JP5887275B2 - アコースティックフローサイトメトリーのための装置、システム、方法、およびコンピュータ読み取り可能な媒体 - Google Patents

アコースティックフローサイトメトリーのための装置、システム、方法、およびコンピュータ読み取り可能な媒体 Download PDF

Info

Publication number
JP5887275B2
JP5887275B2 JP2012542118A JP2012542118A JP5887275B2 JP 5887275 B2 JP5887275 B2 JP 5887275B2 JP 2012542118 A JP2012542118 A JP 2012542118A JP 2012542118 A JP2012542118 A JP 2012542118A JP 5887275 B2 JP5887275 B2 JP 5887275B2
Authority
JP
Japan
Prior art keywords
sample
particles
fluid
flow
acoustically
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2012542118A
Other languages
English (en)
Japanese (ja)
Other versions
JP2013513109A5 (https=
JP2013513109A (ja
Inventor
グレゴリー カデュチャック
グレゴリー カデュチャック
マイケル デニス ワード
マイケル デニス ワード
ジョリーン アン ブラッドフォード
ジョリーン アン ブラッドフォード
アンドリュー トーマス ジョージ パーカー
アンドリュー トーマス ジョージ パーカー
Original Assignee
ライフ テクノロジーズ コーポレーション
ライフ テクノロジーズ コーポレーション
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ライフ テクノロジーズ コーポレーション, ライフ テクノロジーズ コーポレーション filed Critical ライフ テクノロジーズ コーポレーション
Publication of JP2013513109A publication Critical patent/JP2013513109A/ja
Publication of JP2013513109A5 publication Critical patent/JP2013513109A5/ja
Application granted granted Critical
Publication of JP5887275B2 publication Critical patent/JP5887275B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/41—Refractivity; Phase-affecting properties, e.g. optical path length
    • G01N21/45—Refractivity; Phase-affecting properties, e.g. optical path length using interferometric methods; using Schlieren methods
    • G01N21/453—Holographic interferometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404—Handling flow, e.g. hydrodynamic focusing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404—Handling flow, e.g. hydrodynamic focusing
    • G01N2015/142—Acoustic or ultrasonic focussing

Landscapes

  • Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Dispersion Chemistry (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
JP2012542118A 2009-12-04 2010-11-29 アコースティックフローサイトメトリーのための装置、システム、方法、およびコンピュータ読み取り可能な媒体 Active JP5887275B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US26690709P 2009-12-04 2009-12-04
US61/266,907 2009-12-04
US30393810P 2010-02-12 2010-02-12
US61/303,938 2010-02-12
US35931010P 2010-06-28 2010-06-28
US61/359,310 2010-06-28
PCT/US2010/058242 WO2011068764A2 (en) 2009-12-04 2010-11-29 Apparatuses, systems, methods, and computer readable media for acoustic flow cytometry

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016025611A Division JP6336496B2 (ja) 2009-12-04 2016-02-15 アコースティックフローサイトメトリーのための装置、システム、方法、およびコンピュータ読み取り可能な媒体

Publications (3)

Publication Number Publication Date
JP2013513109A JP2013513109A (ja) 2013-04-18
JP2013513109A5 JP2013513109A5 (https=) 2015-01-29
JP5887275B2 true JP5887275B2 (ja) 2016-03-16

Family

ID=44081725

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2012542118A Active JP5887275B2 (ja) 2009-12-04 2010-11-29 アコースティックフローサイトメトリーのための装置、システム、方法、およびコンピュータ読み取り可能な媒体
JP2016025611A Active JP6336496B2 (ja) 2009-12-04 2016-02-15 アコースティックフローサイトメトリーのための装置、システム、方法、およびコンピュータ読み取り可能な媒体

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2016025611A Active JP6336496B2 (ja) 2009-12-04 2016-02-15 アコースティックフローサイトメトリーのための装置、システム、方法、およびコンピュータ読み取り可能な媒体

Country Status (6)

Country Link
US (2) US20110134426A1 (https=)
EP (1) EP2507639B1 (https=)
JP (2) JP5887275B2 (https=)
CN (2) CN102762990B (https=)
AU (1) AU2010326180B2 (https=)
WO (1) WO2011068764A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016128832A (ja) * 2009-12-04 2016-07-14 ライフ テクノロジーズ コーポレーション アコースティックフローサイトメトリーのための装置、システム、方法、およびコンピュータ読み取り可能な媒体

