFFAOYSA-N C=CCCC(C(C1)CC1(Cc(cc1)ccc1Cl)NC=O)=O Chemical compound C=CCCC(C(C1)CC1(Cc(cc1)ccc1Cl)NC=O)=O WJRQXPLHHGJDBM-UHFFFAOYSA-N 0.000 description 1
- PIRMPWUXKSOPHW-UHFFFAOYSA-N C=CCCC(C1CCCC1)=O Chemical compound C=CCCC(C1CCCC1)=O PIRMPWUXKSOPHW-UHFFFAOYSA-N 0.000 description 1
- JNOXVESQYIKGFF-UHFFFAOYSA-N CC1(C)OB(CCCCBr)OC1(C)C Chemical compound CC1(C)OB(CCCCBr)OC1(C)C JNOXVESQYIKGFF-UHFFFAOYSA-N 0.000 description 1
- JSNVPKWJELUHJD-UHFFFAOYSA-N CC1(C)OB(CCCCI)OC1(C)C Chemical compound CC1(C)OB(CCCCI)OC1(C)C JSNVPKWJELUHJD-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
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- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Reproductive Health (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Transplantation (AREA)
- AIDS & HIV (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161548939P | 2011-10-19 | 2011-10-19 | |
| US61/548,939 | 2011-10-19 | ||
| PCT/US2012/060789 WO2013059437A1 (en) | 2011-10-19 | 2012-10-18 | Inhibitors of arginase and their therapeutic applications |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014530866A JP2014530866A (ja) | 2014-11-20 |
| JP2014530866A5 JP2014530866A5 (enExample) | 2015-12-03 |
| JP5993459B2 true JP5993459B2 (ja) | 2016-09-14 |
Family
ID=47116482
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014537234A Active JP5993459B2 (ja) | 2011-10-19 | 2012-10-18 | アルギナーゼ阻害剤およびそれらの治療用途 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9266908B2 (enExample) |
| EP (1) | EP2768491B1 (enExample) |
| JP (1) | JP5993459B2 (enExample) |
| CN (1) | CN104244932B (enExample) |
| AU (1) | AU2012326109A1 (enExample) |
| BR (1) | BR112014009415B1 (enExample) |
| CA (1) | CA2852685C (enExample) |
| IL (1) | IL232113A (enExample) |
| MX (1) | MX343534B (enExample) |
| WO (1) | WO2013059437A1 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG10201503168VA (en) | 2010-04-22 | 2015-06-29 | Mars Inc | Inhibitors of arginase and their therapeutic applications |
| HUE027317T2 (en) | 2010-10-26 | 2016-10-28 | Mars Inc | Boronates as arginase inhibitors |
| JP5993459B2 (ja) | 2011-10-19 | 2016-09-14 | マーズ インコーポレイテッド | アルギナーゼ阻害剤およびそれらの治療用途 |
| WO2015027067A2 (en) * | 2013-08-23 | 2015-02-26 | Virginia Commonwealth University | Ester nitrates derivatives of aromatic aldehydes with multiple pharmalogic properties to treat sickle cell disease |
| RU2574025C2 (ru) * | 2014-04-15 | 2016-01-27 | Государственное Научное Учреждение Научно-исследовательский институт ветеринарии Восточной Сибири Россельхозакадемии | Препарат для лечения острых желудочно-кишечных болезней новорожденных ягнят |
| PL410665A1 (pl) | 2014-12-29 | 2016-07-04 | Oncoarendi Therapeutics Spółka Z Ograniczoną Odpowiedzialnością | Inhibitory arginazy oraz ich zastosowania terapeutyczne |
| UA123700C2 (uk) | 2015-06-23 | 2021-05-19 | Калітера Байосайєнсиз, Інк. | Композиції і способи інгібування активності аргінази |
| CN108601767A (zh) * | 2015-10-05 | 2018-09-28 | 卡利泰拉生物科技公司 | 用谷氨酰胺酶抑制剂和免疫肿瘤学药剂的组合疗法 |
| HRP20201046T1 (hr) | 2015-10-30 | 2020-10-16 | Calithera Biosciences, Inc. | Sastavi i metode za inhibitivnu aktivnost arginase |
| PL417066A1 (pl) | 2016-05-04 | 2017-11-06 | Oncoarendi Therapeutics Spółka Z Ograniczoną Odpowiedzialnością | Inhibitory arginazy oraz ich zastosowania terapeutyczne |
