JP5938473B2 - 多価抗原結合Fv分子 - Google Patents
多価抗原結合Fv分子 Download PDFInfo
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- JP5938473B2 JP5938473B2 JP2014520541A JP2014520541A JP5938473B2 JP 5938473 B2 JP5938473 B2 JP 5938473B2 JP 2014520541 A JP2014520541 A JP 2014520541A JP 2014520541 A JP2014520541 A JP 2014520541A JP 5938473 B2 JP5938473 B2 JP 5938473B2
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- C07K2317/626—Diabody or triabody
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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PCT/EP2011/062673 WO2013013700A1 (en) | 2011-07-22 | 2011-07-22 | Multivalent antigen-binding fv molecule |
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CN (1) | CN103687879B (zh) |
AU (1) | AU2011373925B2 (zh) |
BR (1) | BR112014001573B8 (zh) |
CA (1) | CA2842649C (zh) |
MX (1) | MX347829B (zh) |
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EP3148580B1 (en) | 2014-05-29 | 2021-01-20 | MacroGenics, Inc. | Tri-specific binding molecules that specifically bind to multiple cancer antigens and methods of use thereof |
BR112016030740A2 (pt) | 2014-07-01 | 2018-02-20 | Pfizer Inc. | diacorpos heterodiméricos biespecíficos e seus usos |
US9212225B1 (en) | 2014-07-01 | 2015-12-15 | Amphivena Therapeutics, Inc. | Bispecific CD33 and CD3 binding proteins |
US10501552B2 (en) | 2015-01-26 | 2019-12-10 | Macrogenics, Inc. | Multivalent molecules comprising DR5-binding domains |
EP3302555A4 (en) | 2015-05-29 | 2018-07-11 | Amphivena Therapeutics, Inc. | Methods of using bispecific cd33 and cd3 binding proteins |
TWI773646B (zh) | 2015-06-08 | 2022-08-11 | 美商宏觀基因股份有限公司 | 結合lag-3的分子和其使用方法 |
PT3328419T (pt) | 2015-07-30 | 2021-11-26 | Macrogenics Inc | Moléculas de ligação pd-1 e métodos de utilização |
SG11201804839WA (en) | 2015-12-14 | 2018-07-30 | Macrogenics Inc | Bispecific molecules having immunoreactivity with pd-1 and ctla-4, and methods of use thereof |
WO2017142928A1 (en) | 2016-02-17 | 2017-08-24 | Macrogenics, Inc. | Ror1-binding molecules, and methods of use thereof |
SG11201808979UA (en) | 2016-04-15 | 2018-11-29 | Macrogenics Inc | Novel b7-h3 binding molecules, antibody drug conjugates thereof and methods of use thereof |
BR112019012950A2 (pt) | 2016-12-23 | 2019-11-26 | Macrogenics Inc | molécula de ligação a adam9, composição farmacêutica, uso da molécula de ligação a adam9 e método para tratar uma doença ou condição associada ou caracterizada pela expressão de adam9 em um indivíduo |
CN110944651A (zh) | 2017-02-08 | 2020-03-31 | 蜻蜓疗法股份有限公司 | 用于自然杀伤细胞激活的多特异性结合蛋白及其治疗癌症的治疗性用途 |
CA3054079A1 (en) | 2017-02-20 | 2018-08-23 | Dragonfly Therapeutics, Inc. | Proteins binding her2, nkg2d and cd16 |
AU2018228719B2 (en) * | 2017-02-28 | 2023-03-30 | Affimed Gmbh | Tandem diabody for CD16A-directed NK-cell engagement |
ES2967739T3 (es) * | 2017-06-05 | 2024-05-03 | Numab Therapeutics AG | Formato de anticuerpo heterodimérico multiespecífico dirigido al menos a CD3 y a HSA |
EP3700782B1 (de) | 2017-10-26 | 2022-04-27 | Saint-Gobain Glass France | Fahrzeuganbauteil mit integriertem kameramodul |
AU2018385409A1 (en) | 2017-12-12 | 2020-07-02 | Macrogenics Inc. | Bispecific CD 16-binding molecules and their use in the treatment of disease |
PE20220278A1 (es) | 2018-02-08 | 2022-02-25 | Dragonfly Therapeutics Inc | Dominios variables de anticuerpos que se dirigen al receptor nkg2d |
JP7337079B2 (ja) | 2018-02-15 | 2023-09-01 | マクロジェニクス,インコーポレーテッド | 変異型cd3結合ドメイン、及び疾患の治療のための併用療法におけるその使用 |
AU2019282836A1 (en) * | 2018-06-07 | 2021-01-07 | Cullinan Oncology, Inc. | Multi-specific binding proteins and methods of use thereof |
RU2738802C1 (ru) * | 2019-08-21 | 2020-12-17 | Общество с ограниченной ответственностью "Международный Биотехнологический Центр "Генериум" | Определяющие комплементарность участки для связывания cd3 и содержащая их биспецифическая антигенсвязывающая молекула |
GB201912681D0 (en) | 2019-09-04 | 2019-10-16 | Eth Zuerich | Bispecific binding agent that binds to cd117/c-kit and cd3 |
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CA2150262C (en) | 1992-12-04 | 2008-07-08 | Kaspar-Philipp Holliger | Multivalent and multispecific binding proteins, their manufacture and use |
DE19819846B4 (de) | 1998-05-05 | 2016-11-24 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Multivalente Antikörper-Konstrukte |
JP4386741B2 (ja) * | 2002-04-15 | 2009-12-16 | 中外製薬株式会社 | scDbライブラリーの作成方法 |
EP1400534B1 (en) | 2002-09-10 | 2015-10-28 | Affimed GmbH | Human CD3-specific antibody with immunosuppressive properties |
JPWO2005056605A1 (ja) * | 2003-12-12 | 2007-12-06 | 中外製薬株式会社 | 3量体以上の受容体を認識する改変抗体 |
US9493569B2 (en) * | 2005-03-31 | 2016-11-15 | Chugai Seiyaku Kabushiki Kaisha | Structural isomers of sc(Fv)2 |
GB0510790D0 (en) | 2005-05-26 | 2005-06-29 | Syngenta Crop Protection Ag | Anti-CD16 binding molecules |
US9315584B2 (en) * | 2009-03-25 | 2016-04-19 | Tohoku University | LH-type bispecific antibody |
ES2582001T3 (es) * | 2010-02-25 | 2016-09-08 | Affimed Gmbh | Molécula que se une a antígeno y usos de la misma |
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CN103687879A (zh) | 2014-03-26 |
AU2011373925A1 (en) | 2014-01-16 |
BR112014001573B1 (pt) | 2022-08-30 |
BR112014001573B8 (pt) | 2022-11-08 |
MX2014000816A (es) | 2014-07-09 |
AU2011373925B2 (en) | 2016-04-28 |
RU2613368C2 (ru) | 2017-03-16 |
MX347829B (es) | 2017-05-15 |
CA2842649A1 (en) | 2013-01-31 |
CN103687879B (zh) | 2016-05-04 |
BR112014001573A2 (pt) | 2017-02-21 |
CA2842649C (en) | 2020-01-21 |
JP2014527515A (ja) | 2014-10-16 |
WO2013013700A1 (en) | 2013-01-31 |
RU2013157040A (ru) | 2015-08-27 |
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