IL232113A - Boron-containing compounds, pharmaceuticals containing them and their use in inhibiting arginase - Google Patents
Boron-containing compounds, pharmaceuticals containing them and their use in inhibiting arginaseInfo
- Publication number
- IL232113A IL232113A IL232113A IL23211314A IL232113A IL 232113 A IL232113 A IL 232113A IL 232113 A IL232113 A IL 232113A IL 23211314 A IL23211314 A IL 23211314A IL 232113 A IL232113 A IL 232113A
- Authority
- IL
- Israel
- Prior art keywords
- boron
- pharmaceutical compositions
- containing compounds
- inhibiting arginase
- arginase
- Prior art date
Links
- 102000004452 Arginase Human genes 0.000 title 1
- 108700024123 Arginases Proteins 0.000 title 1
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 title 1
- 229910052796 boron Inorganic materials 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P11/06—Antiasthmatics
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- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- A—HUMAN NECESSITIES
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- A61P7/06—Antianaemics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Molecular Biology (AREA)
- Obesity (AREA)
- Reproductive Health (AREA)
- Tropical Medicine & Parasitology (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161548939P | 2011-10-19 | 2011-10-19 | |
| PCT/US2012/060789 WO2013059437A1 (en) | 2011-10-19 | 2012-10-18 | Inhibitors of arginase and their therapeutic applications |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL232113A0 IL232113A0 (en) | 2014-05-28 |
| IL232113A true IL232113A (en) | 2017-05-29 |
Family
ID=47116482
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL232113A IL232113A (en) | 2011-10-19 | 2014-04-13 | Boron-containing compounds, pharmaceuticals containing them and their use in inhibiting arginase |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9266908B2 (enExample) |
| EP (1) | EP2768491B1 (enExample) |
| JP (1) | JP5993459B2 (enExample) |
| CN (1) | CN104244932B (enExample) |
| AU (1) | AU2012326109A1 (enExample) |
| BR (1) | BR112014009415B1 (enExample) |
| CA (1) | CA2852685C (enExample) |
| IL (1) | IL232113A (enExample) |
| MX (1) | MX343534B (enExample) |
| WO (1) | WO2013059437A1 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112012027034B1 (pt) | 2010-04-22 | 2020-10-13 | Mars, Incorporated | compostos inibidores de arginase, composição farmacêutica compreendendo o referido composto, método in vitro para inibição de arginase i e ii e uso do referido composto |
| RS54750B1 (sr) | 2010-10-26 | 2016-10-31 | Mars Inc | Borati kao inhibitori arginaze |
| AU2012326109A1 (en) | 2011-10-19 | 2014-05-29 | Mars, Incorporated | Inhibitors of arginase and their therapeutic applications |
| US10800751B2 (en) * | 2013-08-23 | 2020-10-13 | Virginia Commonwealth University | Ester nitrates derivatives of aromatic aldehydes with multiple pharmalogic properties to treat sickle cell disease |
| RU2574025C2 (ru) * | 2014-04-15 | 2016-01-27 | Государственное Научное Учреждение Научно-исследовательский институт ветеринарии Восточной Сибири Россельхозакадемии | Препарат для лечения острых желудочно-кишечных болезней новорожденных ягнят |
| PL410665A1 (pl) | 2014-12-29 | 2016-07-04 | Oncoarendi Therapeutics Spółka Z Ograniczoną Odpowiedzialnością | Inhibitory arginazy oraz ich zastosowania terapeutyczne |
| WO2016210106A1 (en) | 2015-06-23 | 2016-12-29 | Calithera Biosciences, Inc. | Compositions and methods for inhibiting arginase activity |
| CA3000996A1 (en) * | 2015-10-05 | 2017-04-13 | Calithera Biosciences, Inc. | Combination therapy with glutaminase inhibitors and immuno-oncology agents |
| DK3368541T3 (da) | 2015-10-30 | 2020-06-29 | Calithera Biosciences Inc | Sammensætninger og metoder til inhibiering af arginaseaktivitet |
| PL417066A1 (pl) | 2016-05-04 | 2017-11-06 | Oncoarendi Therapeutics Spółka Z Ograniczoną Odpowiedzialnością | Inhibitory arginazy oraz ich zastosowania terapeutyczne |
| US11291674B2 (en) | 2016-11-08 | 2022-04-05 | Calithera Biosciences, Inc. | Arginase inhibitor combination therapies |
| EP3842442B1 (en) | 2016-12-22 | 2023-11-01 | Precision Pharmaceuticals, Inc. | Compositions and methods for inhibiting arginase activity |
