JP5872757B2 - ヒト化抗ｂ因子抗体 - Google Patents

ヒト化抗ｂ因子抗体 Download PDF

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Publication number
JP5872757B2
JP5872757B2 JP2009553636A JP2009553636A JP5872757B2 JP 5872757 B2 JP5872757 B2 JP 5872757B2 JP 2009553636 A JP2009553636 A JP 2009553636A JP 2009553636 A JP2009553636 A JP 2009553636A JP 5872757 B2 JP5872757 B2 JP 5872757B2
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Prior art keywords
antibody
seq
antigen
factor
fab
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Expired - Fee Related
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JP2009553636A
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Japanese (ja)
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JP2010521470A5 (https=
JP2010521470A (ja
Inventor
エムレン、ウッドラフ
ホーラーズ、ブイ．マイケル
フリン、ピーター
Original Assignee
アレクシオン ファーマシューティカルズ， インコーポレイテッド
アレクシオン ファーマシューティカルズ， インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Otolaryngology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2009553636A 2007-03-14 2008-03-14 ヒト化抗ｂ因子抗体 Expired - Fee Related JP5872757B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US90681607P 2007-03-14 2007-03-14
US60/906,816 2007-03-14
PCT/US2008/003381 WO2008140653A2 (en) 2007-03-14 2008-03-14 Humaneered anti-factor b antibody

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014080917A Division JP2014133753A (ja) 2007-03-14 2014-04-10 人工ヒト抗ｂ因子抗体

Publications (3)

Publication Number Publication Date
JP2010521470A JP2010521470A (ja) 2010-06-24
JP2010521470A5 JP2010521470A5 (https=) 2011-05-06
JP5872757B2 true JP5872757B2 (ja) 2016-03-01

Family

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Family Applications (2)

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JP2009553636A Expired - Fee Related JP5872757B2 (ja) 2007-03-14 2008-03-14 ヒト化抗ｂ因子抗体
JP2014080917A Pending JP2014133753A (ja) 2007-03-14 2014-04-10 人工ヒト抗ｂ因子抗体

Family Applications After (1)

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JP2014080917A Pending JP2014133753A (ja) 2007-03-14 2014-04-10 人工ヒト抗ｂ因子抗体

Country Status (9)

Country Link
US (3) US7964705B2 (https=)
EP (3) EP2565207A3 (https=)
JP (2) JP5872757B2 (https=)
CN (1) CN101668773B (https=)
AU (1) AU2008251943B2 (https=)
BR (1) BRPI0808227A2 (https=)
CA (1) CA2680344A1 (https=)
ES (1) ES2507542T3 (https=)
WO (1) WO2008140653A2 (https=)

Cited By (1)

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Publication number Priority date Publication date Assignee Title
JP2014133753A (ja) * 2007-03-14 2014-07-24 Alexion Cambridge Corp 人工ヒト抗ｂ因子抗体

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Publication number Priority date Publication date Assignee Title
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AU2008251943A1 (en) 2008-11-20
EP2565207A3 (en) 2013-06-12
EP2236518A3 (en) 2010-12-01
AU2008251943B2 (en) 2013-09-05
EP2118142A2 (en) 2009-11-18
US7964705B2 (en) 2011-06-21
CA2680344A1 (en) 2008-11-20
WO2008140653A2 (en) 2008-11-20
US20110318337A1 (en) 2011-12-29
EP2236518B1 (en) 2014-08-06
WO2008140653A9 (en) 2009-01-08
EP2236518A2 (en) 2010-10-06
US20080299114A1 (en) 2008-12-04
HK1144948A1 (en) 2011-03-18
BRPI0808227A2 (pt) 2014-07-08
CN101668773A (zh) 2010-03-10
US9096677B2 (en) 2015-08-04
WO2008140653A3 (en) 2009-04-02
JP2010521470A (ja) 2010-06-24
ES2507542T3 (es) 2014-10-15
CN101668773B (zh) 2016-08-31
JP2014133753A (ja) 2014-07-24
US20130216529A1 (en) 2013-08-22
EP2565207A2 (en) 2013-03-06

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