JP5872041B2 - 幹細胞由来微小胞を含む神経生成促進用組成物 - Google Patents

幹細胞由来微小胞を含む神経生成促進用組成物 Download PDF

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JP5872041B2
JP5872041B2 JP2014525931A JP2014525931A JP5872041B2 JP 5872041 B2 JP5872041 B2 JP 5872041B2 JP 2014525931 A JP2014525931 A JP 2014525931A JP 2014525931 A JP2014525931 A JP 2014525931A JP 5872041 B2 JP5872041 B2 JP 5872041B2
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stem cells
nerve
cells
stem cell
ischemic
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JP2014524437A5 (https=
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バン，オーヤン
ジューン ムーン，ギィオン
ジューン ムーン，ギィオン
エオン ヒー チョ
エオン ヒー チョ
スク ジェー キム
スク ジェー キム
ドン ヒー キム
ドン ヒー キム
ジン ヒー スン
ジン ヒー スン
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サムスン ライフ パブリック ウェルフェア ファンデーション
サムスン ライフ パブリック ウェルフェア ファンデーション
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    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1352—Mesenchymal stem cells
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JP2014525931A 2011-08-16 2012-08-14 幹細胞由来微小胞を含む神経生成促進用組成物 Active JP5872041B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
KR10-2011-0081147 2011-08-16
KR20110081147 2011-08-16
KR1020120088778A KR101405437B1 (ko) 2011-08-16 2012-08-14 줄기세포 유래 미세소포를 포함하는 신경 생성 촉진용 조성물
PCT/KR2012/006478 WO2013025042A2 (ko) 2011-08-16 2012-08-14 줄기세포 유래 미세소포를 포함하는 신경 생성 촉진용 조성물
KR10-2012-0088778 2012-08-14

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JP2014524437A JP2014524437A (ja) 2014-09-22
JP2014524437A5 JP2014524437A5 (https=) 2015-07-16
JP5872041B2 true JP5872041B2 (ja) 2016-03-01

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US (2) US20150045298A1 (https=)
EP (1) EP2745840B1 (https=)
JP (1) JP5872041B2 (https=)
KR (1) KR101405437B1 (https=)
WO (1) WO2013025042A2 (https=)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201302468D0 (en) * 2013-02-12 2013-03-27 Reneuron Ltd Stem cell product
EP2838995A4 (en) * 2012-04-16 2016-01-06 Univ California EYE THERAPEUTICS WITH MICROVESICLES FROM EMBRYONAL STEM CELLS
US10072247B2 (en) * 2012-10-05 2018-09-11 Samsung Life Public Welfare Foundation Composition comprising ischemic serum for promoting activation of stem cell and method for promoting activation of stem cell
GB201317887D0 (en) 2013-10-09 2013-11-20 Reneuron Ltd Product
US10167448B2 (en) 2013-12-12 2019-01-01 Samsung Life Public Welfare Foundation Pharmaceutical composition for treating cerebrovascular diseases, containing stem cell-derived exosome as active ingredient
CN105520911A (zh) * 2014-09-30 2016-04-27 重庆润泽医药有限公司 一种奥拉西坦脂质微泡及其制备方法
WO2016123100A1 (en) 2015-01-26 2016-08-04 Fate Therapeutics, Inc. Methods and compositions for inducing hematopoietic cell differentiation
SG11201803145RA (en) * 2015-11-04 2018-05-30 Fate Therapeutics Inc Methods and compositions for inducing hematopoietic cell differentiation
WO2017152035A1 (en) * 2016-03-03 2017-09-08 Henry Ford Health System 3-d collagen scaffold-generated exosomes and uses thereof
EP3308795A1 (en) * 2016-10-12 2018-04-18 Unicyte EV AG A composition of extracellular vesicles (evs) and medical uses thereof
EP3568143B1 (en) * 2017-01-11 2023-12-13 Paracelsus Medizinische Privatuniversität Salzburg - Privatstiftung Mesenchymal stem cell-derived extracellular vesicles and their medical use
KR102184722B1 (ko) * 2018-01-31 2020-12-01 서울대학교산학협력단 성체줄기세포 유래의 나노베시클 및 이의 표적 치료용 용도
EP3827076A1 (en) 2018-07-26 2021-06-02 Uniwersytet Jagiellonski In vivo delivery system of the genome dna modifying enzymes and the use thereof
US11351119B2 (en) 2018-10-25 2022-06-07 Samsung Life Public Welfare Foundation Stem cell-derived microvesicles with enhanced efficacy, use thereof, and method for enhancing efficacy
KR102320800B1 (ko) * 2018-10-25 2021-11-02 사회복지법인 삼성생명공익재단 효능이 증진된 줄기세포 유래 미세소포, 이의 용도 및 효능강화 방법
CN114306238A (zh) * 2020-09-29 2022-04-12 中山大学 囊泡在制备治疗肺部疾病的药物中的应用
KR20230047936A (ko) * 2021-10-01 2023-04-10 주식회사 입셀 유도만능줄기세포 배양 배지 유래 성분을 포함하는 조성물 내지 이의 용도
WO2024090922A1 (ko) * 2022-10-24 2024-05-02 주식회사 디자인셀 줄기세포 배양액 및 상기로부터 분리된 세포외소포를 유효성분으로 포함하는 뇌신경계 질환의 예방 또는 치료용 약학적 조성물
WO2025182103A1 (ja) * 2024-02-28 2025-09-04 セルソース株式会社 脳梗塞の機能予後改善用組成物
KR20260010585A (ko) * 2024-07-12 2026-01-21 (주) 테라베스트 조혈모세포 또는 자연살해세포 유래의 세포외 소포체 및 이의 용도

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008020815A1 (en) * 2006-08-15 2008-02-21 Agency For Science, Technology And Research Mesenchymal stem cell conditioned medium
US20100233216A1 (en) 2007-10-15 2010-09-16 Vincenzo Cantaluppi Use of microvesicles (mvs) for preparing a medicament having adjuvant activity on endothelial cell transplantation, particularly in the treatment of diabetes by pancreatic islet transplantation, and related method
CN101854941B (zh) * 2007-10-29 2013-03-27 弗雷森纽斯医疗护理德国有限责任公司 衍生自干细胞的微泡(MVs)用于制备用于受损或损伤组织或器官的内皮/上皮再生的药物的用途、以及相关体外和体内方法
AU2009203638C1 (en) * 2008-01-04 2013-07-25 Lydac Neuroscience Limited Microvesicles
EP2254586B1 (en) * 2008-02-22 2015-04-08 Agency For Science, Technology And Research (A*star) Mesenchymal stem cell particles
EP2376069B1 (en) * 2008-12-19 2019-03-20 Cellerix, S.A. Microparticles comprising adipose stem cells
CN102596177B (zh) * 2009-07-01 2014-05-28 阿昂梅迪克斯公司 来源于有核哺乳动物细胞的微囊泡及其应用
WO2011053257A2 (en) * 2009-11-02 2011-05-05 Agency For Science, Technology And Research (A*Star) Methods of monitoring cellular states

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Publication number Publication date
US20150045298A1 (en) 2015-02-12
EP2745840B1 (en) 2017-07-12
EP2745840A2 (en) 2014-06-25
KR20130019356A (ko) 2013-02-26
US10406180B2 (en) 2019-09-10
US20170368103A1 (en) 2017-12-28
WO2013025042A2 (ko) 2013-02-21
KR101405437B1 (ko) 2014-06-11
JP2014524437A (ja) 2014-09-22
WO2013025042A3 (ko) 2013-06-13
EP2745840A4 (en) 2015-04-22

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