| CN108794517B (zh) * | 2017-04-27 | 2021-03-30 | 南京谷睿生物科技有限公司 | 一种精氨酸酶抑制剂及其制备方法与用途 |
| US10494339B2 (en) | 2017-05-12 | 2019-12-03 | Calithera Biosciences, Inc. | Method of preparing (3R,4S)-3-acetamido-4-allyl-N-(tert-butyl)pyrrolidine-3-carboxamide |
| CA3073116A1 (en) * | 2017-08-16 | 2019-02-21 | Avalon Polytom (Hk) Limited | Compositions and methods for amino acid depletion therapy |
| EP3743510A1 (en) | 2018-01-28 | 2020-12-02 | Universite De Geneve | Arginase suppression for cancer treatment |
| US12054500B2 (en) | 2018-03-05 | 2024-08-06 | Arcus Biosciences, Inc. | Arginase inhibitors |
| WO2019186497A1 (en) | 2018-03-29 | 2019-10-03 | Oncoarendi Therapeutics S.A. | Dipeptide piperidine derivatives |
| US11274111B2 (en) | 2018-06-20 | 2022-03-15 | Merck Sharp & Dohme Corp. | Arginase inhibitors and methods of use |
| CN109053496B (zh) * | 2018-08-09 | 2020-10-20 | 吉尔生化（上海）有限公司 | 一种3-Boc-氨甲基环丁酮的合成方法 |
| WO2020102646A2 (en) | 2018-11-16 | 2020-05-22 | Arcus Biosciences, Inc. | Inhibitors of arg1 and/or arg2 |
| CA3120718A1 (en) * | 2018-11-21 | 2020-05-28 | Black Belt Tx Ltd | Inhibitors of arginase |
| PH12021551902A1 (en) | 2019-02-08 | 2022-08-01 | Astrazeneca Ab | Arginase inhibitors and methods of use thereof |
| CN111848423B (zh) * | 2019-04-30 | 2022-10-14 | 尚科生物医药（上海）有限公司 | 3-氧代环丁基氨基甲酸叔丁酯的制备方法 |
| CN112110944B (zh) * | 2019-06-21 | 2022-02-11 | 南京谷睿生物科技有限公司 | 一种化合物及其制备方法和应用 |
| TW202228720A (zh) | 2020-12-22 | 2022-08-01 | 波蘭商昂科艾倫迪治療法股份公司 | 精胺酸酶抑制劑及其使用方法 |
| CN112645971B (zh) * | 2021-01-20 | 2021-12-24 | 中国科学院兰州化学物理研究所 | 一种烷基卤代物直接制备烷基硼酸酯类化合物的方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU9797998A (en) | 1997-10-10 | 1999-05-03 | Trustees Of The University Of Pennsylvania, The | Compositions and methods for inhibiting arginase activity |
| US20040063666A1 (en) | 1998-10-09 | 2004-04-01 | David Christianson | Compositions for inhibiting arginase activity |
| EP1915143A4 (en) | 2005-07-01 | 2009-11-11 | Univ Johns Hopkins | ARGINASE II: TARGET TREATMENT FOR THE AGING HEART AND HEART FAILURE |
| WO2009008415A1 (ja) | 2007-07-12 | 2009-01-15 | Sanyo Denki Co., Ltd. | 二重反転式軸流送風機 |
| TR201910726T4 (tr) * | 2009-01-26 | 2019-08-21 | Astrazeneca Uk Ltd | Arginaz inhibitörleri ve kullanım yöntemleri. |
| BR112012027034B1 (pt) * | 2010-04-22 | 2020-10-13 | Mars, Incorporated | compostos inibidores de arginase, composição farmacêutica compreendendo o referido composto, método in vitro para inibição de arginase i e ii e uso do referido composto |
| CN103402549A (zh) * | 2010-12-31 | 2013-11-20 | 考瑞多制药公司 | 精氨酸酶抑制剂及其使用方法 |
| AU2012326109A1 (en) | 2011-10-19 | 2014-05-29 | Mars, Incorporated | Inhibitors of arginase and their therapeutic applications |
-
2012
- 2012-10-18 AU AU2012326109A patent/AU2012326109A1/en not_active Abandoned
- 2012-10-18 BR BR112014009415-2A patent/BR112014009415B1/pt not_active IP Right Cessation
- 2012-10-18 CN CN201280061312.2A patent/CN104244932B/zh not_active Expired - Fee Related
- 2012-10-18 US US14/352,554 patent/US9266908B2/en active Active
- 2012-10-18 MX MX2014004766A patent/MX343534B/es active IP Right Grant
- 2012-10-18 JP JP2014537234A patent/JP5993459B2/ja active Active
- 2012-10-18 EP EP12781004.2A patent/EP2768491B1/en active Active
- 2012-10-18 WO PCT/US2012/060789 patent/WO2013059437A1/en not_active Ceased
- 2012-10-18 CA CA2852685A patent/CA2852685C/en active Active
-
2014
- 2014-04-13 IL IL232113A patent/IL232113A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| IL232113A0 (en) | 2014-05-28 |
| EP2768491A1 (en) | 2014-08-27 |
| MX343534B (es) | 2016-11-09 |
| CN104244932A (zh) | 2014-12-24 |
| WO2013059437A1 (en) | 2013-04-25 |
| CA2852685C (en) | 2019-02-26 |
| BR112014009415B1 (pt) | 2021-11-23 |
| BR112014009415A2 (en) | 2017-06-13 |
| MX2014004766A (es) | 2014-05-28 |
| CN104244932B (zh) | 2017-02-22 |
| HK1203853A1 (en) | 2015-11-06 |
| JP2014530866A (ja) | 2014-11-20 |
| EP2768491B1 (en) | 2016-12-21 |
| CA2852685A1 (en) | 2013-04-25 |
| US9266908B2 (en) | 2016-02-23 |
| JP5993459B2 (ja) | 2016-09-14 |
| US20140343019A1 (en) | 2014-11-20 |
| AU2012326109A1 (en) | 2014-05-29 |
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