JP5955396B2 - イコチニブ、イコチニブ塩酸塩、及びそれらの中間体の製造方法 - Google Patents

イコチニブ、イコチニブ塩酸塩、及びそれらの中間体の製造方法 Download PDF

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JP5955396B2
JP5955396B2 JP2014537485A JP2014537485A JP5955396B2 JP 5955396 B2 JP5955396 B2 JP 5955396B2 JP 2014537485 A JP2014537485 A JP 2014537485A JP 2014537485 A JP2014537485 A JP 2014537485A JP 5955396 B2 JP5955396 B2 JP 5955396B2
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compound
icotinib
reaction
acetic acid
mmol
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JP2015504846A5 (enrdf_load_html_response
JP2015504846A (ja
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シャオジン フー，
シャオジン フー，
ウェイ ロン，
ウェイ ロン，
フェイ ワン，
フェイ ワン，
ツォンチュアン リー，
ツォンチュアン リー，
Original Assignee
ベータ ファーマシューティカルズ カンパニー リミテッド
ベータ ファーマシューティカルズ カンパニー リミテッド
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Priority claimed from PCT/CN2012/087802 external-priority patent/WO2013064128A1/zh
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Health & Medical Sciences (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
JP2014537485A 2012-12-28 2012-12-28 イコチニブ、イコチニブ塩酸塩、及びそれらの中間体の製造方法 Active JP5955396B2 (ja)

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PCT/CN2012/087802 WO2013064128A1 (zh) 2011-10-31 2012-12-28 埃克替尼和盐酸埃克替尼的制备方法及其中间体

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JP2015504846A JP2015504846A (ja) 2015-02-16
JP2015504846A5 JP2015504846A5 (enrdf_load_html_response) 2015-11-19
JP5955396B2 true JP5955396B2 (ja) 2016-07-20

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KR (1) KR101672223B1 (enrdf_load_html_response)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007138613A2 (en) * 2006-05-25 2007-12-06 Vittal Mallya Scientific Research Foundation A process for synthesis of [6,7-bis-(2-methoxyethoxy)-quinazolin-4-yl]-(3-ethynylphenyl)amine hydrochloride
AU2009267683B2 (en) * 2008-07-08 2014-04-03 Beta Pharma, Inc. Icotinib hydrochloride, synthesis, crystallographic form, medical combination, and uses thereof
CN102180844B (zh) * 2011-03-25 2014-07-09 浙江海正药业股份有限公司 吉非替尼中间体及吉非替尼的制备方法
CN102659716B (zh) * 2012-05-02 2014-09-10 北京国联诚辉医药技术有限公司 4-甲氧基-2-胺基-3-[3-(4-吗啉基)丙氧基]苯腈的制备方法及吉非替尼的制备工艺

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KR101672223B1 (ko) 2016-11-04
JP2015504846A (ja) 2015-02-16
KR20140112007A (ko) 2014-09-22

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