JP5883222B2 - 心的外傷後ストレス障害の治療のためのテトラヒドロキノリン誘導体 - Google Patents

心的外傷後ストレス障害の治療のためのテトラヒドロキノリン誘導体 Download PDF

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Publication number
JP5883222B2
JP5883222B2 JP2010528515A JP2010528515A JP5883222B2 JP 5883222 B2 JP5883222 B2 JP 5883222B2 JP 2010528515 A JP2010528515 A JP 2010528515A JP 2010528515 A JP2010528515 A JP 2010528515A JP 5883222 B2 JP5883222 B2 JP 5883222B2
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phenyl
treatment
compound
formula
pharmaceutically acceptable
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JP2011500550A (ja
JP2011500550A5 (cg-RX-API-DMAC7.html
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ジェンク フランソワ
ジェンク フランソワ
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Actelion Pharmaceuticals Ltd
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Actelion Pharmaceuticals Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2010528515A 2007-10-10 2008-10-09 心的外傷後ストレス障害の治療のためのテトラヒドロキノリン誘導体 Expired - Fee Related JP5883222B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IBPCT/IB2007/054130 2007-10-10
IB2007054130 2007-10-10
PCT/IB2008/054138 WO2009047723A2 (en) 2007-10-10 2008-10-09 Tetrahydroquinoline derivatives for treating post-traumatic stress disorders

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JP2011500550A JP2011500550A (ja) 2011-01-06
JP2011500550A5 JP2011500550A5 (cg-RX-API-DMAC7.html) 2011-10-20
JP5883222B2 true JP5883222B2 (ja) 2016-03-09

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ID=40467356

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JP2010528515A Expired - Fee Related JP5883222B2 (ja) 2007-10-10 2008-10-09 心的外傷後ストレス障害の治療のためのテトラヒドロキノリン誘導体

Country Status (27)

Country Link
US (1) US9532985B2 (cg-RX-API-DMAC7.html)
EP (1) EP2207550B1 (cg-RX-API-DMAC7.html)
JP (1) JP5883222B2 (cg-RX-API-DMAC7.html)
KR (1) KR101733247B1 (cg-RX-API-DMAC7.html)
CN (1) CN101820878B (cg-RX-API-DMAC7.html)
AR (1) AR068768A1 (cg-RX-API-DMAC7.html)
AU (1) AU2008309194B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0818617A2 (cg-RX-API-DMAC7.html)
CA (1) CA2699504C (cg-RX-API-DMAC7.html)
CY (1) CY1114799T1 (cg-RX-API-DMAC7.html)
DK (1) DK2207550T3 (cg-RX-API-DMAC7.html)
EA (1) EA017443B1 (cg-RX-API-DMAC7.html)
ES (1) ES2444418T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20140214T1 (cg-RX-API-DMAC7.html)
IL (1) IL204838A (cg-RX-API-DMAC7.html)
MA (1) MA31800B1 (cg-RX-API-DMAC7.html)
MX (1) MX2010003711A (cg-RX-API-DMAC7.html)
MY (1) MY153044A (cg-RX-API-DMAC7.html)
NZ (1) NZ585086A (cg-RX-API-DMAC7.html)
PE (1) PE20091010A1 (cg-RX-API-DMAC7.html)
PL (1) PL2207550T3 (cg-RX-API-DMAC7.html)
PT (1) PT2207550E (cg-RX-API-DMAC7.html)
SI (1) SI2207550T1 (cg-RX-API-DMAC7.html)
TW (1) TWI428129B (cg-RX-API-DMAC7.html)
UA (1) UA99150C2 (cg-RX-API-DMAC7.html)
WO (1) WO2009047723A2 (cg-RX-API-DMAC7.html)
ZA (1) ZA201003251B (cg-RX-API-DMAC7.html)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007337659A1 (en) 2006-12-22 2008-07-03 Actelion Pharmaceuticals Ltd. 5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine derivatives
EP2307417A2 (en) 2008-06-25 2011-04-13 Actelion Pharmaceuticals Ltd. 5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine compounds
EP2402322A1 (en) 2010-07-02 2012-01-04 Actelion Pharmaceuticals Ltd. 1,2,3,4-tetrahydroisoquinoline derivative and its use as orexin receptor antagonist
JP5744203B2 (ja) 2010-08-24 2015-07-08 アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ オレキシン受容体拮抗薬としてのプロリンスルフォンアミド誘導体
CN103153963B (zh) 2010-09-22 2014-12-24 卫材R&D管理有限公司 环丙烷化合物
CN103201261A (zh) 2010-11-10 2013-07-10 埃科特莱茵药品有限公司 用作为食欲素受体拮抗剂的内酰胺衍生物
WO2012085852A1 (en) 2010-12-22 2012-06-28 Actelion Pharmaceuticals Ltd 3,8-diaza-bicyclo[4.2.0]oct-8-yl amides
US9303023B2 (en) 2011-02-18 2016-04-05 Actelion Pharmaceuticals Ltd. Pyrazole and imidazole derivatives useful as orexin antagonists
WO2012114252A1 (en) 2011-02-21 2012-08-30 Actelion Pharmaceuticals Ltd Novel indole and pyrrolopyridine amides
WO2013050938A1 (en) 2011-10-04 2013-04-11 Actelion Pharmaceuticals Ltd 3,7-diazabicyclo[3.3.1]nonane and 9-oxa-3,7-diazabicyclo[3.3.1]nonane derivatives
MX343837B (es) 2011-11-08 2016-11-24 Actelion Pharmaceuticals Ltd Derivados de 2 - (1,2,3 -triazol - 2 - il) benzamida y 3 - (1,2,3 - triazol - 2 - il) picolinamida.
ES2617863T3 (es) 2012-06-04 2017-06-20 Actelion Pharmaceuticals Ltd. Derivados de bencimidazol-prolina
SG11201502493XA (en) 2012-10-10 2015-04-29 Actelion Pharmaceuticals Ltd Orexin receptor antagonists which are [ortho bi (hetero )aryl]-[2-(meta bi (hetero )aryl)-pyrrolidin-1-yl]-methanone derivatives
CA2902135A1 (en) 2013-03-12 2014-09-18 Actelion Pharmaceuticals Ltd Azetidine amide derivatives as orexin receptor antagonists
UA119151C2 (uk) 2013-12-03 2019-05-10 Ідорсія Фармасьютікалз Лтд КРИСТАЛІЧНА СОЛЬОВА ФОРМА (S)-(2-(6-ХЛОР-7-МЕТИЛ-1H-БЕНЗО[d]ІМІДАЗОЛ-2-ІЛ)-2-МЕТИЛПІРОЛІДИН-1-ІЛ)(5-МЕТОКСИ-2-(2H-1,2,3-ТРИАЗОЛ-2-ІЛ)ФЕНІЛ)МЕТАНОНУ ЯК АНТАГОНІСТ ОРЕКСИНОВОГО РЕЦЕПТОРА
EA030137B1 (ru) 2013-12-03 2018-06-29 Идорсиа Фармасьютиклз Лтд Кристаллическая форма (s)-(2-(6-хлор-7-метил-1н-бензо[d]имидазол-2-ил)-2-метилпирролидин-1-ил)(5-метокси-2-(2h-1,2,3-триазол-2-ил)фенил)метанона и ее применение в качестве антагонистов орексинового рецептора
ES2696708T3 (es) 2013-12-04 2019-01-17 Idorsia Pharmaceuticals Ltd Uso de derivados de bencimidazol-prolina
RU2703297C2 (ru) 2014-10-23 2019-10-16 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Композиции и способы для лечения бессонницы
CN115710250A (zh) * 2017-08-01 2023-02-24 博健制药有限责任公司 一种食欲素受体拮抗剂的晶型及其制备方法和用途
WO2020007964A1 (en) 2018-07-05 2020-01-09 Idorsia Pharmaceuticals Ltd 2-(2-azabicyclo[3.1.0]hexan-1-yl)-1h-benzimidazole derivatives
WO2020007977A1 (en) 2018-07-06 2020-01-09 Idorsia Pharmaceuticals Ltd 7-trifluoromethyl-[1,4]diazepan derivatives
WO2020099511A1 (en) 2018-11-14 2020-05-22 Idorsia Pharmaceuticals Ltd Benzimidazole-2-methyl-morpholine derivatives
WO2023218023A1 (en) 2022-05-13 2023-11-16 Idorsia Pharmaceuticals Ltd Thiazoloaryl-methyl substituted cyclic hydrazine-n-carboxamide derivatives

