JP5855239B2 - ラクトフェリン融合タンパク質及びその製造方法 - Google Patents

ラクトフェリン融合タンパク質及びその製造方法 Download PDF

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JP5855239B2
JP5855239B2 JP2014512737A JP2014512737A JP5855239B2 JP 5855239 B2 JP5855239 B2 JP 5855239B2 JP 2014512737 A JP2014512737 A JP 2014512737A JP 2014512737 A JP2014512737 A JP 2014512737A JP 5855239 B2 JP5855239 B2 JP 5855239B2
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fusion protein
hlf
lactoferrin
hinge
variant
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JPWO2013162050A1 (ja
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佐藤　淳
佐藤　　淳
伸治 加賀谷
伸治 加賀谷
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NRL Pharma Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/40—Transferrins, e.g. lactoferrins, ovotransferrins
    • A—HUMAN NECESSITIES
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
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    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A01K2217/052—Animals comprising random inserted nucleic acids (transgenic) inducing gain of function
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    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Biophysics (AREA)
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  • Diabetes (AREA)
  • Physics & Mathematics (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
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JP2014512737A 2012-04-23 2013-04-23 ラクトフェリン融合タンパク質及びその製造方法 Active JP5855239B2 (ja)

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JP2012098085 2012-04-23
JP2012098085 2012-04-23
JP2014512737A JP5855239B2 (ja) 2012-04-23 2013-04-23 ラクトフェリン融合タンパク質及びその製造方法
PCT/JP2013/062685 WO2013162050A1 (ja) 2012-04-23 2013-04-23 ラクトフェリン融合タンパク質及びその製造方法

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10562959B2 (en) 2012-04-23 2020-02-18 Nrl Pharma, Inc. Lactoferrin fusion protein and method for preparation thereof
US11041014B2 (en) 2016-10-28 2021-06-22 S & K Biopharma, Inc. Lactoferrin/albumin fusion protein and production method therefor

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EA037256B1 (ru) * 2014-02-24 2021-02-26 Такеда Гмбх Химерный белок мочевого трипсинового ингибитора (мти), содержащий домен мти и fc-домен igg1
EP3291670A1 (en) * 2015-05-04 2018-03-14 Laboratoire Français du Fractionnement et des Biotechnologies Transgenic production of fc fusion proteins
EP3313875A4 (en) 2015-06-24 2018-12-26 Board of Regents of the University of Texas System Methods and compositions for treatment of symptoms associated with intracranial hemorrhage
PT3355913T (pt) * 2015-09-30 2024-12-18 Igm Biosciences Inc Moléculas de ligação com cadeia j modificada
WO2018079701A1 (ja) * 2016-10-28 2018-05-03 株式会社Ｎｒｌファーマ ラクトフェリン活性を有するタンパク質を含む、抗ガン治療補助剤
SI3583120T1 (sl) 2017-02-17 2023-02-28 Denali Therapeutics Inc. Inženirani polipeptidi, ki vezujejo transferinske receptorje
CR20200129A (es) 2017-10-02 2020-08-22 Denali Therapeutics Inc Proteínas de fusión que comprenden enzimas de terapia de reemplazo de enzimas
CN112351791A (zh) * 2018-06-26 2021-02-09 S&K生物制药有限公司 糖胺聚糖抑制剂和促进剂
US20200024329A1 (en) * 2018-07-17 2020-01-23 Bradley G. Thompson Methods for regulating endogenous production of lactoferrin and sub-peptides thereof
CA3165846A1 (en) 2019-12-23 2021-07-01 Denali Therapeutics Inc. Progranulin variants
JP2023551821A (ja) * 2020-11-25 2023-12-13 アヴァイルス，インコーポレイテッド ウイルス感染を治療するための方法及び組成物

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US5723125A (en) 1995-12-28 1998-03-03 Tanox Biosystems, Inc. Hybrid with interferon-alpha and an immunoglobulin Fc linked through a non-immunogenic peptide
US6111081A (en) * 1996-05-31 2000-08-29 Baylor College Of Medicine Lactoferrin variants and uses thereof
US6423509B1 (en) 1998-07-15 2002-07-23 Samyang Genex Corporation Pichia pastoris strain for producing lactoferrin and methods of use
US6660843B1 (en) * 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
EP2294930A3 (en) 2001-02-14 2011-08-03 Ventria Bioscience Expression of human milk proteins in transgenic plants
CA2440221C (en) 2001-03-07 2013-02-05 Merck Patent Gesellschaft Mit Beschraenkter Haftung Expression technology for proteins containing a hybrid isotype antibody moiety
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ES2671631T3 (es) 2018-06-07
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WO2013162050A1 (ja) 2013-10-31
US20150093382A1 (en) 2015-04-02
US10562959B2 (en) 2020-02-18
IN2014DN09815A (enExample) 2015-07-31
BR112014026162A2 (pt) 2017-10-03
CN104245739A (zh) 2014-12-24
US20180072794A1 (en) 2018-03-15
JPWO2013162050A1 (ja) 2015-12-24
JP2016117717A (ja) 2016-06-30
EP2842969A1 (en) 2015-03-04
JP6356115B2 (ja) 2018-07-11
CA2871468A1 (en) 2013-10-31
CA2871468C (en) 2021-09-21
EP2842969A4 (en) 2016-01-13
EP2842969B1 (en) 2018-03-14
US9809641B2 (en) 2017-11-07

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