Families Citing this family (99)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7340957B2 (en) * 2004-07-29 2008-03-11 Los Alamos National Security, Llc Ultrasonic analyte concentration and application in flow cytometry
US7835000B2 (en) 2006-11-03 2010-11-16 Los Alamos National Security, Llc System and method for measuring particles in a sample stream of a flow cytometer or the like
ATE538377T1 (de) 2007-04-02 2012-01-15 Acoustic Cytometry Systems Inc Verfahren zur verbesserten analyse von in einem akustischen feld fokussierten zellen und partikeln
US8083068B2 (en) 2007-04-09 2011-12-27 Los Alamos National Security, Llc Apparatus for separating particles utilizing engineered acoustic contrast capture particles
US7837040B2 (en) 2007-04-09 2010-11-23 Los Alamos National Security, Llc Acoustic concentration of particles in fluid flow
US8528406B2 (en) * 2007-10-24 2013-09-10 Los Alamos National Security, LLP Method for non-contact particle manipulation and control of particle spacing along an axis
US8263407B2 (en) * 2007-10-24 2012-09-11 Los Alamos National Security, Llc Method for non-contact particle manipulation and control of particle spacing along an axis
US9144383B2 (en) 2007-12-13 2015-09-29 The Board Of Trustees Of The University Of Arkansas Device and method for in vivo noninvasive magnetic manipulation of circulating objects in bioflows
US20090156932A1 (en) 2007-12-13 2009-06-18 Board Of Trustees Of The University Of Arkansas Device and method for in vivo flow cytometry using the detection of photoacoustic waves
US9451884B2 (en) 2007-12-13 2016-09-27 Board Of Trustees Of The University Of Arkansas Device and method for in vivo detection of clots within circulatory vessels
US8266950B2 (en) * 2007-12-19 2012-09-18 Los Alamos National Security, LLP Particle analysis in an acoustic cytometer
US8714014B2 (en) * 2008-01-16 2014-05-06 Life Technologies Corporation System and method for acoustic focusing hardware and implementations
US8658734B2 (en) * 2009-05-11 2014-02-25 Stc.Unm Synthesis of stable elastomeric negative acoustic contrast particles
JP5437148B2 (ja) * 2010-04-23 2014-03-12 ベイバイオサイエンス株式会社 フローサイトメータおよびセルソータ
RU2587328C2 (ru) * 2010-05-05 2016-06-20 БЕКМАН КАУЛТЕР БАЙОМЕДИКАЛ, ЭлЭлСи Диагностическая система и компоненты
WO2012098287A1 (en) * 2011-01-19 2012-07-26 Teknologian Tutkimuskeskus Vtt Method and system for determining particle size information
USD698038S1 (en) 2011-03-03 2014-01-21 Life Technologies Corporation Plate loader
JP5973471B2 (ja) 2011-03-03 2016-08-23 ライフ テクノロジーズ コーポレーション サンプリングプローブ、システム、装置、および方法
WO2013003498A2 (en) * 2011-06-27 2013-01-03 Life Technologies Corporation Acoustic cytometry methods and protocols
EP2594334A1 (en) 2011-11-21 2013-05-22 Drive O2 Sample vial for digital holographic analysis of a liquid cell sample
CA2842377C (en) 2011-07-19 2019-08-27 Ovizio Imaging Systems N.V. A method and system for detecting and/or classifying cancerous cells in a cell sample
US9656263B2 (en) 2011-09-28 2017-05-23 Acousort Ab System and method to separate cells and/or particles
EP2626686A1 (en) * 2012-02-13 2013-08-14 Ovizio Imaging Systems NV/SA Flow cytometer with digital holographic microscope
US10704021B2 (en) 2012-03-15 2020-07-07 Flodesign Sonics, Inc. Acoustic perfusion devices
US9950282B2 (en) 2012-03-15 2018-04-24 Flodesign Sonics, Inc. Electronic configuration and control for acoustic standing wave generation
US10967298B2 (en) 2012-03-15 2021-04-06 Flodesign Sonics, Inc. Driver and control for variable impedence load
US9458450B2 (en) 2012-03-15 2016-10-04 Flodesign Sonics, Inc. Acoustophoretic separation technology using multi-dimensional standing waves
JP6110484B2 (ja) * 2012-06-21 2017-04-05 エスティーシー． ユーエヌエムＳｔｃ．Ｕｎｍ ラインフォーカシング式光源で励起した多数のサンプル流れからの空間相関集光
EP2898310B1 (en) 2012-09-20 2019-05-01 Ovizio Imaging Systems NV/SA Digital holographic microscope with fluid systems
