JP5965993B2 - Ｎ−｛３，４−ジフルオロ−２−［（２−フルオロ−４−ヨードフェニル）アミノ］−６−メトキシフェニル｝−１−［２，３−ジヒドロキシ−プロピル］シクロプロパンスルホンアミド類のキラル合成 - Google Patents

Ｎ−｛３，４−ジフルオロ−２−［（２−フルオロ−４−ヨードフェニル）アミノ］−６−メトキシフェニル｝−１−［２，３−ジヒドロキシ−プロピル］シクロプロパンスルホンアミド類のキラル合成 Download PDF

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JP5965993B2
JP5965993B2 JP2014511875A JP2014511875A JP5965993B2 JP 5965993 B2 JP5965993 B2 JP 5965993B2 JP 2014511875 A JP2014511875 A JP 2014511875A JP 2014511875 A JP2014511875 A JP 2014511875A JP 5965993 B2 JP5965993 B2 JP 5965993B2
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compound
formula
butyl
dimethyl
reacted
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JP2014520087A (ja
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ペーター・ファイ
アガーテ・クリスティーネ・マイヤー
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Bayer Intellectual Property GmbH
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Bayer Intellectual Property GmbH
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C07C303/38—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reaction of ammonia or amines with sulfonic acids, or with esters, anhydrides, or halides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C07C303/40—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/71—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/78—Halides of sulfonic acids
    • C07C309/79—Halides of sulfonic acids having halosulfonyl groups bound to acyclic carbon atoms
    • C07C309/82—Halides of sulfonic acids having halosulfonyl groups bound to acyclic carbon atoms of a carbon skeleton substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/28—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/34—Compounds containing oxirane rings with hydrocarbon radicals, substituted by sulphur, selenium or tellurium atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2014511875A 2011-05-27 2012-05-24 Ｎ−｛３，４−ジフルオロ−２−［（２−フルオロ−４−ヨードフェニル）アミノ］−６−メトキシフェニル｝−１−［２，３−ジヒドロキシ−プロピル］シクロプロパンスルホンアミド類のキラル合成 Expired - Fee Related JP5965993B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11167806.6 2011-05-27
EP11167806 2011-05-27
PCT/EP2012/059717 WO2012163799A1 (fr) 2011-05-27 2012-05-24 Synthèse chirale de n-{3,4-difluoro-2-[(2-fluoro-4-iodophényl)amino]-6-méthoxyphényl}-1-[2,3-dihydroxy-propyl]cyclopropanesulfonamides

Publications (2)

Publication Number Publication Date
JP2014520087A JP2014520087A (ja) 2014-08-21
JP5965993B2 true JP5965993B2 (ja) 2016-08-10

Family

ID=46172787

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JP2014511875A Expired - Fee Related JP5965993B2 (ja) 2011-05-27 2012-05-24 Ｎ−｛３，４−ジフルオロ−２−［（２−フルオロ−４−ヨードフェニル）アミノ］−６−メトキシフェニル｝−１−［２，３−ジヒドロキシ−プロピル］シクロプロパンスルホンアミド類のキラル合成

Country Status (30)

Country Link
US (1) US9328066B2 (fr)
EP (1) EP2714652B8 (fr)
JP (1) JP5965993B2 (fr)
KR (1) KR101939682B1 (fr)
CN (1) CN103596921B (fr)
AP (1) AP2013007257A0 (fr)
AR (1) AR086553A1 (fr)
AU (1) AU2012264884B2 (fr)
BR (1) BR112013030387A2 (fr)
CA (1) CA2837162C (fr)
CL (1) CL2013003387A1 (fr)
CO (1) CO6862147A2 (fr)
CR (1) CR20130618A (fr)
CU (1) CU20130156A7 (fr)
DO (1) DOP2013000278A (fr)
EA (1) EA026550B1 (fr)
EC (1) ECSP13013042A (fr)
ES (1) ES2682247T3 (fr)
GT (1) GT201300294A (fr)
IL (1) IL228911A (fr)
MA (1) MA35159B1 (fr)
MX (1) MX362823B (fr)
MY (1) MY186875A (fr)
NZ (1) NZ616783A (fr)
PE (1) PE20140580A1 (fr)
SG (1) SG194544A1 (fr)
TN (1) TN2013000492A1 (fr)
TW (1) TWI551579B (fr)
UA (1) UA113850C2 (fr)
WO (1) WO2012163799A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2013094546A1 (ja) * 2011-12-19 2015-04-27 住友化学株式会社 スルホン酸塩の製造方法
EP2848246A1 (fr) 2013-09-13 2015-03-18 Bayer Pharma Aktiengesellschaft Compositions pharmaceutiques contenant du refametinib

