JP5888853B2 - ４−アミノキノリン−３−カルボニトリルを使用するイマチニブ耐性白血病の処置 - Google Patents
４−アミノキノリン−３−カルボニトリルを使用するイマチニブ耐性白血病の処置 Download PDFInfo
- Publication number
- JP5888853B2 JP5888853B2 JP2010510505A JP2010510505A JP5888853B2 JP 5888853 B2 JP5888853 B2 JP 5888853B2 JP 2010510505 A JP2010510505 A JP 2010510505A JP 2010510505 A JP2010510505 A JP 2010510505A JP 5888853 B2 JP5888853 B2 JP 5888853B2
- Authority
- JP
- Japan
- Prior art keywords
- imatinib
- methoxy
- leukemia
- bcrabl
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Quinoline Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93265007P | 2007-06-01 | 2007-06-01 | |
| US60/932,650 | 2007-06-01 | ||
| PCT/US2008/065215 WO2008150957A2 (en) | 2007-06-01 | 2008-05-30 | Treatment of imatinib resistant leukemia using 4-aminoquinoline-3-carbonitriles |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014016309A Division JP2014111629A (ja) | 2007-06-01 | 2014-01-31 | ４−アミノキノリン−３−カルボニトリルを使用するイマチニブ耐性白血病の処置 |
| JP2015229117A Division JP2016074700A (ja) | 2007-06-01 | 2015-11-24 | ４−アミノキノリン−３−カルボニトリルを使用するイマチニブ耐性白血病の処置 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010529038A JP2010529038A (ja) | 2010-08-26 |
| JP2010529038A5 JP2010529038A5 (https=) | 2016-01-14 |
| JP5888853B2 true JP5888853B2 (ja) | 2016-03-22 |
Family
ID=39639071
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010510505A Active JP5888853B2 (ja) | 2007-06-01 | 2008-05-30 | ４−アミノキノリン−３−カルボニトリルを使用するイマチニブ耐性白血病の処置 |
| JP2014016309A Pending JP2014111629A (ja) | 2007-06-01 | 2014-01-31 | ４−アミノキノリン−３−カルボニトリルを使用するイマチニブ耐性白血病の処置 |
| JP2015229117A Pending JP2016074700A (ja) | 2007-06-01 | 2015-11-24 | ４−アミノキノリン−３−カルボニトリルを使用するイマチニブ耐性白血病の処置 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014016309A Pending JP2014111629A (ja) | 2007-06-01 | 2014-01-31 | ４−アミノキノリン−３−カルボニトリルを使用するイマチニブ耐性白血病の処置 |
| JP2015229117A Pending JP2016074700A (ja) | 2007-06-01 | 2015-11-24 | ４−アミノキノリン−３−カルボニトリルを使用するイマチニブ耐性白血病の処置 |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US11103497B2 (https=) |
| EP (4) | EP2152267A2 (https=) |
| JP (3) | JP5888853B2 (https=) |
| KR (1) | KR101493543B1 (https=) |
| CN (1) | CN101686973B (https=) |
| AU (1) | AU2008260070B9 (https=) |
| BR (1) | BRPI0812355A2 (https=) |
| CA (3) | CA2964162C (https=) |
| CL (1) | CL2008001577A1 (https=) |
| CY (2) | CY1115251T1 (https=) |
| DK (2) | DK2478905T3 (https=) |
| ES (2) | ES2881391T3 (https=) |
| HU (1) | HUE055524T2 (https=) |
| IL (1) | IL202407A0 (https=) |
| MX (1) | MX2009013069A (https=) |
| PA (1) | PA8782301A1 (https=) |
| PL (2) | PL2478905T3 (https=) |
| PT (2) | PT2478905E (https=) |
| RU (1) | RU2464026C2 (https=) |
| SI (2) | SI2478905T1 (https=) |
| TW (1) | TW200908982A (https=) |
| WO (1) | WO2008150957A2 (https=) |
| ZA (1) | ZA200908480B (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016074700A (ja) * | 2007-06-01 | 2016-05-12 | ワイス・エルエルシー | ４−アミノキノリン−３−カルボニトリルを使用するイマチニブ耐性白血病の処置 |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG192769A1 (en) | 2011-03-04 | 2013-09-30 | Glaxosmithkline Ip No 2 Ltd | Amino-quinolines as kinase inhibitors |
| TWI547494B (zh) | 2011-08-18 | 2016-09-01 | 葛蘭素史克智慧財產發展有限公司 | 作為激酶抑制劑之胺基喹唑啉類 |
| AR092529A1 (es) | 2012-09-13 | 2015-04-22 | Glaxosmithkline Llc | Compuesto de aminoquinazolina, composicion farmaceutica que lo comprende y uso de dicho compuesto para la preparacion de un medicamento |
| AR092530A1 (es) | 2012-09-13 | 2015-04-22 | Glaxosmithkline Llc | Compuesto de amino-quinolina, composicion farmaceutica que lo comprende y uso de dicho compuesto para la preparacion de un medicamento |
| RU2662810C2 (ru) | 2013-02-21 | 2018-07-31 | Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед | Хиназолины в качестве ингибиторов киназы |
