JP5902479B2 - マーカーペプチドのレベルを決定することによる脳卒中患者における予後判定及びリスク評価のための方法 - Google Patents

マーカーペプチドのレベルを決定することによる脳卒中患者における予後判定及びリスク評価のための方法 Download PDF

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JP5902479B2
JP5902479B2 JP2011532545A JP2011532545A JP5902479B2 JP 5902479 B2 JP5902479 B2 JP 5902479B2 JP 2011532545 A JP2011532545 A JP 2011532545A JP 2011532545 A JP2011532545 A JP 2011532545A JP 5902479 B2 JP5902479 B2 JP 5902479B2
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JP2012506545A (ja
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ベルグマン，アンドレアス
モルゲンタラー，ニルス
ミューラー，ベアト
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ベー．エル．アー．ハー．エム．エス ゲゼルシャフト ミット ベシュレンクテル ハフツング
ベー．エル．アー．ハー．エム．エス ゲゼルシャフト ミット ベシュレンクテル ハフツング
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    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76—Chemiluminescence; Bioluminescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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    • G01—MEASURING; TESTING
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57527—Calcitonin gene related peptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/575—Hormones
    • C07K14/57536—Endothelin, vasoactive intestinal contractor [VIC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/58—Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Cardionatrin; Cardiodilatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/16—Oxytocins; Vasopressins; Related peptides
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4737—C-reactive protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575—Hormones
    • G01N2333/58—Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Brain natriuretic peptide [BNP, proBNP]; Cardionatrin; Cardiodilatin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575—Hormones
    • G01N2333/585—Calcitonins
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575—Hormones
    • G01N2333/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders

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  • Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
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  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
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  • Food Science & Technology (AREA)
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  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Vascular Medicine (AREA)
  • Organic Chemistry (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plasma & Fusion (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP2011532545A 2008-10-24 2009-10-22 マーカーペプチドのレベルを決定することによる脳卒中患者における予後判定及びリスク評価のための方法 Active JP5902479B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP08167512.6 2008-10-24
EP08167512 2008-10-24
EP08168671 2008-11-07
EP08168671.9 2008-11-07
PCT/EP2009/007738 WO2010046136A1 (en) 2008-10-24 2009-10-22 Prognosis and risk assessment in stroke patients by determining the level of marker peptides

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JP2015222144A Division JP2016029394A (ja) 2008-10-24 2015-11-12 マーカーペプチドのレベルを決定することによる脳卒中患者における予後判定及びリスク評価

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JP2012506545A JP2012506545A (ja) 2012-03-15
JP5902479B2 true JP5902479B2 (ja) 2016-04-13

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JP2011532545A Active JP5902479B2 (ja) 2008-10-24 2009-10-22 マーカーペプチドのレベルを決定することによる脳卒中患者における予後判定及びリスク評価のための方法
JP2015222144A Pending JP2016029394A (ja) 2008-10-24 2015-11-12 マーカーペプチドのレベルを決定することによる脳卒中患者における予後判定及びリスク評価

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US (2) US20110263821A1 (de)
EP (1) EP2356450B1 (de)
JP (2) JP5902479B2 (de)
CN (1) CN102257386B (de)
ES (1) ES2724478T3 (de)
HK (1) HK1162665A1 (de)
WO (1) WO2010046136A1 (de)