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8101799B2 (en) 2005-07-21 2012-01-24 Ardea Biosciences Derivatives of N-(arylamino) sulfonamides as inhibitors of MEK
DE102005042742A1 (de) 2005-09-02 2007-03-08 Schering Ag Substituierte Imidazo[1,2b]pyridazine als Kinase-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel
KR20080045279A (ko) * 2005-09-14 2008-05-22 얀센 파마슈티카 엔.브이. Ｃ-ｆｍｓ 키나제 저해제로서의5-옥소-5,8-디하이드로-피리도-피리미딘
WO2007121269A2 (fr) 2006-04-11 2007-10-25 Ardea Biosciences, Inc. N-aryl-n'alkyle sulfamides utilisés comme inhibiteurs de mek
AU2007286808B2 (en) 2006-08-21 2012-12-06 Genentech, Inc. Aza-benzofuranyl compounds and methods of use
EP1900739A1 (fr) 2006-08-30 2008-03-19 Cellzome Ag Dérivés de diazolodiazine comme inhibiteurs de kinases
MX2010001244A (es) * 2007-07-30 2010-08-31 Ardea Biosciences Inc Derivados de n-(arilamino) sulfonamidas que incluyen polimorfos como inhibidores de mek asi como composiciones, metodos de uso y de preparacion de los mismos.
CN102134218A (zh) * 2009-06-15 2011-07-27 凯美隆(北京)药业技术有限公司 6-芳氨基吡啶酮磺酰胺和6-芳氨基吡嗪酮磺酰胺mek抑制剂
TWI524890B (zh) * 2009-07-24 2016-03-11 亞德生化公司 （ｒ）－ｎ－（３，４－二氟－２－（２－氟－４－碘苯胺基）－６－甲氧基苯基）－１－（２，３－二羥丙基）環丙烷－１－磺醯胺及（ｓ）－ｎ－（３，４－二氟－２－（２－氟－４－碘苯胺基）－６－甲氧基苯基）－１－（２，３－二羥丙基）環丙烷－１－磺醯胺之製備

Also Published As

Publication number Publication date
MX362823B (es) 2019-02-18
NZ616783A (en) 2016-01-29
US9328066B2 (en) 2016-05-03
CL2013003387A1 (es) 2014-09-22
BR112013030387A2 (pt) 2016-12-13
JP2014520087A (ja) 2014-08-21
CO6862147A2 (es) 2014-02-10
ECSP13013042A (es) 2014-01-31
EP2714652B1 (fr) 2018-07-18
KR101939682B1 (ko) 2019-01-17
TW201249791A (en) 2012-12-16
EA026550B1 (ru) 2017-04-28
AU2012264884B2 (en) 2017-03-09
AR086553A1 (es) 2014-01-08
UA113850C2 (xx) 2017-03-27
MX2013013667A (es) 2014-08-01
PE20140580A1 (es) 2014-06-01
SG194544A1 (en) 2013-12-30
MA35159B1 (fr) 2014-06-02
CU20130156A7 (es) 2014-02-28
AP2013007257A0 (en) 2013-11-30
EP2714652A1 (fr) 2014-04-09
US20140155637A1 (en) 2014-06-05
KR20140032433A (ko) 2014-03-14
AU2012264884A1 (en) 2013-11-07
IL228911A (en) 2017-10-31
WO2012163799A1 (fr) 2012-12-06
CN103596921A (zh) 2014-02-19
ES2682247T3 (es) 2018-09-19
MY186875A (en) 2021-08-26
CA2837162C (fr) 2019-04-02
DOP2013000278A (es) 2013-12-31
TWI551579B (zh) 2016-10-01
CA2837162A1 (fr) 2012-12-06
GT201300294A (es) 2014-11-13
EP2714652B8 (fr) 2018-09-05
CR20130618A (es) 2014-01-09
TN2013000492A1 (en) 2015-03-30
IL228911A0 (en) 2013-12-31
CN103596921B (zh) 2016-08-03
EA201301333A1 (ru) 2014-06-30

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