JP5872041B2 - 幹細胞由来微小胞を含む神経生成促進用組成物 - Google Patents
幹細胞由来微小胞を含む神経生成促進用組成物 Download PDFInfo
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- JP5872041B2 JP5872041B2 JP2014525931A JP2014525931A JP5872041B2 JP 5872041 B2 JP5872041 B2 JP 5872041B2 JP 2014525931 A JP2014525931 A JP 2014525931A JP 2014525931 A JP2014525931 A JP 2014525931A JP 5872041 B2 JP5872041 B2 JP 5872041B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/44—Vessels; Vascular smooth muscle cells; Endothelial cells; Endothelial progenitor cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/51—Umbilical cord; Umbilical cord blood; Umbilical stem cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0623—Stem cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/069—Vascular Endothelial cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
- C12N2502/1352—Mesenchymal stem cells
- C12N2502/1358—Bone marrow mesenchymal stem cells (BM-MSC)
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Developmental Biology & Embryology (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Virology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Vascular Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Reproductive Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2011-0081147 | 2011-08-16 | ||
| KR20110081147 | 2011-08-16 | ||
| KR1020120088778A KR101405437B1 (ko) | 2011-08-16 | 2012-08-14 | 줄기세포 유래 미세소포를 포함하는 신경 생성 촉진용 조성물 |
| KR10-2012-0088778 | 2012-08-14 | ||
| PCT/KR2012/006478 WO2013025042A2 (ko) | 2011-08-16 | 2012-08-14 | 줄기세포 유래 미세소포를 포함하는 신경 생성 촉진용 조성물 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014524437A JP2014524437A (ja) | 2014-09-22 |
| JP2014524437A5 JP2014524437A5 (https=) | 2015-07-16 |
| JP5872041B2 true JP5872041B2 (ja) | 2016-03-01 |
Family
ID=47897528
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014525931A Active JP5872041B2 (ja) | 2011-08-16 | 2012-08-14 | 幹細胞由来微小胞を含む神経生成促進用組成物 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20150045298A1 (https=) |
| EP (1) | EP2745840B1 (https=) |
| JP (1) | JP5872041B2 (https=) |
| KR (1) | KR101405437B1 (https=) |
| WO (1) | WO2013025042A2 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201302468D0 (en) * | 2013-02-12 | 2013-03-27 | Reneuron Ltd | Stem cell product |
| AU2013249786A1 (en) * | 2012-04-16 | 2014-11-06 | The Regents Of The University Of California | Ocular therapeutics using embryonic stem cell microvesicles |
| KR101540698B1 (ko) * | 2012-10-05 | 2015-07-30 | 사회복지법인 삼성생명공익재단 | 허혈혈청을 포함하는 줄기세포 활성화 촉진용 조성물 및 줄기세포의 활성화 촉진 방법 |
| GB201317887D0 (en) | 2013-10-09 | 2013-11-20 | Reneuron Ltd | Product |
| KR101662405B1 (ko) * | 2013-12-12 | 2016-10-05 | 사회복지법인 삼성생명공익재단 | 줄기세포 유래 엑소좀을 유효성분으로 포함하는 뇌혈관 질환 치료용 약학적 조성물 |
| CN105520911A (zh) * | 2014-09-30 | 2016-04-27 | 重庆润泽医药有限公司 | 一种奥拉西坦脂质微泡及其制备方法 |
| AU2016211671B2 (en) | 2015-01-26 | 2022-05-26 | Fate Therapeutics, Inc. | Methods and compositions for inducing hematopoietic cell differentiation |
| CA3003152A1 (en) | 2015-11-04 | 2017-05-11 | Fate Therapeutics, Inc. | Methods and compositions for inducing hematopoietic cell differentiation |
| EP3423070B1 (en) * | 2016-03-03 | 2022-05-04 | Henry Ford Health System | 3-d collagen scaffold-generated exosomes and uses thereof |
| EP3308795A1 (en) * | 2016-10-12 | 2018-04-18 | Unicyte EV AG | A composition of extracellular vesicles (evs) and medical uses thereof |