WO2014052449A1 (en) 2012-09-25 2014-04-03 The Board Of Trustees Of The University Of Arkansas Device and method for in vivo photoacoustic diagnosis and photothermal purging of infected blood
CN105008895B (zh) * 2012-10-15 2019-02-15 纳诺赛莱克特生物医药股份有限公司 颗粒分选的系统、设备和方法
US9757726B2 (en) 2013-03-14 2017-09-12 Inguran, Llc System for high throughput sperm sorting
US10371622B2 (en) 2013-03-14 2019-08-06 Inguran, Llc Device for high throughput sperm sorting
US10662408B2 (en) 2013-03-14 2020-05-26 Inguran, Llc Methods for high throughput sperm sorting
CA3005826C (en) 2013-04-15 2021-11-23 Becton, Dickinson And Company Biological fluid collection device and biological fluid separation and testing system
EP2986383B1 (en) * 2013-04-15 2020-08-26 Becton, Dickinson and Company Biological fluid separation device and biological fluid separation and testing system
US9645080B2 (en) * 2013-04-16 2017-05-09 University Of Washington Systems, devices, and methods for separating, concentrating, and/or differentiating between cells from a cell sample
WO2014191003A1 (en) 2013-05-28 2014-12-04 Chemometec A/S Image forming cytometer
US10126220B2 (en) * 2013-07-22 2018-11-13 National Oilwell Varco, L.P. Systems and methods for determining specific gravity and minerological properties of a particle
US9535000B2 (en) * 2013-09-05 2017-01-03 Bio-Rad Laboratories, Inc. On-demand particle dispensing system
US9920313B2 (en) * 2013-10-21 2018-03-20 Biomet Biologics, Llc Cell washing device using a wave
WO2015105955A1 (en) 2014-01-08 2015-07-16 Flodesign Sonics, Inc. Acoustophoresis device with dual acoustophoretic chamber
US9377400B2 (en) 2014-03-31 2016-06-28 Redshift Systems Corporation Motion modulation fluidic analyzer system
JP6104475B2 (ja) 2014-08-28 2017-04-05 シスメックス株式会社 粒子撮像装置および粒子撮像方法
CN106796169B (zh) * 2014-10-01 2021-01-15 水光科技私人有限公司 探测流体中颗粒的传感器
EP3209402B1 (en) 2014-10-24 2019-11-20 Life Technologies Corporation Acoustically settled liquid-liquid sample purification system
JP6646298B2 (ja) * 2014-12-16 2020-02-14 国立大学法人 東京大学 ロープ状構造体の製造方法
WO2016100954A1 (en) * 2014-12-19 2016-06-23 Captl Llc Flow cytometry using hydrodynamically planar flow
EP3240472B1 (en) 2014-12-31 2023-07-26 Bioventures, LLC. Devices and methods for fractionated photoacoustic flow cytometry
EP4406654A3 (en) * 2015-01-12 2024-10-23 Instrumentation Laboratory Company Spatial separation of particles in a particle containing solution for biomedical sensing and detection
US11708572B2 (en) 2015-04-29 2023-07-25 Flodesign Sonics, Inc. Acoustic cell separation techniques and processes
US11021699B2 (en) 2015-04-29 2021-06-01 FioDesign Sonics, Inc. Separation using angled acoustic waves
US11377651B2 (en) 2016-10-19 2022-07-05 Flodesign Sonics, Inc. Cell therapy processes utilizing acoustophoresis
KR102341153B1 (ko) * 2015-05-13 2021-12-17 가부시키가이샤 에아렉크스 파티클 제어 방법
JP6713730B2 (ja) * 2015-05-20 2020-06-24 シスメックス株式会社 細胞検出装置および細胞検出方法
US10036698B2 (en) 2015-06-19 2018-07-31 Captl Llc Time-sequential cytometry
US11459540B2 (en) 2015-07-28 2022-10-04 Flodesign Sonics, Inc. Expanded bed affinity selection
US11474085B2 (en) 2015-07-28 2022-10-18 Flodesign Sonics, Inc. Expanded bed affinity selection
WO2017054839A1 (en) * 2015-09-28 2017-04-06 Siemens Healthcare Gmbh A technique for aligning a non-spherical biological entity in a flow cell
US10648900B2 (en) * 2015-12-23 2020-05-12 Becton, Dickinson And Company Multi-color flow cytometric analysis of samples with low cell numbers
HUE061715T2 (hu) * 2015-12-23 2023-08-28 Siemens Healthcare Gmbh Áramlási cella részecskék elemzéséhez egy vizsgálni kívánt folyadékban, eljárás és alkalmazás
EP3196631A1 (en) 2016-01-19 2017-07-26 Ovizio Imaging Systems NV/SA Digital holographic microscope with electro-fluidic system, said electro-fluidic system and methods of use
US11085035B2 (en) 2016-05-03 2021-08-10 Flodesign Sonics, Inc. Therapeutic cell washing, concentration, and separation utilizing acoustophoresis
US11214789B2 (en) 2016-05-03 2022-01-04 Flodesign Sonics, Inc. Concentration and washing of particles with acoustics
