JP5922107B2 - 新規抗真菌５，６−ジヒドロ−４−［（ジフルオロエチル）フェニル］−４Ｈ−ピロロ［１，２−ａ］［１，４］ベンゾジアゼピンおよび４−（ジフルオロエチル）フェニル−６Ｈ−ピロロ［１，２−ａ］［１，４］ベンゾジアゼピン誘導体 - Google Patents

新規抗真菌５，６−ジヒドロ−４−［（ジフルオロエチル）フェニル］−４Ｈ−ピロロ［１，２−ａ］［１，４］ベンゾジアゼピンおよび４−（ジフルオロエチル）フェニル−６Ｈ−ピロロ［１，２−ａ］［１，４］ベンゾジアゼピン誘導体 Download PDF

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JP5922107B2
JP5922107B2 JP2013513625A JP2013513625A JP5922107B2 JP 5922107 B2 JP5922107 B2 JP 5922107B2 JP 2013513625 A JP2013513625 A JP 2013513625A JP 2013513625 A JP2013513625 A JP 2013513625A JP 5922107 B2 JP5922107 B2 JP 5922107B2
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species
compound
trichophyton
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chloro
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JP2013528192A (ja
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メールポール，リーベン
マース，ルイ・ジユール・ロジエ・マリー
ドウ・ウイツト，ケリー
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Janssen Pharmaceutica NV
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2013513625A 2010-06-07 2011-06-01 新規抗真菌５，６−ジヒドロ−４−［（ジフルオロエチル）フェニル］−４Ｈ−ピロロ［１，２−ａ］［１，４］ベンゾジアゼピンおよび４−（ジフルオロエチル）フェニル−６Ｈ−ピロロ［１，２−ａ］［１，４］ベンゾジアゼピン誘導体 Expired - Fee Related JP5922107B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10165076.0 2010-06-07
EP10165076 2010-06-07
PCT/EP2011/059058 WO2011154298A1 (en) 2010-06-07 2011-06-01 NOVEL ANTIFUNGAL 5,6-DIHYDRO-4-[(DIFLUOROETHYL)PHENYL]-4H-PYRROLO[1,2-a][1,4]BENZODIAZEPINE AND 4-(DIFLUOROETHYL)PHENYL-6H-PYRROLO[1,2-a][1,4]BENZODIAZEPINE DERIVATIVES

Related Child Applications (1)

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JP2016004295A Division JP6208263B2 (ja) 2010-06-07 2016-01-13 新規抗真菌５，６−ジヒドロ−４−［（ジフルオロエチル）フェニル］−４Ｈ−ピロロ［１，２−ａ］［１，４］ベンゾジアゼピンおよび４−（ジフルオロエチル）フェニル−６Ｈ−ピロロ［１，２−ａ］［１，４］ベンゾジアゼピン誘導体

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JP2013528192A JP2013528192A (ja) 2013-07-08
JP5922107B2 true JP5922107B2 (ja) 2016-05-24

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JP2013513625A Expired - Fee Related JP5922107B2 (ja) 2010-06-07 2011-06-01 新規抗真菌５，６−ジヒドロ−４−［（ジフルオロエチル）フェニル］−４Ｈ−ピロロ［１，２−ａ］［１，４］ベンゾジアゼピンおよび４−（ジフルオロエチル）フェニル−６Ｈ−ピロロ［１，２−ａ］［１，４］ベンゾジアゼピン誘導体
JP2016004295A Active JP6208263B2 (ja) 2010-06-07 2016-01-13 新規抗真菌５，６−ジヒドロ−４−［（ジフルオロエチル）フェニル］−４Ｈ−ピロロ［１，２−ａ］［１，４］ベンゾジアゼピンおよび４−（ジフルオロエチル）フェニル−６Ｈ−ピロロ［１，２−ａ］［１，４］ベンゾジアゼピン誘導体
JP2017170727A Expired - Fee Related JP6505176B2 (ja) 2010-06-07 2017-09-06 新規抗真菌５，６−ジヒドロ−４−［（ジフルオロエチル）フェニル］−４Ｈ−ピロロ［１，２−ａ］［１，４］ベンゾジアゼピンおよび４−（ジフルオロエチル）フェニル−６Ｈ−ピロロ［１，２−ａ］［１，４］ベンゾジアゼピン誘導体
JP2019057689A Active JP6653036B2 (ja) 2010-06-07 2019-03-26 新規抗真菌５，６−ジヒドロ−４−［（ジフルオロエチル）フェニル］−４Ｈ−ピロロ［１，２−ａ］［１，４］ベンゾジアゼピンおよび４−（ジフルオロエチル）フェニル−６Ｈ−ピロロ［１，２−ａ］［１，４］ベンゾジアゼピン誘導体