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100393703C (zh) * 2000-03-14 2008-06-11 埃科特莱茵药品有限公司 1,2,3,4-四氢异喹啉的衍生物
JP4637089B2 (ja) * 2003-03-26 2011-02-23 アクテリオン ファーマシューティカルズ リミテッド アセトアミド誘導体
HRP20150371T1 (hr) * 2004-03-01 2015-05-08 Actelion Pharmaceuticals Ltd. Supstituirani derivati 1,2,3,4-tetrahidroizokinolina
US7501395B2 (en) * 2005-04-25 2009-03-10 Eisai R & D Management Co., Ltd. Method of screening for antianxiety drugs
JP4582722B2 (ja) 2006-03-15 2010-11-17 アクテリオン ファーマシューティカルズ リミテッド 記憶機能を向上させるテトラヒドロイソキノリン誘導体
EP2402322A1 (en) 2010-07-02 2012-01-04 Actelion Pharmaceuticals Ltd. 1,2,3,4-tetrahydroisoquinoline derivative and its use as orexin receptor antagonist

Also Published As

Publication number Publication date
TW200932231A (en) 2009-08-01
MX2010003711A (es) 2010-04-30
TWI428129B (zh) 2014-03-01
EA201000557A1 (ru) 2010-10-29
JP2011500550A (ja) 2011-01-06
ZA201003251B (en) 2011-07-27
US9532985B2 (en) 2017-01-03
ES2444418T3 (es) 2014-02-25
PL2207550T3 (pl) 2014-05-30
WO2009047723A2 (en) 2009-04-16
CN101820878B (zh) 2012-02-01
KR101733247B1 (ko) 2017-05-08
KR20100065203A (ko) 2010-06-15
HK1145440A1 (en) 2011-04-21
PT2207550E (pt) 2014-02-07
MA31800B1 (fr) 2010-10-01
DK2207550T3 (da) 2014-01-27
AU2008309194B2 (en) 2013-10-03
CA2699504A1 (en) 2009-04-16
BRPI0818617A2 (pt) 2015-04-07
HRP20140214T1 (hr) 2014-04-11
WO2009047723A3 (en) 2009-05-28
IL204838A (en) 2014-09-30
UA99150C2 (ru) 2012-07-25
EP2207550B1 (en) 2013-12-11
NZ585086A (en) 2012-03-30
MY153044A (en) 2014-12-31
EP2207550A2 (en) 2010-07-21
SI2207550T1 (sl) 2014-03-31
CN101820878A (zh) 2010-09-01
IL204838A0 (en) 2010-11-30
US20100234420A1 (en) 2010-09-16
AR068768A1 (es) 2009-12-02
CY1114799T1 (el) 2016-12-14
PE20091010A1 (es) 2009-08-08
EA017443B1 (ru) 2012-12-28
AU2008309194A1 (en) 2009-04-16
CA2699504C (en) 2015-11-24

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