JP2013520440A5 - - Google Patents

Info

Publication number

JP2013520440A5

JP2013520440A5 JP2012554079A JP2012554079A JP2013520440A5 JP 2013520440 A5 JP2013520440 A5 JP 2013520440A5 JP 2012554079 A JP2012554079 A JP 2012554079A JP 2012554079 A JP2012554079 A JP 2012554079A JP 2013520440 A5 JP2013520440 A5 JP 2013520440A5

Authority

JP

Japan

Prior art keywords

compound

formula

pharmaceutically acceptable

acceptable salt

group

Prior art date

2011-02-19

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 150000001875 compounds Chemical class 0.000 claims 51
• 150000003839 salts Chemical class 0.000 claims 17
• 229910052799 carbon Inorganic materials 0.000 claims 7
• 238000000034 method Methods 0.000 claims 6
• -1 4-t-butoxyphenyl Chemical group 0.000 claims 4
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
• 125000000217 alkyl group Chemical group 0.000 claims 4
• 201000010099 disease Diseases 0.000 claims 4
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 3
• 201000004624 Dermatitis Diseases 0.000 claims 3
• 208000010668 atopic eczema Diseases 0.000 claims 3
• 239000003814 drug Substances 0.000 claims 3
• 229940079593 drug Drugs 0.000 claims 3
• 230000001404 mediated effect Effects 0.000 claims 3
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
• 125000004203 4-hydroxyphenyl group Chemical group [H]OC1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
• 206010012438 Dermatitis atopic Diseases 0.000 claims 2
• 201000004681 Psoriasis Diseases 0.000 claims 2
• 125000003118 aryl group Chemical group 0.000 claims 2
• 201000008937 atopic dermatitis Diseases 0.000 claims 2
• 125000001072 heteroaryl group Chemical group 0.000 claims 2
• 230000028993 immune response Effects 0.000 claims 2
• 229910052757 nitrogen Inorganic materials 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• 208000023275 Autoimmune disease Diseases 0.000 claims 1
• 208000011231 Crohn disease Diseases 0.000 claims 1
• 206010020751 Hypersensitivity Diseases 0.000 claims 1
• 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
• 208000006877 Insect Bites and Stings Diseases 0.000 claims 1
• 206010033733 Papule Diseases 0.000 claims 1
• 206010039793 Seborrhoeic dermatitis Diseases 0.000 claims 1
• 206010040880 Skin irritation Diseases 0.000 claims 1
• 206010040914 Skin reaction Diseases 0.000 claims 1
• 206010052779 Transplant rejections Diseases 0.000 claims 1
• 208000024780 Urticaria Diseases 0.000 claims 1
• 208000030961 allergic reaction Diseases 0.000 claims 1
• 125000003277 amino group Chemical group 0.000 claims 1
• 230000001363 autoimmune Effects 0.000 claims 1
• 239000003085 diluting agent Substances 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 208000024908 graft versus host disease Diseases 0.000 claims 1
• 208000015181 infectious disease Diseases 0.000 claims 1
• 230000002458 infectious effect Effects 0.000 claims 1
• 230000004054 inflammatory process Effects 0.000 claims 1
• 208000002551 irritable bowel syndrome Diseases 0.000 claims 1
• 201000011486 lichen planus Diseases 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 201000006417 multiple sclerosis Diseases 0.000 claims 1
• 230000004770 neurodegeneration Effects 0.000 claims 1
• 208000015122 neurodegenerative disease Diseases 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
• 208000008742 seborrheic dermatitis Diseases 0.000 claims 1
• 230000036556 skin irritation Effects 0.000 claims 1
• 231100000475 skin irritation Toxicity 0.000 claims 1
• 230000035483 skin reaction Effects 0.000 claims 1
• 231100000430 skin reaction Toxicity 0.000 claims 1
• 210000004243 sweat Anatomy 0.000 claims 1
• LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
• 230000002588 toxic effect Effects 0.000 claims 1
• 231100000563 toxic property Toxicity 0.000 claims 1
• 230000002110 toxicologic effect Effects 0.000 claims 1
• 231100000723 toxicological property Toxicity 0.000 claims 1