JP5901543B2 - 環式テトラペプチド及びその治療応用 - Google Patents
環式テトラペプチド及びその治療応用 Download PDFInfo
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- JP5901543B2 JP5901543B2 JP2012554079A JP2012554079A JP5901543B2 JP 5901543 B2 JP5901543 B2 JP 5901543B2 JP 2012554079 A JP2012554079 A JP 2012554079A JP 2012554079 A JP2012554079 A JP 2012554079A JP 5901543 B2 JP5901543 B2 JP 5901543B2
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Classifications
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- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
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- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| PLP.390493 | 2010-02-19 | ||
| PL390493A PL219569B1 (pl) | 2010-02-19 | 2010-02-19 | Cykliczne tetrapeptydy i ich zastosowanie |
| PCT/US2011/025571 WO2011103524A2 (en) | 2010-02-19 | 2011-02-19 | Cyclic tetrapeptides and therapeutic applications thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013520440A JP2013520440A (ja) | 2013-06-06 |
| JP2013520440A5 JP2013520440A5 (enExample) | 2014-04-10 |
| JP5901543B2 true JP5901543B2 (ja) | 2016-04-13 |
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| JP2012554079A Expired - Fee Related JP5901543B2 (ja) | 2010-02-19 | 2011-02-19 | 環式テトラペプチド及びその治療応用 |
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| EP (1) | EP2536732B1 (enExample) |
| JP (1) | JP5901543B2 (enExample) |
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| PL219569B1 (pl) | 2010-02-19 | 2015-05-29 | Peptaderm Spółka Z Ograniczoną Odpowiedzialnością | Cykliczne tetrapeptydy i ich zastosowanie |
| WO2016179398A1 (en) | 2015-05-05 | 2016-11-10 | Washington University | Isoform-selective lysine deacetylase inhibitors |
| US10154997B2 (en) | 2015-08-04 | 2018-12-18 | Washington University | Treatment of parasitic diseases using KDAC inhibitor compounds |
| US11325944B2 (en) | 2017-06-16 | 2022-05-10 | University Of Florida Research Foundation, Incorporated | Macrocyclic peptides and derivatives thereof with opioid activity |
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| US3862925A (en) | 1973-07-05 | 1975-01-28 | American Home Prod | Preparation of somatotropin release inhibiting factor and intermediates therefor |
| US3842067A (en) * | 1973-07-27 | 1974-10-15 | American Home Prod | Synthesis of(des-asn5)-srif and intermediates |
| JPS5726506B2 (enExample) * | 1974-03-08 | 1982-06-04 | ||
| IT1077010B (it) * | 1976-09-01 | 1985-04-27 | Snam Progetti | Processo per la preparazione di copolimeri dell isobutilene contenenti insaturazioni ed atomi di alogeno reattivi |
| US4105603A (en) | 1977-03-28 | 1978-08-08 | The Salk Institute For Biological Studies | Peptides which effect release of hormones |
| JPH0334991A (ja) * | 1989-06-30 | 1991-02-14 | Shionogi & Co Ltd | 環状テトラペプチドおよびその製造法 |
| US5216124A (en) * | 1989-12-15 | 1993-06-01 | G. D. Searle & Co. | Substituted cyclic tetrapeptides |
| US5541287A (en) | 1992-06-09 | 1996-07-30 | Neorx Corporation | Pretargeting methods and compounds |
| US6777217B1 (en) * | 1996-03-26 | 2004-08-17 | President And Fellows Of Harvard College | Histone deacetylases, and uses related thereto |