| KR101733665B1 (ko) | 2015-05-06 | 2017-05-10 | 재단법인 지능형 바이오 시스템 설계 및 합성 연구단 | 진세노사이드 Ｆ1 또는 Ｒｇ3을 유효성분으로 포함하는 글리벡 내성 백혈병 예방 또는 치료용 약학 조성물 |
| JP2022544700A (ja) * | 2019-08-22 | 2022-10-20 | バイオヘイブン・セラピューティクス・リミテッド | 筋萎縮性側索硬化症および関連障害の治療のためにｔｄｐ－４３に結合する分子 |
| CN115944636A (zh) * | 2022-11-01 | 2023-04-11 | 华南师范大学 | 博舒替尼在抑制i-motif结构上的应用 |
| WO2025024311A2 (en) * | 2023-07-21 | 2025-01-30 | Icahn School Of Medicine At Mount Sinai | G9a/glp inhibitors and methods of use |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6002008A (en) | 1997-04-03 | 1999-12-14 | American Cyanamid Company | Substituted 3-cyano quinolines |
| US6297258B1 (en) | 1998-09-29 | 2001-10-02 | American Cyanamid Company | Substituted 3-cyanoquinolines |
| AU2002245296B2 (en) * | 2001-01-25 | 2006-12-21 | Bristol-Myers Squibb Company | Methods of administering epothilone analogs for the treatment of cancer |
| PT2017335E (pt) | 2001-10-05 | 2011-03-02 | Novartis Ag | Domínios da cinase abl mutados |
| TWI275390B (en) * | 2002-04-30 | 2007-03-11 | Wyeth Corp | Process for the preparation of 7-substituted-3- quinolinecarbonitriles |
| US20050010780A1 (en) * | 2003-07-09 | 2005-01-13 | Kane John Richard | Method and apparatus for providing access to personal information |
| EP1680119A1 (en) * | 2003-11-06 | 2006-07-19 | Wyeth | 4-anilino-3-quinolinecarbonitriles for the treatment of chronic myelogenous leukemia (cml) |
| NL1031674C2 (nl) | 2005-04-25 | 2007-04-26 | Pfizer | Antilichamen tegen myostatine. |
| DE602006014540D1 (en) * | 2005-05-16 | 2010-07-08 | Irm Llc | Pyrrolopyridinderivate als proteinkinaseinhibitoren |
| EP1904654A2 (en) | 2005-07-15 | 2008-04-02 | Brystol-Myers Squibb Company | Methods of identifying and treating individuals exhibiting mutant src kinase polypeptides |
| BRPI0616923A2 (pt) | 2005-10-06 | 2011-07-05 | Lilly Co Eli | anticorpos monoclonais, seus usos e composição farmacêutica |
| EP1948820A2 (en) * | 2005-11-04 | 2008-07-30 | Bristol-Myers Squibb Pharma Company | T315a and f317i mutations of bcr-abl kinase domain |
| CA2964162C (en) | 2007-06-01 | 2019-12-31 | Wyeth Llc | Treatment of imatinib resistant leukemia using 4-aminoquinoline-3-carbonitriles having mutation in the bcrabl gene |
-
2008
- 2008-05-30 CA CA2964162A patent/CA2964162C/en active Active
- 2008-05-30 SI SI200831212T patent/SI2478905T1/sl unknown
- 2008-05-30 WO PCT/US2008/065215 patent/WO2008150957A2/en not_active Ceased
- 2008-05-30 EP EP08769857A patent/EP2152267A2/en not_active Withdrawn
- 2008-05-30 MX MX2009013069A patent/MX2009013069A/es active IP Right Grant
- 2008-05-30 TW TW097120369A patent/TW200908982A/zh unknown
- 2008-05-30 PT PT121606388T patent/PT2478905E/pt unknown
- 2008-05-30 HU HUE15191756A patent/HUE055524T2/hu unknown
- 2008-05-30 PT PT151917564T patent/PT3002009T/pt unknown
- 2008-05-30 PL PL12160638T patent/PL2478905T3/pl unknown
- 2008-05-30 CN CN2008800219346A patent/CN101686973B/zh active Active
- 2008-05-30 EP EP15191756.4A patent/EP3002009B1/en active Active
- 2008-05-30 RU RU2009144128/15A patent/RU2464026C2/ru active
- 2008-05-30 ES ES15191756T patent/ES2881391T3/es active Active
- 2008-05-30 EP EP12160638.8A patent/EP2478905B1/en active Active
- 2008-05-30 PA PA20088782301A patent/PA8782301A1/es unknown
- 2008-05-30 SI SI200832178T patent/SI3002009T1/sl unknown
- 2008-05-30 CA CA2868899A patent/CA2868899C/en active Active
- 2008-05-30 KR KR1020097027540A patent/KR101493543B1/ko active Active
- 2008-05-30 DK DK12160638.8T patent/DK2478905T3/da active
- 2008-05-30 CL CL200801577A patent/CL2008001577A1/es unknown
- 2008-05-30 AU AU2008260070A patent/AU2008260070B9/en active Active
