JP2013518111A5 - - Google Patents
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- JP2013518111A5 JP2013518111A5 JP2012551251A JP2012551251A JP2013518111A5 JP 2013518111 A5 JP2013518111 A5 JP 2013518111A5 JP 2012551251 A JP2012551251 A JP 2012551251A JP 2012551251 A JP2012551251 A JP 2012551251A JP 2013518111 A5 JP2013518111 A5 JP 2013518111A5
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- 238000000034 method Methods 0.000 claims description 42
- 150000001875 compounds Chemical class 0.000 claims description 31
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 24
- JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-Diisopropylethylamine (DIPEA) Chemical compound CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 claims description 24
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 20
- 230000001404 mediated effect Effects 0.000 claims description 19
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 18
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 claims description 18
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 18
- 125000005842 heteroatom Chemical group 0.000 claims description 18
- 239000000203 mixture Substances 0.000 claims description 17
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims description 16
- 208000023275 Autoimmune disease Diseases 0.000 claims description 12
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 12
- 125000000217 alkyl group Chemical group 0.000 claims description 12
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims description 12
- 150000003839 salts Chemical class 0.000 claims description 11
- SCZNXLWKYFICFV-UHFFFAOYSA-N 1,2,3,4,5,7,8,9-octahydropyrido[1,2-b]diazepine Chemical compound C1CCCNN2CCCC=C21 SCZNXLWKYFICFV-UHFFFAOYSA-N 0.000 claims description 8
- GQHTUMJGOHRCHB-UHFFFAOYSA-N 2,3,4,6,7,8,9,10-octahydropyrimido[1,2-a]azepine Chemical compound C1CCCCN2CCCN=C21 GQHTUMJGOHRCHB-UHFFFAOYSA-N 0.000 claims description 8
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 8
- 150000001412 amines Chemical class 0.000 claims description 8
- 229910052799 carbon Inorganic materials 0.000 claims description 8
- 239000003054 catalyst Substances 0.000 claims description 8
- ZCSHNCUQKCANBX-UHFFFAOYSA-N lithium diisopropylamide Chemical compound [Li+].CC(C)[N-]C(C)C ZCSHNCUQKCANBX-UHFFFAOYSA-N 0.000 claims description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 201000006417 multiple sclerosis Diseases 0.000 claims description 6
- 229910000027 potassium carbonate Inorganic materials 0.000 claims description 6
- 206010039073 rheumatoid arthritis Diseases 0.000 claims description 6
- 239000002904 solvent Substances 0.000 claims description 6
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims description 4
- 102000003923 Protein Kinase C Human genes 0.000 claims description 4
- 208000000389 T-cell leukemia Diseases 0.000 claims description 4
- 208000028530 T-cell lymphoblastic leukemia/lymphoma Diseases 0.000 claims description 4
- 206010042971 T-cell lymphoma Diseases 0.000 claims description 4
- 208000027585 T-cell non-Hodgkin lymphoma Diseases 0.000 claims description 4
- 206010003246 arthritis Diseases 0.000 claims description 4
- 229910052736 halogen Inorganic materials 0.000 claims description 4
- 150000002367 halogens Chemical class 0.000 claims description 4
- 208000002551 irritable bowel syndrome Diseases 0.000 claims description 4
- 125000006239 protecting group Chemical group 0.000 claims description 4
- 108091000080 Phosphotransferase Proteins 0.000 claims description 3
- 102000001253 Protein Kinase Human genes 0.000 claims description 3
- 102000020233 phosphotransferase Human genes 0.000 claims description 3
- 108060006633 protein kinase Proteins 0.000 claims description 3
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims description 2
- 201000004681 Psoriasis Diseases 0.000 claims description 2
- 206010052779 Transplant rejections Diseases 0.000 claims description 2
- 239000002671 adjuvant Substances 0.000 claims description 2
- 150000001408 amides Chemical class 0.000 claims description 2
- 208000006673 asthma Diseases 0.000 claims description 2
- 206010012601 diabetes mellitus Diseases 0.000 claims description 2
