JP5960612B2 - 固定された生物学的実体 - Google Patents

固定された生物学的実体 Download PDF

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Publication number
JP5960612B2
JP5960612B2 JP2012556539A JP2012556539A JP5960612B2 JP 5960612 B2 JP5960612 B2 JP 5960612B2 JP 2012556539 A JP2012556539 A JP 2012556539A JP 2012556539 A JP2012556539 A JP 2012556539A JP 5960612 B2 JP5960612 B2 JP 5960612B2
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Prior art keywords
heparin
layer
polymer
cationic polymer
linker
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Japanese (ja)
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JP2013521838A5 (enExample
JP2013521838A (ja
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ベストベルイ ロベルト
ベストベルイ ロベルト
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カルメダ アクティエボラーグ
カルメダ アクティエボラーグ
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6957—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a device or a kit, e.g. stents or microdevices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • A61L33/0029—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate using an intermediate layer of polymer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Materials Engineering (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Materials For Medical Uses (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
JP2012556539A 2010-03-12 2011-03-11 固定された生物学的実体 Active JP5960612B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1004101.0 2010-03-12
GBGB1004101.0A GB201004101D0 (en) 2010-03-12 2010-03-12 Immobilised biological entities
PCT/EP2011/053745 WO2011110684A1 (en) 2010-03-12 2011-03-11 Immobilised biological entities

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016124560A Division JP6683551B2 (ja) 2010-03-12 2016-06-23 固定された生物学的実体

Publications (3)

Publication Number Publication Date
JP2013521838A JP2013521838A (ja) 2013-06-13
JP2013521838A5 JP2013521838A5 (enExample) 2014-05-01
JP5960612B2 true JP5960612B2 (ja) 2016-08-02

Family

ID=42261450

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2012556539A Active JP5960612B2 (ja) 2010-03-12 2011-03-11 固定された生物学的実体
JP2016124560A Active JP6683551B2 (ja) 2010-03-12 2016-06-23 固定された生物学的実体
JP2018034545A Active JP6693983B2 (ja) 2010-03-12 2018-02-28 固定された生物学的実体
JP2020073602A Pending JP2020108864A (ja) 2010-03-12 2020-04-16 固定された生物学的実体

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2016124560A Active JP6683551B2 (ja) 2010-03-12 2016-06-23 固定された生物学的実体
JP2018034545A Active JP6693983B2 (ja) 2010-03-12 2018-02-28 固定された生物学的実体
JP2020073602A Pending JP2020108864A (ja) 2010-03-12 2020-04-16 固定された生物学的実体

Country Status (8)

Country Link
US (3) US8501212B2 (enExample)
EP (1) EP2544728B1 (enExample)
JP (4) JP5960612B2 (enExample)
AU (1) AU2011225982B2 (enExample)
CA (1) CA2791545C (enExample)
ES (1) ES2644369T3 (enExample)
GB (1) GB201004101D0 (enExample)
WO (1) WO2011110684A1 (enExample)

Families Citing this family (11)

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GB201004101D0 (en) * 2010-03-12 2010-04-28 Carmeda Ab Immobilised biological entities
RU2625756C2 (ru) 2011-03-11 2017-07-18 В.Л. Гор Энд Ассошиейтс, Инк. Усовершенствованные иммобилизованные биологические объекты
US11839698B2 (en) 2014-03-13 2023-12-12 W. L. Gore & Associates, Inc. Drug composition and coating
US10561766B2 (en) 2015-09-15 2020-02-18 W. L. Gore & Associates, Inc. Drug composition and coating
US20190275213A1 (en) 2018-03-09 2019-09-12 Carmeda Ab Immobilising biological entities
AU2019232163B2 (en) 2018-03-09 2025-11-20 Carmeda Ab Improvements to processes for immobilising biological entities
AU2019354085B2 (en) 2018-10-03 2025-06-05 Carmeda Ab Immobilised biological entities
JP2022528428A (ja) 2019-03-19 2022-06-10 ジェイメドテック・コーティング・テクノロジーズ・プライベイト・リミテッド 共有結合したヘパリン・コーティングを備える医療デバイス
AU2021324051A1 (en) * 2020-08-14 2023-02-09 Idris Oncology B.V. A process for applying a coating comprising one or more polysaccharides with binding affinity for bioanalytes onto the surface of a medical sampling device, and the medical sampling device for capture of bioanalytes provided with the coating
CN114470324B (zh) * 2022-02-08 2023-04-04 福建医科大学附属协和医院 通用的骨植入物改性新策略用于伴糖尿病骨缺损的干预

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Also Published As

Publication number Publication date
US20160228572A9 (en) 2016-08-11
ES2644369T3 (es) 2017-11-28
CA2791545A1 (en) 2011-09-15
US10016512B2 (en) 2018-07-10
US20180140713A1 (en) 2018-05-24
JP2016193219A (ja) 2016-11-17
JP2018099543A (ja) 2018-06-28
AU2011225982B2 (en) 2014-09-04
GB201004101D0 (en) 2010-04-28
US20130273122A1 (en) 2013-10-17
WO2011110684A1 (en) 2011-09-15
US20110223229A1 (en) 2011-09-15
JP6683551B2 (ja) 2020-04-22
JP6693983B2 (ja) 2020-05-13
US10842880B2 (en) 2020-11-24
AU2011225982A1 (en) 2012-09-20
JP2013521838A (ja) 2013-06-13
EP2544728A1 (en) 2013-01-16
JP2020108864A (ja) 2020-07-16
US8501212B2 (en) 2013-08-06
EP2544728B1 (en) 2017-07-19
CA2791545C (en) 2018-12-11

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