- 2008-05-30 ES ES12160638.8T patent/ES2477567T3/es active Active
- 2008-05-30 EP EP14167958.9A patent/EP2777704A3/en not_active Withdrawn
- 2008-05-30 BR BRPI0812355-1A2A patent/BRPI0812355A2/pt not_active Application Discontinuation
- 2008-05-30 US US12/129,935 patent/US11103497B2/en active Active
- 2008-05-30 DK DK15191756.4T patent/DK3002009T3/da active
- 2008-05-30 JP JP2010510505A patent/JP5888853B2/ja active Active
- 2008-05-30 PL PL15191756T patent/PL3002009T3/pl unknown
- 2008-05-30 CA CA2688467A patent/CA2688467C/en active Active
-
2009
- 2009-11-29 IL IL202407A patent/IL202407A0/en unknown
- 2009-11-30 ZA ZA200908480A patent/ZA200908480B/xx unknown
-
2014
- 2014-01-31 JP JP2014016309A patent/JP2014111629A/ja active Pending
- 2014-06-03 CY CY20141100395T patent/CY1115251T1/el unknown
-
2015
- 2015-11-24 JP JP2015229117A patent/JP2016074700A/ja active Pending
-
2021
- 2021-08-03 CY CY20211100693T patent/CY1124391T1/el unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016074700A (ja) * | 2007-06-01 | 2016-05-12 | ワイス・エルエルシー | ４−アミノキノリン−３−カルボニトリルを使用するイマチニブ耐性白血病の処置 |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5888853B2 (ja) | ４−アミノキノリン−３−カルボニトリルを使用するイマチニブ耐性白血病の処置 | |
| US7919625B2 (en) | 4-anilino-3-quinolinecarbonitriles for the treatment of chronic myelogenous leukemia (CML) | |
| CN119733053A (zh) | Kras g12c抑制剂与米托蒽醌的药物组合及其用途 | |
| CN112426424A (zh) | 一种egfr/her2受体酪氨酸激酶抑制剂在制备治疗her2突变癌症药物中的用途 | |
| JP7640033B2 (ja) | ピリド［１，２－ａ］ピリミジノン類似体の使用 | |
| TWI872311B (zh) | 一種吡啶并[1,2-a]嘧啶酮類似物的應用 | |
| HK1142812B (en) | Treatment of imatinib resistant leukemia using 4-aminoquinoline-3-carbonitriles | |
| WO2005047259A1 (en) | 4-anilino-3-quinolinecarbonitriles for the treatment of chronic myelogenous leukemia (cml) | |
| WO2008060283A1 (en) | 4-anilino-3-quinolinecarbonitriles for the treatment of acute myelogenous leukemia (aml) | |
| JPH10236953A (ja) | ｐ２１誘導剤 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RD03 | Notification of appointment of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7423 Effective date: 20110124 |
|
| RD04 | Notification of resignation of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7424 Effective date: 20110202 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20110525 |
|
| RD04 | Notification of resignation of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7424 Effective date: 20121121 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20130409 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20130708 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20130716 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20130808 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20131001 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20140131 |
|
| A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20140325 |
|
| A912 | Re-examination (zenchi) completed and case transferred to appeal board |
Free format text: JAPANESE INTERMEDIATE CODE: A912 Effective date: 20140418 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20141216 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20141219 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20150121 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20150223 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20150819 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20151124 |
|
| A524 | Written submission of copy of amendment under article 19 pct |
Free format text: JAPANESE INTERMEDIATE CODE: A524 Effective date: 20151124 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20160216 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 5888853 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |