CA2791545C - Immobilised biological entities - Google Patents

Immobilised biological entities Download PDF

Info

Publication number
CA2791545C
CA2791545C CA2791545A CA2791545A CA2791545C CA 2791545 C CA2791545 C CA 2791545C CA 2791545 A CA2791545 A CA 2791545A CA 2791545 A CA2791545 A CA 2791545A CA 2791545 C CA2791545 C CA 2791545C
Authority
CA
Canada
Prior art keywords
solid object
coagulant
polyamine
heparin
linker
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2791545A
Other languages
English (en)
French (fr)
Other versions
CA2791545A1 (en
Inventor
Robert Vestberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Carmeda AB
Original Assignee
Carmeda AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Carmeda AB filed Critical Carmeda AB
Publication of CA2791545A1 publication Critical patent/CA2791545A1/en
Application granted granted Critical
Publication of CA2791545C publication Critical patent/CA2791545C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6957—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a device or a kit, e.g. stents or microdevices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • A61L33/0029—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate using an intermediate layer of polymer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Materials Engineering (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Materials For Medical Uses (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
CA2791545A 2010-03-12 2011-03-11 Immobilised biological entities Active CA2791545C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1004101.0 2010-03-12
GBGB1004101.0A GB201004101D0 (en) 2010-03-12 2010-03-12 Immobilised biological entities
PCT/EP2011/053745 WO2011110684A1 (en) 2010-03-12 2011-03-11 Immobilised biological entities

Publications (2)

Publication Number Publication Date
CA2791545A1 CA2791545A1 (en) 2011-09-15
CA2791545C true CA2791545C (en) 2018-12-11

Family

ID=42261450

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2791545A Active CA2791545C (en) 2010-03-12 2011-03-11 Immobilised biological entities

Country Status (8)

Country Link
US (3) US8501212B2 (enExample)
EP (1) EP2544728B1 (enExample)
JP (4) JP5960612B2 (enExample)
AU (1) AU2011225982B2 (enExample)
CA (1) CA2791545C (enExample)
ES (1) ES2644369T3 (enExample)
GB (1) GB201004101D0 (enExample)
WO (1) WO2011110684A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0816783D0 (en) 2008-09-15 2008-10-22 Carmeda Ab Immobilised biological entities
GB201004101D0 (en) * 2010-03-12 2010-04-28 Carmeda Ab Immobilised biological entities
RU2625756C2 (ru) 2011-03-11 2017-07-18 В.Л. Гор Энд Ассошиейтс, Инк. Усовершенствованные иммобилизованные биологические объекты
US11839698B2 (en) 2014-03-13 2023-12-12 W. L. Gore & Associates, Inc. Drug composition and coating
US10561766B2 (en) 2015-09-15 2020-02-18 W. L. Gore & Associates, Inc. Drug composition and coating
US20190275213A1 (en) 2018-03-09 2019-09-12 Carmeda Ab Immobilising biological entities
AU2019232163B2 (en) 2018-03-09 2025-11-20 Carmeda Ab Improvements to processes for immobilising biological entities
AU2019354085B2 (en) 2018-10-03 2025-06-05 Carmeda Ab Immobilised biological entities
JP2022528428A (ja) 2019-03-19 2022-06-10 ジェイメドテック・コーティング・テクノロジーズ・プライベイト・リミテッド 共有結合したヘパリン・コーティングを備える医療デバイス
AU2021324051A1 (en) * 2020-08-14 2023-02-09 Idris Oncology B.V. A process for applying a coating comprising one or more polysaccharides with binding affinity for bioanalytes onto the surface of a medical sampling device, and the medical sampling device for capture of bioanalytes provided with the coating
CN114470324B (zh) * 2022-02-08 2023-04-04 福建医科大学附属协和医院 通用的骨植入物改性新策略用于伴糖尿病骨缺损的干预