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CA2648382C (en) 2006-04-04 2016-10-11 Singulex, Inc. Methods and compositions for highly sensitive analysis of markers and detection of molecules
US7838250B1 (en) 2006-04-04 2010-11-23 Singulex, Inc. Highly sensitive system and methods for analysis of troponin
DK2084543T3 (en) 2006-10-26 2018-01-22 Brahms Gmbh Risk stratification of acute coronary syndrome using fragments / sub-peptides of provasopressin, especially copeptin or neurophysin II
WO2010046136A1 (en) 2008-10-24 2010-04-29 B.R.A.H.M.S. Ag Prognosis and risk assessment in stroke patients by determining the level of marker peptides
CA2751090A1 (en) * 2009-01-30 2010-08-05 Bio-Rad Innovations Method for the in vitro diagnosis of stroke
AU2010259022B2 (en) 2009-06-08 2016-05-12 Singulex, Inc. Highly sensitive biomarker panels
CN102702324B (zh) * 2011-09-15 2015-04-22 重庆业为基生物科技有限公司 人降钙素原b细胞表位肽段及其单克隆抗体的应用
WO2013057135A1 (en) * 2011-10-17 2013-04-25 Roche Diagnostics Gmbh Troponin and bnp based diagnosis of risk patients and cause of stroke
EP2786154B1 (de) * 2011-12-01 2017-11-01 Roche Diagnostics GmbH Nt-pro-anp und nt-pro-bnp zur diagnose eines schlaganfalls
GB2497138A (en) * 2011-12-02 2013-06-05 Randox Lab Ltd Biomarkers for stroke and stroke subtype diagnosis.
CA2897327A1 (en) * 2013-01-08 2014-07-17 Sphingotec Gmbh Fasting levels of growth hormone as a predictive marker of cardiovascular risk
US20150302155A1 (en) * 2014-04-16 2015-10-22 Xerox Corporation Methods and systems for predicting health condition of human subject
US10172568B2 (en) * 2014-07-14 2019-01-08 Medtronic, Inc. Determining prospective risk of heart failure hospitalization
CA3190715A1 (en) 2014-08-14 2016-02-18 Memed Diagnostics Ltd. Computational analysis of biological data using manifold and a hyperplane
SG11201702053TA (en) * 2014-10-01 2017-04-27 Sphingotec Gmbh Hgh determination for use to guide prevention of a major adverse cardiac event or a cardiovascular disease in a subject
EP3423590A4 (de) 2016-03-03 2020-02-26 Memed Diagnostics Ltd. Rna-determinanten zur unterscheidung zwischen bakteriellen und viralen infektionen
WO2018011796A1 (en) 2016-07-10 2018-01-18 Memed Diagnostics Ltd. Early diagnosis of infections
CN109661578B (zh) 2016-07-10 2022-05-10 米密德诊断学有限公司 用于区分细菌和病毒感染的蛋白质特征
US11353456B2 (en) * 2016-09-29 2022-06-07 Memed Diagnostics Ltd. Methods of risk assessment and disease classification for appendicitis
JP6933033B2 (ja) * 2017-07-31 2021-09-08 ブラザー工業株式会社 画像形成装置
CN108761092A (zh) * 2018-07-18 2018-11-06 长春恒晓生物科技有限责任公司 建立时间分辨荧光免疫层析法检测和肽素试剂盒
CN109975532A (zh) * 2019-03-21 2019-07-05 王鑫 缺血性卒中人群康复治疗的预后评估
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KR102362951B1 (ko) * 2020-08-13 2022-02-14 연세대학교 원주산학협력단 프로칼시토닌 대 ｃ­반응성 단백질의 비율을 이용한 허혈성 뇌졸중의 단기 사망률 예측 방법

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DK2084543T3 (en) * 2006-10-26 2018-01-22 Brahms Gmbh Risk stratification of acute coronary syndrome using fragments / sub-peptides of provasopressin, especially copeptin or neurophysin II
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WO2010046136A1 (en) 2008-10-24 2010-04-29 B.R.A.H.M.S. Ag Prognosis and risk assessment in stroke patients by determining the level of marker peptides

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ES2724478T3 (es) 2019-09-11
US10067063B2 (en) 2018-09-04
US20140017808A1 (en) 2014-01-16
HK1162665A1 (en) 2012-08-31
JP2012506545A (ja) 2012-03-15
CN102257386A (zh) 2011-11-23
US20110263821A1 (en) 2011-10-27
EP2356450A1 (de) 2011-08-17
JP2016029394A (ja) 2016-03-03
WO2010046136A1 (en) 2010-04-29
CN102257386B (zh) 2014-12-31
EP2356450B1 (de) 2019-02-06

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