FR3051556A1 (fr) * 2016-05-18 2017-11-24 Biocytex Utilisation de marqueurs fluorescents pour la detection de cible biologique dans un echantillon
SG11201811220UA (en) * 2016-07-01 2019-01-30 Life Technologies Corp Methods, systems and devices for concentration of particles
US11207683B2 (en) * 2016-08-02 2021-12-28 Imec Vzw Method and arrangement for focusing objects in a flow
US10994281B2 (en) * 2016-09-30 2021-05-04 Arkray, Inc. Method for separating particles, separation apparatus, and separation system
CA3041517A1 (en) 2016-10-19 2018-04-26 Flodesign Sonics, Inc. Affinity cell extraction by acoustics
EP3541536B1 (en) 2016-11-19 2025-10-22 Cytek Biosciences, Inc. Flow cytometry systems with stepper flow control valve
US10436697B2 (en) 2016-11-19 2019-10-08 Cytek Biosciences, Inc. Flow cytometery system with fluidics control system
CN106556561A (zh) * 2016-11-28 2017-04-05 中国科学院苏州生物医学工程技术研究所 一种流体粒子运动控制装置
CN106872339A (zh) * 2017-01-10 2017-06-20 中国科学院苏州生物医学工程技术研究所 一种粒子排序方法及其装置和用途
US11525765B2 (en) * 2017-02-10 2022-12-13 Tosoh Corporation Particle detection device and particle detection method
EP3602003B1 (en) 2017-03-31 2026-04-22 Life Technologies Corporation Apparatuses, systems and methods for imaging flow cytometry
CN107202773B (zh) * 2017-06-01 2019-07-05 重庆大学 一种利用聚苯乙烯球的细胞周期散射光强模型建立方法
EP4292520A3 (en) 2017-10-16 2024-07-10 Massachusetts Institute of Technology Systems, devices and methods for non-invasive hematological measurements
DE102017126128A1 (de) 2017-11-08 2019-05-09 Endress+Hauser SE+Co. KG System und Verfahren zur ortsaufgelösten Bestimmung von zumindest einer physikalischen oder chemischen Prozessgröße
WO2019118921A1 (en) 2017-12-14 2019-06-20 Flodesign Sonics, Inc. Acoustic transducer drive and controller
CN109946217B (zh) * 2017-12-21 2021-08-24 深圳先进技术研究院 一种声驱动的流式细胞检测装置
WO2019119368A1 (zh) * 2017-12-21 2019-06-27 深圳先进技术研究院 一种声驱动的流式细胞检测装置
CN108120665A (zh) * 2017-12-28 2018-06-05 无锡奥芬光电科技有限公司 单色结构光检查微小颗粒的方法及设备
CN108444897B (zh) * 2018-03-06 2021-04-13 山东大学 基于光片照明与鞘流技术的免标记微流控细胞仪及方法
US11698364B2 (en) 2018-06-27 2023-07-11 University Of Washington Real-time cell-surface marker detection
EP3874254B1 (en) * 2018-10-30 2025-04-30 Becton, Dickinson and Company Particle sorting module with alignment window, systems and methods of use thereof
CN109540771B (zh) * 2018-12-18 2020-12-08 武汉大学 一种精准分选白细胞亚型的声光微流控芯片及其分选方法
US11788965B2 (en) * 2019-02-21 2023-10-17 Arizona Board Of Regents On Behalf Of Arizona State University Folic acid functionalized copper sulfide nanoparticles for the detection of ovarian cancer cells in flow
WO2020212628A1 (es) * 2019-04-18 2020-10-22 Fundació Institut De Ciències Fotòniques Aparato fluídico para interrogación óptica de microorganismos individuales
BR112021021504A2 (pt) * 2019-05-15 2021-12-21 Flodesign Sonics Inc Efeito de orla acústica
EP4529839A3 (en) 2019-07-24 2025-04-16 Massachusetts Institute of Technology Finger inserts for a nailfold imaging device
EP3842149A1 (en) * 2019-12-29 2021-06-30 Applied Cells Inc. Biological entity separation device
EP4157088A4 (en) 2020-05-28 2024-04-24 Leuko Labs, Inc. METHODS FOR DETECTING WHITE BLOOD CELLS AND/OR WHITE BLOOD CELL SUBTYPES FROM NON-INVASIVE CAPILLARY VIDEOS
WO2021247918A1 (en) 2020-06-03 2021-12-09 Kinetic River Corp. Configurable particle analyzer apparatuses and methods
JP7042301B2 (ja) * 2020-06-04 2022-03-25 シスメックス株式会社 細胞検出方法
JP2023553838A (ja) * 2020-11-25 2023-12-26 シリス，インコーポレイテッド 個人化された医薬品及び薬剤の開発で使用される有機マイクロ球状体
EP4086607B1 (en) * 2021-05-07 2024-12-04 Deutsches Elektronen-Synchrotron DESY Device and system for bunching of sample particles
US12584902B2 (en) 2023-12-10 2026-03-24 Instrumentation Laboratory Company Acoustic separation of a test sample
WO2025264676A1 (en) * 2024-06-17 2025-12-26 Lumacyte, Inc. Apparatus, systems, and methods of analyzing biological particles
CN119101655A (zh) * 2024-10-09 2024-12-10 上海交通大学 一种基于单波束聚焦声场三维空间捕获细胞方法