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4919202B1 (enExample) 1968-05-14 1974-05-16
US3852253A (en) * 1972-12-22 1974-12-03 Exxon Research Engineering Co Heterogeneous process for preparing conjugated diene butyl
SE456347B (sv) 1982-02-09 1988-09-26 Ird Biomaterial Ab Ytmodifierat fast substrat samt forfarande for framstellning derav
SE8200751L (sv) 1982-02-09 1983-08-10 Olle Larm Forfarande for kovalent koppling for framstellning av konjugat och hervid erhallna produkter
JP2710444B2 (ja) 1989-09-18 1998-02-10 旭化成工業株式会社 医療材料の製造法
US5213898A (en) * 1989-10-12 1993-05-25 Norsk Hydro A.S. Process for the preparation of surface modified solid substrates
US5049403A (en) 1989-10-12 1991-09-17 Horsk Hydro A.S. Process for the preparation of surface modified solid substrates
DE19604173C2 (de) 1996-02-06 2000-07-06 Hartwig Hoecker Verfahren zur Erzeugung antithrombogener Oberflächen auf extrakorporal und/oder intrakorporal zu verwendenden medizinischen Gegenständen
US6200955B1 (en) * 1996-06-11 2001-03-13 Commonwealth Biotechnologies, Inc. Heparin binding peptides
JP3188868B2 (ja) 1997-07-02 2001-07-16 昌子 小田切 金属線たわし
FR2772770B1 (fr) * 1997-12-19 2000-01-28 Oreal Nouveaux composes choisis parmi les polymeres hyperbranches et les dendrimeres ayant un groupement particulier, procede de preparation, utilisation et compositions les comprenant
NO984143L (no) 1998-09-09 2000-03-10 Norsk Hydro As Ny prosess for å fremstille overflatemodifiserende stoffer
SE515295C2 (sv) 1999-11-23 2001-07-09 Medicarb Ab Förfarande för framställning av konjugat av en biologiskt aktiv polysackarid och ett fast substrat, samt sådana konjugat
KR100378109B1 (ko) * 2000-10-24 2003-03-29 주식회사 메디프렉스 소수성 다중복합 헤파린 결합체, 그의 제조방법 및 용도
US6509104B2 (en) * 2000-12-05 2003-01-21 Michigan Biotechnology Institute Antithrombogenic polymer coating
US20050059068A1 (en) 2001-05-23 2005-03-17 Stratagene California Compositions and methods using dendrimer-treated microassays
EP1441865A4 (en) 2001-09-18 2010-04-07 Eidgenoess Tech Hochschule METHOD AND DEVICE FOR COATING SURFACES FOR REDUCING PROTEIN ADSORPTION AND CELL ADHESION AND PRESENTING LIGANDS
US7163553B2 (en) * 2001-12-28 2007-01-16 Advanced Cardiovascular Systems, Inc. Intravascular stent and method of use
SI1501566T1 (sl) * 2002-05-09 2008-12-31 Hemoteq Ag S hemakompatibilnim slojem prekriti medicinski proizvodi, njihova izdelava in uporaba
ATE469135T1 (de) * 2002-05-30 2010-06-15 Scripps Research Inst Kupferkatalysierte ligierung von aziden und acetylenen
US20040115151A1 (en) 2002-10-04 2004-06-17 Franck Giroud Use of non-film-forming cationic latices for increasing the volume of the hair
FR2845279B1 (fr) 2002-10-04 2006-06-16 Oreal Utilisation de latex cationiques non filmogenes pour l'augmentation de volume de la chevelure.
JP2004189724A (ja) 2002-11-29 2004-07-08 Toray Ind Inc 生理活性物質を含む材料およびその製造方法
JP2004189627A (ja) 2002-12-09 2004-07-08 Toray Ind Inc リガンドの脱離可能なリガンド−カチオン性ポリマー複合体および、該ポリマー複合体を固定化させた材料およびそれを用いたカラム
WO2004055160A2 (en) 2002-12-13 2004-07-01 The Trustees Of Columbia University In The City Of New York Biomolecular coupling methods using 1,3-dipolar cycloaddition chemistry
PL1603603T3 (pl) * 2003-02-28 2015-07-31 Biointeractions Ltd System sieci polimerowych dla urządzeń medycznych oraz sposoby zastosowania
US9561309B2 (en) * 2004-05-27 2017-02-07 Advanced Cardiovascular Systems, Inc. Antifouling heparin coatings
CA2573561A1 (en) 2004-07-22 2006-02-02 The Scripps Research Institute Polymeric materials via click chemistry
US9290617B2 (en) 2005-07-06 2016-03-22 Molly S. Shoichet Method of biomolecule immobilization on polymers using click-type chemistry
US20070020620A1 (en) 2005-07-14 2007-01-25 Finn M G Compositions and methods for coupling a plurality of compounds to a scaffold
EP1934265A4 (en) 2005-09-15 2009-06-24 Univ Utah Res Found POLYMER COMPOSITIONS AND METHODS OF MAKING AND USING SAME
US7811555B2 (en) * 2005-12-30 2010-10-12 Cordis Corporation Tri-branched biologically active copolymer
US8021677B2 (en) 2006-05-12 2011-09-20 Gore Enterprise Holdings, Inc. Immobilized biologically active entities having a high degree of biological activity
US8986713B2 (en) 2006-05-12 2015-03-24 W. L. Gore & Associates, Inc. Medical device capable of being compacted and expanded having anti-thrombin III binding activity
EP2052045A4 (en) 2006-08-18 2012-09-12 Commw Scient Ind Res Org POLYMERIC COATINGS AND METHODS FOR FORMING SAME
ITMI20061726A1 (it) 2006-09-11 2008-03-12 Fidia Farmaceutici Derivati crosslinkati a base di acido ialuronico reticolato via click chemistry
WO2008090554A2 (en) 2007-01-22 2008-07-31 Elutex Ltd. Modified conductive surfaces prepared by electrografting of diazonium salts
US20090018646A1 (en) * 2007-07-10 2009-01-15 Zhao Jonathon Z Coating Employing an Anti-Thrombotic Conjugate
FR2920436A1 (fr) 2007-08-30 2009-03-06 Rhodia Operations Sas Composition de traitement de fils ou fibres d'articles textiles
US8153268B1 (en) * 2008-03-26 2012-04-10 Loctite (R&D) Limited Polymer to metal bonding and compounds and compositions useful therefor
GB0816783D0 (en) * 2008-09-15 2008-10-22 Carmeda Ab Immobilised biological entities
US8308699B2 (en) * 2008-12-05 2012-11-13 Semprus Biosciences Corp. Layered non-fouling, antimicrobial antithrombogenic coatings
EP2352797B1 (en) * 2008-12-05 2013-07-24 Semprus Biociences Corporation Non-fouling, anti-microbial, anti-thrombogenic graft-from compositions
CN101649011B (zh) * 2009-08-13 2011-01-19 同济大学 硫醇-烯点击化学功能化超支化聚乙烯亚胺的制备方法
JP2011092491A (ja) * 2009-10-30 2011-05-12 Kanazawa Inst Of Technology 埋め込み部材
GB201004101D0 (en) * 2010-03-12 2010-04-28 Carmeda Ab Immobilised biological entities

Also Published As

Publication number Publication date
US20160228572A9 (en) 2016-08-11
ES2644369T3 (es) 2017-11-28
CA2791545A1 (en) 2011-09-15
US10016512B2 (en) 2018-07-10
US20180140713A1 (en) 2018-05-24
JP2016193219A (ja) 2016-11-17
JP2018099543A (ja) 2018-06-28
AU2011225982B2 (en) 2014-09-04
GB201004101D0 (en) 2010-04-28
US20130273122A1 (en) 2013-10-17
WO2011110684A1 (en) 2011-09-15
US20110223229A1 (en) 2011-09-15
JP6683551B2 (ja) 2020-04-22
JP6693983B2 (ja) 2020-05-13
US10842880B2 (en) 2020-11-24
AU2011225982A1 (en) 2012-09-20
JP2013521838A (ja) 2013-06-13
EP2544728A1 (en) 2013-01-16
JP2020108864A (ja) 2020-07-16
JP5960612B2 (ja) 2016-08-02
US8501212B2 (en) 2013-08-06
EP2544728B1 (en) 2017-07-19

Similar Documents

Publication Publication Date Title
CA2791545C (en) Immobilised biological entities
AU2009290833B2 (en) Immobilised biological entities
CA2828797C (en) Single point attachment of heparin to hyperbranched polymers and coatings thereof
HK1174861A (en) Immobilised biological entities
HK1174861B (en) Immobilised biological entities
HK1159530B (en) Immobilised biological entities

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20160223