- 201000010099 disease Diseases 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 238000010438 heat treatment Methods 0.000 claims description 2
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 2
- 230000003463 hyperproliferative effect Effects 0.000 claims description 2
- 208000027866 inflammatory disease Diseases 0.000 claims description 2
- 208000018937 joint inflammation Diseases 0.000 claims description 2
- 206010025135 lupus erythematosus Diseases 0.000 claims description 2
- 230000002062 proliferating effect Effects 0.000 claims description 2
- 239000003981 vehicle Substances 0.000 claims description 2
- 238000010835 comparative analysis Methods 0.000 description 1
- 230000031146 intracellular signal transduction Effects 0.000 description 1
- 229940043355 kinase inhibitor Drugs 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29864910P | 2010-01-27 | 2010-01-27 | |
| US61/298,649 | 2010-01-27 | ||
| US41042610P | 2010-11-05 | 2010-11-05 | |
| US61/410,426 | 2010-11-05 | ||
| PCT/US2011/022522 WO2011094273A1 (en) | 2010-01-27 | 2011-01-26 | Pyrazolopyridine kinase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013518111A JP2013518111A (ja) | 2013-05-20 |
| JP2013518111A5 true JP2013518111A5 (enExample) | 2014-03-13 |
| JP5769733B2 JP5769733B2 (ja) | 2015-08-26 |
Family
ID=44088992
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012551251A Active JP5769733B2 (ja) | 2010-01-27 | 2011-01-26 | ピラゾロピリジンキナーゼ阻害剤 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US9067932B2 (enExample) |
| EP (1) | EP2528917B1 (enExample) |
| JP (1) | JP5769733B2 (enExample) |
| CN (1) | CN102858769A (enExample) |
| AR (1) | AR080856A1 (enExample) |
| AU (1) | AU2011209726A1 (enExample) |
| CA (1) | CA2787315A1 (enExample) |
| MX (1) | MX2012008644A (enExample) |
| WO (1) | WO2011094273A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8569337B2 (en) | 2008-07-23 | 2013-10-29 | Vertex Pharmaceuticals Incorporated | Tri-cyclic pyrazolopyridine kinase inhibitors |
| CA2732765A1 (en) * | 2008-08-06 | 2010-02-11 | Vertex Pharmaceuticals Incorporated | Aminopyridine kinase inhibitors |
| MX2012008643A (es) * | 2010-01-27 | 2013-02-26 | Vertex Pharma | Inhibidores de cinasas de pirazolopiridinas. |
| EP2528916A1 (en) * | 2010-01-27 | 2012-12-05 | Vertex Pharmaceuticals Incorporated | Pyrazolopyridine kinase inhibitors |
| CA2923765C (en) | 2013-09-18 | 2021-06-29 | University Of Canberra | Stem cell modulation ii |
| AU2015309686B2 (en) * | 2014-08-25 | 2020-05-14 | Epiaxis Therapeutics Pty Ltd | Compositions for modulating cancer stem cells and uses therefor |
| JP2021502405A (ja) * | 2017-11-08 | 2021-01-28 | エピアクシス セラピューティクス プロプライエタリー リミテッド | 免疫原性組成物及びその使用 |
| CN118923682B (zh) * | 2024-07-22 | 2025-09-05 | 中国农业大学 | 一种化合物作为病原真菌Pmk1的抑制剂的应用 |
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| AU2009274017A1 (en) * | 2008-07-23 | 2010-01-28 | Vertex Pharmaceuticals Incorporated | Pyrazolopyridine kinase inhibitors |
| JP5631310B2 (ja) * | 2008-07-23 | 2014-11-26 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | 三環式ピラゾロピリジンキナーゼ阻害剤 |
| KR20110033299A (ko) | 2008-07-23 | 2011-03-30 | 버텍스 파마슈티칼스 인코포레이티드 | 트리-사이클릭 피라졸로피리딘 키나제 억제제 |
| EP2318407B1 (en) * | 2008-07-23 | 2013-01-02 | Vertex Pharmaceuticals Incorporated | Pyrazolopyridine kinase inhibitors |
| US8569337B2 (en) * | 2008-07-23 | 2013-10-29 | Vertex Pharmaceuticals Incorporated | Tri-cyclic pyrazolopyridine kinase inhibitors |
| EP2528916A1 (en) * | 2010-01-27 | 2012-12-05 | Vertex Pharmaceuticals Incorporated | Pyrazolopyridine kinase inhibitors |
-
2011
- 2011-01-26 US US13/014,505 patent/US9067932B2/en active Active
- 2011-01-26 CN CN2011800130461A patent/CN102858769A/zh active Pending
- 2011-01-26 MX MX2012008644A patent/MX2012008644A/es active IP Right Grant
- 2011-01-26 AU AU2011209726A patent/AU2011209726A1/en not_active Abandoned
- 2011-01-26 CA CA2787315A patent/CA2787315A1/en not_active Abandoned
- 2011-01-26 WO PCT/US2011/022522 patent/WO2011094273A1/en not_active Ceased
- 2011-01-26 JP JP2012551251A patent/JP5769733B2/ja active Active
- 2011-01-26 EP EP11703958.6A patent/EP2528917B1/en active Active
- 2011-01-27 AR ARP110100282A patent/AR080856A1/es unknown
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