| US6013763A (en) | 1996-06-04 | 2000-01-11 | Genentech, Inc. | Peptide variants of protein A |
| US6281331B1 (en) | 1998-03-23 | 2001-08-28 | Trimeris, Inc. | Methods and compositions for peptide synthesis |
| NZ507083A (en) * | 1998-03-23 | 2003-10-31 | Trimeris Inc | Methods and compositions for peptide synthesis, in particular T-20 (DP-178) and T-20-like peptides |
| DE19816922A1 (de) | 1998-04-16 | 1999-10-21 | Wolfgang Beck | Einfache Synthese von cyclischen Tetrapeptiden aus nichtaktivierten Peptidestern an Metallzentren |
| AUPP505798A0 (en) * | 1998-08-04 | 1998-08-27 | Fujisawa Pharmaceutical Co., Ltd. | Novel compound fr225497 substance |
| WO2000021979A2 (en) | 1998-10-13 | 2000-04-20 | Fujisawa Pharmaceutical Co., Ltd. | Cyclic tetrapeptide and their use as histone deacetylase inhibitor |
| GB9903087D0 (en) * | 1999-02-12 | 1999-03-31 | Glaxo Group Ltd | Process |
| WO2005063791A2 (en) * | 2003-12-31 | 2005-07-14 | F. Hoffmann-La Roche Ag | Process for peptide synthesis using a reduced amount of deprotection agent |
| WO2006049597A1 (en) | 2004-10-27 | 2006-05-11 | Avanir Pharmaceuticals | Amino acid-derived compounds as modulators of the reverse cholesterol transport |
| CA2591443A1 (en) * | 2004-12-14 | 2006-06-22 | Biorunx Co. Ltd. | Method to enhance the bone formation activity of bmp by runx2 acetylation |
| RU2450018C2 (ru) | 2006-08-23 | 2012-05-10 | Йеда Рисерч Энд Диверлопмент Ко. Лтд | Конъюгаты rgd-пептидов и фотосенсибилизаторов порфирина или (бактерио)хлорофилла и их применение |
| PT2257309T (pt) | 2008-02-27 | 2020-01-22 | Yeda Res And Development Company Ltd | Conjugados rgd-(bacterio)clorofila para utilização no diagnóstico de tumores compreendendo domínios necróticos |
| US8809278B2 (en) * | 2008-07-11 | 2014-08-19 | University Of Kansas | Cyclic tetrapeptides |
| GB0918579D0 (en) | 2009-10-22 | 2009-12-09 | Imp Innovations Ltd | Gadd45beta targeting agents |
| PL219569B1 (pl) | 2010-02-19 | 2015-05-29 | Peptaderm Spółka Z Ograniczoną Odpowiedzialnością | Cykliczne tetrapeptydy i ich zastosowanie |
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Also Published As
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|---|---|
| RU2012139668A (ru) | 2014-03-27 |
| CN102858779A (zh) | 2013-01-02 |
| RU2568436C2 (ru) | 2015-11-20 |
| IL221535A (en) | 2016-08-31 |
| US20170157204A1 (en) | 2017-06-08 |
| EP2536732B1 (en) | 2016-10-19 |
| ES2611663T3 (es) | 2017-05-09 |
| US9382292B2 (en) | 2016-07-05 |
| US20130108655A1 (en) | 2013-05-02 |
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| AU2011217882A1 (en) | 2012-10-11 |
| US10238713B2 (en) | 2019-03-26 |
| BR112012020833A2 (pt) | 2017-12-19 |
| WO2011103524A3 (en) | 2011-12-29 |
| WO2011103524A8 (en) | 2012-09-13 |
| PL219569B1 (pl) | 2015-05-29 |
| KR101704665B1 (ko) | 2017-02-08 |
| CN102858779B (zh) | 2016-08-03 |
| EP2536732A2 (en) | 2012-12-26 |
| CA2827694C (en) | 2018-09-18 |
| IL224410A (en) | 2017-07-31 |
| US20130224232A1 (en) | 2013-08-29 |
| EP2536732A4 (en) | 2014-04-30 |
| JP2013520440A (ja) | 2013-06-06 |
| WO2011103524A2 (en) | 2011-08-25 |
| CA2827694A1 (en) | 2011-08-25 |
| PL390493A1 (pl) | 2011-08-29 |
| KR20130088004A (ko) | 2013-08-07 |
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