| EP3568143B1 (en) * | 2017-01-11 | 2023-12-13 | Paracelsus Medizinische Privatuniversität Salzburg - Privatstiftung | Mesenchymal stem cell-derived extracellular vesicles and their medical use |
| KR102184722B1 (ko) * | 2018-01-31 | 2020-12-01 | 서울대학교산학협력단 | 성체줄기세포 유래의 나노베시클 및 이의 표적 치료용 용도 |
| US20210228643A1 (en) | 2018-07-26 | 2021-07-29 | Uniwersytet Jagiellonski | N vivo delivery system of the genome dna modifying enzymes and the use thereof |
| KR102320800B1 (ko) * | 2018-10-25 | 2021-11-02 | 사회복지법인 삼성생명공익재단 | 효능이 증진된 줄기세포 유래 미세소포, 이의 용도 및 효능강화 방법 |
| US11351119B2 (en) | 2018-10-25 | 2022-06-07 | Samsung Life Public Welfare Foundation | Stem cell-derived microvesicles with enhanced efficacy, use thereof, and method for enhancing efficacy |
| CN114306238A (zh) * | 2020-09-29 | 2022-04-12 | 中山大学 | 囊泡在制备治疗肺部疾病的药物中的应用 |
| WO2023055222A1 (ko) * | 2021-10-01 | 2023-04-06 | 주식회사 입셀 | 유도만능줄기세포 배양 배지 유래 성분을 포함하는 조성물 내지 이의 용도 |
| WO2024090922A1 (ko) * | 2022-10-24 | 2024-05-02 | 주식회사 디자인셀 | 줄기세포 배양액 및 상기로부터 분리된 세포외소포를 유효성분으로 포함하는 뇌신경계 질환의 예방 또는 치료용 약학적 조성물 |
| WO2025182103A1 (ja) * | 2024-02-28 | 2025-09-04 | セルソース株式会社 | 脳梗塞の機能予後改善用組成物 |
| KR20260010585A (ko) * | 2024-07-12 | 2026-01-21 | (주) 테라베스트 | 조혈모세포 또는 자연살해세포 유래의 세포외 소포체 및 이의 용도 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2617428A1 (en) * | 2006-08-15 | 2013-07-24 | Agency for Science, Technology and Research | Mesenchymal stem cell conditioned medium |
| EP2209481B1 (en) | 2007-10-15 | 2013-03-13 | Fresenius Medical Care Deutschland GmbH | Use of microvesicles (mvs) for preparing a medicament having adjuvant activity on endothelial cell transplantation, particularly in the treatment of diabetes by pancreatic islet transplantation, and related method |
| ES2523098T3 (es) * | 2007-10-29 | 2014-11-20 | Fresenius Medical Care Deutschland Gmbh | Microvesícula (MV) derivada de células madre para su uso en la inhibición de la apoptosis inducida por un agente citostático |
| CA2711218C (en) * | 2008-01-04 | 2019-08-06 | Lydac Neuroscience Limited | A method of producing a population of differentiated cells |
| CN102014934B (zh) * | 2008-02-22 | 2014-08-20 | 新加坡科技研究局 | 间充质干细胞颗粒 |
| WO2010070141A2 (en) * | 2008-12-19 | 2010-06-24 | Cellerix, S.A. | Compositions comprising adipose stem cells |
| JP5667180B2 (ja) * | 2009-07-01 | 2015-02-12 | イオン メディックス インコーポレイテッド | 哺乳類の有核細胞に由来するマイクロベシクル及びその用途 |
| SG2014010698A (en) * | 2009-11-02 | 2014-05-29 | Agency Science Tech & Res | Methods of monitoring cellular states |
-
2012
- 2012-08-14 WO PCT/KR2012/006478 patent/WO2013025042A2/ko not_active Ceased
- 2012-08-14 US US14/238,798 patent/US20150045298A1/en not_active Abandoned
- 2012-08-14 EP EP12824443.1A patent/EP2745840B1/en active Active
- 2012-08-14 JP JP2014525931A patent/JP5872041B2/ja active Active
- 2012-08-14 KR KR1020120088778A patent/KR101405437B1/ko active Active
-
2017
- 2017-07-14 US US15/649,842 patent/US10406180B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2013025042A3 (ko) | 2013-06-13 |
| KR101405437B1 (ko) | 2014-06-11 |
| JP2014524437A (ja) | 2014-09-22 |
| US20170368103A1 (en) | 2017-12-28 |
| EP2745840A4 (en) | 2015-04-22 |
| EP2745840A2 (en) | 2014-06-25 |
| EP2745840B1 (en) | 2017-07-12 |
| US10406180B2 (en) | 2019-09-10 |
| US20150045298A1 (en) | 2015-02-12 |
| KR20130019356A (ko) | 2013-02-26 |
| WO2013025042A2 (ko) | 2013-02-21 |
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