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JP2016004295A Active JP6208263B2 (ja) 2010-06-07 2016-01-13 新規抗真菌５，６−ジヒドロ−４−［（ジフルオロエチル）フェニル］−４Ｈ−ピロロ［１，２−ａ］［１，４］ベンゾジアゼピンおよび４−（ジフルオロエチル）フェニル−６Ｈ−ピロロ［１，２−ａ］［１，４］ベンゾジアゼピン誘導体
JP2017170727A Expired - Fee Related JP6505176B2 (ja) 2010-06-07 2017-09-06 新規抗真菌５，６−ジヒドロ−４−［（ジフルオロエチル）フェニル］−４Ｈ−ピロロ［１，２−ａ］［１，４］ベンゾジアゼピンおよび４−（ジフルオロエチル）フェニル−６Ｈ−ピロロ［１，２−ａ］［１，４］ベンゾジアゼピン誘導体
JP2019057689A Active JP6653036B2 (ja) 2010-06-07 2019-03-26 新規抗真菌５，６−ジヒドロ−４−［（ジフルオロエチル）フェニル］−４Ｈ−ピロロ［１，２−ａ］［１，４］ベンゾジアゼピンおよび４−（ジフルオロエチル）フェニル−６Ｈ−ピロロ［１，２−ａ］［１，４］ベンゾジアゼピン誘導体

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US (1) US9637490B2 (https=)
EP (1) EP2576557B1 (https=)
JP (4) JP5922107B2 (https=)
KR (1) KR101886136B1 (https=)
CN (1) CN102947307B (https=)
AP (1) AP3285A (https=)
AR (1) AR081642A1 (https=)
AU (1) AU2011263946B2 (https=)
BR (1) BR112012030895A2 (https=)
CA (1) CA2799634C (https=)
EA (1) EA021220B1 (https=)
ES (1) ES2489191T3 (https=)
JO (1) JO3029B1 (https=)
MX (1) MX2012014271A (https=)
MY (1) MY156731A (https=)
NZ (1) NZ602981A (https=)
PH (1) PH12012502293A1 (https=)
SG (1) SG185650A1 (https=)
TW (1) TWI500619B (https=)
UA (1) UA107963C2 (https=)
WO (1) WO2011154298A1 (https=)
ZA (1) ZA201209246B (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ587490A (en) * 2010-08-20 2013-03-28 Greentide Ltd Anti-Microbial Compounds containing compounds with a sugar substituent
MX2013005857A (es) * 2010-11-24 2013-07-03 Janssen Pharmaceutica Nv 5,6-dihidro-4h-pirrolo[1,2-a][1,4]-benzodiazepinas y 6h-pirrolo[1,2-a][1,4] benzodiazepinas sustituidas con derivados de fenilo antimicoticas.
AU2013204604B2 (en) * 2012-05-30 2016-05-19 Biodiem Limited Method of treating Scedosporium spp. infection
JP6197348B2 (ja) * 2013-04-25 2017-09-20 セントラル硝子株式会社 α，α−ジフルオロ芳香族化合物の保存安定性の向上方法
RU2771019C1 (ru) * 2021-06-29 2022-04-25 Федеральное государственное автономное образовательное учреждение высшего образования "Пермский государственный национальный исследовательский университет" (ПГНИУ) Применение 10-метил-2-(трифторметил)-6,7-дигидро-5Н-бензо[b]пирроло[1,2-d][1,4]диазепина в качестве антибактериального средства в отношении грамположительных микроорганизмов

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE431826T1 (de) * 2000-10-23 2009-06-15 Janssen Pharmaceutica Nv In der 4-stellung substituierte 5,6-dihydro-4h- pyrroloä1,2-aü ä1,4ü benzodiazepine als fungizide

Also Published As

Publication number Publication date
CN102947307A (zh) 2013-02-27
ZA201209246B (en) 2015-06-24
CA2799634C (en) 2018-07-10
MX2012014271A (es) 2013-01-24
US20130085136A1 (en) 2013-04-04
AP3285A (en) 2015-05-31
JP2018021060A (ja) 2018-02-08
JP2019112460A (ja) 2019-07-11
ES2489191T3 (es) 2014-09-01
KR20130113922A (ko) 2013-10-16
AR081642A1 (es) 2012-10-10
EA201291401A1 (ru) 2013-04-30
JP6653036B2 (ja) 2020-02-26
NZ602981A (en) 2013-11-29
JP2016128450A (ja) 2016-07-14
TW201211045A (en) 2012-03-16
JP2013528192A (ja) 2013-07-08
AU2011263946B2 (en) 2014-10-30
AP2012006502A0 (en) 2012-10-31
EP2576557A1 (en) 2013-04-10
KR101886136B1 (ko) 2018-08-07
CA2799634A1 (en) 2011-12-15
TWI500619B (zh) 2015-09-21
JP6208263B2 (ja) 2017-10-04
WO2011154298A1 (en) 2011-12-15
CN102947307B (zh) 2015-03-18
UA107963C2 (xx) 2015-03-10
AU2011263946A1 (en) 2012-11-08
BR112012030895A2 (pt) 2016-11-08
EP2576557B1 (en) 2014-05-21
JP6505176B2 (ja) 2019-04-24
US9637490B2 (en) 2017-05-02
SG185650A1 (en) 2012-12-28
HK1178152A1 (en) 2013-09-06
MY156731A (en) 2016-03-15
JO3029B1 (ar) 2016-09-05
PH12012502293A1 (en) 2022-10-05
EA021220B1 (ru) 2015-04-30

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