| KR20190104521A (ko) | 2016-11-08 | 2019-09-10 | 칼리테라 바이오사이언시즈, 인코포레이티드 | 아르기나제 억제제 병용 요법들 |
| PE20191541A1 (es) | 2016-12-22 | 2019-10-23 | Calithera Biosciences Inc | Composiciones y metodos para inhibir la accion de la arginasa |
| CN108794517B (zh) * | 2017-04-27 | 2021-03-30 | 南京谷睿生物科技有限公司 | 一种精氨酸酶抑制剂及其制备方法与用途 |
| BR112019023582A2 (pt) | 2017-05-12 | 2020-06-02 | Calithera Biosciences Inc. | Método de preparar (3r,4s)-3-acetamido-4-alil-n-(terc-butil)pirrolidina-3-carboxamida |
| TW201910513A (zh) * | 2017-08-16 | 2019-03-16 | 香港商鎧耀波麗堂（香港）有限公司 | 胺基酸耗竭治療的組合物及方法 |
| JP2021517454A (ja) | 2018-01-28 | 2021-07-26 | ユニベルシテ ドゥ ジュネーブ | 癌治療のためのアルギナーゼ抑制 |
| UA127897C2 (uk) | 2018-03-05 | 2024-02-07 | Аркус Байосайєнсіз, Інк. | Інгібітори аргінази |
| TWI723366B (zh) | 2018-03-29 | 2021-04-01 | 波蘭商昂科艾倫迪治療法股份公司 | 二肽哌啶衍生物 |
| US11274111B2 (en) | 2018-06-20 | 2022-03-15 | Merck Sharp & Dohme Corp. | Arginase inhibitors and methods of use |
| CN109053496B (zh) * | 2018-08-09 | 2020-10-20 | 吉尔生化（上海）有限公司 | 一种3-Boc-氨甲基环丁酮的合成方法 |
| CA3120196A1 (en) | 2018-11-16 | 2020-05-22 | Arcus Biosciences, Inc. | Inhibitors of arg1 and/or arg2 |
| WO2020104626A1 (en) * | 2018-11-21 | 2020-05-28 | Black Belt Tx Ltd | Inhibitors of arginase |
| BR112021015581A2 (pt) | 2019-02-08 | 2021-10-05 | Astrazeneca Ab | Inibidores de arginase e seus métodos de uso |
| CN111848423B (zh) * | 2019-04-30 | 2022-10-14 | 尚科生物医药（上海）有限公司 | 3-氧代环丁基氨基甲酸叔丁酯的制备方法 |
| CN112110944B (zh) * | 2019-06-21 | 2022-02-11 | 南京谷睿生物科技有限公司 | 一种化合物及其制备方法和应用 |
| TW202228720A (zh) | 2020-12-22 | 2022-08-01 | 波蘭商昂科艾倫迪治療法股份公司 | 精胺酸酶抑制劑及其使用方法 |
| CN112645971B (zh) * | 2021-01-20 | 2021-12-24 | 中国科学院兰州化学物理研究所 | 一种烷基卤代物直接制备烷基硼酸酯类化合物的方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999019295A1 (en) | 1997-10-10 | 1999-04-22 | Trustees Of The University Of Pennsylvania | Compositions and methods for inhibiting arginase activity |
| US20040063666A1 (en) | 1998-10-09 | 2004-04-01 | David Christianson | Compositions for inhibiting arginase activity |
| US20090298912A1 (en) | 2005-07-01 | 2009-12-03 | The Johns Hopkins University | Arginase II: A Target treatment of aging heart and heart failure |
| CN101755130B (zh) | 2007-07-12 | 2012-10-17 | 山洋电气株式会社 | 双重反转式轴流鼓风机 |
| SMT201900320T1 (it) * | 2009-01-26 | 2019-07-11 | Astrazeneca Uk Ltd | Inibitori dell'arginasi e metodi di utilizzo |
| SG10201503168VA (en) * | 2010-04-22 | 2015-06-29 | Mars Inc | Inhibitors of arginase and their therapeutic applications |
| WO2012091757A1 (en) * | 2010-12-31 | 2012-07-05 | Corridor Pharmaceuticals, Inc. | Arginase inhibitors and methods of use thereof |
| JP5993459B2 (ja) | 2011-10-19 | 2016-09-14 | マーズ インコーポレイテッド | アルギナーゼ阻害剤およびそれらの治療用途 |
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| BR112014009415B1 (pt) | 2021-11-23 |
| WO2013059437A1 (en) | 2013-04-25 |
| US9266908B2 (en) | 2016-02-23 |
| CA2852685A1 (en) | 2013-04-25 |
| CN104244932B (zh) | 2017-02-22 |
| CN104244932A (zh) | 2014-12-24 |
| EP2768491B1 (en) | 2016-12-21 |
| MX2014004766A (es) | 2014-05-28 |
| IL232113A (en) | 2017-05-29 |
| MX343534B (es) | 2016-11-09 |
| HK1203853A1 (en) | 2015-11-06 |
| EP2768491A1 (en) | 2014-08-27 |
| AU2012326109A1 (en) | 2014-05-29 |
| BR112014009415A2 (pt) | 2017-06-13 |
| US20140343019A1 (en) | 2014-11-20 |
| CA2852685C (en) | 2019-02-26 |
| JP2014530866A (ja) | 2014-11-20 |
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