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4284412A (en) * 1979-07-13 1981-08-18 Ortho Diagnostics, Inc. Method and apparatus for automated identification and enumeration of specified blood cell subclasses
US4298836A (en) * 1979-11-23 1981-11-03 Coulter Electronics, Inc. Particle shape determination
JPS61153546A (ja) * 1984-12-26 1986-07-12 Canon Inc 粒子解析装置
JPS61159135A (ja) * 1984-12-31 1986-07-18 Canon Inc 粒子解析装置
JPS62207933A (ja) * 1986-03-08 1987-09-12 Canon Inc 粒子解析装置
US4786165A (en) * 1986-07-10 1988-11-22 Toa Medical Electronics Co., Ltd. Flow cytometry and apparatus therefor
JPH0449573Y2 (https=) * 1987-08-28 1992-11-20
JPH0277636A (ja) * 1988-09-13 1990-03-16 Canon Inc 粒子測定装置
JP3052665B2 (ja) * 1993-01-26 2000-06-19 株式会社日立製作所 フローセル装置
JPH07270301A (ja) * 1994-03-31 1995-10-20 Hitachi Ltd フロー式粒子画像解析方法およびその装置
JP3375203B2 (ja) * 1994-08-08 2003-02-10 シスメックス株式会社 細胞分析装置
JPH08297121A (ja) * 1995-04-26 1996-11-12 Hitachi Ltd 粒子分析装置
JPH09126989A (ja) * 1995-11-07 1997-05-16 Hitachi Ltd フロー式粒子画像解析装置
US5895869A (en) * 1995-11-17 1999-04-20 Mwi, Inc. Method and apparatus for analyzing particulate matter
GB9707096D0 (en) * 1997-04-08 1997-05-28 Smithkline Beecham Plc Novel device
US6074879A (en) * 1997-06-23 2000-06-13 Bayer Corporation Synthetic polymer particles for use as standards and calibrators in flow cytometry
US5880474A (en) * 1997-08-29 1999-03-09 Becton Dickinson And Company Multi-illumination-source flow particle analyzer with inter-location emissions crosstalk cancelation
US5895764A (en) * 1997-11-24 1999-04-20 University Of New Mexico Controlled sheath flow injection cytometry
US6067157A (en) * 1998-10-09 2000-05-23 University Of Washington Dual large angle light scattering detection
US6473171B1 (en) * 1999-01-15 2002-10-29 Coors Brewing Company Biocompatible apparatus for ultrasensitive and rapid detection of contaminants in liquids
US6249341B1 (en) * 1999-01-25 2001-06-19 Amnis Corporation Imaging and analyzing parameters of small moving objects such as cells
US6890487B1 (en) * 1999-09-30 2005-05-10 Science & Technology Corporation ©UNM Flow cytometry for high throughput screening
US6263745B1 (en) * 1999-12-03 2001-07-24 Xy, Inc. Flow cytometer nozzle and flow cytometer sample handling methods
WO2002061112A2 (en) * 2001-01-29 2002-08-08 The University Of Tennessee Research Corporation Methods for detection of incorporation of a nucleotide onto a nucleic acid primer
US6467350B1 (en) * 2001-03-15 2002-10-22 The Regents Of The University Of California Cylindrical acoustic levitator/concentrator
JP2004535572A (ja) * 2001-06-13 2004-11-25 ケニス エフ． ウーヘンハイマー， 自動化流体操作システムおよび方法
US20030110840A1 (en) * 2001-07-24 2003-06-19 Arriaga Edgar A. Systems and methods for detecting a particle
US7201875B2 (en) * 2002-09-27 2007-04-10 Becton Dickinson And Company Fixed mounted sorting cuvette with user replaceable nozzle
US7340957B2 (en) * 2004-07-29 2008-03-11 Los Alamos National Security, Llc Ultrasonic analyte concentration and application in flow cytometry
ATE538377T1 (de) * 2007-04-02 2012-01-15 Acoustic Cytometry Systems Inc Verfahren zur verbesserten analyse von in einem akustischen feld fokussierten zellen und partikeln
US8083068B2 (en) * 2007-04-09 2011-12-27 Los Alamos National Security, Llc Apparatus for separating particles utilizing engineered acoustic contrast capture particles
US7837040B2 (en) * 2007-04-09 2010-11-23 Los Alamos National Security, Llc Acoustic concentration of particles in fluid flow
US8266950B2 (en) * 2007-12-19 2012-09-18 Los Alamos National Security, LLP Particle analysis in an acoustic cytometer
US8714014B2 (en) * 2008-01-16 2014-05-06 Life Technologies Corporation System and method for acoustic focusing hardware and implementations
US20100009333A1 (en) * 2008-07-08 2010-01-14 Beckman Coulter, Inc. Methods for Acoustic Particle Focusing in Biological Sample Analyzers
JP5887275B2 (ja) * 2009-12-04 2016-03-16 ライフ テクノロジーズ コーポレーション アコースティックフローサイトメトリーのための装置、システム、方法、およびコンピュータ読み取り可能な媒体

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016128832A (ja) * 2009-12-04 2016-07-14 ライフ テクノロジーズ コーポレーション アコースティックフローサイトメトリーのための装置、システム、方法、およびコンピュータ読み取り可能な媒体

Also Published As

Publication number Publication date
CN102762990A (zh) 2012-10-31
EP2507639A4 (en) 2017-12-27
US20180067044A1 (en) 2018-03-08
WO2011068764A3 (en) 2011-10-13
JP2013513109A (ja) 2013-04-18
WO2011068764A2 (en) 2011-06-09
EP2507639A2 (en) 2012-10-10
AU2010326180A1 (en) 2012-07-12
CN104330346B (zh) 2017-04-12
AU2010326180B2 (en) 2015-06-18
JP6336496B2 (ja) 2018-06-06
CN104330346A (zh) 2015-02-04
CN102762990B (zh) 2014-10-29
US20110134426A1 (en) 2011-06-09
JP2016128832A (ja) 2016-07-14
EP2507639B1 (en) 2020-04-01

Similar Documents

Publication Publication Date Title
JP6336496B2 (ja) アコースティックフローサイトメトリーのための装置、システム、方法、およびコンピュータ読み取り可能な媒体
JP2013513109A5 (https=)
US12188856B2 (en) Particle analyzing systems and methods using acoustic radiation pressure
JP4782844B2 (ja) 少なくとも２つの細胞集団を区別する方法及び応用
AU2015224429B2 (en) Apparatuses, systems, methods, and computer readable media for acoustic flow cytometry

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20131126

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20131126

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20140702

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20140716

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20141014

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20141021

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20141111

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20141118

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20141204

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20141205

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20150323

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20150603

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20150819

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20160127

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20160215

R150 Certificate of patent or registration of utility model

Ref document number: 5887275

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250